[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"patient-reported-outcome-measurements\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:patient-reported-outcome-measurements":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100648108","adequacy-of-haemodiafiltration-middle-molecules-clearance-patients-reported-outcomes-and-sodium-balance-100648108",false,"NCT07717255","Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance","Inclusion Criteria:\n\n* Age 18 years or above.\n* Ability to give informed consent.\n* End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.\n* Prognosis \\> 6 months as assessed by principal investigator (PI)","ALL","18 Years",{"count":18,"type":19},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (\\>23Litres (L)) vs Low (\\\u003C23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol\u002FL) on overhydration volume in patients on HD and HDF.",[23,24,25,26,27,28],"Haemodiafiltration","Haemodialysis","Patient Reported Outcome Measurements","Nutrition","Malnutrition (Calorie)","Fluid Balance Outcomes",[30,31,32,33],"Middle molecules clearance in haemodiafiltraion","Effect of dialysis clearance on nutritional status","Effect of dialysis clearance on patient reported outcome measure","Effect of dialysate sodium on fluid status","RECRUITING","2026-07-16",{"date":37,"type":38},"2026-07-21","ACTUAL",{"date":40,"type":38},"2025-01-09",{"date":42,"type":19},"2030-11-01",{"name":44,"class":45},"East and North Hertfordshire NHS Trust","OTHER_GOV",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100629062","multidisciplinary-care-pathway-tailored-on-frailty-in-cancer-patients-referred-to-outpatient-palliative-care-100629062","NCT07469761","MultidISciplinary Care paThway tailoRed on frAilty in Cancer Patients Referred to Outpatient paLliative Care","MISTRAL","Inclusion Criteria:\n\n* diagnosis of advanced\u002Fmetastatic cancer\n* age \\> 18\n* Eastern Cooperative Oncology Group (ECOG) performance status ≥2\n* prognostic clinical prediction \\>1 month.\n\nExclusion Criteria:\n\n* Serious medical or psychiatric illness that can interfere with informed consent and participation in this clinical study\n* any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study.",{"count":55,"type":19},120,"INTERVENTIONAL",[58],"NA","The goal of this clinical trial is to learn whether a structured, Patient-Reported Outcome Measures (PROMs)-tailored palliative care pathway improves clinical outcomes and care experience in adults with advanced cancer referred to outpatient palliative care.\n\nPatients with advanced cancer often experience multiple symptoms and complex needs. Standard outpatient palliative care is usually guided by clinical judgment on patient-reported questionnaires. In this study, researchers aim to test whether a more structured approach, based on predefined cut-offs from PROMs, can improve symptom control, satisfaction with care, and use of healthcare resources. The main questions the study aims to answer are:\n\nDoes a structured, PROM-driven palliative care pathway reduce symptom burden and psychological distress compared with usual care? And through this, to improve patients' and caregivers' satisfaction with care or reduce emergency room visits, hospital admissions, healthcare costs, and aggressive treatments near the end of life?\n\nResearchers will compare two groups:\n\nControl group: Participants will receive standard outpatient palliative care. PROMs are collected as usual, but without predefined cut-offs or structured intervention checklists.\n\nExperimental group: Participants will receive a structured palliative care pathway tailored to symptoms\u002Fneeds identified at baseline using PROM cut-offs. Specific multidisciplinary interventions are activated according to identified needs.",[61,62,63,25,64,65,66],"Palliative Care","Palliative Care, Health Services","Patient Reported Outcome (PRO)","Frailty","Cancer","Outpatient",[68,66,61,69,64,70],"Patient Reported Outcome Measurements (PROMs)","Advanced cancer","Palliative Care intervention","2026-03-09",{"date":73,"type":38},"2026-03-13",{"date":75,"type":38},"2025-11-02",{"date":77,"type":19},"2027-02-28",{"name":79,"class":80},"Augusto Caraceni","OTHER"]