[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pediatric-heart-transplant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pediatric-heart-transplant":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100652159","non-invasive-prediction-of-early-cardiac-rejection-100652159",false,"NCT07770659","Non-invasive Prediction of EArly Cardiac rEjection","Predictive Modeling of Acute Rejection in Pediatric Heart Transplant Recipients","PEACE","Inclusion Criteria:\n\n* Received heart transplant at age \\\u003C 21 years old\n* \\> 2 months from transplant\n* ≥6 years old and ≤ 25 years old and able to undergo cardiac MRI (CMR)\n* CMR can be scheduled within 5 days from heart biopsy\\*\n* Heart catheterization with biopsy is scheduled \"for cause\" to confirm suspected AR or Heart catheterization with biopsy is scheduled for surveillance\n\nExclusion Criteria:\n\n* No endomyocardial biopsy scheduled\n* Other illness or disease process that could potentially lead to myocardial edema or fibrosis\n* Contraindication to CMR with contrast\n* Previously enrolled in this study, UNLESS previous enrollment was heart biopsy scheduled for surveillance with no suspicion of AR AND final study status was documented as \"no AR\" AND current enrollment is heart biopsy is scheduled \"for cause\" to confirm suspected AR\n* Multiple transplanted organs\n* Requires anesthesia for CMR","ALL","6 Years","25 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","Acute rejection remains a major cause of morbidity and mortality in pediatric patients after heart transplant. In order to screen for rejection, most centers perform heart catheterizations with endomyocardial biopsies frequently in the first year post transplant and then every 1-2 years thereafter; these biopsies are associated with complications, can cause significant anxiety in patients and family members, and are a significant cost for the healthcare system. This project will evaluate non-invasive methods of detecting rejection using cardiac magnetic resonance imaging and blood testing with a goal to reduce the required number of cardiac catheterizations.",[26,27,28,29,30],"Heart Transplant","Pediatric Heart Transplant","Rejection","Cardiac MRI","Cell Free DNA",[32,33,34,35,36,37],"Pediatric heart transplant","acute rejection","acute cellular rejection","antibody mediated rejection","cardiac mri","cell free DNA","RECRUITING","2026-08-17",{"date":41,"type":42},"2026-08-20","ACTUAL",{"date":44,"type":42},"2023-03-29",{"date":46,"type":22},"2027-06-30",{"name":48,"class":49},"Vanderbilt University Medical Center","OTHER",22,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100495559","mobile-video-directly-observed-therapy-dot-for-immunosuppression-medication-adherence-in-adolescent-heart-transplant-recipients-100495559","NCT05732779","Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients","Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients: Enhancing Technological Innovation and Strengthening the Role of Small Businesses in Meeting Needs of Adolescent Organ Transplant","Inclusion Criteria:\n\n* Eligible participants are 10-21 years of age\n* Have received a heart transplant and are followed participating pediatric heart transplant centers\n* English-speaking or Spanish-speaking\n* Own a smart-phone or have access to the mobile app through other devices\n* Are willing to receive information through it\n* Have a MLVI score of greater than 2.0 over the last year\n\nExclusion Criteria:\n\n• Those with cognitive impairments will not be eligible for enrollment due to inability to provide informed assent","10 Years","21 Years",{"count":61,"type":22},100,"INTERVENTIONAL",[64],"NA","We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nonadherence remains a primary cause of late acute rejection (LAR) episodes, increased number of hospitalizations, graft failure, and patient mortality. Herein, we propose an innovative approach to promote medication adherence and improve patient and graft outcomes.",[67,68,27,69,70,71,72],"Heart Transplant Rejection","Immune Suppression","Medication Nonadherence","Health Behavior","Remote Monitoring","Patient Engagement","2026-07-15",{"date":75,"type":42},"2026-07-16",{"date":77,"type":42},"2024-10-01",{"date":79,"type":22},"2027-05-01",{"name":81,"class":49},"University of Florida",4,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100577258","non-invasive-detection-of-acute-cell-mediated-graft-rejection-in-pediatric-heart-transplant-recipients-100577258","NCT06795958","Non-invasive Detection of Acute Cell-mediated Graft Rejection in Pediatric Heart Transplant Recipients","Non-invasive Detection of Acute Cell-mediated Graft Rejection in Pediatric Heart Transplant Recipients: the Role of Cardiovascular Magnetic Resonance","Inclusion Criteria:\n\n* children and young adults (transplanted when they were ≤ 18 years) who undergo an EMB for routine surveillance without contraindications to contrast-enhanced CMR\n\nExclusion Criteria:\n\n* We also don't recruit recipients who were \\\u003C 3 months post-heart transplantation to reduce the possibility of confounding from ischemia-reperfusion injury that occurs with the heart transplant procedure","18 Years",{"count":92,"type":22},30,"Acute cardiac rejection is currently diagnosed by endomyocardial biopsy (EMB), but multiparametric cardiac magnetic resonance (CMR) may be a non-invasive alternative by its capacity for myocardial structure and function characterization. Our primary aim was to determine the utility of multiparametric CMR in identifying acute graft rejection in paediatric heart transplant recipients. The second aim was to compare textural features of parametric maps in cases of rejection versus those without rejection.",[27],[96,97,98,99,100],"acute cardiac rejection","paediatric heart transplant","endomyocardial biopsy","multiparametric cardiac","magnetic resonance","2025-01-26",{"date":103,"type":42},"2025-01-28",{"date":105,"type":42},"2023-12-12",{"date":107,"type":22},"2029-12-31",{"name":109,"class":49},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",1]