[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perinatal-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perinatal-brain-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100649867","neuro-mod-neuroplasticity-with-motor-development-100649867",false,"NCT07738432","Neuro-MoD: Neuroplasticity With Motor Development","Harnessing Early Neuroplasticity in Infants With Perinatal Brain Injury: A Study of Combined Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) Paired With Constraint Induced Movement Therapy (CIMT) and Transcranial Magnetic Stimulation (TMS)","Inclusion Criteria:\n\n* Infants aged 8 to 24 months, diagnosed with hemiplegia or with an evident unilateral upper-limb weakness due to perinatal brain injury\n* Gross Motor Function Classification System (GMFCS) level I-IV\n* Infants who have not received previous CIMT in the preceding 3 months\n* Able to make consecutive appointments for assessments and intervention over 2 weeks, and complete the 3-month follow-up.\n\nExclusion Criteria:\n\n* GMFCS level V\n* Prior CIMT within the past 3 months\n* Severe motor impairment\u002Fquadriplegic involvement.\n* Uncontrolled seizure disorders, cardiomyopathy, severe congenital malformations,\n* significant sensory impairments, or conditions preventing safe participation in therapy sessions","ALL","8 Months","24 Months",{"count":20,"type":21},8,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is for infants and toddlers between 8 and 24 months old who use one arm and\u002For hand differently following a perinatal brain injury. This is a time when investigators think they can best help improve how the brain controls movement. Investigators are testing whether the combination of transcutaneous auricular vagus nerve stimulation (taVNS) with 40 hours of constraint-induced movement therapy (CIMT) can help infants move their weaker arm and hand better and make the brain pathways for movement stronger.",[27],"Perinatal Brain Injury",[29,30,31,32,33,34,35,36],"hypoxic-ischemic encephalopathy (HIE)","perinatal stroke","intracranial hemorrhage","hemiplegic cerebral palsy (CP)","Constraint-Induced Movement Therapy (CIMT)","transcutaneous auricular vagus nerve stimulation (taVNS)","motor-evoked potentials (MEPs)","Single Pulse Transcranial Magnetic Stimulation (spTMS)","NOT_YET_RECRUITING","2026-07-27",{"date":40,"type":41},"2026-07-31","ACTUAL",{"date":43,"type":21},"2026-08",{"date":45,"type":21},"2027-06",{"name":47,"class":48},"University of Wisconsin, Madison","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":18,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100622939","sparking-potential-revealing-infant-neurocognitive-traits-100622939","NCT07390136","Sparking Potential, Revealing Infant Neurocognitive Traits","SPRINT: Sparking Potential, Revealing Infant Neurocognitive Traits","SPRINT","Inclusion Criteria:\n\n* Child-parent dyads will be recruited to the study.\n* Children 3-24 months with and without a history of a perinatal brain injury (PBI) will be included in this study.\n* Children with PBIs will include:\n\n  * Children diagnosed during the neonatal period with hypoxic-ischemic encephalopathy,\n  * Children born at a premature gestational age (born at less than 32 weeks gestational age).\n  * Children diagnosed with cerebral palsy\n* Healthy control participants meeting inclusion criteria will include:\n\n  * healthy infants with no prior neurological (brain disorder) history\n* For all parents: the only research inclusion criteria is to be the parent or legal guardian of a newborn with perinatal brain injury or healthy control participant.\n\nExclusion Criteria:\n\n* Healthy infants to be included in the control group will not have:\n\n  * a prior history of brain injury\n  * a diagnosis of cerebral palsy\n  * a history of a neurological disorder\n  * prior admission to the Neonatal Intensive Care Unit (NICU)\n* Children with chromosomal abnormalities, genetic syndromes and major congenital malformations will be excluded from both the patient groups and the control group.\n* Parents will have no exclusionary criteria.",true,"3 Months",{"count":60,"type":21},200,"OBSERVATIONAL","This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury. As part of this research study, children complete virtual game and assessments. Parents will be asked to fill out questionnaires about their child's behavior and stress in the home. All study visits will take place online via Zoom.",[27,64],"Healthy Participants","RECRUITING","2026-02-04",{"date":68,"type":41},"2026-02-09",{"date":70,"type":41},"2024-07-30",{"date":72,"type":21},"2030-07",{"name":47,"class":48},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":74},"100597819","stms-combined-with-cimt-and-tavns-in-infants-with-hemiplegia-100597819","NCT07063446","sTMS Combined With CIMT and taVNS In Infants With Hemiplegia","Integrating Corticospinal Tract Assessment Via sTMS And taVNS-Augmented CIMT In Infants With Hemiplegia","Inclusion Criteria:\n\n* Infants 8-24mo with hemiplegia or asymmetric weakness of one arm, with or without truncal and transitional motor delays\n* Gross Motor function Classification system (GMFCS) I - IV\n* Parents are able to make consecutive appointments for assessments and intervention over 2wks and complete the 3mo follow-up.\n* Parents are willing to fill out developmental questionnaires and provide the study team feedback on tolerability and outcomes.\n\nExclusion Criteria:\n\n* previous CIMT within 3 months\n* GMFCS V or severe motor impairment\u002Fquadriplegia\n* uncorrected blindness\u002Fdeafness, cardiomyopathy\n* poorly controlled seizure disorder",{"count":83,"type":21},10,[24],"Preterm and term infants with brain injury frequently have delayed motor skills, and one hand and arm may become stronger than the other, which can signal early cerebral palsy. A new treatment, transcutaneous vagus nerve stimulation (taVNS), boosts specific brain circuits and may improve function when paired with intensive motor activities. This study will test taVNS-paired constraint induced movement therapy in infants who have greater weakness on one side and determine if a single pulse of transcranial brain stimulation over the motor area can cause a measurable movement of the hand or thumb, and indicate which infants can benefit from 40h taVNS-paired CIMT.",[87,27],"Hemiplegia",[89,90,91,92,93],"constraint induced movement therapy","infants","taVNS","sTMS","hemiplegia","2025-11-20",{"date":96,"type":41},"2025-11-26",{"date":98,"type":41},"2025-11-07",{"date":100,"type":21},"2026-12-31",{"name":102,"class":48},"Medical University of South Carolina"]