[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perineal-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perineal-trauma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,83,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100648867","relieve-study--platelet-rich-plasma-to-reduce-postpartum-pain-after-perineal-tears-or-episiotomy-100648867",false,"NCT07727213","RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy","RELIEVE Study (REducing Labour-Induced Episiotomy and Vaginal Tear Pain Using Platelet Rich Plasma (PRP) for Enhanced Healing): A Triple-blind, Randomised, Placebo-controlled Trial Assessing PRP for Reducing Postpartum Pain After Perineal Tears or Episiotomies.","RELIEVE","Inclusion Criteria:\n\n* Age 18 years or older\n* Vaginal birth with a second-degree or more severe perineal tear and\u002For an episiotomy\n* Written informed consent obtained before any study-specific procedure\n\nExclusion Criteria:\n\n* Refusal to participate or lack of decision-making capacity at the time of consent\n* Inability to ensure an adequately informed consent process despite appropriate support measures, including adapted oral information and, when required, faithful translation or assistance from a professional interpreter\n* Clinically significant hereditary or acquired coagulation disorder, including platelet count below 100 × 10\\^9\u002FL, international normalized ratio above 1.5, activated partial thromboplastin time above 1.5 times the upper limit of normal, congenital coagulation factor deficiency, von Willebrand disease, or prophylactic or therapeutic anticoagulation administered less than 24 hours before venous blood sampling for PRP preparation\n* Aspirin or clopidogrel taken within 7 days before venous blood sampling for PRP preparation\n* Previous enrolment in the RELIEVE study","FEMALE","18 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.\n\nPlatelet-rich plasma (PRP) is prepared from a participant's own blood and contains a concentrated amount of platelets that release growth factors that may support tissue repair. The purpose of this study is to determine whether a single local injection of autologous non-activated PRP during the primary repair of a perineal tear and\u002For an episiotomy reduces postpartum perineal pain compared with an injection of 0.9% sodium chloride solution.\n\nParticipants will be randomly assigned in a 1:1 ratio to receive PRP or saline. Participants, the clinician administering the injection, the clinicians assessing the outcomes, and the statistician will be unaware of the assigned treatment. Follow-up will assess perineal pain, wound healing, scar quality, sexual function, genital self-image, and safety through 6 months postpartum.\n\nThe study hypothesis is that PRP will reduce average perineal pain at 3 months postpartum compared with saline.",[27,28,29,30],"Perineal Trauma","Postpartum Pain","Episiotomy","Perineal Laceration",[32,33,34,35,36,37,38,39,40,41],"Platelet-rich plasma","PRP","Vaginal birth","Perineal tear","Perineal wound healing","Postpartum perineal pain","Dyspareunia","Sexual function","Genital self-image","Scar assessment","NOT_YET_RECRUITING","2026-07-24",{"date":45,"type":46},"2026-07-27","ACTUAL",{"date":48,"type":21},"2026-10-01",{"date":50,"type":21},"2028-08-31",{"name":52,"class":53},"University Hospital, Geneva","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100643236","papaverine-for-prevention-of-perineal-trauma-100643236","NCT07641543","Papaverine for Prevention of Perineal Trauma","The Impact of Intrapartum Papaverine 80 mg on Perineal Trauma Among Primiparous Women: a Prospective Randomized Double-blind Study.","Inclusion Criteria:\n\n* Primiparous patients aged 18 years or older\n* Singleton pregnancy\n* Term pregnancy (37+0 to 42+0 weeks of gestation)\n* Cephalic presentation\n* Undergoing labor with at least with 2 cm cervical dilatation.\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Multiple gestation\n* Major fetal congenital anomalies\n* Contraindication to vaginal delivery\n* Known hypersensitivity or allergy to papaverine hydrochloride\n* Known supraventricular tachycardia (SVT)\n* Maternal tachycardia (heart rate \\>100 bpm) or clinically significant cardiac arrhythmia\n* Known liver disease or hepatic dysfunction\n* Active psychiatric condition impairing the ability to provide informed consent\n* Inability to provide written informed consent\n* Planned cesarean delivery","45 Years",{"count":64,"type":21},412,[24],"Perineal trauma is a common complication of vaginal delivery, particularly among primiparous patients, and may result in short- and long-term maternal morbidity, including pain, dyspareunia, and pelvic floor dysfunction. Papaverine hydrochloride, a smooth muscle relaxant with vasodilatory properties, has been shown to improve tissue relaxation and has been used safely in obstetric settings.\n\nThis prospective randomized double-blind placebo-controlled study aims to evaluate whether intrapartum intravenous papaverine hydrochloride (80 mg), administered at full cervical dilatation, reduces the rate of perineal trauma among primiparous patients undergoing vaginal delivery. Eligible participants will be randomized in a 1:1 ratio to receive either intravenous papaverine hydrochloride or placebo (normal saline). Maternal, obstetric, and neonatal outcomes, including the rate and severity of perineal trauma, obstetric anal sphincter injuries (OASIS), postpartum hemorrhage, and neonatal outcomes, will be assessed.",[27,68],"Obstetric Anal Sphincter Injury",[70,27,71,72],"Papaverine","Labor","Vaginal Delivery","2026-06-06",{"date":75,"type":46},"2026-06-11",{"date":77,"type":21},"2026-06-03",{"date":79,"type":21},"2027-06-03",{"name":81,"class":82},"Dr Raneen Abu Shqara","OTHER_GOV",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":54},"100630843","hands-on-vs-hands-off-techniques-in-perineal-protection-100630843","NCT07492940","Hands-on vs Hands-off Techniques in Perineal Protection","The Midwife's Hands Between Waiting and Support: Hands-off vs hands-on Techniques in Manual Perineal Protection.","MPP","Criteri di inclusione:\n\n* Donne incinte nullipare o multipare\n* Gravidanza a termine\n* Feto nella presentazione cefalica\n* Consegna eutocic (spontanea)\n* Uso di ossitocina\n* Uso di analgesici\n\nCriteri di esclusione:\n\n* Parto prematuro: prematuro tardivo -Disagio fetale acuto durante la fase di espulsione-\n* Consegna della gretta\n* Distocia della spalla\n* Parto chirurgico (uso del vuoto ostetrico, manovra di Kristeller, taglio cesareo) --Episiotomia",{"count":92,"type":21},737,"OBSERVATIONAL","Perineal tears are frequent during vaginal delivery. This study evaluates the impact of hands-on versus hands-off techniques on perineal and neonatal outcomes to determine the most effective protective strategy.",[27,96,97,98],"Hands-on Technique","Hands-of Technique","Manual Perineal Protection",[100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119],"Perineal trauma","Perineal injury","Perineal lacerations","Perineal tears","Obstetric anal sphincter injuries","OASIS","Genital tract trauma","Labial lacerations","Labial tears","Vaginal tears","Pelvic floor muscle injury","Levator ani muscle avulsion","First-degree perineal tear","Second-degree perineal tear","Third-degree perineal tear","Fourth-degree perineal tear","hands on","hands off","hands-on technique","hands-off technique","RECRUITING","2026-03-20",{"date":123,"type":46},"2026-03-25",{"date":125,"type":21},"2026-03-05",{"date":127,"type":21},"2027-03",{"name":129,"class":53},"Azienda ULSS 8 Berica",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":136,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":137,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":139,"conditions":140,"keywords":146,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":4},"100629706","maternal-musculoskeletal-factors-of-the-hip-lumbopelvic-abdominal-and-pelvic-floor-regions-and-their-association-with-mode-of-delivery-and-postpartum-pelvic-floor-dysfunction-100629706","NCT07478159","Maternal Musculoskeletal Factors of the Hip, Lumbopelvic, Abdominal and Pelvic Floor Regions and Their Association With Mode of Delivery and Postpartum Pelvic Floor Dysfunction","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Singleton pregnancy\n* Gestational age of 36 weeks at the time of the baseline assessment\n* Receiving prenatal care in primary healthcare centers of Zaragoza (Spain)\n* Ability to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Multiple pregnancy\n* High-risk pregnancy conditions that may affect labor progression or maternal musculoskeletal assessment (e.g., severe obstetric complications requiring planned cesarean section)\n* Previous pelvic floor surgery\n* Neurological or musculoskeletal disorders affecting the lumbopelvic or pelvic floor region\n* Inability to complete the assessment protocol or questionnaires",true,{"count":138,"type":21},376,"This prospective observational cohort study aims to investigate the association between maternal musculoskeletal factors of the hip, lumbopelvic, abdominal, and pelvic floor regions and childbirth outcomes, as well as their consequences on pelvic floor function during the postpartum period. A total of 376 pregnant women will be recruited at 36 weeks of gestation and followed until 12 weeks postpartum. Musculoskeletal assessments will include hip range of motion, lumbopelvic mobility, abdominal muscle function, and pelvic floor strength and morphology. Obstetric outcomes such as mode of delivery and perineal trauma will be recorded after childbirth. The study will analyze whether maternal musculoskeletal function during late pregnancy is associated with delivery mode and pelvic floor dysfunction in the postpartum period.",[141,142,27,143,144,145],"Pelvic Floor Disorders","Urinary Incontinence","Pelvic Floor Dysfunction","Pregnancy","Puerperium",[141,147,148,142],"Obstetric Labor","Complications Perineal Trauma","2026-03-12",{"date":151,"type":46},"2026-03-17",{"date":153,"type":21},"2026-05-01",{"date":155,"type":21},"2028-01-01",{"name":157,"class":53},"Universitat Internacional de Catalunya"]