[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periodontal-diseases-inflammation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periodontal-diseases-inflammation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":40,"locationsCount":43},"100658867","retinal-and-choroidal-changes-in-periodontal-disease-100658867",false,"NCT07856901","Retinal and Choroidal Changes in Periodontal Disease","RETİNAL AND CHOROİDAL STRUCTURAL ALTERATİONS ACROSS THE PERİODONTAL DİSEASE CONTİNUUM: A CROSS-SECTİONAL OBSERVATİONAL STUDY","Inclusion Criteria:\n\nSystemically healthy adults. Non-smokers (no current or previous tobacco use). Participants who underwent optical coherence tomography (OCT) imaging. Participants who provided written informed consent and agreed to participate in the study.\n\nExclusion Criteria:\n\nPresence of any systemic disease. Current or former smokers. Participants with incomplete clinical or OCT data. Individuals who did not provide written informed consent.\n\n\\-",true,"ALL","20 Years","54 Years",{"count":21,"type":22},80,"ESTIMATED","1 Day","OBSERVATIONAL","Advanced PeriodontitisIn this cross-sectional study, the relationship between periodontal disease severity and retinal and choroidal structural changes was evaluated using SD-OCT. Data from a total of 80 participants were examined. It was found that choroidal thickness increased and ganglion cell layer thickness decreased as periodontal disease severity increased, while no significant relationship was found in RNFL and IPL thicknesses. The findings support a possible association between periodontal disease and ocular structural changes.",[27,28,29],"Periodontal Diseases","Periodontal Diseases Inflammation","Retinal Thickening",[31],"Retinal degeneration ; Tomography, Optical Coherence ; Periodontitis ; gingivitis; Retinal Ganglion Cells ; Periodontal Index","NOT_YET_RECRUITING","2026-09-28",{"date":35,"type":36},"2026-10-05","ACTUAL",{"date":38,"type":22},"2026-10",{"date":38,"type":22},{"name":41,"class":42},"Zeliha Başak Çakır Erdil","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100605313","evaluation-of-nucleotide-binding-oligomerization-domain-containing-protein-nod-1-and-nod-2-100605313","NCT07160894","Evaluation of Nucleotide-Binding Oligomerization Domain-Containing Protein (NOD) 1 and NOD 2","Evaluation of Nucleotide-Binding Oligomerization Domain-Containing Protein (NOD) 1 and NOD 2 in Different Periodontal Conditions","Inclusion Criteria:\n\n* systemically healthy\n\n  * clinical diagnosis of periodontal health\n  * clinical diagnosis of periodontitis\n  * clinical diagnosis of gingivitis\n\nExclusion Criteria:\n\n* • history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)\n\n  * nonsurgical periodontal treatment (previous 6 months)\n  * surgical periodontal treatment (previous 12 months)\n  * presence of\\\u003C10 teeth\n  * current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)\n  * diabetes\n  * diagnosis of rheumatoid arthritis\n  * pregnancy\n  * lactating\n  * smoking\n  * excessive alcohol consumption.","18 Years","65 Years",{"count":54,"type":22},75,"INTERVENTIONAL",[57],"NA","The host immune response to microorganisms is primarily recognized by pattern recognition receptors (PRRs), including toll-like receptors and nucleotide-binding oligomeric domain (NOD) receptors (NLRs). The aim of this study was to examine the relationship between periodontal disease and NOD in serum and saliva samples.",[28],[61],"periodontal disease NOD","2025-08-29",{"date":64,"type":36},"2025-09-08",{"date":66,"type":22},"2025-09-15",{"date":68,"type":22},"2026-07-20",{"name":70,"class":42},"Medipol University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":78,"targetDuration":4,"studyType":55,"phases":80,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":43},"100600583","micro-ribonucleic-acid-mirna-expression-and-inflammatory-factors-in-patients-with-parkinsons-and-periodontal-disease-100600583","NCT07099378","Micro Ribonucleic Acid (miRNA) Expression and Inflammatory Factors in Patients With Parkinson's and Periodontal Disease","Relationship Between Micro Ribonucleic Acid (miRNA) Expression and Inflammatory Factors in Patients With Parkinson's and Periodontal Disease","Inclusion Criteria:\n\n* dentally and periodontally healthy\n\n  * Systemically healthy with no uncontrolled chronic and\u002For autoimmune disease\n  * No systemic, neurological, or autoimmune disease in addition to Parkinson's disease.\n\nExclusion Criteria:\n\n* history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)\n* nonsurgical periodontal treatment (previous 6 months)\n* surgical periodontal treatment (previous 12 months)\n* presence of\\\u003C20 teeth\n* current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)\n* diabetes\n* diagnosis of rheumatoid arthritis\n* pregnancy\n* lactating\n* smoking\n* excessive alcohol consumption.",{"count":79,"type":22},51,[57],"MicroRNAs are important regulators of the immune and inflammatory response to bacterial pathogens during periodontal disease.The aim of this study was to evaluate the possible miRNA type for Parkinson's in saliva of orally healthy individuals.",[28],[84],"periodontal disease miRNA","2025-07-25",{"date":87,"type":36},"2025-08-01",{"date":87,"type":22},{"date":90,"type":22},"2026-02-01",{"name":70,"class":42}]