[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-myocardial-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-myocardial-injury":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,88,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100650787","nerve-block-and-perioperative-myocardial-injury-in-elderly-hip-fracture-100650787",false,"NCT07751146","Nerve Block and Perioperative Myocardial Injury in Elderly Hip Fracture","Effect of Single-Injection Peripheral Nerve Block on Perioperative Myocardial Injury in Elderly Patients Undergoing Delayed Hip Fracture Surgery: A Single-Center Retrospective Cohort Study","PNB-CARD","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Radiological evidence of non-pathological hip fractures (femoral neck, intertrochanteric or subtrochanteric fractures)\n* Time from injury to surgery \\> 48 hours\n* Underwent general anesthesia or intraspinal anesthesia\n* Had at least one troponin I\u002FT test result during preoperative or postoperative hospitalization\n\nExclusion Criteria:\n\n* Preoperative presence of acute myocardial infarction (onset \\\u003C 7 days), acute heart failure or sepsis\n* Multiple fractures or concurrent surgeries at other sites\n* Neuroblock as the sole anesthesia method\n* Continuous nerve block or epidural analgesia\n* Severe lack of key variables","ALL","65 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","This single-center, retrospective cohort study evaluates whether a single preoperative peripheral nerve block can reduce the risk of perioperative myocardial injury in elderly patients undergoing delayed hip fracture surgery, defined as surgery performed more than 48 hours after injury.\n\nHip fracture is a serious and common injury in older adults worldwide. When surgery cannot be performed within the recommended 48-hour window, patients face a much higher risk of heart muscle damage (myocardial injury), which is strongly linked to increased complications and death. Peripheral nerve blocks are a standard, safe method for pain control in hip fracture care, but their potential protective effect on the heart has not been specifically studied in patients with delayed surgery.\n\nThis study will review medical records of patients aged 65 years and older who received hip fracture surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 1, 2019 and December 31, 2025, with time from injury to surgery longer than 48 hours. Patients who received a single peripheral nerve block before surgery will be compared with patients who did not receive any peripheral nerve block.\n\nThe main measure of the study is the rate of myocardial injury during hospital stay, detected by elevated troponin levels in routine blood tests. The study will also examine new-onset myocardial injury within 72 hours after surgery, major heart-related adverse events and all-cause death within 30 days after surgery, length of hospital stay, and other common postoperative complications. Researchers will also explore whether the timing of nerve block placement and different block techniques have different heart-protective effects.\n\nThe findings may provide evidence for a simple, safe and practical strategy to reduce heart complications in older hip fracture patients who cannot receive timely surgery, and help clinicians improve perioperative care for this high-risk population.",[25,26,27],"Hip Fracture","Perioperative Myocardial Injury","Myocardial Injury After Noncardiac Surgery",[29,30,31,32,33,34,35,36,37],"Peripheral Nerve Block","Single-injection nerve block","PENG block","Delayed hip fracture surgery","Elderly patients","Troponin","Perioperative cardioprotection","Retrospective cohort study","Fascia iliaca compartment block","NOT_YET_RECRUITING","2026-08-03",{"date":41,"type":42},"2026-08-07","ACTUAL",{"date":44,"type":21},"2026-07-15",{"date":46,"type":21},"2027-07-05",{"name":48,"class":49},"Tongji Hospital","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100605891","phase-4-landiolol-to-avoid-tachycardia-in-patients-at-risk-for-cardiovascular-events-undergoing-major-non-cardiac-surgery-100605891","NCT07168421","LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery","LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery: a Feasibility Trial","LANTA-P","Inclusion Criteria:\n\n* Patients undergoing elective non-cardiac surgery defined as intermediate or high-risk by the 2022 european society of cardiology (ESC) guidelines\n* surgery performed under general anesthesia;\n* expected length of hospital stay ≥ 24 hours;\n* age ≥ 45 years;\n* at least two of the following risk factors:\n\n  * age ≥ 75 years\n  * arterial hypertension;\n  * ischemic heart disease (history of myocardial infarction or positive exercise test, current complaint of chest pain considered to be secondary to myocardial ischemia, use of nitrates, pathological Q waves, prior coronary revascularization);\n  * history of congestive heart failure;\n  * history of cerebrovascular disease;\n  * peripheral artery disease;\n  * diabetes mellitus;\n  * GFR ≤ 59 ml\u002Fmin pro 1.73 m2;\n  * pre-operative NTproBNP \\> 200 pg\u002Fml;\n* excessive sympathetic outflow as proven by exercise testing:\n\n  * impaired heart rate recovery (≤ 12 bpm within 1 minute after cessation of exercise); OR\n  * exaggerated heart rate response (≥ 12 bpm after 3 minutes of unloaded pedalling);\n\nExclusion Criteria:\n\n* unable to consent or follow study procedures;\n* absolute contraindications for exercise testing;\n* pregnancy or intention to become pregnant;\n* active cardiac conditions (such as unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease);\n* urgent \u002F emergency surgery;\n* already on β-blocker (within the last 30 days prior to recruitment);\n* contraindication for β-blocker therapy (bradycardia (HR \\\u003C 55 bpm), hypotension (systolic blood pressure \\\u003C 100 mmHg), severe peripheral vascular disease, severe asthma, allergy, higher-degree atrioventricular block);\n* severe preoperative anaemia (haemoglobin \\\u003C 100 g\u002FL) unless there is a plan set up and followed for correction prior to surgery;\n* planned intermediate care or intensive care admission;\n* prior enrolment in this trial.","45 Years",{"count":60,"type":21},114,"INTERVENTIONAL",[63],"PHASE4","Limiting perioperative tachycardia (aiming for a heart rate \\\u003C90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing major surgery might lower the incidence of perioperative myocardial injury. Feasibility of the intervention needs to be proven prior to conduction of a larger trial.",[26,66,67,68,69,70],"Autonomic Dysfunction","Cardiovascular (CV) Risk","Major Surgery","Beta Blocker","Myocardial Injury After Non-cardiac Surgery",[72,73,74,75,76],"perioperative myocardial injury","major surgery","beta blocker","myocardial injury after non-cardiac surgery","autonomic dysfunction","RECRUITING","2026-05-04",{"date":80,"type":42},"2026-05-05",{"date":82,"type":42},"2026-04-24",{"date":84,"type":21},"2028-03-01",{"name":86,"class":49},"Insel Gruppe AG, University Hospital Bern",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":87},"100606705","anesthesia-induced-myocardial-injury-in-non-cardiac-surgery-aimy-100606705","NCT07179029","Anesthesia Induced Myocardial Injury in Non-cardiac Surgery (AIMY)","AIMY","Inclusion Criteria:\n\n* Elective or emergency non-cardiac surgery\n* Cardiovascular risk: At least two of the following: Age \\>60 years, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial occlusive disease, cerebrovascular disease, chronic renal insufficiency, chronic heart failure, chronic obstructive pulmonary disease, active smoking\n* Age criteria: Adults aged 40-80 years.\n* ASA status: ASA classification II-IV.\n* Written consent after prior explanation\n\nExclusion Criteria:\n\n* o Patients unable to give consent: intubated and sedated patients\n\n  * Types of surgery: cardiac surgery, including coronary artery bypass grafting, heart valve repair or replacement, and heart transplantation; obstetric procedures, including cesarean section; minor surgical procedures that do not require general or regional anesthesia (e.g., minor dermatological or ophthalmological procedures)\n  * Cardiovascular risk: patients without at least two of the following risk factors: age \\\u003C40 or \\>80, no history of hypertension, diabetes, coronary artery disease, peripheral arterial disease, cerebrovascular disease, chronic renal failure, chronic heart failure, chronic obstructive pulmonary disease, and non-smoker status\n  * Age criteria: Patients under 40 or over 80 years of age\n  * ASA status: ASA classification of I.","40 Years","80 Years",{"count":98,"type":21},3000,"Myocardial injury during non-cardiac surgery (PMI) affects up to 16% of high-risk patients and represents a significant burden on healthcare systems. An acute myocardial infarction is defined by a dynamic increase in cardiac troponin (cTn) above the 99th percentile and is accompanied by clinical signs of myocardial ischemia. Myocardial injury, on the other hand, is characterized by an increase in cardiac troponin, but without meeting the diagnostic criteria for myocardial infarction. In the perioperative interval, however, it is irrelevant whether a myocardial infarction according to the universal definition or merely an increase in troponin is present, as there is no difference in mortality between the two patient groups. The comprehensive study by Botto et al. provides valuable insights into the severity of MINS and found that 8.0% of patients met the diagnostic criteria. An important finding of this study is that the majority of MINS cases (87.1%) occurred within the first two days after surgery, highlighting the immediate risk of the condition (Botto et al., 2014).\n\nWe would like to emphasize the necessity of our prospective, multicenter observational study by highlighting anesthesia-dependent variables such as hemodynamics, type of medication, their potential role, and surgical aspects such as duration of surgery, which represent risk factors for MINS. Identifying and understanding modifiable and non-modifiable risk factors is essential for targeted preoperative intervention. Understanding these factors is crucial for subsequent interventional studies and can also provide criteria for increased monitoring of high-risk patients, as suggested in the current guidelines.",[26],[102,103],"troponin","Perioperative myocardial injury","2025-09-10",{"date":106,"type":42},"2025-09-17",{"date":108,"type":42},"2025-05-01",{"date":110,"type":21},"2028-05",{"name":112,"class":49},"University Hospital Tuebingen",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":95,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":87},"100505860","monitoring-of-vital-signs-for-phenotyping-of-perioperative-myocardial-infarctioninjury-after-noncardiac-surgery-100505860","NCT05866874","Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction\u002FInjury After Noncardiac Surgery","Continuous Monitoring of Vital Signs for Improved Phenotyping of Perioperative Myocardial Infarction\u002FInjury After Noncardiac Surgery in High Risk Patients: PMI-VITAL","PMI-VITAL","Inclusion Criteria:\n\n* Patient eligible for routine PMI-screening\n* Patient requiring hospitalisation with ≥ 2 overnight stays after surgery\n* Age ≥ 40 years to ≤ 85 AND history of coronary artery disease (CAD), peripheral artery disease (PAD), cerebrovascular disease\u002Fstroke, insulin-dependent diabetes mellitus (IDDM), or chronic heart failure (CHF)\n* Elective surgery\n* Patients undergoing orthopaedic, traumatology, vascular, spinal, thoracic, neurosurgical, urological or visceral surgery\n* Patient consent available\n\nExclusion Criteria:\n\n* Patient's refusal\n* Heart surgery, cardiac arrest, acute mycardial infarction (AMI), cardiac valve intervention, or cardiac catheter ablation within 14 days prior to surgery OR involvement of heart surgery at index surgery OR surgery planned on cardiopulmonary bypass\n* Patients undergoing plastic\u002Freconstructive, ophthalmologic, dental, hand surgery, or ear-nose-and-throat surgery\n* Chronic renal failure on dialysis, unless undergoing renal transplant surgery\n* Moderate to severe dementia\n* Inclusion into study within the last year","85 Years",{"count":123,"type":21},875,"The goal of this observational prospective cohort study is to learn about the pathophysiology of perioperative myocardial infarction\u002Finjury in high-risk patients undergoing major non-cardiac surgery.\n\nParticipants will:\n\n* Wear wearable device (Basler Band) for up to seven days after the operation or until hospital discharge\n* Provide three blood samples. A venous specimen of blood (25 mL) will be collected preoperatively and on postoperative days 1 and 2.\n* Be contacted to answer a questionnaire one year after the surgery.",[126,26],"Perioperative Myocardial Infarction",[128,129,130,131,132],"Perioperative myocardial injury\u002Finfraction","Myocardial ischemia\u002Fdiagnosis","Myocardial ischemia\u002Fepidemiology","Perioperative complications\u002Fdiagnosis","PMI","2025-01-24",{"date":135,"type":42},"2025-01-28",{"date":137,"type":42},"2022-09-20",{"date":139,"type":21},"2026-12",{"name":141,"class":49},"University Hospital, Basel, Switzerland"]