[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-oxygenation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-oxygenation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100652700","individualized-vs-standard-peep-and-oxygen-reserve-index-in-laparoscopic-hernia-surgery-100652700",false,"NCT07775573","Individualized vs Standard PEEP and Oxygen Reserve Index in Laparoscopic Hernia Surgery","The Effect of Individualized Positive End-Expiratory Pressure Application on Perioperative Oxygenation Assessed by Oxygen Reserve Index Compared to Standard PEEP in Patients Undergoing Laparoscopic Inguinal Hernia Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Aged 18-75 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic unilateral inguinal hernia repair under general anesthesia\n* Body mass index (BMI) \\\u003C 35 kg\u002Fm²\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age below 18 or above 75 years\n* ASA physical status IV-V\n* Emergency surgical procedure\n* Severe chronic or restrictive pulmonary disease\n* Pulmonary hypertension\n* Obstructive sleep apnea syndrome\n* Preoperative peripheral oxygen saturation \\\u003C 94% on room air\n* Respiratory tract infection within the last two weeks\n* Severe cardiac failure (NYHA III-IV)\n* Pregnancy\n* Communication difficulties preventing NRS assessment\n* Surgical complications during the procedure\n* Operation duration exceeding 3 hours\n* Refusal to provide informed consent","ALL","18 Years","75 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","During laparoscopic surgery under general anesthesia, lung function can be affected by increased abdominal pressure and patient positioning. Positive end-expiratory pressure (PEEP) is a ventilator setting that helps keep the lungs open during surgery. In standard practice, a fixed PEEP level is applied to all patients. An individualized PEEP approach tailors this setting to each patient based on lung recruitment maneuvers.\n\nThis study investigates whether individualized PEEP improves oxygenation compared to standard PEEP in patients undergoing laparoscopic inguinal hernia surgery. Oxygenation will be continuously monitored using the Oxygen Reserve Index (ORI), a non-invasive sensor. Lung aeration will also be assessed before and after surgery using bedside lung ultrasound.",[25,26,27,28],"Atelectasis","Perioperative Oxygenation","Laparoscopic Inguinal Hernia Repair","Mechanical Ventilation",[30,31,32,33,34,35,36,37,38,39],"Positive End-Expiratory Pressure","PEEP titration","Oxygen Reserve Index","ORI","Lung Ultrasound","Recruitment Maneuver","Lung Protective Ventilation","Dynamic Compliance","Pneumoperitoneum","Trendelenburg Position","NOT_YET_RECRUITING","2026-08-18",{"date":43,"type":44},"2026-08-20","ACTUAL",{"date":46,"type":21},"2026-09",{"date":48,"type":21},"2027-10",{"name":50,"class":51},"Fatih Sultan Mehmet Training and Research Hospital","OTHER"]