[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pfas-exposure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pfas-exposure":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100657960","effect-of-a-dietary-supplement-versus-placebo-on-serum-pfas-levels-in-male-firefighters-100657960",false,"NCT07846371","Effect of a Dietary Supplement Versus Placebo on Serum PFAS Levels in Male Firefighters","A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Pilot Study Evaluating a Dietary Supplement Supporting Natural Elimination Processes in Male Firefighters","AFCRO202","Inclusion Criteria:\n\n* Able to give written informed consent\n* Male firefighter with previous career exposure to PFAS\n* BMI between 18.5 and 35 kg\u002Fm²\n* Serum PFOS level ≥5 ng\u002FmL at screening\n* Willing to consume the study product daily for the duration of the study\n\nExclusion Criteria:\n\n* History of drug and\u002For alcohol abuse (\\>15 standard drinks per week)\n* Food allergy, intolerance or dietary restriction that, in the opinion of the investigator, would preclude consumption of the study product\n* Blood donation within the past 3 months\n* Current smoker of \\>20 cigarettes per day, or former smoker with a history of ≥20 cigarettes per day who quit within 6 months prior to Visit 1\n* Any significant acute or chronic health condition that would prevent participation, pose a risk, or confound interpretation of results, including: diagnosed gastrointestinal disorders (irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, coeliac disease, or other chronic diarrhoeal disorders); uncontrolled medical conditions; history of chronic kidney or liver disease; chronic inflammatory or autoimmune disease; history of gastrointestinal surgery; hospitalisation within the past 3 months\n* Current or recent (past 12 weeks) use of medications affecting bile acid metabolism (e.g. bile acid sequestrants, fibrates) or antibiotics\n* Current or recent (past 4 weeks) use of supplements affecting gut microbiota (prebiotics, probiotics, postbiotics, fibres, synbiotics), detoxification pathways (milk thistle, N-acetylcysteine, glutathione) or bile acid metabolism (e.g. psyllium husk)\n* Current or recent (past 2 weeks) consumption of prohibited foods, including probiotic yoghurts\n* Considered by the investigator unlikely to comply with study requirements\n* Current participation in another clinical study, or insufficient time elapsed since a previous experimental study",true,"MALE","18 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is designed to evaluate the effect of a probiotic dietary supplement containing Streptococcus salivarius on serum PFAS levels in male firefighters with documented occupational PFAS exposure, following twice-daily use over a 12-week period.",[28,29],"Environmental Exposure","PFAS Exposure",[31,32,33,34,35,36,37,38,39,40],"Cross-over study","Serum PFAS levels","Gut Microbiome","Streptococcus salivarius","Dietary Supplement","Probiotic","Occupational Exposure","Firefighters","Forever Chemicals","Per- and Polyfluoroalkyl Substances","RECRUITING","2026-10-07",{"date":44,"type":45},"2026-10-08","ACTUAL",{"date":44,"type":45},{"date":48,"type":22},"2027-11-01",{"name":50,"class":51},"Cambiotics ApS","INDUSTRY"]