[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"photo-damage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:photo-damage":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100653731","multimodal-laser-treatment-of-photodamaged-skin-100653731",false,"NCT07789002","Multimodal Laser Treatment of Photodamaged Skin","Inclusion Criteria:\n\n* Age ≥18 years\n* Clinical signs of facial photodamage, including low-grade actinic keratosis (Olsen grade I-II) , solar lentigines, mottled hyper- and hypopigmentation, telangiectasia, skin thinning or atrophy, loss of skin elasticity (solar elastosis), coarse, leathery texture\n\nExclusion Criteria:\n\n* Fitzpatrick skin type ≥ 4\n* Active skin disease in the treatment area that may interfere with study treatment or assessments\n* Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments\n* Pregnancy or breastfeeding\n* Contraindications to the three lasers or topical anesthetics\n* Fitzpatrick skin type ≥ 4\n* Active skin disease in the treatment area that may interfere with study treatment or assessments\n* Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments\n* Pregnancy or breastfeeding\n* Contraindications to the three lasers or topical anesthetics","ALL","18 Years",{"count":18,"type":19},35,"ESTIMATED","INTERVENTIONAL",[22],"NA","The Multimodal Laser Project is a prospective, randomized, split-face clinical study investigating a novel combination of laser and light-based treatments for facial photodamage with the long-term perspective of improving skin cancer prevention.\n\nThe study includes 35 patients with facial photodamage and AKs. One side of the face receives a multimodal treatment combining three complementary technologies: 1927-nm thulium laser, 1550-nm non-ablative fractional laser, and intense pulsed light (IPL), while the contralateral side serves as an untreated control.\n\nParticipants are followed for 14 months to assess both clinical efficacy and longer-term preventive effects.\n\nThe overall aim is not only to determine whether multimodal laser treatment improves photodamaged skin, but also to gain a deeper understanding of how the treatment affects the underlying biology of chronically sun-damaged skin and its potential role in skin cancer prevention.",[25,26],"Photo-damage","Actinic Keratosis (AK)",[28,29,30,31,32,33,34],"laser","photodamaged skin","IPL","non-ablative fractional laser","fractional laser","Thulium laser","UV damage","RECRUITING","2026-09-04",{"date":38,"type":39},"2026-09-09","ACTUAL",{"date":41,"type":19},"2026-09-01",{"date":43,"type":19},"2028-12-31",{"name":45,"class":46},"Merete Haedersdal","OTHER"]