[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"photon-counting-computed-tomography\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:photon-counting-computed-tomography":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100656277","pcct-defined-high-risk-plaque-and-future-coronary-events-the-predict-study-100656277",false,"NCT07822737","PCCT-Defined High-Risk Plaque and Future Coronary Events: The PREDICT Study","Prognostic Value of Photon-Counting Detector CT-Derived High-Risk Coronary Plaque Features for Predicting Major Adverse Cardiovascular Events: a Prospective Cohort Study","PREDICT","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled for clinically indicated, non-emergent invasive coronary angiography\n* Provision of written informed consent and willingness to comply with long-term follow-up\n\nExclusion Criteria:\n\n* Estimated glomerular filtration rate \\\u003C45 mL\u002Fmin\u002F1.73 m²\n* Known allergy to iodinated contrast media\n* Pregnancy or breastfeeding\n* Persistent atrial fibrillation or other arrhythmia precluding adequate ECG-gated CT acquisition\n* Body mass index \\>40 kg\u002Fm²\n* Target vessel with a previously implanted stent\n* Life expectancy \\\u003C2 years or any condition that, in the opinion of the investigator, makes follow-up unlikely or participation inappropriate","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","2 Years","OBSERVATIONAL","This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE). Participants will be followed for MACE and revascularization. The primary hypothesis is that the incidence of MACE is significantly higher in patients with PCCT-defined high-risk plaque than in those without. Additionally, patients will undergo Optical Coherence Tomography (OCT) and angiography within a month after PCCT; PCCT results will be compared with OCT in a cross-sectional analysis, and diagnostic performance will be evaluated against follow-up data.",[26,27,28],"Coronary Artery Disease","Plaque","Photon-Counting Computed Tomography",[28,26,30],"High risk plaque","RECRUITING","2026-09-14",{"date":34,"type":35},"2026-09-16","ACTUAL",{"date":37,"type":35},"2025-01-18",{"date":39,"type":21},"2030-12-30",{"name":41,"class":42},"Beijing Chao Yang Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":43},"100637200","diagnostic-value-of-photon-counting-ct-in-subsegmental-pulmonary-embolism-100637200","NCT07575503","Diagnostic Value of Photon-Counting CT in Subsegmental Pulmonary Embolism","Application of Photon-Counting Computed Tomography in the Diagnosis of Subsegmental Pulmonary Embolism","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Clinical manifestations supporting the diagnosis of acute pulmonary embolism, including:\n\n   Acute onset or progressive dyspnea Unexplained hypoxemia Chest pain Hemoptysis Syncope or presyncope Combined with abnormal findings on electrocardiogram, echocardiography, or pulse oximetry\n3. Revised simplified Geneva score ≥ 3\n4. Written informed consent obtained from the patient or the patient's legally authorized representative\n\nExclusion Criteria:\n\n1. Patients requiring prophylactic or therapeutic doses of anticoagulant medication for reasons other than venous thromboembolism (VTE).\n2. Life expectancy less than three months.\n3. Patients unable to undergo CT scanning due to severe condition or hemodynamic instability.\n4. History of allergy to contrast media, renal insufficiency (creatinine clearance \\\u003C 30 mL\u002Fmin), or ongoing long-term dialysis.\n5. Pregnancy.\n6. Refusal to provide informed consent or inability to complete follow-up for any reason.",{"count":52,"type":21},696,"Pulmonary embolism (PE) is a serious and potentially life-threatening condition caused by blood clots in the lungs. A particular type, subsegmental pulmonary embolism (SSPE), involves very small branches of the pulmonary arteries. Although these clots occur in smaller vessels, their risk of recurrence and complications may be similar to larger clots.\n\nConventional CT pulmonary angiography (CTPA) is the standard imaging test for suspected PE, but image quality can sometimes be limited by motion artifacts, poor contrast filling, or body habitus, making the detection of SSPE challenging.\n\nPhoton-counting computed tomography (PCCT) is a new CT technology that provides higher image resolution, lower radiation dose, and improved visualization of small blood vessels. Early studies suggest PCCT may reduce motion artifacts and increase the accuracy of detecting SSPE compared with conventional CT.\n\nThis prospective cohort study will compare PCCT with dual-source CT in patients with suspected acute PE. The study aims to determine whether PCCT improves the detection rate and image quality for SSPE, and whether it can provide more reliable diagnostic information to guide clinical care.",[55,28],"Subsegmental Pulmonary Embolism","2026-05-04",{"date":58,"type":35},"2026-05-08",{"date":60,"type":35},"2026-01-01",{"date":62,"type":21},"2027-01",{"name":64,"class":42},"Second Affiliated Hospital, School of Medicine, Zhejiang University"]