[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-activity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-activity":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,143,0,25,[9,49,88,125,165,194,224,258,292,325,349,371,412,438,458,488,512,541,569,600,630,652,678,704,735],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100641826","charge-pilot-trial-of-self-directed-use-of-resources-for-physical-activity-100641826",false,"NCT07654868","Self-directed Use of Resources for Physical Activity","CHARGE: Pilot Trial of Self-directed Use of Resources for Physical Activity","CHARGE","Inclusion Criteria:\n\n* Age 18-75\n* Reports a desire to increase physical activity level\n* Not meeting minimum aerobic PA as indicated by L-CAT endorsement indicating level of activity below moderate (moderate defined as \\>= 5x\u002Fweek activity or higher)\n* Reports willingness to use LLMs to help with exercise goals.\n* Access to internet through phone data plan or home Wi-Fi.\n\nExclusion Criteria:\n\n* Conditions warranting more extensive supervision of physical activity, including:\n\n  * Any history of MI or stroke, arrhythmias, or heart failure\n  * Uncontrolled hypertension\n  * Type 1 or 2 diabetes\n  * COPD or asthma\n  * Recent orthopedic surgery or fracture\n  * Advanced Parkinson's\n  * Pregnant or planning to become pregnant in next 9 months\n  * Active cancer undergoing treatment\n  * Recent major surgery (\\\u003C12 weeks)\n  * Use of assistive devices for ambulation\n  * History of eating disorder diagnosis\n* Dementia diagnosis\n* Unable to read on own.\n* Hospitalization for mental health reasons in past year\n* Has used LLM to support physical activity goals in prior 3 months.\n* Currently enrolled in a structured program to promote physical activity or weight loss.","ALL","18 Years","75 Years",{"count":22,"type":23},39,"ESTIMATED","INTERVENTIONAL",[26],"NA","This is a pilot RCT examining physical activity outcomes at 3 months across 3 conditions: use of large language model (LLM) fully self-directed; use of LLM with guidance; and use of online tools to help with sleep.",[29],"Physical Activity",[31,32,33,34,35,36],"exercise","large language model","generative AI","artificial intelligence","physical activity","chatbot","NOT_YET_RECRUITING","2026-08-19",{"date":40,"type":41},"2026-08-21","ACTUAL",{"date":43,"type":23},"2026-09-01",{"date":45,"type":23},"2026-12-15",{"name":47,"class":48},"University of Florida","OTHER",{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100652087","ai-based-personalized-exercise-prescription-through-mobile-health-on-physical-activity-and-health-outcomes-in-older-adults-a-feasibility-study-100652087","NCT07768670","AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Artificial Intelligence-based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Inclusion Criteria:\n\n* Be aged 65 years or older.\n* Own a smartphone (Android or iOS) compatible with study applications.\n* Have reliable access to the internet or Wi-Fi.\n* Demonstrate basic digital literacy sufficient to operate a smartphone (e.g., ability to open applications, navigate simple interfaces, and follow on-screen instructions), with or without initial guidance from the research staff.\n* Be able to safely engage in physical activity, as determined by the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) or physician approval if indicated.\n* Report engaging in less than 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Be able to communicate in English sufficiently to complete study procedures and assessments.\n\nExclusion Criteria:\n\n* Are younger than 65 years of age.\n* Do not own a compatible smartphone (Android or iOS) or do not have reliable internet\u002FWi-Fi access.\n* Are deemed unable to safely participate in physical activity based on the screening process (including PAR-Q+, STEADI, and research staff assessment), or do not obtain required physician clearance when indicated.\n* Currently meet or exceed 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Are unable to communicate in English sufficiently to understand study procedures, provide informed consent, or complete study-related assessments.\n* Have any medical, physical, or cognitive condition that, in the judgment of the research team, would make participation unsafe or prevent completion of study procedures.",true,"65 Years",{"count":59,"type":23},20,[26],"The purpose of this research is to investigate the feasibility, acceptability, appropriateness, and preliminary efficacy of a wearable and artificial intelligence-driven mobile application-based exercise prescription grounded in self-determination theory (SDT) and behavioral change techniques (BCTs) among older adults. As no data exists on the feasibility of AI-driven exercise programs grounded in SDT and multiple BCTs specifically for older adults, this will be a pioneering study to explore the feasibility of wearable and AI-driven exercise program protocols and the rates of acceptance and appropriateness of the exercise prescription intervention among older adults. In addition, this study will test the preliminary efficacy of the intervention on physical activity (PA), mental health, and quality of life. This study follows the National Institute of Health (NIH) stage model, and it represents stage 1b of the NIH stage model, which emphasizes the feasibility and actionable processes for delivering a new health intervention. Specifically, this study will: 1.Evaluate the research protocol feasibility of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs (of goal setting, self-monitoring, graded task, and demonstration) on older adults over 8 weeks 2. Evaluate the acceptability and appropriateness of a wearable, AI-driven, mobile application-based exercise prescription grounded in SDT and BCTs among older adults over 8 weeks. 3. Evaluate the preliminary impact of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs on older adult PA (steps per day and daily duration of light PA and Moderate-vigorous PA), sedentary time, sleep, mental health (depression and anxiety), and quality of life.",[63,29,64,65,66],"Feasibility Studies","Mental Health (Depression)","Anxiety","Quality of Life",[68,69,70,71,72,73,74,75,76],"AI-based intervention","mobile health technology","wearable","fitness app","feasibility study","study acceptability and appropriateness","older adult","age 65 years","60 years","RECRUITING","2026-08-18",{"date":80,"type":41},"2026-08-20",{"date":82,"type":23},"2026-10-01",{"date":84,"type":23},"2026-12-31",{"name":86,"class":48},"The University of Tennessee, Knoxville",1,{"id":89,"slug":90,"hasResults":12,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":56,"sex":18,"minAge":96,"maxAge":57,"enrollmentInfo":97,"targetDuration":4,"studyType":24,"phases":99,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":87},"100591501","cardiovascular-disease-prevention-strategies-for-high-risk-urban-sedentary-employees-in-karachi-pakistan-100591501","NCT06981247","Cardiovascular Disease Prevention Strategies for High-risk Urban Sedentary Employees in Karachi, Pakistan","m-Lifestyle Intervention for Employees (m-LIfE): Protocol for a Pilot Cluster Randomized Controlled Trial on Cardiovascular Disease Prevention Strategies","m-LIfE","Inclusion Criteria:\n\n• At least 6 months of job experience in any bank\n\nExclusion Criteria:\n\n* Diagnosed case of myocardial infarction, stroke, coronary heart disease, cerebrovascular disease, or peripheral arterial diseases\n* Pregnant women\n* Individuals with acute illnesses that limit physical activity","20 Years",{"count":98,"type":23},84,[26],"Heart diseases and other non-communicable diseases are serious health issues in countries like Pakistan. Many people who work in offices, like bank employees, sit for more than 8 hours a day. This is called a sedentary lifestyle, and it increases the risk of heart diseases.\n\nThis research project aims to find out if a newly developed context specific mobile phone application can help these sedentary employees to improve their lifestyle. The app, called m-LIfE (mHealth-based Lifestyle Intervention for Employees), will be designed to help employees to move more during the day and eat healthier food like fruits and vegetables.\n\nThe study will involve bank employees in urban Karachi, Pakistan. They will be divided into two arms:\n\nIntervention arm: Participants in this arm will use the m-LIfE app for 12 weeks. They will get reminders and tips to take breaks, exercise, and eat healthy.\n\nRoutine care arm: Participants in this arm will receive printed basic educational material about prevention of risk factors of heart diseases and improving lifestyle.\n\nAfter the 12 weeks of intervention, there will be a follow-up period at 4th week to check if participants are maintaining healthy habits.\n\nThis study could help find simple and affordable ways to improve the health of office workers and reduce pressure on the healthcare system.",[29,102,103,104],"Life Style","Dietary Habits","Cardiovascular Diseases",[106,107,108,109,110,111,112,113,114,115],"Primary care","Cardiology","Preventive medicine","risk perception","cardiovascular health","CVD","Sedentary lifestyle","mHealth","Digital health","Feasibility","2026-08-11",{"date":118,"type":41},"2026-08-12",{"date":120,"type":41},"2026-06-22",{"date":122,"type":23},"2026-11",{"name":124,"class":48},"Aga Khan University",{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":12,"sex":18,"minAge":133,"maxAge":20,"enrollmentInfo":134,"targetDuration":4,"studyType":24,"phases":136,"briefSummary":137,"conditions":138,"keywords":148,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100643083","effectiveness-of-neomayor-in-improving-cardiovascular-health-in-chilean-older-adults-100643083","NCT07633392","Effectiveness of NeoMayor in Improving Cardiovascular Health in Chilean Older Adults","A Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial of NeoMayor, a Mobile Health Intervention to Improve Cardiovascular Health in Chilean Older Adults","NEOMAYOR","Inclusion criteria\n\n* Age between 55 and 75 years\n* Able to read and understand written instructions\n* Ownership of a smartphone and ability to use it independently\n* Physically inactive, defined as performing less than 30 minutes of daily physical activity or less than 2,5 h a week.\n* Intermediate or high cardiovascular risk, defined as the presence of at least three of the following: Hypertension (history diagnosed by specialist or general practitioner or ≥ 140 mmHg systolic or ≥90 mm Hg diastolic blood pressure at baseline or current antihypertensive treatment);Diabetes Mellitus (history diagnosed by specialist or general practitioner or fasting blood glucose ≥126 mg\u002FdL or current pharmacologic treatment);Obesity (BMI ≥30 kg\u002Fm²); Dyslipidaemia (history diagnosed by specialist or general practitioner or lipid-lowering drugs or baseline total cholesterol ≥ 200 mg\u002FdL or LDL cholesterol ≥100 mg\u002FdL).\n\nExclusion Criteria\n\n* Dementia defined as a score in the MEFO \\\u003C 9\n* Significant limitations for independent mobility, including use of assistive devices, frailty, gait instability, or lower-limb painful conditions limiting physical activity\n* Uncorrected hearing or visual impairment preventing adequate use of a smartphone\n* Chronic neurological, psychiatric, or psychological disorders without regular treatment or follow-up.\n* Present severe alcohol or illicit drug use.\n* Severe or terminal illness","55 Years",{"count":135,"type":23},240,[26],"This study aims to evaluate the effectiveness of NeoMayor, a mobile health (mHealth) intervention designed to improve cardiovascular health among older adults at elevated cardiovascular risk in Chile. NeoMayor is a smartphone-based application that provides personalized guidance on physical activity, diet, sleep, and mental well-being through a multidomain lifestyle approach.\n\nThis multicenter randomized controlled trial will enroll community-dwelling older adults aged 55 to 75 years recruited from primary healthcare centers in urban and rural settings. Participants will be randomized in a 2:1 ratio to either the NeoMayor intervention or a control group receiving standard health information and usual care. The intervention duration will be four months.\n\nThe primary objective is to determine whether the NeoMayor intervention improves cardiovascular health as measured by the Life's Essential 8 Cardiovascular Health Index. Secondary objectives include evaluating changes in cognitive performance, depressive symptoms, anxiety symptoms, quality of life and physical performance outcomes. The study will also assess feasibility and adherence to digital intervention.",[139,140,29,141,142,143,144,145,146,147],"Cardiovascular Health Status","Smoking Status","Diet Quality","Sleep Duration","Body Mass Index","Blood Pressure","LDL Cholesterol","Fasting Glucose","Urinary Albumin-to-Creatinine Ratio",[149,150,151,152,153,154,155],"Cardiovascular Health Index","cardiovascular risk","Life's Essential 8","mhealth","older adults","implementation science","hybrid effectiveness-implementation trial","2026-08-05",{"date":158,"type":41},"2026-08-10",{"date":43,"type":23},{"date":161,"type":23},"2027-05",{"name":163,"class":48},"University of Chile",2,{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":56,"sex":173,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":178,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":87},"100628834","the-ehealth-integrated-maternal-physical-activity-programme-in-prenatal-care-trial-e-impact-100628834","NCT07466797","The eHealth Integrated Maternal Physical Activity Programme in Prenatal Care Trial (E-IMPACT)","e-IMPACT: Evaluating an eHealth and Healthcare Professional Support Program to Promote Physical Activity During Pregnancy","e-IMPACT","Inclusion Criteria:\n\n1. Pregnant women (First trimester at least 4 weeks gestation)\n2. Age 21 years and above\n3. BMI 23 kg\u002Fm2 and above\n4. Physically fit to participate in moderate intensity exercise\n5. Singleton pregnancy\n\nExclusion Criteria:\n\n1. Women who have severe chronic disease such as chronic kidney disease, hypertension, asthma OR\n2. Obstetric or medical complications which might preclude women in normal levels of physical activity or exercise during pregnancy.\n3. Women who participated in other weight management programmes, or physical activity intervention studies recently (past 6 months) or concurrently\n4. Difficulty in understanding the English language","FEMALE","21 Years","45 Years",{"count":177,"type":23},100,[26],"This will be a proof-of-concept randomised control trial (RCT) study, where 100 pregnant women will be recruited in the first trimester of pregnancy and followed-up until delivery. It aims to test these following hypotheses:\n\n1. pregnancy is a window of opportunity to implement good lifestyle habits of physical activity and exercise as pregnant women are in regular contact with health professionals and are likely motivated and be more confident to carry out these activities according to the guidelines\n2. this integrated programme will effective in a healthcare setting, and will bring Singapore's \"Guidelines on Physical Activity and Exercise in Pregnancy\" guidelines to implementation\n3. with enhanced self-efficacy and motivation, the proportion of women engaging in adequate physical activity during pregnancy will increase to meet recommended guidelines.",[29,181],"Health Behavior",[183,184,185],"pregnancy","exercise in pregnancy","physical activity in pregnancy",{"date":158,"type":41},{"date":188,"type":41},"2026-03-09",{"date":190,"type":23},"2028-12-31",{"name":192,"class":193},"KK Women's and Children's Hospital","OTHER_GOV",{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":173,"minAge":19,"maxAge":175,"enrollmentInfo":202,"targetDuration":4,"studyType":24,"phases":203,"briefSummary":204,"conditions":205,"keywords":209,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":219,"completionDateStruct":220,"leadSponsor":222,"locationsCount":87},"100650401","posh-ex-physiotherapist-led-telerehabilitation-exercise-programme-for-postpartum-sexual-health-100650401","NCT07747285","POSH-Ex: Physiotherapist-Led Telerehabilitation Exercise Programme for Postpartum Sexual Health","POSH-Ex: Randomized Controlled Trial Evaluating a Standardized Physiotherapist-Led Telerehabilitation Programme for Postpartum Sexual Health","POSH-Ex","Inclusion Criteria:\n\n* Women aged 18 to 45 years.\n* Between 10 and 12 weeks postpartum at the time of enrolment.\n* Singleton live birth.\n* Ability to understand and communicate in the Croatian language.\n* Ability to participate safely in moderate-intensity exercise.\n* Access to a computer, tablet, or smartphone with a stable internet connection for participation in online exercise sessions.\n* Willingness to comply with the study protocol and attend supervised exercise sessions.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* • Medical contraindications to exercise according to current clinical recommendations.\n\n  * Pregnancy during the study period.\n  * Severe musculoskeletal, neurological, cardiovascular, or other medical conditions preventing safe participation in exercise.\n  * Current participation in another structured postpartum rehabilitation or exercise programme.\n  * Severe psychiatric disorder requiring immediate specialist treatment.\n  * Positive response to Item 10 of the Edinburgh Postnatal Depression Scale indicating current thoughts of self-harm. Such participants will be referred for appropriate clinical assessment before potential study participation.\n  * Inability to complete study questionnaires or follow study procedures.",{"count":98,"type":23},[26],"Postpartum women frequently experience impairments in sexual function, pelvic floor dysfunction, fatigue, and depressive symptoms, all of which may adversely affect their quality of life during the postpartum period. Although pelvic floor muscle training is recommended as part of postpartum rehabilitation, evidence regarding comprehensive physiotherapist-led exercise programmes specifically targeting postpartum sexual health remains limited. Furthermore, no standardized telerehabilitation programme has yet been evaluated using a randomized controlled trial design.\n\nThe aim of this randomized controlled trial is to evaluate the effectiveness of the POSH-Ex (Postpartum Sexual Health Exercise) programme, a standardized 12-week physiotherapist-led telerehabilitation intervention designed to improve female sexual function and overall postpartum health after childbirth. Secondary objectives are to evaluate its effects on pelvic floor muscle strength, physical activity, fatigue, depressive symptoms, health-related quality of life, and body composition.\n\nA total of 84 postpartum women will be randomly allocated in a 1:1 ratio to either the intervention group or the control group. Participants in the intervention group will complete supervised online exercise sessions twice weekly for 12 weeks, while participants in the control group will receive usual postpartum care. Outcome assessments will be performed at baseline and immediately after completion of the intervention.\n\nThe primary outcome is female sexual function assessed using the Female Sexual Function Index (FSFI). Secondary outcomes include pelvic floor muscle strength, physical activity, fatigue, depressive symptoms, health-related quality of life, and body composition. The findings are expected to provide high-quality evidence regarding the effectiveness of a standardized telerehabilitation programme for postpartum rehabilitation and may contribute to the development of evidence-based postpartum rehabilitation programmes and future clinical practice guidelines.",[206,207,208,29],"Postpartum Sexual Dysfunction","Postpartum Depression","Fatigue",[210,211,212,213,214,215,216,200],"postpartum","Postpartum rehabilitation","Postpartum sexual health","Female sexual function","Pelvic floor muscle training","Telerehabilitation","Exercise","2026-07-30",{"date":156,"type":41},{"date":43,"type":23},{"date":221,"type":23},"2027-09-30",{"name":223,"class":48},"University Medical Centre Ljubljana",{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":18,"minAge":231,"maxAge":19,"enrollmentInfo":232,"targetDuration":4,"studyType":24,"phases":234,"briefSummary":235,"conditions":236,"keywords":240,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":4},"100640447","digitalized-exercise-fit-tool-intervention-for-adolescents-with-blood-cancer-100640447","NCT07621887","Digitalized Exercise Fit Tool Intervention for Adolescents With Blood Cancer","Digitalised Exercise Fit Tool Intervention for Adolescents With Hematologic Cancer","Inclusion Criteria:\n\n* (1) they are 12-18 years old;\n* (2) they had been diagnosed with hematologic cancer such as leukaemia and lymphoma;\n* (3) they are regarded by the responsible physicians as stable, able to conduct PA, and without any PA restrictions,\n* (4) they completed all cancer treatment;\n* (5) they speak Cantonese and read Chinese.\n\nExclusion Criteria:\n\n* (1) Receiving palliative care\n* (2) Have physical or cognitive impairment and learning problems as identified from medical records\n* (3) Identified by physicians that no physical activity should be conducted at the time of recruitment","12 Years",{"count":233,"type":23},30,[26],"The goal of this clinical trial is to learn if a digitalised Exercise Fit Tool (EFT) mobile application can promote physical activity in adolescents aged 12-18 years who have completed treatment for hematologic cancer (e.g., leukaemia and lymphoma). The main questions it aims to answer are:\n\n1. Is it feasible to conduct a larger randomised controlled trial of the digitalised EFT intervention?\n2. Does the digitalised EFT intervention improve physical activity levels, physical activity self-efficacy, and quality of life at 6 months?\n\nResearchers will compare the digitalised EFT intervention group to a usual care group to see if the mobile application can promote physical activity levels, physical activity self-efficacy, and quality of life in adolescents with hematologic cancer.Participants will:\n\n1. Receive a 20-minute educational session on how to use the mobile application\n2. Use the mobile application to self-assess their appropriate physical activity level and exercise with a virtual coach\n3. Complete questionnaires and wear an accelerometer at 1, 3, and 6 months after enrollment\n4. Attend a 20-30-minute individual interview at 6 months (intervention group only, 10 participants)",[237,238,239,29],"Hematologic Cancer","Leukaemia","Lymphoma",[241,242,243,244,245,246,247,248],"Adolescents","Cancer","Physical activity","Mobile application","Feasibility randomised controlled trial","Exercise Fit Tool","Quality of life","Digital intervention","2026-07-24",{"date":251,"type":41},"2026-07-27",{"date":253,"type":23},"2026-07-20",{"date":255,"type":23},"2027-12-31",{"name":257,"class":48},"The Hong Kong Polytechnic University",{"id":259,"slug":260,"hasResults":12,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":56,"sex":18,"minAge":174,"maxAge":266,"enrollmentInfo":267,"targetDuration":4,"studyType":24,"phases":269,"briefSummary":270,"conditions":271,"keywords":275,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":287,"completionDateStruct":288,"leadSponsor":290,"locationsCount":87},"100648882","advancing-precision-medicine-for-cardiovascular-disease-and-diabetes-in-asian-populations-digital-intervention-cohort-100648882","NCT07728799","Advancing Precision Medicine for Cardiovascular Disease and Diabetes in Asian Populations: Digital Intervention Cohort","Advancing Precision Medicine for Cardiovascular Disease and Diabetes in Asian Populations: Digital Intervention Cohort (COBRA+)","COBRA+","Inclusion Criteria:\n\n* are currently enrolled in the Singapore Population Health Studies - Multi-Ethnic Cohort Phase 3 (MEC3) or Second Follow-up (F2),\n* are of Chinese, Malay, or Indian ethnicity,\n* are 21 to 69 years old, and\n* can read and write English,\n* own or use a smartphone (iOS ≥ 12.4 or Android ≥ 8 with at least 5 GB of free storage, and data plan and internet access),\n* are able and willing to download and use study smartphone apps,\n* are able and willing to wear the smartwatch provided throughout the study period, and\n* can walk independently.\n\nExclusion Criteria:\n\n* have a history or current condition of stroke, heart attack, kidney failure, diabetes mellitus, thyroid disease, or cancer, or have had a vascular bypass surgery or angioplasty procedure (either stent or balloon) performed, or\n* a serious mental health condition including schizophrenia, psychotic depression, or severe dementia, or\n* are currently pregnant or planning to get pregnant during the study period, or\n* are participating or planning to participate in other lifestyle intervention studies.\n* have a known sensitivity to medical-grade adhesives or a bleeding disorder will be \\[applicable to continuous glucose monitoring component only\\]\n* with contraindications specified by the blood pressure monitoring device manufacturer \\[applicable to continuous blood pressure monitoring component only\\]\n* participated in the pilot study \\[applicable to main trial only\\].","69 Years",{"count":268,"type":23},600,[26],"The overarching aim is to improve cardiometabolic health and promote healthy ageing by supporting adults to adopt favourable lifestyle patterns identified through our observational research. The trial will recruit n=600 to be involved in Phase I (referred to as the \"Optimisation Phase\") of a two-phase project (Phase II trial registration will be submitted separately). All participants will complete a baseline study visit where, after consent taking, will complete a baseline questionnaire, receive a smartwatch each and additional wearables if applicable, and download the study app for the receiving and testing of interventions and completion of short form surveys. Participants will be involved in the continual evaluation and optimisation of ecological momentary interventions (EMIs) in adaptive, factorial, micro-randomised trials over 12 months. Consenting participants may also be contacted to participate in interviews to be involved in the co-design of interventions, or to provide insights to the feasibility and process evaluation of the trial.",[29,141,272,273,274],"Sleep","Cardiometabolic Health","Digital Intervention",[276,277,278,279,280,281,282,113,283,284],"smartphone","smartwatch","ecological momentary assessment","EMA","ecological momentary intervention","EMI","microrandomised trial","digital health","intervention","2026-07-23",{"date":251,"type":41},{"date":253,"type":23},{"date":289,"type":23},"2031-06-30",{"name":291,"class":48},"National University of Singapore",{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":56,"sex":173,"minAge":299,"maxAge":57,"enrollmentInfo":300,"targetDuration":4,"studyType":24,"phases":302,"briefSummary":304,"conditions":305,"keywords":309,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":87},"100542041","phase-2-smart-walk-a-culturally-tailored-smartphone-delivered-physical-activity-intervention-for-african-american-women-100542041","NCT06337708","Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women","Smart Walk: An Efficacy Trial of a Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women","Inclusion Criteria:\n\n* Self-reported African American\u002FBlack female\n* Aged of 24-65 years\n* Insufficiently Active (\\\u003C 60 minutes of moderate-to-vigorous physical activity per week as measured by Exercise Vital Sign Questionnaire)\n* BMI \\> 25 kg\u002Fm2\n* English speaking and reading\n* Ownership of a smartphone with the ability to download applications (i.e., apps)\n* Ownership of a smartphone with the ability to receive text messages\n* Willingness to receive a physical activity intervention delivered through their smartphone\n* Willingness to include their first name or create an alias to be used on their profile page on the Smart Walk app\n\nExclusion Criteria:\n\n* Plans to relocate out of Phoenix area in next 12 months\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a doctor's note for study participation in provided\n* Resting systolic blood pressure greater than 180 mmHG and\u002For a diastolic blood pressure greater than 120 mmHG , as assessed at baseline or at any other study assessment\n* Self-reported participation in another diet or weight loss study at screening\n* Pregnant or planning to become pregnant in the next 12 months","24 Years",{"count":301,"type":23},210,[303],"PHASE2","The purpose of this study is to test a culturally tailored, smartphone-delivered intervention designed to increase physical activity and reduce risk for heart disease and type 2 diabetes among African American women.",[29,216,306,307,308],"Heart Diseases","Diabetes Mellitus","Physical Inactivity",[113,310,311,312,313,31,35,314,315],"women's health","health equity","African American women","Black women","heart disease","diabetes","2026-07-16",{"date":318,"type":41},"2026-07-17",{"date":320,"type":41},"2024-04-08",{"date":322,"type":23},"2029-03-31",{"name":324,"class":48},"Arizona State University",{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":56,"sex":18,"minAge":175,"maxAge":57,"enrollmentInfo":332,"targetDuration":4,"studyType":24,"phases":334,"briefSummary":335,"conditions":336,"keywords":337,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":343,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":87},"100514557","goal-setting-to-promote-physical-activity-adherence-in-midlife-adults-100514557","NCT05980052","Goal Setting to Promote Physical Activity Adherence in Midlife Adults","Goal Setting to Promote Physical Activity Adherence in Midlife to Reduce Risk of Alzheimer's Disease and Related-Dementias: A Randomized Mechanistic Proof-Of-Concept Trial","Inclusion Criteria:\n\n* Aged 45 to 65 years\n* BMI between 30 kg\u002Fm2 to 50 kg\u002Fm2\n* Participants must weigh a minimum of 110 pounds\n* Engaging in 60 minutes or less of self-reported moderate-to-vigorous physical activity at screening (based on Exercise Vital Sign Questionnaire)\n* Self-reported ownership of a smartphone with an iOS or Android operating system (necessary for participants to track their activity using a Fitbit activity monitor)\n\nExclusion Criteria:\n\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a physician's note is provided\n* Resting blood pressure greater than 200\u002F110 mmHG as assessed at the baseline study assessment (unless a physician's note is provided)\n* Pregnant or planning to become pregnant in next 8-months (Phase 1) or 12 months (Phase 2)\n* Plans to relocate out of metropolitan Phoenix, Arizona area in the next 8-months (Phase 1) or 12 months (Phase 2)\n* Participation in another physical activity, nutrition or weight loss program at time of screening or at any time during the intervention\n* Individuals with mild cognitive impairment (MCI), as determined by either a self-report of receiving a diagnosis of MCI from a health care provider or as assessed by the Montreal Cognitive Assessment (MoCA) at the study orientation session. A score \\\u003C 26 is an exclusion criterion for US born participants. A score of \\\u003C23 is an exclusion for participants born outside of the US who completed their high school education in a country where English is not the primary language.\n* Being previously prescribed one of the 5 approved Alzheimer's medications, including: Donepezil (Aricept), Rivastigmine (Exelon), Galantamine (Razadyne), Memantine (Namenda), Memantine + Donepezil (Namzaric)\n* Score of 16 or higher on the Center for Epidemiological Studies-Depression Scale (CES-D)\n* Self-reported current diagnosis of major depression\n* Currently taking 2 or more ant-depression drugs\n* History of stroke\n* Incarcerated individuals (i.e., Prisoners)",{"count":333,"type":23},144,[26],"Engaging in regular physical activity during midlife is a key lifestyle behavior associated with reduced risk for Alzheimer's disease and related dementias (AD\u002FADRD). Yet nearly half of midlife adults (48%) do not meet national physical activity guidelines. The purpose of this mechanistic trial is to identify effective goal setting techniques to enhance psychosocial processes of self-regulation for the successful promotion of PA and adherence to national PA guidelines among midlife adults, with the long-term goal of reducing AD\u002FADRD risk",[29,216],[31,35,338,339,340,341,342],"mild cognitive impairment","Alzheimer's disease","dementia","behavior change","midlife",{"date":318,"type":41},{"date":345,"type":41},"2023-07-17",{"date":347,"type":23},"2027-05-31",{"name":324,"class":48},{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":355,"eligibilityCriteria":356,"healthyVolunteers":56,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":24,"phases":358,"briefSummary":359,"conditions":360,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":87},"100647586","ecological-momentary-cognitive-assessment-100647586","NCT07710339","Ecological Momentary Cognitive Assessment","Characterizing Daily Activity and Cognition in Older Adults","DEACS","Inclusion Criteria:\n\n* age ≥65\n* fluent in English\n* own a smartphone\n* able to provide digital informed consent\n* able to walk without assistance from others (a cane or walker is allowed)\n* low-active as defined by participating in purposeful aerobic exercise two days or less per week\n\nExclusion Criteria:\n\n* potential neurological cofounders (stroke, seizure disorder, recent head injury or loss of consciousness)\n* diagnosis of clinical mental abnormalities (e.g., schizophrenia, bipolar disorder, Parkinson's Disease, Alzheimer's disease and related dementias)\n* any other conditions that may impact their ability to complete the ecological momentary cognitive tasks or physical activity (e.g., visual or auditory impairments, uncontrolled arthritis)\n* A score lower than 32 on the TICS-M.",{"count":233,"type":23},[26],"The purpose of this study is to characterize the relationships between changes in cognitive functioning across the day and patterns of physical activity in older adults. Those who participate in the program will complete tests of cognition and several surveys at the start. They will then wear an activity monitor and complete four cognitive tests plus surveys per day for one week. After this week concludes, they will continue completing the surveys and cognitive tests, and will engage in one week of structured exercise at a research center and one week where they work to move throughout the day.",[29,361,362],"Cognition","Aging","2026-07-13",{"date":318,"type":41},{"date":366,"type":23},"2026-08-15",{"date":368,"type":23},"2027-04-01",{"name":370,"class":48},"Wake Forest University",{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":12,"sex":18,"minAge":379,"maxAge":4,"enrollmentInfo":380,"targetDuration":4,"studyType":24,"phases":381,"briefSummary":382,"conditions":383,"keywords":395,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":87},"100646109","evaluation-of-choose-to-move-replacement-ready-ctm-rr-100646109","NCT07696650","Evaluation of Choose to Move Replacement Ready (CTM-RR)","Choose to Move Replacement Ready: Implementation and Effectiveness of a Virtual Health-Promoting Intervention for People Awaiting Total Hip or Knee Replacement Surgery","CTM-RR","Inclusion Criteria:\n\n1. Activity coach hired by the Active Aging Society (activity coaches must speak English to participate in the evaluation);\n2. English-speaking older adults (aged \\>=50 years) who participate in CTM-RR will be invited to participate in the evaluation;\n3. Referral partner (People who work in a healthcare setting who refer patients into the program)\n\nExclusion Criteria:\n\n1. non-English speaking activity coach\n2. non-English speaking referral partner","50 Years",{"count":301,"type":23},[26],"Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \\>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR\u002FTHR) for osteoarthritis (OA). The primary goals of this observational study are to describe how the adapted program, Choose to Move Replacement Ready (CTM-RR), is implemented in BC and determine if the adapted program improves health outcomes in people with hip and\u002For knee osteoarthritis who are on surgical waitlists for TKR\u002FTHR. The investigators will also evaluate whether any health benefits achieved by CTM-RR participants are maintained three months after they finish the program and also during the remaining time that they wait for their TKR\u002FTHR surgery.\n\nThe investigators will work with referral partners from hospitals and orthopaedic clinics in BC to recruit participants into CTM-RR. Participants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.",[384,385,386,387,388,389,29,390,391,392,393,394],"Osteoarthritis (OA)","Osteoarthritis (OA) of the Hip","Osteoarthritis (OA) of the Knee","Total Knee Anthroplasty","Total Hip Arthroplasty (THA)","Mobility Limitation","Older Adults","Social Isolation or Loneliness","Pain","Implementation Science","Sedentary Behaviors",[396,397,243,398,399,400,401,402,392],"Osteoarthritis","Implementation science","Social isolation","Older adults","Mobility","Joint replacement","Loneliness","2026-07-08",{"date":405,"type":41},"2026-07-10",{"date":407,"type":23},"2026-08",{"date":409,"type":23},"2028-08",{"name":411,"class":48},"University of British Columbia",{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":418,"eligibilityCriteria":419,"healthyVolunteers":12,"sex":18,"minAge":420,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":24,"phases":422,"briefSummary":423,"conditions":424,"keywords":427,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":4},"100645437","effects-of-adapted-snacktivity-intervention-on-cognition-and-self-care-in-copd-patients-100645437","NCT07702994","Effects of Adapted Snacktivity™ Intervention on Cognition and Self-Care in COPD Patients","Development and Evaluation of a Culturally Adapted Snacktivity™ Intervention to Enhance Cognition and Self-Care in Patients With Chronic Obstructive Pulmonary Disease (COPD)","Snacktivity™","* Inclusion Criteria:\n\n  1. Confirmed diagnosis of COPD in accordance with the 2026 Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guideline, with a post-bronchodilator ratio of FEV₁\u002FFVC \\\u003C 70%;\n  2. Aged ≥ 60 years;\n  3. Clinically stable condition;\n  4. Score at or below the age- and education-adjusted cutoff (16th percentile) on the Hong Kong Montreal Cognitive Assessment (HK-MoCA) 5-minute Protocol, indicating mild cognitive impairment;\n  5. No exercise contraindications;\n  6. No active wrist skin conditions that would prevent wearing an activity tracker (Phase 2 \\& 3);\n  7. Willingness to wear an activity tracker during the intervention (Phase 2 \\& 3);\n  8. Possession of a smartphone capable of receiving instant messages (Phase 2 \\& 3);\n  9. Proficiency in Cantonese or Mandarin;\n  10. Willingness to provide written informed consent and commitment to trial completion.\n* Exclusion Criteria\n\n  1. Receipt of oxygen therapy for ≥ 15 hours per day or requirement for mechanical ventilation;\n  2. History of brain injury or stroke;\n  3. Presence of severe comorbidities including coronary artery disease, severe hepatic or renal dysfunction;\n  4. Diagnosis of psychiatric disorders, deafness, severely limited physical mobility, or inability to cooperate with trial interventions;\n  5. For Phase 2 and Phase 3: Use of medications documented to impact cognitive function.","60 Years",{"count":301,"type":23},[26],"This clinical trial aims to evaluate whether a culturally adapted Snacktivity™ program can improve cognitive function and self-care abilities in patients with Chronic Obstructive Pulmonary Disease (COPD) in Hong Kong.\n\nThe main questions it aims to answer are:\n\n1. Does the Snacktivity™ program improve the cognitive function of participants (including both global cognition and targeted subdomains)?\n2. Does the program improve participants' self-care abilities?\n\nThe study consists of three sequential phases:\n\nPhase 1 (Co-design workshops): Co-design workshops will be conducted with COPD patients, healthcare professionals (nurses, physical therapists, occupational therapists), and family caregivers to culturally adapt the Snacktivity™ program for Hong Kong COPD patients.\n\nPhase 2 (Feasibility Pilot RCT): The adapted program will be tested in a small-scale pilot study to assess its feasibility and short-term clinical effects.\n\nPhase 3 (Full-scale RCT): A full-scale randomised controlled trial will be conducted to evaluate the program's efficacy on the primary and secondary outcomes.\n\nParticipants in the intervention group will be asked to:\n\nParticipate in the culturally adapted Snacktivity™ program that integrates short, manageable \"snacks\" of physical activity into daily routines.\n\nWear an activity tracker to monitor physical activity levels. Complete questionnaires at multiple time points assessing cognitive function, self-care abilities, physical activity levels, self-efficacy, exercise capacity, quality of life, anxiety, and depression.\n\nResearchers will compare the intervention group to an attention control group (receiving usual care with health education) to see if the Snacktivity™ program leads to greater improvements in these outcomes.",[425,29,361,426],"COPD","Self Care",[425,428,429],"cognitive function","self care",{"date":431,"type":41},"2026-07-14",{"date":433,"type":23},"2026-07-15",{"date":435,"type":23},"2028-06-30",{"name":437,"class":48},"The University of Hong Kong",{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":56,"sex":18,"minAge":444,"maxAge":445,"enrollmentInfo":446,"targetDuration":4,"studyType":24,"phases":448,"briefSummary":449,"conditions":450,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":452,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":456,"locationsCount":87},"100599092","healthy-school-recognized-campus-a-hybrid-type-2-implementation-effectiveness-trial-100599092","NCT07079995","Healthy School Recognized Campus: A Hybrid Type 2 Implementation-Effectiveness Trial","School Inclusion Criteria:\n\n* located in Central and East Texas\n* Public school\n\nStudent Inclusion Criteria\n\n* enrolled in the 4th, 5th, 6th, 7th, 8th, or 9th grade\n* able to read, speak, and write in English\n\nStudent Exclusion Criteria:\n\n* any motor or cognitive impairments or other health conditions that would prevent them from completing a physical assessment","8 Years","16 Years",{"count":447,"type":23},900,[26],"Healthy School Recognized Campus is a Texas A\\&M AgriLife Extension initiative that supports the delivery of school-based physical activity and nutrition programs for diverse youth across Texas. The purpose of this study is to conduct a type 2 hybrid implementation-effectiveness, cluster dual randomized controlled trial (DRCT) to assess both Healthy School Recognized Campus (HSRC) and the mentoring program.",[104,29,451],"Nutrition",{"date":405,"type":41},{"date":454,"type":41},"2025-09-01",{"date":435,"type":23},{"name":457,"class":48},"Texas A&M University",{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":18,"minAge":379,"maxAge":4,"enrollmentInfo":466,"targetDuration":4,"studyType":24,"phases":468,"briefSummary":469,"conditions":470,"keywords":473,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":87},"100535061","healthy-aging-as-black-adults-in-it-together-a-comparative-effectiveness-study-of-chronic-pain-and-cognitive-decline-100535061","NCT06246929","Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline","Comorbidity of Chronic Pain and Early Cognitive Decline Among Older, Community-Based Black Adults: Comparative Effectiveness of Mindfulness-Based Cognitive Therapy With Walking (MBCT+w) vs Active Living Every Day (ALED)","HABIT","Inclusion Criteria:\n\n* Black adults, male and females, age 50 or older\n* Have nonmalignant musculoskeletal chronic pain for more than three months\n* Reports early cognitive decline (subjective and objective)\n* Telephone Interview for Cognitive Status-41 score greater than or equal to 31\n* Functional Activities Questionnaire score less than 9\n* English fluency\u002Fliteracy\n* Free of concurrent psychotropic or pain medication for at least 2 weeks prior to initiation of treatment, OR stable on current psychotropic or pain medication for a minimum of 6 weeks and willing to maintain stable dose\n* Cleared by medical doctor for study participation and no self-reported concerns about physical functioning on the revised Physical Activity Readiness Questionnaire (PAR-Q; score 0)\n\nExclusion Criteria:\n\n* Diagnosed with dementia or neurodegenerative disease\n* Regular use of nonpharmacological pain management\n* Diagnosed with serious mental illness or substance abuse\n* Current suicidal ideation on self-report\n* Engagement of regular exercise for more than 30 minutes daily\n* Unable to walk",{"count":467,"type":23},400,[26],"The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active Living Every Day (ALED). The investigators will assess how each program may help in improving physical, cognitive, and emotional function. The investigators will also assess whether improvements in outcomes from the two programs are maintained through a 6-month follow-up.",[471,29,390,472],"Chronic Pain","Mild Cognitive Impairment",[474,475,476,477,392,478],"Black Older Adults","African Americans","Subjective Cognitive Decline","Memory Related Problems","Cognition Disorders","2026-07-02",{"date":481,"type":41},"2026-07-07",{"date":483,"type":41},"2025-01-10",{"date":485,"type":23},"2028-12-15",{"name":487,"class":48},"Massachusetts General Hospital",{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":494,"eligibilityCriteria":495,"healthyVolunteers":12,"sex":173,"minAge":96,"maxAge":4,"enrollmentInfo":496,"targetDuration":4,"studyType":498,"phases":4,"briefSummary":499,"conditions":500,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":4},"100644996","health-body-composition-and-nutrition-research-among-women-in-kazakhstan-100644996","NCT07675486","Health, Body Composition, and Nutrition Research Among Women in Kazakhstan","Understanding Women's Health in Kazakhstan: Body Composition as a Key Indicator for Precision Nutrition and Predictive Healthcare","HER-KZ","Inclusion Criteria:\n\n* Female sex\n* Age ≥20 years at the time of consent\n* Natural postmenopause (≥12 consecutive months of amenorrhoea not attributable to other pathological or pharmacological causes) OR surgical postmenopause (bilateral oophorectomy)\n* Resident of Astana or the surrounding region with no planned relocation during the study period\n* Able to provide written informed consent independently\n* Able to complete the questionnaire in Kazakh, Russian, or English\n\nExclusion Criteria:\n\n* Active malignancy or systemic anti-cancer treatment (chemotherapy, radiotherapy, immunotherapy) within the past 5 years\n* Conditions causing secondary changes in muscle mass or body composition: hyperthyroidism (untreated), Cushing's syndrome, acromegaly, severe liver disease (Child-Pugh B or C), advanced chronic kidney disease (Stage 4 or 5, eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²)\n* Neuromuscular disorders that independently affect skeletal muscle mass (e.g., myopathy, motor neurone disease, multiple sclerosis)\n* Long-term systemic corticosteroid therapy (\\>3 months in the past year, equivalent to ≥5 mg\u002Fday prednisolone)\n* Severe skeletal deformity (kyphoscoliosis, limb absence) or presence of metallic implants (hip or knee prosthesis on both sides, bilateral rods) that would significantly compromise DEXA body composition validity\n* Physical inability to stand or to complete the functional assessments safely\n* Cognitive impairment or psychiatric condition precluding independent informed consent, as determined by the recruiting research team member",{"count":497,"type":23},200,"OBSERVATIONAL","This study aims to investigate the association between dietary intake, physical activity, sleep quality, and body composition in women in Kazakhstan. The study will recruit approximately 200 women aged 20 years and older undergoing routine DEXA examinations in Astana. Participants will complete validated questionnaires assessing diet, physical activity, sleep quality, and sarcopenia risk, alongside functional assessments. DEXA scans will provide measurements of fat mass, lean mass, visceral adipose tissue, bone mineral density, and appendicular skeletal muscle mass. The primary objective is to evaluate associations between dietary quality and DEXA-derived outcomes. Secondary objectives include assessing sarcopenia prevalence and examining relationships between physical activity, sleep quality, supplement use, and body composition. An optional second stage will explore associations between body composition and existing inflammatory and metabolic biomarkers from medical records. The findings are expected to provide the first comprehensive DEXA-based dataset on women's body composition and lifestyle factors in Kazakhstan and inform public health strategies.",[501,502,272,29],"Body Composition Changes","Dietary Intakes","2026-06-26",{"date":505,"type":41},"2026-06-30",{"date":507,"type":23},"2026-07",{"date":509,"type":23},"2029-07",{"name":511,"class":48},"Nazarbayev University",{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":517,"acronym":518,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":18,"minAge":96,"maxAge":520,"enrollmentInfo":521,"targetDuration":4,"studyType":498,"phases":4,"briefSummary":523,"conditions":524,"keywords":529,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":87},"100645093","the-muscle-monitor-early-skeletal-muscle-indicators-of-insulin-resistance-and-cardiometabolic-risk-100645093","NCT07678736","The Muscle Monitor: Early Skeletal Muscle Indicators of Insulin Resistance and Cardiometabolic Risk","The Muscle Phenotype and Cardiometabolic Health Monitoring Project","MUSCLE MONITOR","Inclusion Criteria:\n\n* Sex: Males and females\n* Age: 20-30 years\n* BMI \\\u003C35\n* Healthy (no diagnosed chronic disease)\n\nExclusion Criteria:\n\n* Chronic disease deemed to affect study outcomes\n* Disease that increase haemorrhage risk\n* Daily intake of medication that could confound study outcomes\n* Regular smokers\n* Active pregnancy\n* Immobilization (inactivity due to injury or illness, e.g. cast or brace) for more than a week in the month prior to the study or for more than 4 weeks in the past 6 months prior to the study\n* Very high structured physical exercise level (\\>10 h\u002Fweek).\n* Participants not willing to adhere to standardized meal prescriptions included in the study protocols will also be excluded (due to e.g. allergies or specific dietary preferences)","30 Years",{"count":522,"type":23},250,"Insulin resistance is an early etiological factor in the development of type-2 diabetes (T2D), which constitutes a large societal health burden with an expected additional rise in the years to come.\n\nSkeletal muscle is the body's largest lean tissue mass and the major site of glucose disposal in response to insulin stimulation. Prior studies have suggested that a fast skeletal muscle phenotype, including a predominant fast muscle fiber composition, reduced capillary density, low fat oxidation and muscle oxidative capacity may be implicated in insulin resistance and TD2 development. However, key questions pertain in relation to the cause and effect of these relationships as well as the interaction with potential confounders and effect-modifiers including life-style factors (e.g. diet and physical activity levels) and general participant characteristics (e.g. body composition and training status).\n\nIn the present project, we therefore aim to derive muscle fiber type and extensively map the proteomic signature of the early stages of insulin resistance in a large cross-sectional study using a young and apparently healthy cohort prior to T2D development, including a thorough participant characterization. We will recruit \\~250 participants (men and women) in the age of 20-30 years and conduct extensive phenotyping and tissue sampling across one laboratory-based test day and a scan visit, as well as measurements of physical activity level and glucose handling in free-living conditions with wearable sensors.\n\nThe study has a longitudinal aspect as participants will be re-invited at 5-year intervals for up to 20 years to delineate the trajectory of metabolic health in relation to muscle phenotype measures.\n\nThe results of the project are expected to lead to significant advancements in our understanding of the importance of muscle phenotype for early-stage insulin resistance and metabolic health trajectories. Such understanding has potentially important clinical implications, as it can open new avenues for targeted interventions and individualized early preventive strategies to counter or delay the progression of insulin resistance and associated metabolic and cardiovascular disorders.",[525,526,527,29,528],"Insulin Resistance","Insulin Resistance and Type 2 Diabetes","Cardiometabolic Risk Factors","Muscle Fiber Type",[530,531,243],"Insulin sensitivity","Skeletal muscle","2026-06-24",{"date":534,"type":41},"2026-07-01",{"date":536,"type":41},"2025-05-19",{"date":538,"type":23},"2046-12-31",{"name":540,"class":48},"University Ghent",{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":547,"eligibilityCriteria":548,"healthyVolunteers":56,"sex":18,"minAge":19,"maxAge":549,"enrollmentInfo":550,"targetDuration":4,"studyType":498,"phases":4,"briefSummary":552,"conditions":553,"keywords":555,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":563,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":567,"locationsCount":87},"100644995","effects-of-sustainable-exercise-habits-in-university-students-100644995","NCT07676292","Effects of Sustainable Exercise Habits in University Students","From Mind to Body: Evaluating the Effects of Sustainable Exercise Habits on Cognitive Awareness, Body Awareness, and Sleep Quality in University Students","SUSTAIN-EX","Inclusion Criteria:\n\n* Being a university student aged between 18 and 25 years\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Having any diagnosed psychiatric disorder\n* Regularly using medications that affect sleep patterns or cognitive functions\n* Having been diagnosed with a sleep disorder\n* Having a history of substance or alcohol addiction\n* Having had an acute illness within the last 1 month\n* Having undergone surgery within the last 6 months","25 Years",{"count":551,"type":23},140,"This cross-sectional comparative study aims to evaluate the effects of sustainable exercise habits on cognitive awareness, body awareness, and sleep quality in university students.\n\nThe main hypotheses are:\n\nH0: There is no difference in cognitive awareness, body awareness, and sleep quality between university students with sustainable exercise habits and those with a sedentary lifestyle.\n\nH1: There is a difference in cognitive awareness, body awareness, and sleep quality between university students with sustainable exercise habits and those with a sedentary lifestyle.",[554,29],"Sedentary Lifestyle",[556,557,558,559,560,561,562],"University Students","Sustainable Exercise","Sedentary Behavior","Cognitive Awareness","Decision Making","Sleep Quality","body awareness",{"date":505,"type":41},{"date":565,"type":23},"2026-06-10",{"date":217,"type":23},{"name":568,"class":48},"Yeditepe University",{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":574,"acronym":575,"eligibilityCriteria":576,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":577,"targetDuration":4,"studyType":24,"phases":579,"briefSummary":580,"conditions":581,"keywords":586,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":596,"leadSponsor":598,"locationsCount":87},"100644394","the-shape-project-hospital-system-for-physical-activity-and-active-participation-after-hospitalized-decompensation-of-respiratory-chronic-diseases-100644394","NCT07663955","The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases","The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Disease in Respiratory Patients","SHAPE","Inclusion Criteria:\n\n* Age 65 years or older\n* Admission at risk of functional decline (hospital admission lasting \\> 5 days) Discharge destination: Home or residence where the patient lived prior to admission\n* Favorable multidisciplinary assessment by the healthcare team responsible for the patient during admission regarding the patient's physical fitness to perform the SHAPE program\n\nExclusion Criteria:\n\n* Explicit decision by the patient not to participate\n* Musculoskeletal problem that limits mobility\n* Limiting sociopathy (socio-family environment not optimal to guarantee program adherence)\n* Drug dependence (condition at discharge not optimal to guarantee program adherence)\n* Insufficient digital literacy and\u002For lack of online resources that do not guarantee participation in telematic sessions\n* Discharge destination: Long-term convalescent care center\n* Advanced and\u002For terminal stage of lung disease (patients with the following resources activated: Home Care and Support Teams Program for advanced disease (PADES), intensive home care at discharge due to extreme frailty (AT-DOM), advanced chronic disease requiring palliative care and a life expectancy of 12 months or less (MACA))Unstable underlying non-pulmonary disease (whether medical or mental, for example: acute myocardial infarction) Recent myocardial infarction (MI), recent stroke, recent hospitalization for psychiatric decompensation\\*) \\*Recent = within the last 3 months\n* Unstable underlying pulmonary disease (vital hemoptysis, new thoracic neoplasm, high-intermediate risk pulmonary thromboembolism)",{"count":578,"type":23},90,[26],"It is widely established that a lack of adapted physical activity (APA) and sedentary behaviors increase the prevalence of frailty, which exacerbates chronic diseases. Hospital stays amplify this phenomenon, leading to physical deconditioning, often irreparable, especially in older patients if it is not detected and treated promptly. To date, there is no standard of care focused on APA to address frailty acquired during hospital stays. In this context, the SHAPE project (Hospital System for Physical Activity and Active Participation) aims to prevent dependency in older adults with chronic diseases by developing an innovative patient journey based on APA. The project seeks to reduce frailty acquired during hospital stays by establishing standards for APA prescription, based on early diagnosis and intervention. SHAPE ensures equal access to care through an accessible and user-friendly web platform, designed for older users and also including those in rural areas. It fosters the resilience of healthcare systems by integrating a preventive and multidisciplinary approach into hospital treatments and optimizes resources through a tiered care model that provides progressive and personalized care.\n\nAlthough hospital stays have been shown to trigger physical deconditioning, there is no adapted physical activity program initiated by the hospital and followed at home after hospital discharge from a severe exacerbation in patients with chronic respiratory diseases. The SHAPE Project offers a highly beneficial tool for patients with acute or exacerbated chronic respiratory disease requiring hospitalization, promoting better overall recovery after discharge. Furthermore, this project will foster healthy lifestyles and promote health from a sustainability and prevention perspective. Of particular interest is the opportunity to offer a lifestyle change program (physical activity and hygiene-dietary measures) focused on respiratory patients and adapted to their specific needs. Moreover, the project is considered innovative in implementing healthy clinical practices through telemedicine. In addition, it offers post-hospital discharge services that, to date, have not been considered in a generic way for respiratory patients except in selective subgroups (post-COVID, patients included in lung transplant program, etc.).\n\nIn respiratory patients who have required high-risk admission due to decompensation, the implementation of the SHAPE program after hospital discharge as a support program that combines an adapted physical activity plan and general hygiene and dietary advice will improve the health indicators (frailty, sarcopenia, dyspnea, exercise tolerance, quality of life) of these patients.",[582,583,584,29,585],"Frailty","Sarcopenia","Hospital Discharge","Acute Exacerbation Chronic Pulmonary Disease",[587,588,589,590,591],"adapted physical activity","frailty","sarcopenia","hospital discharge","acute exacerbation chronic pulmonary disease","2026-06-17",{"date":594,"type":41},"2026-06-23",{"date":43,"type":23},{"date":597,"type":23},"2028-03-30",{"name":599,"class":48},"Hospital Universitari de Bellvitge",{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":4,"eligibilityCriteria":606,"healthyVolunteers":56,"sex":18,"minAge":607,"maxAge":19,"enrollmentInfo":608,"targetDuration":4,"studyType":24,"phases":610,"briefSummary":611,"conditions":612,"keywords":618,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":87},"100641968","the-effects-of-game-based-exercise-programs-100641968","NCT07660822","THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS","THE EFFECTS OF VIRTUAL REALITY AND VIDEO GAME-BASED EXERCISE PROGRAMS ON PHYSICAL FITNESS AND ATTENTION LEVELS IN HEALTHY ADOLESCENTS","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Being an adolescent aged 10-18 years\n* Having a score below 4 on the Physical Activity Scale for Adolescents\n\nExclusion Criteria:\n\n* Having any physical disability that would prevent participation in the exercise program\n* Having upper or lower extremity orthopedic disease\n* Having a score above 4 on the Physical Activity Scale for Adolescents","10 Years",{"count":609,"type":23},48,[26],"Studies comparing aerobic exercise with virtual reality or video game technologies to traditional games and classical exercise have been conducted in healthy adolescents, but no studies comparing virtual reality and video game technologies have been found. Based on all this, we aimed to investigate the effect of virtual reality and video game-based exercise programs on physical fitness and attention levels in healthy adolescents. The study was planned as a quantitative experimental randomized controlled trial. Healthy individuals aged 10-18 years who meet the inclusion criteria will be evaluated during the dates of the study. Individuals will be divided into 3 groups: a classical physical activity group, a virtual reality group, and a video-based game group. Each program will be implemented for 20-30 minutes, three days a week for eight weeks. The Physical Activity Scale for Adolescents was used to evaluate the physical activity of the individuals, the Multidimensional Body-Self Relationship Scale was used to measure body image, and the Exercise Benefit\u002FBarrier Scale was used to measure exercise perception. To measure attention, balance, and reaction time, the D2 Attention Test, Y-Balance Test, and Nelson's Hand Reaction Test will be administered, respectively. In the virtual reality and video-based game group, the games played by participants will be similar to the physical activities performed in the classic exercise group. One or more games incorporating these physical activities will be selected.",[29,613,614,615,616,617],"Body Image","Exercise Perception","Balance","Reaction Time","Attention",[619,620,621],"Healthy adolescent","virtual reality","attention level)","2026-06-16",{"date":120,"type":41},{"date":625,"type":41},"2025-11-15",{"date":627,"type":23},"2026-08-30",{"name":629,"class":48},"Gaziantep Islam Science and Technology University",{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":4,"eligibilityCriteria":636,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":637,"targetDuration":4,"studyType":498,"phases":4,"briefSummary":639,"conditions":640,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":644,"lastUpdatePostDateStruct":645,"startDateStruct":647,"completionDateStruct":648,"leadSponsor":650,"locationsCount":4},"100641843","symptom-severity-posture-pain-and-physical-activity-in-gastroesophageal-reflux-disease-100641843","NCT07643779","Symptom Severity, Posture, Pain, and Physical Activity in Gastroesophageal Reflux Disease","Investigation of Symptom Severity, Posture, Musculoskeletal Pain, and Physical Activity Levels in Patients With Gastroesophageal Reflux Disease","Inclusion Criteria:\n\n* Being diagnosed with gastroesophageal reflux disease (GERD)\n* Age between 18 and 65 years\n* Willingness to participate in the study assessments\n\nExclusion Criteria:\n\n* Presence of a diagnosed psychiatric disorder\n* Pregnancy or breastfeeding status",{"count":638,"type":23},51,"This study is a cross-sectional research designed to investigate symptom severity, posture, musculoskeletal pain, and physical activity levels in individuals with gastroesophageal reflux disease (GERD).",[641,642,643,29],"Gastroesophageal Reflux Disease (GERD)","Symptom","Musculoskeletal Pain","2026-06-11",{"date":646,"type":41},"2026-06-15",{"date":534,"type":23},{"date":649,"type":23},"2026-12-30",{"name":651,"class":48},"Karabuk University",{"id":653,"slug":654,"hasResults":12,"nctId":655,"briefTitle":656,"officialTitle":656,"acronym":4,"eligibilityCriteria":657,"healthyVolunteers":12,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":658,"targetDuration":4,"studyType":24,"phases":660,"briefSummary":661,"conditions":662,"keywords":667,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":672,"startDateStruct":673,"completionDateStruct":675,"leadSponsor":677,"locationsCount":164},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933","NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors",{"count":659,"type":23},64,[26],"The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[663,390,664,665,666,29,308],"Older Adults With Cognitive Decline","AI-Based Fitness","Wearables","Cognitive Decline",[399,668,664,29,308,669,670,671],"Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults",{"date":646,"type":41},{"date":674,"type":41},"2026-06-08",{"date":676,"type":23},"2028-06-08",{"name":86,"class":48},{"id":679,"slug":680,"hasResults":12,"nctId":681,"briefTitle":682,"officialTitle":683,"acronym":684,"eligibilityCriteria":685,"healthyVolunteers":56,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":686,"targetDuration":688,"studyType":498,"phases":4,"briefSummary":689,"conditions":690,"keywords":691,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":697,"lastUpdatePostDateStruct":698,"startDateStruct":699,"completionDateStruct":701,"leadSponsor":702,"locationsCount":87},"100643262","my-wellness-begins-with-the-steps-100643262","NCT07639814","My Wellness Begins With the Steps!","My Wellness Begins With the Steps! \u002F Mi Bienestar se Inicia en Los Peldaños! (Mi BIP!) N-of-1 Pilot Trial","Mi BIP!","Inclusion Criteria:\n\n* All subway users\n\nExclusion Criteria:\n\n* None",{"count":687,"type":23},2000,"1 Day","This study evaluates the effect of street signs inviting to use the conventional stairs instead of escalators at a subway station without and with active pop music.",[29],[692,693,694,695,696],"Subway","Phsysical activity","Chile","Street signs","Music","2026-06-06",{"date":565,"type":41},{"date":700,"type":23},"2026-06-01",{"date":627,"type":23},{"name":703,"class":48},"Pontificia Universidad Catolica de Chile",{"id":705,"slug":706,"hasResults":12,"nctId":707,"briefTitle":708,"officialTitle":708,"acronym":4,"eligibilityCriteria":709,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":710,"targetDuration":4,"studyType":24,"phases":712,"briefSummary":713,"conditions":714,"keywords":718,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":726,"lastUpdatePostDateStruct":727,"startDateStruct":729,"completionDateStruct":731,"leadSponsor":733,"locationsCount":87},"100636075","addressing-food-access-and-physical-activity-to-improve-diabetes-prevention-outcomes-among-underserved-african-americans-100636075","NCT07560969","Addressing Food Access and Physical Activity to Improve Diabetes Prevention Outcomes Among Underserved African Americans","Inclusion Criteria:\n\n* Members of a participating church or user of a participating church's outreach services\n* Age 18 years or older\n* Prediabetic (score of 5 or higher in the National Diabetes Prevention Program Risk Score or (\\[body mass index \\> 24 or history of gestational diabetes\\] and (5.7-6.4 A1v, 100-125 mg\u002FdL fasting plasma glucose, or 140-149 mg\u002FdL oral glucose tolerance test)\n\nExclusion Criteria:\n\n* Individuals who are pregnant, breastfeeding or planning to become pregnant in the next year\n* Individuals with unsafe blood pressure levels (160 systolic or higher or 100 diastolic or higher) without a medical clearance firn\n* Individuals who are not able to engage in low-impact physical activity\n* Individuals who do not speak English\n* Individuals who live in a household with a participant in this study at a different church",{"count":711,"type":23},408,[26],"The goal of this clinical trial is to learn if an enhanced, culturally, socially, and structurally tailored Diabetes Prevention Program (E-DPP) can improve weight loss and related diabetes risk factors in African American adults with prediabetes living in low-income, socially vulnerable communities.\n\nThe main questions it aims to answer are:\n\n* Does the enhanced DPP (E-DPP) lead to greater percent weight loss at 6 and 12 months compared to the standard culturally tailored DPP (S-DPP)?\n* How do social determinants (e.g., food insecurity, stigma, access to resources) influence weight loss and engagement in lifestyle behaviors?\n\nResearchers will compare a standard culturally tailored DPP (S-DPP) to an enhanced DPP (E-DPP) to see if improving access to healthy food, physical activity, and community resources increases weight loss and improves diabetes-related outcomes.\n\nParticipants will\n\n1. Attend DPP sessions delivered in community settings (e.g., churches)\n2. Receive lifestyle education focused on diet, physical activity, and weight loss\n3. Engage in physical activity (including in-class exercise sessions \\[E-DPP only\\] and community-based options)\n4. Receive support for healthy eating, including food deliveries (\\[E-DPP only\\]), food selection guidance, and referrals to food assistance programs\n5. Receive information and support for accessing community resources for food and physical activity",[715,29,716,717],"Diabetes","Food Security","Nutrition Security",[315,719,720,721,722,723,724,725],"obesity","community-based participatory research","Weight loss","Cluster randomized trial","lifestyle change program","faith-based organizations","African American","2026-06-05",{"date":728,"type":41},"2026-06-09",{"date":730,"type":23},"2027-01-04",{"date":732,"type":23},"2031-02-28",{"name":734,"class":48},"University of Missouri, Kansas City",{"id":736,"slug":737,"hasResults":12,"nctId":738,"briefTitle":739,"officialTitle":740,"acronym":4,"eligibilityCriteria":741,"healthyVolunteers":12,"sex":18,"minAge":520,"maxAge":57,"enrollmentInfo":742,"targetDuration":4,"studyType":24,"phases":743,"briefSummary":744,"conditions":745,"keywords":749,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":754,"lastUpdatePostDateStruct":755,"startDateStruct":756,"completionDateStruct":757,"leadSponsor":759,"locationsCount":87},"100642932","exercise-interventions-in-obstructive-sleep-apnea-syndrome-100642932","NCT07634029","Exercise Interventions in Obstructive Sleep Apnea Syndrome","The Effect of Exercise Snacks and Aerobic Exercise on Circadian Rhythm and Functional Capacity in Individuals With Obstructive Sleep Apnea Syndrome","Inclusion Criteria:\n\n* Individuals diagnosed with OSAHS (AHI ≥ 15) confirmed by polysomnography, with moderate or severe disease, who have been receiving CPAP therapy for at least 3 months.\n* Adults aged 30-65 years.\n* No participation in any regular exercise program within the last 6 months.\n\nExclusion Criteria:\n\n* Individuals with OSAHS and a body mass index (BMI) \\> 35 kg\u002Fm²\n* Severe chronic pulmonary disease\n* Neurological or musculoskeletal disorders that prevent exercise\n* Unstable cardiovascular conditions\n* Unstable metabolic conditions\n* Severe psychiatric disorders such as bipolar disorder or schizophrenia\n* Pregnancy or breastfeeding\n* Individuals working night shifts or with schedules that may cause jet lag\n* Use of steroid or hormone therapy\n* Use of melatonin or sleep-regulating medications within the last 3 months\n* Presence of acute infection or inflammation",{"count":22,"type":23},[26],"Obstructive Sleep Apnea Syndrome (OSA) is a condition characterized by repeated pauses or reductions in breathing during sleep, which can negatively affect sleep quality, daytime functioning, and physical capacity. Although regular exercise is known to have beneficial effects in OSA, the effects of different exercise approaches on circadian rhythm and functional capacity have not been sufficiently investigated.The primary aim of this study is to compare the effects of exercise snacking and aerobic exercise on circadian rhythm and functional capacity in individuals with OSA, in comparison with a control group. The secondary aim is to evaluate the effects of these exercise interventions on peripheral muscle strength, fatigue level, body composition, quality of life, and physical activity level.Participants will be randomly assigned to three groups: an aerobic exercise group, an exercise snacking group, and a control group. While the exercise groups will follow their respective intervention programs, the control group will continue their routine treatment.This study aims to answer whether exercise snacking, which consists of short bouts of exercise distributed throughout the day, may be an alternative or complementary approach to traditional aerobic exercise in individuals with OSA. In addition, this study aims to be the first randomized controlled trial evaluating the effects of exercise snacking on circadian rhythm and functional capacity in individuals with OSA.",[746,747,29,748,272],"Obstructive Sleep Apnea (OSA)","Exercise Snacks","Circadian Rhythm",[750,751,752,753],"Obstructive Sleep Apnea","exercise training","circadian rhythm","exercise snacks","2026-06-03",{"date":674,"type":41},{"date":43,"type":23},{"date":758,"type":23},"2028-02",{"name":760,"class":48},"Istanbul University - Cerrahpasa"]