[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physiologic-gingival-melanin-pigmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physiologic-gingival-melanin-pigmentation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100657782","gingival-depigmentation-using-a-940-nm-diode-laser-versus-ceramic-bur-100657782",false,"NCT07841119","Gingival Depigmentation Using a 940 nm Diode Laser Versus Ceramic Bur","Comparison of Gingival Depigmentation Using a 940 nm GaAlAs Diode Laser and Ceramic Bur: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Periodontal health, with gingival index (GI) ≤1, bleeding on probing (BOP) ≤10%, probing depths ≤3 mm, and no periodontitis.\n* Thick gingival phenotype with moderate to severe physiologic melanin pigmentation, corresponding to DOPI scores of 2-3, affecting the facial gingiva of the anterior and premolar regions bilaterally.\n* Good oral hygiene, with plaque index (PI) ≤1 and calculus index (CI) ≤1.\n\nExclusion Criteria:\n\n* Thin gingival phenotype at the treatment sites.\n* Uncontrolled systemic diseases, including cardiovascular disease, hypertension, or diabetes mellitus.\n* Pregnancy or lactation.\n* Use of medications or presence of conditions affecting hemostasis or wound healing.\n* Oral pigmentation attributable to causes other than physiologic melanin pigmentation, including metallic pigmentation, amalgam tattoo, traumatic tattoo, or pigmentation associated with malignant conditions.\n* Use of medications or chemical agents known to induce oral pigmentation, including antimalarial drugs, minocycline, ketoconazole, or oral contraceptives.\n* Current smoking.","ALL","18 Years",{"count":19,"type":20},17,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized split-mouth clinical trial will compare the effectiveness of a 940 nm GaAlAs diode laser and a ceramic soft tissue trimmer for the treatment of physiologic gingival melanin pigmentation. Each participant will receive both treatment modalities in separate gingival regions according to a randomized allocation. Changes in gingival pigmentation will be evaluated using clinical pigmentation indices and digital image analysis. Participants will be followed at 1, 3, and 6 months after treatment to assess pigmentation reduction and repigmentation.",[26],"Physiologic Gingival Melanin Pigmentation",[28,29,30,31,32],"Gingival depigmentation","Gingival melanin pigmentation","Diode laser","Ceramic soft tissue trimmer","Split-mouth randomized clinical trial","NOT_YET_RECRUITING","2026-09-19",{"date":36,"type":37},"2026-09-25","ACTUAL",{"date":39,"type":20},"2026-09-20",{"date":41,"type":20},"2027-04-30",{"name":43,"class":44},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER"]