[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pics":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,73,108,138,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100651556","measuring-the-effects-of-music-listening-on-distress-after-intensive-care-100651556",false,"NCT07762196","Measuring the Effects of Music-Listening On Distress After Intensive Care","Measuring the Effects of Music-Listening On Distress After Intensive Care (MELODIC): A Single Case Experimental Design Study.","MELODIC","Inclusion Criteria:\n\n* 18 years or older.\n* Experienced an admission to an ICU\u002FHDU of any length and not yet participated in InS:PIRE.\n* Access to an internet-enabled device and internet connection whilst at home.\n* Experiencing some distress relating to their ICU\u002FHDU admission - a cut-off score of 4 on the VAS 'Distress Thermometer' has been used previously (Hofhuis et al., 2025).\n\nExclusion Criteria:\n\n* Are unable to give informed consent e.g. have a significant cognitive impairment due to illness, injury or neurological condition, or are currently experiencing delirium or acute psychotic illness.\n* Have significant communication difficulties or limited English and cannot access validated outcome measures or translation services in the given language.\n* Are experiencing a mental health crisis or have recently attempted suicide, where ongoing significant risk of harm to themselves or others remains.\n* Have an uncorrected hearing impairment that would prevent them from hearing their music playlist.\n* Are participating in another study aimed at reducing distress.","ALL","18 Years",{"count":20,"type":21},9,"ESTIMATED","INTERVENTIONAL",[24],"NA","The primary goal of this single-case experimental design study is to investigate the effectiveness of personalised music listening on daily levels of distress after discharge from a critical care ward. The study will also aim to understand the effect of personalised music listening on symptoms of post-traumatic stress, anxiety, depression and health-related quality of life post-discharge.\n\nThe main questions the study aims to answer are included below.\n\nAfter discharge from critical care, does personalised music-listening:\n\n* Reduce psychological distress?\n* Reduce symptoms of anxiety and depression?\n* Improve health-related quality of life (HRQoL)?\n\nThe study will have 3 phases, allowing for participant data gathered during the baseline phase (treatment as usual) to be compared to data gathered during intervention (music-listening) and follow-up phases.\n\nParticipants will:\n\n* rate their distress on a visual analogue scale each day.\n* listen to a minimum of 30 minutes of self-selected music each day during the intervention phase.\n* complete measures of mood, anxiety, post-traumatic stress and health-related quality of life at baseline, intervention and follow-up phases.",[27,28],"Post-ICU Patients","PICS",[30,31,32],"music-listening","post-ICU","psychological distress","NOT_YET_RECRUITING","2026-08-07",{"date":36,"type":37},"2026-08-13","ACTUAL",{"date":39,"type":21},"2026-08",{"date":41,"type":21},"2027-05",{"name":43,"class":44},"University of Edinburgh","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100456016","remotely-monitored-mobile-health-supported-multidomain-rehabilitation-program-with-high-intensity-interval-training-for-covid-19-100456016","NCT05218083","REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19","REMM-HIIT-CoV","Inclusion Criteria:\n\n* Primary diagnosis of COVID-19 requiring hospital admission\n* Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)\n* Able to ambulate with or without a gait aid prior to hospital discharge\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Hospital discharge \\> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \\> 60 days\n* Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)\n* Functional impairment resulting in inability to exercise at baseline\n* Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction\n* Any absolute contraindications to exercise, including but not limited to:\n\n  * Recent (\\\u003C 5 days) acute primary cardiac event\n  * Unstable Angina\n  * Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise\n  * Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure\n  * Symptomatic aortic stenosis\n  * Uncontrolled symptomatic heart failure\n  * Acute myocarditis or pericarditis\n  * Suspected or known dissecting aneurysm\n* Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \\\u003C 60 mmHg on 2 consecutive readings within 1 minute)\n* High risk for non-adherence as determined by screening evaluation\n* Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study\n* Pregnant",{"count":54,"type":21},120,[24],"Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.",[58,59,60,28,61],"COVID-19","Critical Illness","ICU Acquired Weakness","Cardiorespiratory Fitness","RECRUITING","2026-05-27",{"date":65,"type":37},"2026-05-28",{"date":67,"type":37},"2023-02-23",{"date":69,"type":21},"2027-04-01",{"name":71,"class":44},"Duke University",5,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":93,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100621589","behavioral-health-collaborative-care-model-in-an-icu-recovery-clinic-100621589","NCT07372586","Behavioral Health Collaborative Care Model in an ICU Recovery Clinic","Integration of a Behavioral Health Collaborative Care Model Into an ICU Recovery Clinic","BeColM","Inclusion Criteria:\n\n\\- Attendance at the MUSC ICU Recovery Clinic within 180 days of discharge from the hospital\n\nExclusion Criteria:\n\n* ICU Admission was due to a primary addiction diagnosis (eg alcohol withdrawal or delirium tremens requiring ICU care)\n* Serious Mental Illness such as Schizophrenia, psychotic disorder, acute mania\n* Late Stage Dementia or Cognitive Impairment\n* Limited English or Spanish Proficiency\n* Lack of regular access to a computer, tablet or mobile device with internet access",{"count":82,"type":21},150,[24],"Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to compare outcomes between a behavioral health Collaborative Care Model (BH CoCM) and usual care (attention control). The intervention includes digital tools (Neuroflow), behavioral health coaching, and psychiatric support.",[28,86,87,88,89,90,59,91,92],"Anxiety","Depression - Major Depressive Disorder","Post-Traumatic Stress","PTSD","Critical Illness Recovery","Collaborative Care","Behavioral Health Concerns",[94,31,28,95,96,89,97,98],"critical illness","anxiety","depression","collaborative care model","behavioral health","2026-03-11",{"date":101,"type":37},"2026-03-12",{"date":103,"type":37},"2026-01-30",{"date":105,"type":21},"2028-06-30",{"name":107,"class":44},"Medical University of South Carolina",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":117,"studyType":118,"phases":4,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":137},"100615292","post-intensive-care-syndrome---multicentre-prospective-registry-database-of-the-dach-region-100615292","NCT07290712","Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region","PICS-DACH","Inclusion Criteria:\n\n* Patients with an ICU stay longer than 72 hours will be included\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old\n* Patients who receive end-of-life care at the time of screening",{"count":116,"type":21},5000,"5 Years","OBSERVATIONAL","Post-Intensive Care Syndrome (PICS) refers to long-term cognitive, physical, and psychological impairments that can arise after intensive care treatment. These symptoms may begin within 24 hours of ICU admission and persist for years. Affected patients and their families (PICS-F) face significant burdens, with up to 94% of relatives impacted. Given its high prevalence and socioeconomic impact, this prospective registry study aims to identify risk factors and long-term consequences of PICS and PICS-F.\n\nThe study consists of six modules, starting with data collection during ICU stays and continuing with follow-ups at various intervals post-discharge (up to five years). The primary goal is to investigate diagnostic and therapeutic strategies, while secondary objectives include identifying risk factors, determining impairment severity, and exploring biological mechanisms. Standardized questionnaires and biological samples (blood) are used for data collection.",[28,121],"PICS-F",[28,121,123,124,125,59,126,127],"ICU","Intensive Care Unit","Critical Care","Post Intensive Care Syndrome","Post Intensive Care Syndrome Family","2026-02-17",{"date":130,"type":37},"2026-02-19",{"date":132,"type":37},"2026-02-04",{"date":134,"type":21},"2035-11-01",{"name":136,"class":44},"Medical University of Vienna",4,{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":144,"maxAge":4,"enrollmentInfo":145,"targetDuration":147,"studyType":118,"phases":4,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":45},"100593151","impact-of-persistent-inflammation-immunosuppression-catabolism-syndrome-pics-on-the-respiratory-physiology-in-patients-with-prolonged-mechanical-ventilation-100593151","NCT07002710","Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients With Prolonged Mechanical Ventilation","Inclusion Criteria:\n\n* Patients are still receiving ventilator support when transferred to the ward where the study is conducted.\n* Use the respirator continuously for at least 10 days.\n* Vital signs are stable: blood pressure systolic blood pressure is not lower than 70 mmHg; heartbeat is not lower than 50\u002Fmin and not higher than 160\u002Fmin; respiratory rate is not higher than 50\u002Fmin.\n* When using respirator support, the oxygen concentration should not exceed 60%.\n\nExclusion Criteria:\n\n．At least one of the following conditions occurs: 1. Pregnancy. 2. The patient refuses to undergo weaning from the respirator training. 3. The patient has no ability to drive spontaneous breathing.","20 Years",{"count":146,"type":21},40,"12 Weeks","Past research on PICS has mainly focused on the predictability and prognosis of PICS occurrence in ICU patients. Still, there is currently insufficient research on the role of PICS in the care setting of patients who have stabilized and are transferred to respiratory care units such as Respiratory Care Centers (RCCs) for weaning attempts. To understand the impact of PICS on the respiratory physiology of patients undergoing weaning from prolonged mechanical ventilation, investigators propose a one-year research plan",[28],[28],"2025-05-25",{"date":153,"type":37},"2025-06-03",{"date":155,"type":37},"2025-03-18",{"date":157,"type":21},"2026-12-31",{"name":159,"class":44},"National Taiwan University Hospital",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":167,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":186,"locationsCount":45},"100461399","efficacy-of-the-use-of-diaries-in-intensive-care-units-100461399","NCT05288140","Efficacy of the Use of Diaries in Intensive Care Units","QUADERN","Inclusion Criteria:\n\n* admitted intensive care unit\n* sedated and mechanically ventilated for 24hours\n* signed consent\n* not language barrier\n* willingness to attend follow-up visits\n\nExclusion Criteria:\n\n* verbal manifestation of psychiatric, mental or cognitive antecedents\n* who do not coluntarily agree to participate",true,"100 Years",{"count":170,"type":21},240,[24],"Randomized clinical trial that aims to evaluate the impact of the use of a diary in patients and relatives of patients admitted to an ICU in relation to usual practice in terms of health-related quality of life, the post-traumatic stress and anxiety\u002Fdepression at 2, 6 and 12 months after ICU discharge.",[174,124,175,176,28,177,86,178,179],"Diary (Blank Journal)","Patient","Family","Stress","Depression","Quality of Life","2024-03-26",{"date":182,"type":37},"2024-03-27",{"date":184,"type":37},"2022-01-01",{"date":157,"type":21},{"name":187,"class":44},"University of Barcelona"]