[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pituitary-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pituitary-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100649224","phase-2-evaluating-intranasal-oxytocin-tnx-1900-for-pain-relief-and-recovery-after-pituitary-surgery-100649224",false,"NCT07730294","Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery","Investigating the Effect of TNX-1900 on Pain Management, Neural and Socio-Emotional Functioning in Patients Undergoing Pituitary Surgery","Inclusion Criteria:\n\n* Age: Between 30 to 75 years old.\n* Consent: Ability to give informed consent.\n* Language: Proficiency in the English language.\n* Medical Condition: Diagnosed with a pituitary lesion requiring surgery.\n* Menopausal Status: Post-menopause for women (at least 1 year since last menstrual period).\n\nExclusion Criteria:\n\n* Medication: Individuals on stable doses of psychotropic medication for at least the past six weeks are eligible, excluding those with changes in medication within that timeframe.\n* Neurological Conditions: A history of seizures, current use of anticonvulsants.\n* Pregnancy: Currently pregnant, currently lactating, or up to 1-year post partum.\n* Any history of renal impairment (serum creatinine \\>1.2 x ULN)\n* Any history of hepatic impairment (AST and\u002For ALT \\>2 x ULN)\n* Surgical History: Any history of previous pituitary surgery procedures\n* Subjects who require 24-hour coverage with NSAIDs, e.g., arthritis, should not be included in the study.\n* Any known hypersensitivity to TNX-1900","ALL","30 Years","75 Years",{"count":20,"type":21},75,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This study is testing whether oxytocin can help lessen pain by changing how people process emotions and social experiences. The goal is to better understand how the brain links emotions, relationships, and pain, and whether this connection can be used to improve pain treatment.",[27,28],"Pain","Pituitary Surgery",[30,31,32,33],"pain","pain perception","oxytocin","intranasal","NOT_YET_RECRUITING","2026-07-23",{"date":37,"type":38},"2026-07-28","ACTUAL",{"date":40,"type":21},"2026-08",{"date":42,"type":21},"2028-08",{"name":44,"class":45},"Yale University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100613979","effect-of-protein-supplementation-and-fluid-restriction-on-plasma-sodium-levels-in-patients-undergoing-pituitary-surgery-100613979","NCT07273630","Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery","Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery - a Randomized Open-label Active-controlled Trial -","TREASURE-PIT","Inclusion Criteria:\n\n* Adult patients (aged 18 or older) undergoing trans-sphenoidal or trans-cranial surgery for sellar \u002F suprasellar pathology\n* No pre-existing AVP-deficiency and SIAD or other causes of hyponatremia\n\nExclusion Criteria:\n\n* AVP deficiency diagnosed before surgery based on established criteria\n* Other type of neurosurgery \u002F intracranial pathology \u002F pre-existing spontaneous CSF -rhinorrhea\n* Traumatic brain injury or intracranial hemorrhage\n* Systemic infection or other causes for systemic stress\n* Lactose intolerance, milk protein allergy, soy allergy, nuts allergy or known hypersensitivity or allergy to one of the components of the protein supplementation\n* Inborn metabolic disorders implying carbohydrate, lipid, or protein metabolism\n* Severe hepatic impairment (ALAT\u002FASAT \\>3x upper limit) or advanced symptomatic liver disease defined as past or current hepatic encephalopathy, liver cirrhosis Child C, or decompensated (bleeding, jaundice, hepatorenal syndrome)\n* Reduction of eGFR \\\u003C45 mL\u002Fmin\u002F1.73m² (KDIGO G3b, G4 and G5) or end stage renal disease (dialysis)\n* Recently initiated (within the last 5 days) SGLT2 inhibitors, vaptans, or oral urea therapy\n* Pregnancy or breastfeeding\n* Lack of capacity or other reason preventing from giving informed consent or following study procedures.\n\nPost-Inclusion Exclusion criteria (day 3 post-surgery, i.e.,time of randomization): - AVP deficiency diagnosed on post-operative day 3","18 Years",{"count":57,"type":21},282,[59],"NA","The investigators are conducting this study to investigate new preventive measures for patients with low sodium levels (hyponatremia), which can occur after surgery on the pituitary gland. This hyponatremia is often caused by the syndrome of inappropriate antidiuresis (SIAD). SIAD occurs when the pituitary gland secretes too much antidiuretic hormone. The antidiuretic hormone causes the kidneys to absorb more water. This dilutes the sodium in the blood and leads to hyponatremia. Low sodium levels are particularly common after pituitary surgery, as the procedure on the pituitary gland can lead to increased reactive secretion of antidiuretic hormone. At present, apart from educating patients about the symptoms of hyponatremia, there are no established standard measures for prevention after pituitary surgery. If hyponatremia is present, it is currently treated primarily by fluid restriction, which is not always pleasant or easy to adhere to. With this study, the investigators want to investigate whether protein supplementation or fluid restriction between day 4 and day 9 after surgery can serve as a preventive measure to stabilize sodium levels after pituitary surgery and improve the quality of life of patients.",[62,28],"Hyponatremia",[64,65,66,67,68,28,69],"postoperative hyponatremia","hyponatremia","SIAD-related complications","protein supplementation","fluid restriction","Plasma Sodium Levels","RECRUITING","2026-02-02",{"date":73,"type":38},"2026-02-03",{"date":75,"type":38},"2026-01-20",{"date":77,"type":21},"2028-10-01",{"name":79,"class":45},"University Hospital, Basel, Switzerland"]