[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pneumnia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pneumnia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100648667","systemic-traditional-chinese-medicine-in-multidrug-resistant-bacterial-pneumonia-100648667",false,"NCT07726095","Systemic Traditional Chinese Medicine in Multidrug-Resistant Bacterial Pneumonia","A Multicenter Prospective Observational Cohort Study of Systemic Traditional Chinese Medicine Treatment in Multidrug-Resistant Bacterial Pneumonia","MDRBP-TCM","Inclusion Criteria\n\n1. Hospitalized patients aged 18 years or older with a clinical diagnosis of pneumonia.\n2. Microbiological testing identifies at least one bacterial isolate that meets the definition of multidrug resistance, defined as acquired non-susceptibility to at least one antimicrobial agent in each of three or more antimicrobial categories, based on standard antimicrobial susceptibility testing.\n3. The multidrug-resistant bacterial isolate is judged to be a causative pathogen of the current pneumonia episode rather than colonization or contamination, based on clinical manifestations, imaging findings, microbiological results, and the clinical course.\n4. Willing to participate in the study and able to provide written informed consent.\n\nExclusion Criteria:\n\n1\\. Patients who are unable to complete data collection due to unconsciousness, dementia, impaired consciousness, psychiatric illness, or other conditions, and for whom relevant information cannot be obtained through a legally authorized representative or family member.","ALL","18 Years",{"count":20,"type":21},528,"ESTIMATED","OBSERVATIONAL","This is a multicenter prospective observational cohort study of hospitalized patients with multidrug-resistant bacterial pneumonia. The study will compare patients who receive systemic traditional Chinese medicine treatment during routine clinical care with those who do not receive systemic traditional Chinese medicine treatment. Systemic traditional Chinese medicine treatment may include Chinese herbal decoctions, oral Chinese patent medicines, or Chinese medicine injections.\n\nThe primary objective is to evaluate whether systemic traditional Chinese medicine treatment is associated with a lower risk of lower respiratory tract infection events within 180 days after hospital discharge. Secondary outcomes include mortality, rehospitalization, bacterial clearance, clinical cure at hospital discharge, duration of antibacterial therapy, pneumonia-related clinician-reported and patient-reported outcome scores, health-related quality of life, inflammatory markers, imaging changes, safety outcomes, and direct medical costs.",[25,26],"Multi Drug Resistant Infections","Pneumnia",[28,29,30,31,32,33,34,35,36],"Drug-resistant bacteria","Traditional Chinese medicine","Prospective cohort","Lower respiratory tract infection","Hospital-acquired pneumonia","Ventilator-associated pneumonia","Community-acquired pneumonia","Antimicrobial resistance","Rehospitalization","NOT_YET_RECRUITING","2026-07-26",{"date":40,"type":41},"2026-07-28","ACTUAL",{"date":43,"type":21},"2026-08-01",{"date":45,"type":21},"2028-06-30",{"name":47,"class":48},"Henan University of Traditional Chinese Medicine","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100568193","use-of-simplified-lung-ultrasound-score-for-predicting-icu-outcomes-in-patients-with-acute-respiratory-failure-100568193","NCT06678035","Use of Simplified Lung Ultrasound Score for Predicting ICU Outcomes in Patients With Acute Respiratory Failure","Inclusion Criteria:\n\n* Age is or more than 18 years old.\n* Admission to ICU in the first24 hours at time of recruitment to the study.\n* Patients in respiratory failure \\[PaO2 is less then 60 % mmHg\\]\n\nExclusion Criteria:\n\n* Co- existing chronic lung disease, pathology of which is known display abnormalities on US examination (interstitial lung diseases, bronchiectasis).\n* Large pneumothorax or massive pleural effusion causing significant collapse and precluding proper visualization of underlying lung.\n* Conditions that may interfere with lung ultrasound quality or probe contact such as marked obesity, severe chest wall deformities, burns or wounds.","18 Days",{"count":58,"type":21},72,"This study aims to\n\nPrimary Aims:\n\nVerify the predictability of the PLIS at admission in predicting major clinical outcomes including:\n\n* ICU mortality (or discharge) and time to death (or discharge)\n* Escalation of ventilatory support antibiotic therapy or supportive medications (inotropes, steroids, sedation, neuromuscular blockers).\n\nSecondary Aims:\n\n* Determine the correlation between initial PLIS and the degree of disease severity (as evaluated per SOFA and APACHE II scores)\n* Determine the correlation between initial PLIS and partial pressure of oxygen in arterial blood (PaO2) to Fraction of inspired oxygen (FiO2): PaO2\u002FFiO2\n* Explore the potential association between the type of ventilatory support, ventilatory settings and PLIS at different time points.\n* Verify whether the site of consolidation (anterior vs. posterior lung zones) can reliably predict mortality in in ALI patients.\n* Determine the correlation between the PLIS score and the degree of ALI as quantified by CT of the chest (whenever a CT study is available) at the time of admission.",[26,61,62],"Chest Infection","Critically-ill Patients Admitted to the ICU for Acute Respitatory Failure, Regardless the Aetilogy",[64,65,66],"LUS","Acute respiratory failure","Critically-ill patients","2024-11-05",{"date":69,"type":41},"2024-11-07",{"date":71,"type":21},"2024-11-20",{"date":73,"type":21},"2025-10-01",{"name":75,"class":48},"Assiut University"]