[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"polyp-colorectal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:polyp-colorectal":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100648544","gelpoint-path-assisted-endoscopic-removal-of-colon-and-rectal-polyps-a-feasibility-and-safety-study-100648544",false,"NCT07723937","GelPOINT® Path-Assisted Endoscopic Removal of Colon and Rectal Polyps: A Feasibility and Safety Study","GelPOINT® Path-Assisted Endoscopic Submucosal Dissection for Colorectal Polyps: A Feasibility and Safety Study","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Able and willing to provide written informed consent.\n* Colorectal polyps located in the transverse colon, descending colon, rectosigmoid colon, or rectum (rectal lesions located at least 2 cm from the anal verge).\n* Referred for endoscopic submucosal dissection (ESD) of colorectal neoplastic lesions meeting at least one of the following criteria:\n* Lesions with prior resection or scarring proximal to the sigmoid colon.\n* Granular lateral spreading tumors (GLST) \\>30 mm.\n* Non-granular lateral spreading tumors (NGLST) \\>20 mm.\n* Lesions with suspected submucosal invasion, including Paris classification IIa+IIc lesions or lesions with a positive non-lifting sign\n\nExclusion Criteria:\n\n* Younger than 18 years of age.\n* Unable or unwilling to provide informed consent.\n* Pregnant.\n* Pedunculated lesions (Paris classification Ip or Isp).\n* Lesions involving the appendix or ileocecal valve","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","4 Weeks","OBSERVATIONAL","This prospective, single-center, observational feasibility and safety study will evaluate the use of the GelPOINT® Path transanal access platform during endoscopic submucosal dissection (ESD) for the removal of colorectal polyps. The GelPOINT® Path system is designed to improve access, maintain stable insufflation, and enhance visualization during advanced endoscopic procedures.\n\nThe study will enroll adult patients undergoing ESD for eligible colorectal lesions. The primary objective is to evaluate the technical feasibility, procedural performance, and safety of GelPOINT® Path-assisted ESD. Procedural outcomes, including procedure speed, technical success, resection outcomes, and procedure-related adverse events, will be collected prospectively. Participants will receive standard clinical care and will be followed for approximately 4 weeks after the procedure to assess delayed adverse events.",[25,26,27],"Polyp Colorectal","Rectal Adenoma","Adenoma Colon Polyp","RECRUITING","2026-07-20",{"date":31,"type":32},"2026-07-23","ACTUAL",{"date":34,"type":32},"2026-05-19",{"date":36,"type":20},"2027-04-30",{"name":38,"class":39},"Baylor College of Medicine","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":40},"100618183","delayed-surveillance-colonoscopy-following-piecemeal-emr-100618183","NCT07328308","Delayed Surveillance Colonoscopy Following Piecemeal EMR","Delayed Surveillance Colonoscopy Following Piecemeal EMR - a Randomized Study","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Undergoing pEMR of LNPCPs\n* Able to provide informed consent and comply with follow-up requirements\n\nExclusion Criteria:\n\n* Patients with invasive cancer identified during the index procedure\n* en bloc resection\n* Patients unable to attend follow-up colonoscopies due to comorbid conditions\n* Patients who require additional surgery for polyp removal or other complications",{"count":49,"type":20},760,"INTERVENTIONAL",[52],"NA","This multicenter, prospective, randomized non inferiority trial, conducted at four Israeli hospitals, will evaluate whether a relaxed surveillance strategy after piecemeal endoscopic mucosal resection (pEMR) of large non pedunculated colorectal polyps (LNPCPs, ≥20 mm) is as safe and effective as the current standard intensive surveillance. Approximately 760 adults undergoing complete pEMR with margin ablation will be randomized 1:1 into:\n\nStandard Surveillance: Colonoscopy at 6, 18, and 48 months\n\nRelaxed Surveillance: Colonoscopy at 12 and 48 months\n\nAll colonoscopies will be performed using high definition white light and narrow band imaging, with biopsies obtained only if recurrence is suspected. The investigators hypothesize that a relaxed surveillance strategy will be non inferior to the current standard intensive surveillance. If non inferiority is demonstrated, the study may support guideline changes toward reduced surveillance frequency after pEMR with margin ablation, potentially decreasing patient burden and healthcare costs.",[55,25],"Colon Cancer Prevention","NOT_YET_RECRUITING","2026-01-03",{"date":59,"type":32},"2026-01-09",{"date":61,"type":20},"2026-01",{"date":63,"type":20},"2031-01",{"name":65,"class":39},"Rambam Health Care Campus"]