[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"positive-surgical-margin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:positive-surgical-margin":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100656477","spectra-intraoperative-hyperspectral-imaging-for-prostate-cancer-100656477",false,"NCT07826858","SPECTRA: Intraoperative Hyperspectral Imaging for Prostate Cancer","SPECTRA","Inclusion Criteria:\n\n* Histological diagnosis (biopsy) of Pca\n* Prostate volume \\\u003C 100 cm3 (measured on preoperative MRI) for a smooth acquisition with the hyperspectral device\n* Capable of forming his own views\n\nExclusion Criteria:\n\n* Unwilling to participate.\n* Inability to follow study procedures, for example due to language problems, psychological disorders, dementia, etc.","MALE","18 Years",{"count":19,"type":20},26,"ESTIMATED","INTERVENTIONAL",[23],"NA","Radical prostatectomy (RP) is currently one of the gold standard of care in managing localized prostate cancer (Pca). However, despite advances in Robot-Assisted RP (RARP), cancer cells may still be found (up to 42%) at the edge of the removed prostate specimen, commonly referred as Positive Surgical Margins (PSM). PSM are well-known risk factors of adverse oncological outcomes (biochemical recurrence).\n\nIt is therefore essential to characterize intraoperatively the tumor extent. In RARP, the leading intraoperative margin assessment (IMA) technique, NeuroSAFE is based on Intra-operative frozen section (IFS) of both prostate lateral sides sampled at 3-5 mm intervals. However, despite proven oncological benefit, adoption is still limited to expert centers due to a prolonged operative time, loss of integrity of the surgical specimen for definitive histopathological analysis, omission of regions (apex, base), and logistical complexity (trained uropathologist, cryostat…).\n\nWith this prospective single-center project, we wish to explore the use of non-invasive optical imaging technology, HyperSpectral Imaging (HSI), as a reliable alternative for examination of the ex-vivo prostate specimen to\n\n1. Distinguish normal versus tumor tissue at the surgical margin in fresh specimen.\n2. Quantify whether HSI can be integrated into the intraoperative workflow (feasibility), thus, image acquisition time and inference time should then be evaluated.",[26,27,28],"Localized Prostate Cancer","Positive Surgical Margin","Hyperspectral Imaging",[30,31,32,33,34,35],"Radical prostatectomy","Localized prostate cancer","Positive Surgical Margins","HyperSpectral Imaging (HSI)","Hyperspectral Reflectance Imaging","Resection margins","RECRUITING","2026-09-14",{"date":39,"type":40},"2026-09-17","ACTUAL",{"date":42,"type":40},"2026-08-01",{"date":44,"type":20},"2027-12-31",{"name":46,"class":47},"Massimo Valerio","OTHER"]