[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-endodontic-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-endodontic-pain":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,71,96,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100651995","influence-of-sealer-composition-on-post-endodontic-pain-100651995",false,"NCT07767084","Influence of Sealer Composition on Post-Endodontic Pain","Influence of Sealer Composition on Post-Endodontic Pain: A Prospective Comparative Analysis of Three Root Canal Sealers","Inclusion Criteria:\n\n* Patients requiring primary root canal treatment.\n* Patients with acute irreversible pulpitis.\n* Patients in good general health\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting pain perception or healing.\n* Patients who had taken analgesics or antibiotics within 12-24 hours prior to treatment.\n* Pregnant or lactating women.\n* Previously treated teeth or teeth with root resorption, fractures, or severe periodontal disease","ALL","18 Years","45 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","Postoperative pain (PP) is one of the most common and clinically significant complications following endodontic therapy, occurring shortly after treatment and potentially lasting from a few hours to several days, thereby compromising the patient's quality of life.\n\nThe incidence of PP varies widely in the literature, ranging from 1.7% to 70%, with some studies reporting values up to 80% within the first 24 hours, gradually decreasing over a week.",[27],"Post Endodontic Pain","RECRUITING","2026-08-11",{"date":31,"type":32},"2026-08-17","ACTUAL",{"date":34,"type":32},"2026-04-14",{"date":36,"type":21},"2027-04-14",{"name":38,"class":39},"Minia University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":40},"100651541","silver-nanoparticle-reinforced-double-antibiotic-paste-in-symptomatic-apical-periodontitis-a-randomized-controlled-trial-100651541","NCT07762599","Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial","Evaluation of Effect of Silver Nanoparticles Reinforced Double Antibiotic Paste on Inflammatory Biomarkers , Post Endodontic Pain and Periapical Healing in Teeth With Symptomatic Apical Periodontitis :a Parallel, Double-blind, Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Adult participants (aged 18-60 years) with SAP and Periapical Pathology in single rooted teeth.\n2. Preoperative pain score will be assessed and recorded using the NRS on a scale 0 to 10. Patients will be asked to mark their current pain level on the scale of 0-10. Patients with pain level ≥7 will be included in the study (NRS categorized as none (0), mild (1-3), moderate (4-6), and severe (7-10).\n3. Periapical pathology will be diagnosed according to PAI and patient with PAI ≥3 will be included in the study (PAI -Score 1 Normal periapical structure, Score2: Minor changes in bone structure, Score 3 Changes in bone structure with some mineral loss, Score4: A well-defined radiolucent area, Score 5 Severe periodontitis with exacerbated features)\n4. Systemic Health will be assessed using ASA. Patient with ASA II will be included in the study.\n\nExclusion Criteria:\n\n1. Previous endodontic treatment\n2. Absence of antagonist tooth\n3. Teeth with Immature apex\n4. Severe periodontal disease or root resorption\n5. Use of antibiotics within 1 month or analgesics within 3 days\n6. Pregnancy or lactation.\n7. Allergy to study medicaments","60 Years",{"count":50,"type":21},50,[24],"Background Apical periodontitis (AP) is an inflammatory condition of the periapical tissues. The Symptomatic Apical periodontitis (SAP) represents the active phase of the disease, presenting with pain and tenderness. In SAP, levels of inflammatory mediators such as Interleukin-1β (IL-1β) and Matrix Metalloproteinase-9 (MMP-9) are elevated in gingival crevicular fluid (GCF). Assessing these biomarkers in GCF provides a novel, non-invasive method to evaluate periapical inflammation and healing. Due to the polymicrobial nature of root canal infections, the use of Intracanal medicaments (ICM) has been recommended to achieve effective disinfection. Traditionally used ICMs have their own inherent limitations. Hence, ICMs such as Triple antibiotic paste (TAP), double antibiotic paste (DAP), Silver nanoparticles (AgNPs) and their various combinations are gaining popularity. Currently, various combinations of AgNPs with other agents such as chitosan, calcium hydroxide, antibiotics and various herbal products are being tried to improve its effectiveness when used as an ICM. However, to the best of investigators knowledge, no study reinforced the DAP with AgNPs. Hence, the current double-blind, randomized, parallel clinical trial is planned to compare the effects of DAP with and without reinforcement of AgNPs on inflammatory biomarkers (IL-1β and MMP-9), postendodontic pain, and periapical healing in SAP. Moreover, this DAP+AgNPs formulation will undergo characterization such as FTIR, TEM\u002FSEM, Zeta potential to assess its properties.\n\nMethods A total of 50 adult participants with SAP in single-rooted teeth were randomly divided into two groups based on the type of ICM used: Group I received DAP, while Group II received DAP reinforced with AgNPs. Before starting the root canal treatment, GCF will be collected and marked as baseline. Then under rubber dam isolation all teeth underwent root canal treatment and ICM will be placed according to the specific group. Patient will be recalled after 14 days and again GCF sample will be collected after removal of the ICM. The samples will be stored at -800C for analysis. All samples will undergo enzyme-linked immunosorbent assay (ELISA) to estimate IL1β and MMP-9 levels. Pain levels will be recorded using the Numerical Rating scale (NRS) at various intervals. Data will be analyzed using STATA, SPSS or R. P value \\\u003C 0.05 will be considered statistically significant.\n\nDiscussion Most conventional ICM have limited ability to penetrate where residual microorganisms often persist. Nanoparticle-based formulations such as AgNPs have gained attention because of their extremely small size, surface charge, and potent antimicrobial activity, which enable them to penetrate dentinal tubules and disrupt bacterial biofilms that are resistant to conventional antibiotics. Incorporating AgNPs into DAP could therefore enhance their antibacterial efficacy. Furthermore, since most endodontic pathogens cannot be routinely cultivated, monitoring the changes in inflammatory biomarkers in GCF provides a reliable and non-invasive method to assess the biological response and healing. Hence, the current double-blind, randomized, parallel clinical trial is planned to compare the effects of DAP with and without reinforcement of AgNPs on inflammatory biomarkers (IL-1β and MMP-9), postendodontic pain, and periapical healing in SAP. The findings may support the use of nanoparticle-assisted ICM as a safer and more effective approach for endodontic disinfection and healing",[54,27,55,56],"Apical Periodontitis","Periapical Healing","Inflammatory Biomarkers",[58,59,60],"silver nanoparticles","Double antibiotic paste","Intracanal Medicament","NOT_YET_RECRUITING","2026-08-09",{"date":64,"type":32},"2026-08-13",{"date":66,"type":21},"2026-08-30",{"date":68,"type":21},"2027-12-30",{"name":70,"class":39},"All India Institute of Medical Sciences",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100645566","pain-during-infiltration-injection-in-anterior-maxillary-region-by-transcodent-painless-needle-tips-versus-regular-needle-tips-100645566","NCT07703410","Pain During Infiltration Injection in Anterior Maxillary Region by Transcodent Painless Needle Tips Versus Regular Needle Tips","Comparison of Pain During Infiltration Injection in Anterior Maxillary Region by Transcodent Painless Needle Tips Versus Regular Needle Tips: a Split-mouth Controlled Randomized Clinical Trial","Inclusion Criteria:\n\nAdults aged 18 to 60 years. Patients requiring bilateral maxillary anterior infiltration anesthesia for dental treatment.\n\nPatients undergoing endodontic procedures involving maxillary canines or premolars.\n\nPresence of healthy maxillary teeth on both sides suitable for infiltration anesthesia.\n\nIndividuals with no systemic disease or neurological disorder affecting pain perception.\n\nAbility to understand the study procedures and provide written informed consent.\n\nBoth male and female participants.\n\nExclusion Criteria:\n\nPregnant or lactating women. Use of analgesics, sedatives, or other pain-modifying medications within the previous 12 hours.\n\nKnown allergy or hypersensitivity to local anesthetics, benzocaine, lidocaine, or epinephrine.\n\nPresence of active infection, inflammation, swelling, or pathology at the injection site.\n\nSevere dental anxiety, needle phobia, or inability to cooperate with study procedures.\n\nIndividuals unable or unwilling to provide informed consent.",true,{"count":80,"type":21},60,[24],"This randomized split-mouth controlled clinical trial will compare pain experienced during anterior maxillary infiltration anesthesia using Transcodent painless needle tips and conventional dental needle tips. Sixty adult patients requiring bilateral maxillary anterior infiltration anesthesia will receive injections with both needle types in a randomized order. Pain perception will be assessed immediately after each injection using a 100-mm Visual Analog Scale (VAS). The study aims to determine whether the Transcodent needle tip reduces injection-related pain compared with a conventional needle tip, thereby improving patient comfort during routine dental procedures.",[84,27],"Pain",[84,86],"anxiety","2026-07-11",{"date":89,"type":32},"2026-07-14",{"date":91,"type":21},"2026-06-23",{"date":93,"type":21},"2026-07-15",{"name":95,"class":39},"Saidu College of Dentistry",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":107,"conditions":108,"keywords":112,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":40},"100623733","early-phase-1-the-effects-of-preemptive-multimodal-analgesic-on-endodontic-pain-following-root-canal-therapy-100623733","NCT07400471","The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.","The Effects of Preemptive Multimodal Analgesic on Endodontic Pain.","Inclusion Criteria:\n\n1. Patient's aged 18 years more.\n2. ASA physical status I-II.\n3. Patient with the complain of pain originated from teeth and surrounding structure.\n4. Preoperative pain severity is moderate to severe.\n5. Patient can be able to make communication about their pain.\n6. Patients give consent to attain this research.\n7. Patients have others concomitant chronic pain.\n8. Patients who will have non-surgical endodontic treatment.\n9. Patients who will have non-surgical endodontic retreatment.\n10. Patients who will have surgical endodontic treatment.\n\nExclusion Criteria:\n\n1. Patient would not like to attain in research.\n2. Patients have any medical condition those are contra indication for study drug.\n3. ASA physical status III, IV, V.\n4. Patient already under treated any anti convulsent drug.\n5. Patient participant in other clinical trials.\n6. Lack of motivation or poor adharence to study protocols.\n7. Patient with Pregnancy\n8. Severe organ dysfunction\n9. Patient have Hepatitis B, and other cross infection disease like (HIV)\n10. Uncontrolled comorbidities that patient do not fit for endodontic treatment.\n11. Severe cognitive impaired patients.\n12. History of certain cancers or severe hematological issues.",{"count":104,"type":21},280,[106],"EARLY_PHASE1","A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain. The study utilizes statistical methods such as chi-squared, T-tests, and regression analysis, accounting for multiple outcomes with the Bonferroni adjustment. Duloxetine hydrochloride and pregabalin, both available in Bangladesh, are evaluated as experimental drugs, while placebos are used to assess psychological effects on pain. All participants receive standard interventional treatments, with acetaminophen provided as needed, and ethical considerations are addressed according to international guidelines.",[27,109,110,111],"Mechanical Detection Threshold","Mechanical Pain Threshold","Mechanical Pain Sensitivity",[113,114,115,116],"post endodontic pain","Root canal Therapy","Multimodal Analgesia","Dynamic sensory test","2026-02-09",{"date":119,"type":32},"2026-02-11",{"date":121,"type":21},"2026-02-06",{"date":123,"type":21},"2027-04-30",{"name":125,"class":39},"Chattogram International Dental College",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":138,"conditions":139,"keywords":143,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":40},"100591472","phase-2-effect-of-pre-medication-with-anti-inflammatory-drugsibuprofen-and-dexamethasoneon-post-endodontic-pain-100591472","NCT06980870","Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain","Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain With Symptomatic Irreversible Pulpitis","Inclusion Criteria:\n\n1. Permanent teeth with acutely inflamed pulp without swelling or draining sinus.\n2. Patients of either gender aged between 18-50 years old.\n3. Systemically healthy patients.\n4. Patients who agree to attend for recall appointments and provide a written consent.\n\nExclusion Criteria:\n\n1. Patients on preoperative analgesics and antibiotics.\n2. Teeth with calcified canals and previously treated teeth.\n3. Pregnant and lactating mothers.\n4. Patients who are immunocompromised, anxious and mentally handicapped.\n5. Patients who are allergic to any of the test medications.","50 Years",{"count":135,"type":21},130,[137],"PHASE2","Effect of pre-medication with anti-inflammatory drugs(ibuprofen and dexamethasone)on Post-Endodontic pain with symptomatic irreversible pulpitis",[140,141,142],"Post-endodontic Pain","Ibuprofen","Dexamethasone",[144,145,146],"post-endodontic pain","ibuprofen","dexamethasone","2025-05-17",{"date":149,"type":32},"2025-05-20",{"date":151,"type":32},"2025-02-15",{"date":153,"type":21},"2025-06-15",{"name":155,"class":39},"Armed Forces Institute of Dentistry, Pakistan"]