[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-icu-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-icu-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100658697","protocol-for-a-hybrid-implementation-effectiveness-feasibility-study-of-a-transdisciplinary-icu-to-home-recovery-model-100658697",false,"NCT07854080","Protocol for a Hybrid Implementation-effectiveness Feasibility Study of a Transdisciplinary ICU-to-home Recovery Model","Transition Support and Holistic Recovery Interventions for Vulnerable Ex-ICU Patients @ Tan Tock Seng Hospital (THRIVE@TTSH): Protocol for a Hybrid Implementation-effectiveness Feasibility Study of a Transdisciplinary ICU-to-home Recovery Model","THRIVE@TTSH","Inclusion criteria\n\n1. Received invasive mechanical ventilation for ≥ 48 hours;\n2. Aged ≥ 21 years;\n3. Premorbidly independent in basic activities of daily living;\n4. Had decision-making capacity before the acute illness and are expected to regain capacity before acute hospital discharge;\n5. Have evidence of new or worsening physical, cognitive, mental-health or swallowing impairment compared with their premorbid state; and\n6. Are ultimately planned for discharge to the community\u002Fhome setting. Worsening in PICS domains is defined as an increase in CFS score compared with premorbid status, newly acquired swallowing dysfunction, new cognitive impairment after exclusion of delirium, suspected anxiety or depressive symptoms, or clinically important deterioration in physical or functional performance.\n\nMental-health screening will not be interpreted as diagnostic criteria for anxiety or depressive disorders.\n\nExclusion criteria\n\n* cognitive or psychiatric impairment that precludes meaningful participation in the study;\n* are already enrolled in, or expected to enter, a structured follow-up pathway that substantially duplicates the rehabilitation intervention; or\n* have treatment primarily directed towards palliation or end-of-life care","ALL","21 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a prospective, single-centre study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at Month 12. There will be volunteer-supported home visits for 6 months post hospital discharge.",[27],"Post ICU Syndrome",[29,30,31,32],"post icu syndrome","critical care","implementation study","rehabilitation","NOT_YET_RECRUITING","2026-09-30",{"date":36,"type":37},"2026-10-02","ACTUAL",{"date":39,"type":21},"2026-10-31",{"date":41,"type":21},"2028-12-31",{"name":43,"class":44},"Tan Tock Seng Hospital","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100653032","iron-deficiency-at-icu-discharge-100653032","NCT07781540","Iron Deficiency at ICU Discharge","Iron Deficiency at ICU Discharge and Its Impact on Post-critical Illness Recovery. The IRON-ICU Study","IRON-ICU","Inclusion criteria:\n\n* Age ≥18 years\n* ICU length of stay ≥72 hours\n* Survival to ICU discharge\n\nExclusion criteria:\n\n* Known hematologic diseases affecting erythropoiesis (e.g., aplastic anemia, myelodysplastic syndromes)\n* Pregnancy","18 Years",{"count":55,"type":21},462,"OBSERVATIONAL","IRON-RECOVERY is a prospective, multicenter, observational cohort study designed to determine the prevalence of iron deficiency at intensive care unit (ICU) discharge and to evaluate its association with post-ICU clinical recovery.\n\nAnemia is highly prevalent in critically ill patients and frequently persists after ICU discharge. Although inflammation-induced iron dysregulation is considered one of the main mechanisms underlying persistent anemia, iron deficiency remains largely under-recognized in this population because conventional biomarkers, particularly ferritin, are influenced by the inflammatory response. Transferrin saturation (TSAT) has emerged as a more reliable marker of iron availability and may better identify patients with iron-restricted erythropoiesis.\n\nAdult patients admitted to participating ICUs for at least 72 hours will undergo assessment of iron status at ICU discharge using routine laboratory tests, including hemoglobin, serum iron, transferrin, ferritin, TSAT, and inflammatory markers. When available, admission iron parameters will also be collected to evaluate changes during the ICU stay. No study-specific therapeutic intervention will be mandated, and all treatment decisions, including intravenous iron administration, will remain at the discretion of the treating physicians.\n\nThe primary objective is to determine the prevalence of iron deficiency (defined as TSAT \\\u003C20%) at ICU discharge. Secondary objectives include evaluating the association between iron deficiency and post-ICU red blood cell transfusion requirements, hemoglobin recovery, functional status assessed by EQ-5D, hospital readmission, mortality, and days alive and out of hospital. Exploratory analyses will assess the association between intravenous iron therapy and clinical outcomes after adjustment for confounding factors. Also, risk factors for ICU-acquired iron deficiency will be investigated.\n\nThe findings of this study are expected to provide the first prospective multicenter estimate of iron deficiency at ICU discharge and to inform the design of future interventional trials evaluating iron replacement as part of post-ICU patient blood management strategies.",[59,27,60,61],"Anemia","Red Blood Cell Transfusions","Iron Deficiencies",[59,63],"Iron deficiencies","RECRUITING","2026-08-20",{"date":67,"type":37},"2026-08-24",{"date":69,"type":37},"2026-07-29",{"date":71,"type":21},"2028-01-30",{"name":73,"class":44},"Università degli Studi di Ferrara",4]