[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-complicaiton\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-complicaiton":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100648475","intraperitoneal-dexamethasone-spraying-on-vagal-nerve-rich-areas-for-prevention-of-hoarseness-after-upper-abdominal-surgery-100648475",false,"NCT07722091","Intraperitoneal Dexamethasone Spraying on Vagal Nerve-Rich Areas for Prevention of Hoarseness After Upper Abdominal Surgery","Intraperitoneal Dexamethasone Spraying on Vagal Nerve-Rich Areas for Prevention of Hoarseness After Upper Abdominal Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 75 years, both sexes.\n* Elective abdominal surgery (including gastric, hepatobiliary, and pancreaticoduodenal surgery) under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n* Preoperative GRBAS Grade (G) score = 0 (no hoarseness).\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Need for systemic glucocorticoid therapy during hospitalization for other reasons.\n* Pre-existing hoarseness, vocal cord paralysis, or organic vocal cord lesions.\n* History of neck surgery, neck radiotherapy, or laryngeal surgery.\n* Known allergy to dexamethasone or other glucocorticoids.\n* Active peptic ulcer or gastrointestinal bleeding within 6 months prior to enrollment.\n* Uncontrolled diabetes mellitus or severe active infection.","ALL","18 Years","75 Years",{"count":20,"type":21},584,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate whether intraoperative spraying of dexamethasone onto the abdominal vagal nerve-rich areas can prevent postoperative hoarseness in patients undergoing elective upper abdominal surgery. The main questions it aims to answer are:\n\n* Does intraoperative topical dexamethasone spraying reduce the incidence of postoperative hoarseness after upper abdominal surgery?\n* Does postoperative intravenous dexamethasone accelerate recovery in patients who develop hoarseness? Researchers will compare a dexamethasone group (intraoperative spraying of 10 mg dexamethasone in 10 mL normal saline) to a placebo group (intraoperative spraying of 10 mL normal saline alone) to see if dexamethasone reduces the rate of postoperative hoarseness.\n\nParticipants will:\n\n* Undergo voice assessment (GRBAS scale) and voice recording before surgery and daily for 10 days after surgery.\n* Be randomly assigned to receive either dexamethasone or placebo sprayed onto the surgical field at the end of the operation.\n* If hoarseness develops in the placebo group, be randomly assigned again to receive either intravenous dexamethasone (5 mg daily for 3 days) or placebo.",[27,28],"Hoarseness","Post Operative Complicaiton",[30,31,32],"Dexamethasone","Postoperative Hoarseness","Upper Abdominal Surgery","NOT_YET_RECRUITING","2026-07-18",{"date":36,"type":37},"2026-07-23","ACTUAL",{"date":39,"type":21},"2026-07-27",{"date":41,"type":21},"2027-03-01",{"name":43,"class":44},"Fujian Medical University Union Hospital","OTHER"]