[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-spinal-anesthesia-shivering\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-spinal-anesthesia-shivering":56},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100653517","comparison-of-low-dose-intravenous-ketamine-and-tramadol-for-prevention-of-post-spinal-anaesthesia-shivering-in-orthopedic-surgical-patients-100653517",false,"NCT07787702","Comparison of Low-Dose Intravenous Ketamine and Tramadol for Prevention of Post-Spinal Anaesthesia Shivering in Orthopedic Surgical Patients","To Compare the Prophylactic Use of Low Doses of Intravenous Ketamine and Tramadol for the Prevention of Post Spinal Anaesthesia Shivering in Orthopedic Surgical Patients at Shaheed Mohtarma Benazir Bhutto Institute of Trauma (SMBBIT) Karachi, Sindh, Pakistan","Inclusion Criteria:\n\n* \\* ASA I and II patients aged 18-60 years.\n\n  * Both genders.\n  * Patients undergoing orthopedic surgery under spinal anesthesia.\n\nExclusion Criteria:\n\n* \\* Patient refusal.\n\n  * ASA III and ASA IV.\n  * Prolonged surgical procedures expected to be more than 90 minutes.\n  * Patients who received blood transfusion or study drugs other than for the study purpose.","ALL","18 Years","60 Years",{"count":20,"type":21},106,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial will compare the prophylactic effectiveness of low-dose intravenous ketamine and tramadol in preventing post-spinal anesthesia shivering in patients undergoing orthopedic surgery at Shaheed Mohtarma Benazir Bhutto Institute of Trauma (SMBBIT), Karachi,",[27],"Post-spinal Anesthesia Shivering","NOT_YET_RECRUITING","2026-08-22",{"date":31,"type":32},"2026-08-26","ACTUAL",{"date":34,"type":21},"2026-08-21",{"date":36,"type":21},"2027-02-21",{"name":38,"class":39},"Shaheed Mohtarma Benazir Bhutto Institue of Trauma","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100592871","the-effect-of-different-doses-of-dexamethasone-on-post-spinal-anesthesia-shivering-100592871","NCT06999070","The Effect of Different Doses of Dexamethasone on Post Spinal Anesthesia Shivering","A Randomized, Comparative Study of Different Doses of Intravenous Dexamethasone for Management of Post Spinal Anesthesia Shivering in Lower Limb Orthopedic Surgeries","Inclusion Criteria:\n\n* ASA physical status I-II.\n* Both sexes.\n* Age: 21-55 years old.\n* Scheduled for lower limb orthopedic surgery.\n* BMI less than 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* ASA physical status more than II.\n* History of corticosteroid therapy or allergic reaction to any of the medication used in the study\n* Patients with cognitive impairment.\n* Pregnancy.\n* Basal body temperatures of more than 38° or less than 36° C.\n* BMI more than 35 kg\u002Fm2.",true,"21 Years","55 Years",{"count":52,"type":21},150,[24],"The precise etiology of post-spinal anesthesia shivering (PSAS) is not fully understood. The incidence ranges between 20 to 80%. Heat loss, reduced sympathetic tone and pyrogen release are termed as the main causes of intra\u002Fpostoperative shivering.\n\nThe redistribution of heat from the core to the periphery of the body is facilitated by the vasodilatation associated with neuraxial anesthesia. Shivering causes tachycardia, lactic acidosis, hyperalgesia at the site of surgery, releases catecholamines, increases oxygen demand, and increases the risk of hypoxemia. \\[1\\]\\[3\\] The most common causes of shivering include fever, shivering with spinal anesthesia movement disorders, post-anesthetic shivering, fear, excitement, stress, tremors, low blood sugar, anxiety, and shivering. Shivering with spinal anesthesia is an involuntary, oscillatory muscular activity that significantly increases metabolic heat production, potentially reaching up to 600% above the basal metabolic level.\n\nPost-spinal shivering is one of the main sources of discomfort for patients recovering from surgery. Furthermore, it worsens wound pain and impedes electrocardiographic monitoring.\n\nProphylactic intravenous administration of dexamethasone has been currently used for controlling intra-operative and post spinal anesthesia shivering. Dexamethasone's anti-inflammatory effects may thereby lessen post-anesthesia shivering by reducing the gradient between skin and core body temperatures.",[56],"Post Spinal Anesthesia Shivering",[58,59],"Dexamethasone","Post spinal anesthesia shivering","2025-05-30",{"date":62,"type":32},"2025-05-31",{"date":64,"type":21},"2025-05",{"date":66,"type":21},"2027-03",{"name":68,"class":39},"Assiut University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100588484","phase-3-intrathecal-dex-with-bupivacaine-inpost-spinal-shivering-after-cs-100588484","NCT06942000","Intrathecal DEX With Bupivacaine Inpost-spinal Shivering After CS.","Efficacy of Dexmedetomidine as Adjuvant to Intrathecal Bupivacaine in Decreasing Incidence of Post-spinal Shivering in Pregnant Women Undergoing Cesarean Section.","DEX","Inclusion Criteria:\n\n* Full-term pregnant women undergoing elective cesarean section under spinal anesthesia.\n* singleton pregnancy\n* Age: 20 \\~ 40 years;\n* ASA physical status II \\~ III;\n\nExclusion Criteria:\n\n* parturient less than 20 years and more than 40 years.\n* History of uncontrolled comorbidities, cardiac (e.g., pre-eclampsia and hypertension), respiratory, renal or hepatic disease.\n* parturients who had allergy to any medication in the study.\n* parturients with contraindications to spinal anesthesia (coagulation disorder, infection at site of puncture, raised intracranial tension or any spine deformity)\n* parturient who has history of alcohol intake.\n* parturient received any medication likely to affect thermoregulation or Veno dilation.\n* Refusing to sign informed consent.","FEMALE","20 Years","40 Years",{"count":81,"type":21},40,[83],"PHASE3","This prospective, randomized, double-blind, placebo-controlled study to determine whether intrathecal dexmedetomidine, administered along with hyperbaric bupivacaine for covering Cesarean delivery decreases the incidence of shivering associated with spinal anesthesia",[56],[87,88,89,90],"Cesarean Section","Dexmedetomidine","Intrathecal Anesthesia","Shivering","2025-04-20",{"date":93,"type":32},"2025-04-24",{"date":95,"type":21},"2025-05-01",{"date":97,"type":21},"2025-12-30",{"name":99,"class":39},"Al-Azhar University",2]