[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-tonsillectomy-emergence-agitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-tonsillectomy-emergence-agitation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100621801","melatonin-for-post-tonsillectomy-emergence-agitation-in-pediatric-100621801",false,"NCT07375342","Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric","Effect of Preoperative Oral Melatonin on Emergence Agitation Following Pediatric Tonsillectomy: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Parent\u002Flegal guardian provides written informed consent\n\nExclusion Criteria:\n\n* • Known allergy or contraindication to melatonin.\n\n  * Pre-existing neurological or psychiatric disorders (e.g., epilepsy, autism, ADHD).\n  * Children receiving any sedative or psychoactive medication within 48 hours of surgery.\n  * Emergency surgery or any procedure other than tonsillectomy\u002Fadenoidectomy.\n  * Children with known sleep disorders or those taking melatonin supplements.\n  * Developmental delay, neurologic disorders, sleep disorders, or known obstructive sleep apnea requiring ICU postoperatively.\n  * Hepatic or renal dysfunction (ALT\u002FAST \\>2×ULN, Cr \\>1.5 mg\u002FdL)","ALL","4 Years","10 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if melatonin can decrease emergence agitation in pediatric post tonsillectomy. The main questions it aims to answer are:\n\nDoes melatonin decrease emergence agitation in pediatric post tonsillectomy? What medical problems do participants have when taking melatonin? Researchers will compare melatonin to a placebo (a look-alike substance that contains no drug) to see if melatonin works todecrease emergence agitation in pediatric post tonsillectomy\n\nParticipants will receive Oral melatonin at a dose of 0.5 mg\u002Fkg (maximum 20 mg) administered 30 minutes before induction of anesthesia. Dose chosen based on prior pediatric studies and safety data.",[27],"Post Tonsillectomy Emergence Agitation",[29,30,31],"agitation","tonsillectomy","pediatric","RECRUITING","2026-07-16",{"date":35,"type":36},"2026-07-17","ACTUAL",{"date":38,"type":36},"2025-12-10",{"date":40,"type":21},"2026-08-01",{"name":42,"class":43},"Benha University","OTHER"]