[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-tuberculosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-tuberculosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,69,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100649124","mechanisms-biomarkers-and-pulmonary-rehabilitation-in-post-tb-lung-disease-100649124",false,"NCT07731009","Mechanisms, Biomarkers and Pulmonary Rehabilitation in Post-TB Lung Disease","Advancing Prevention, Treatment, and Pulmonary Rehabilitation of Post-Tuberculosis Lung Disease Via Approaches That Reveal Mechanisms and Identify Diagnostic, Progression, and Treatment-Response Markers","AFTER-TB","Inclusion Criteria:\n\n\\*Criteria aplicable to all participants:\\*\n\n* Ability and willingness to provide written informed consent (or assent with parental\u002Flegal guardian consent for minors).\n* Willingness and ability to comply with study procedures and scheduled visits.\n* Willingness and ability to participate in a pulmonary rehabilitation programme, including: supervised exercise, respiratory physiotherapy, health education and psychosocial support.\n* Enrolment at one of the participating study sites.\n\n\\*COHORT 1: People with pulmonary tuberculosis\\*\n\n* Diagnosis of pulmonary TB confirmed by bacteriological methods (genotypic or phenotypic assays).\n* Drug-susceptible or drug-resistant TB are both eligible.\n* Initiation of anti-TB treatment within ≤14 days prior to enrolment.\n* Identified through passive, active or intensified case finding strategies, including healthcare facilities, contact tracing, or community screening.\n\n\\*COHORT 2: People with PTLD\\*\n\n* History of bacteriologically confirmed pulmonary TB and completion of anti-TB treatment.\n* No evidence of active TB disease at the time of enrolment.\n* Enrolment must occur within 6 months after completion of TB treatment, or at study entry if the participant already has a previously established diagnosis of PTLD.\n* Presence of post-tuberculosis lung disease (PTLD), defined as abnormalities in at least two of the following domains:\n* \\_Impaired lung function\\_\n* \\_Persistent respiratory symptoms (e.g., cough, dyspnoea)\\_\n* \\_Structural abnormalities on chest imaging\\_\n\nExclusion Criteria:\n\n* Diagnosis with extrapulmonary TB without pulmonary TB.\n* Anti-TB treatment initiated more than 14 days before study enrolment.\n* Pregnant women or those with suspected pregnancy will be excluded from the study, since chest X-rays are contraindicated to avoid any potential adverse effect on foetal development.\n* Participants who are unable or unwilling to give their written informed consent to participate in the study or whose parents\u002Flegal guardians are unable or unwilling to provide consent for paediatric participants.\n* Participants aged \\\u003C5 or \\>65 years old due to age-related biological response impairments that can bias the analyses.","ALL","5 Years","65 Years",{"count":21,"type":22},760,"ESTIMATED","INTERVENTIONAL",[25],"NA","Tuberculosis (TB) affects millions of people worldwide, and many individuals continue to experience long-term health problems even after completing TB treatment. One of the most important of these complications is post-tuberculosis lung disease (PTLD), which can cause persistent breathing problems, reduced physical capacity, and poor quality of life. Despite its high burden, PTLD is still poorly understood, and effective strategies for prevention, early detection, and long-term management are limited.\n\nThe AFTER-TB study aims to address these gaps by combining long-term follow-up of people with TB with the evaluation of pulmonary rehabilitation (PR) strategies for those who develop PTLD. The study includes three groups: people with active TB who are followed over time, people with established PTLD, and healthy individuals without TB to provide basal values. By following people from the start of TB treatment, the study will identify who develops PTLD and which clinical, biological, and imaging factors contribute to lung damage or recovery. In addition, the study will collect detailed information on symptoms, lung function, imaging, and biological samples over time. Advanced laboratory techniques will be used to identify biomarkers linked to disease progression or protection, as well as bacterial genetic factors that may influence long-term lung outcomes. This information will help improve early diagnosis and risk stratification. AFTER-TB study will also implement a comprehensive pulmonary rehabilitation programme that includes exercise training, respiratory physiotherapy, education for healthy habits, and psychosocial support. The impact of rehabilitation on physical capacity, lung function, and quality of life will be assessed over time. Overall, the AFTER-TB study combines clinical follow-up, biological research, and pulmonary rehabilitation to generate new knowledge that can improve the prevention and management of PTLD, ultimately supporting better long-term health and quality of life for TB survivors.",[28],"Post Tuberculosis","NOT_YET_RECRUITING","2026-07-23",{"date":32,"type":33},"2026-07-28","ACTUAL",{"date":35,"type":22},"2027-01",{"date":37,"type":22},"2031-12",{"name":39,"class":40},"Jose Antonio Dominguez Benitez","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100627689","tb-type-and-spirometry-result-vs-functional-capacity-based-on-6mwt-in-people-with-post-tb-lung-disease-100627689","NCT07451899","TB Type and Spirometry Result vs. Functional Capacity Based on 6MWT in People With Post-TB Lung Disease","Correlation Between Types of Tuberculosis, Spirometry Result, and Functional Capacity Based on the 6-Minute Walk Test (6MWT) in Adolescents With Post-Tuberculosis Lung Disease.","Inclusion Criteria:\n\n* Adolescents (10-18 year old)\n* Diagnosed with post tuberculosis lung disease by pediatrician\n* Capable of performing the 6MWT\n\nExclusion Criteria:\n\n* Diagnosed with another lung disease\n* Having physical limitations that hinder the 6MWT","10 Years","18 Years",{"count":51,"type":22},20,"OBSERVATIONAL","Post-Tuberculosis Lung Disease (PTLD) is defined as chronic respiratory impairment due to previous pulmonary TB. Children recovering from pulmonary TB undergo ongoing respiratory health challenges, including more frequent respiratory symptoms, reduced lung volumes, and a threefold higher rate of pulmonary dysfunction compared to healthy children. These conditions could lead to long-term health consequences such as difficulties in performing daily activities. Pulmonary function impairment in PTLD includes approximately 10% of patients losing more than 50% of lung function. Adolescents who have undergone TB treatment often experience pulmonary function impairment and reduced physical capacity. This aims of this study is to analyze the correlation between type of tuberculosis, spirometry result, and functional capacity in adolescents with post-tuberculosis lung disease.\n\nThis study is an analytical observational study with a cross-sectional approach. This study is conducted at Department of Physical Medicine and Rehabilitation, Hasan Sadikin Hospital, Bandung, starting in March until May 2026. Inclusion criteria including: adolescents (10-18 year old), and diagnosed with post tuberculosis lung disease by pediatrician, and capable of performing the 6MWT. The participants with post TB lung disease will undergo spirometry and functional capacity assessment using the 6-minute walk test (6MWT). Outcomes include spirometry result and functional capacity using 6MWT.",[28,55,56,57],"Lung Disease","Functional Capacity","Spirometry","RECRUITING","2026-05-09",{"date":61,"type":33},"2026-05-12",{"date":63,"type":33},"2026-03-01",{"date":65,"type":22},"2026-05-31",{"name":67,"class":40},"Universitas Padjadjaran",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":68},"100600474","paediatric-post-tb-pulmonary-rehab-study-100600474","NCT07097961","Paediatric Post-TB Pulmonary Rehab Study","Paediatric Post-TB Home-based Pulmonary Rehabilitation Feasibility Study","PPT Rehab","Inclusion Criteria:\n\n* Aged 6-17 years\n* Previously diagnosed with post-TB lung disease,\n* Willing to remain in the study catchment area during the study period\n* Able to participate in mild-to-moderate physical activity (late inclusion criterion)\n\nExclusion Criteria:\n\n* Currently participating in another rehabilitation program\n* Residence outside the Kampala metropolitan area\n* Active respiratory infection (late exclusion criterion)","6 Years","17 Years",{"count":80,"type":22},40,[25],"The goal of this clinical trial is to learn if a home-based pulmonary rehabilitation program is feasible and acceptable for children ages 6-15 who have recently completed treatment for pulmonary tuberculosis. The main questions it aims to answer are:\n\nCan children and caregivers follow a 6-week rehabilitation program?\n\nIs the program acceptable and feasible for children and caregivers?\n\nResearchers will also explore preliminary changes in walking distance and quality of life.\n\nParticipants will:\n\nAttend a clinic visit for baseline testing, including a 6-minute walk test (6MWT) and the St. George's Respiratory Questionnaire (SGRQ)\n\nReceive exercise instructions and a pedometer\n\nComplete home-based walking and wall sit exercises twice per week for 6 weeks\n\nReceive weekly follow-up from study staff (by phone or home visit)\n\nReturn to clinic at 6 weeks for follow-up testing",[84,85,28],"Tuberculosis in Children","Chronic Lung Disease",[87,88,89,90],"Post-TB lung disease","Uganda","Pulmonary rehabilitation","pediatric tuberculosis","2025-08-06",{"date":93,"type":33},"2025-08-11",{"date":95,"type":33},"2025-07-29",{"date":97,"type":22},"2026-02-23",{"name":99,"class":40},"University of Iowa",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":68},"100588851","life-tb--long-term-impacts-on-lung-health-and-life-after-tuberculosis-in-korea-100588851","NCT06946784","LIFE-TB ; Long-Term Impacts on Lung Health and Life After Tuberculosis in Korea","Inclusion Criteria:\n\n* Age ≥19 years\n* Diagnosed with pulmonary TB and either initiating or undergoing treatment or history of treated pulmonary TB\n\nExclusion Criteria:\n\n* Age \\\u003C19 years\n* Extrapulmonary TB without lung involvement\n* Refusal to provide informed consent","19 Years",{"count":108,"type":22},360,"This is a prospective, multicenter observational cohort study aimed at establishing a nationwide post-TB lung disease registry in Korea. The study will enroll adult participants either undergoing treatment for pulmonary tuberculosis or with a history of treated TB. Over a five-year follow-up period, the study will assess the long-term health consequences of TB, focusing on respiratory symptoms, radiological changes, pulmonary function, and quality of life.",[111,28],"Tuberculosis",[113],"post tuberculosis","2025-04-20",{"date":116,"type":33},"2025-04-27",{"date":118,"type":33},"2025-02-25",{"date":120,"type":22},"2031-12-31",{"name":122,"class":40},"Yonsei University"]