[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postinduction-hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postinduction-hypotension":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100648550","intermittent-ephedrine-boluses-for-prophylaxis-against-postinduction-hypotension-100648550",false,"NCT07722013","Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension","Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension in High-risk Patients Undergoing Major Abdominal Surgery: a Randomized Double-blinded Controlled Trial: a Randomized Double-blinded Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged \\>50 years,\n* weight \\>50 kg,\n* American Society of Anesthesiologists (ASA) Physical Status score of \\> I,\n* undergoing major abdominal surgery\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 40%, heart block, significant uncontrolled arrhythmias, tight stenotic valvular lesions)\n* Acute cardiovascular pathologies: acute\u002Fdecompensated heart failure, acute coronary syndrome\n* Uncontrolled hypertension (systolic blood pressure\\>150 mmHg)\n* Preoperative HR more than 110 bpm despite proper fluid management and patients with renal impairment\n* Renal impairment\n* Patients on vasopressor infusion,\n* Allergy of any of the study drugs","ALL","50 Years",{"count":19,"type":20},124,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this work is to assess the efficacy of intermittent ephedrine boluses in prophylaxis against postinduction hypotension in high-risk patients undergoing major abdominal surgery, compared to standard care.",[26],"Postinduction Hypotension",[28,29,30,31,32],"major abdominal surgery","high risk patients","ephedrine","prophylaxis","postinduction hypotension","RECRUITING","2026-08-04",{"date":36,"type":37},"2026-08-06","ACTUAL",{"date":34,"type":37},{"date":40,"type":20},"2026-12",{"name":42,"class":43},"Cairo University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":71,"locationsCount":73},"100634338","continuous-versus-bolus-norepinephrine-administration-to-treat-postinduction-hypotension-100634338","NCT07538388","Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension","Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension in High-Risk Non-Cardiac Surgery Patients - The Multicenter INDUCT Trial (INDUCT-Multi)","INDUCT-Multi","Inclusion Criteria:\n\nWe will include consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:\n\n* Age ≥65 years\n* ASA physical status III or IV\n* Chronic arterial hypertension\n* Diabetes mellitus requiring medication\n* Intra-abdominal surgery\n* Preoperative renal insufficiency (serum creatinine ≥1.2 mg\u002FdL)\n\nExclusion Criteria:\n\n* Pregnancy\n* Cardiac arrhythmia\n* History of intracranial hemorrhage or intracranial aneurysm\n* Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)\n* Patients who are unable to understand, read, and provide informed consent in German","45 Years",{"count":55,"type":20},446,[23],"INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.",[26],[32,60,61,62,63,64],"non-cardiac surgery","norepinephrine","bolus","hypotension","continuous","2026-06-24",{"date":67,"type":37},"2026-06-29",{"date":69,"type":37},"2026-05-07",{"date":40,"type":20},{"name":72,"class":43},"Universitätsklinikum Hamburg-Eppendorf",4]