[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-complications":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,127,0,25,[9,54,88,127,150,198,225,253,279,313,346,368,403,429,460,498,531,566,602,632,659,690,724,748,779],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100652772","axillary-web-syndrome-after-breast-cancer-surgery-incidence-risk-factors-and-functional-outcomes-100652772",false,"NCT07780240","Axillary Web Syndrome After Breast Cancer Surgery: Incidence, Risk Factors, and Functional Outcomes","A Prospective Multicenter Cohort Study on the Incidence, Risk Factors, and Postoperative Functional Outcomes of Axillary Web Syndrome After Breast Cancer Surgery","Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of breast cancer with planned surgical treatment\n* Axillary staging performed by sentinel lymph node biopsy or axillary lymph node dissection\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Preoperative restriction of shoulder range of motion\n* History of neuromuscular disease affecting the upper extremity\n* Metastatic disease\n* Anticipated inability to comply with the follow-up protocol","FEMALE","18 Years","80 Years",{"count":21,"type":22},250,"ESTIMATED","6 Months","OBSERVATIONAL","Axillary web syndrome (AWS), sometimes called \"cording,\" is a condition that can develop after breast cancer surgery in which the lymph nodes under the arm are removed or sampled. It appears as one or more tight, painful cord-like structures running from the armpit down the inner arm. It can limit shoulder movement, cause pain, and interfere with daily activities.\n\nIt is not yet clear how often AWS occurs, when it typically appears after surgery, which patients are most likely to develop it, or whether it is related to the arm swelling (lymphedema) that some patients experience after breast cancer treatment. Most previous studies looked back at patient records rather than following patients forward in time, so the answers remain uncertain.\n\nIn this study, women who are having breast cancer surgery with either sentinel lymph node biopsy or axillary lymph node dissection will be examined before their operation and then at set times afterward: 2, 4, and 8 weeks, and 3 and 6 months. At each visit, the study doctor will examine the armpit and arm for cords, measure how far the shoulder can move, ask the patient to rate any pain, and measure the circumference of both arms to check for swelling.\n\nThe study does not change the surgery or treatment a patient receives. It adds only these examinations and measurements, which are not painful and do not require blood tests or imaging. The researchers hope the results will help identify which patients are at higher risk, so that rehabilitation can be started earlier.",[27,28,29,30],"Axillary Web Syndrome","Breast Cancer","Breast Cancer Lymphedema","Postoperative Complications",[32,33,34,35,36,37,38,39,40],"axillary web syndrome","cording","lymphatic cording","sentinel lymph node biopsy","axillary lymph node dissection","shoulder range of motion","breast cancer surgery","postoperative morbidity","prospective cohort","RECRUITING","2026-08-19",{"date":44,"type":45},"2026-08-21","ACTUAL",{"date":47,"type":45},"2026-05-01",{"date":49,"type":22},"2027-10",{"name":51,"class":52},"Antalya City Hospital","OTHER",2,{"id":55,"slug":56,"hasResults":12,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100652947","heated-humidified-oxygen-in-pacu-patients-100652947","NCT07778420","Heated Humidified Oxygen in PACU Patients","Effect of Heated and Humidified Oxygen Therapy on the Incidence of Early Hypoxemia in Adult Patients During General Anesthesia Recovery in the Post-Anesthesia Care Unit: A Prospective, Multicenter, Randomized, Superiority Trial","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Undergoing elective or emergency surgery under general anesthesia with endotracheal intubation\n3. Ramsay Sedation Score of 2-4 at 1 minute after extubation\n4. ASA physical status class I-III\n5. Expected PACU stay ≥ 30 minutes\n6. Patient or legally authorized representative provides written informed consent\n\nExclusion Criteria:\n\n1. Pre-existing hypoxemia (SpO₂ \\\u003C 90% on room air)\n2. Pre-existing diagnosis of severe chronic obstructive pulmonary disease (GOLD grade 3-4), interstitial lung disease, or uncontrolled asthma\n3. Severe cardiovascular disease (NYHA class III-IV heart failure, unstable angina)\n4. Neuromuscular disease affecting respiratory function\n5. Maxillofacial surgery, severe spinal deformity, or other contraindications to face mask oxygen therapy or positioning\n6. Use of cardiopulmonary bypass during surgery or planned postoperative ICU admission with endotracheal tube in place\n7. Known intolerance to heated gas","ALL",{"count":63,"type":22},2000,"INTERVENTIONAL",[66],"NA","This study aims to determine whether heated and humidified oxygen therapy, compared with conventional room-temperature oxygen therapy, reduces the incidence of early hypoxemia in adult patients recovering from general anesthesia in the Post-Anesthesia Care Unit (PACU).\n\nHypoxemia is a common and potentially life-threatening complication during PACU recovery, resulting from residual anesthetics, decreased upper airway muscle tone, atelectasis, and suppression of hypoxic pulmonary vasoconstriction (HPV). Heated and humidified oxygen may offer benefits by preserving optimal HPV function, protecting airway mucosa, and reducing respiratory resistance.\n\nThis is a prospective, multicenter, randomized, superiority trial with a parallel-group design. A total of 2,000 adult patients (ASA class I-III) undergoing general anesthesia will be enrolled and randomly assigned in a 1:1 ratio to receive either heated and humidified oxygen (37°C, 5 L\u002Fmin via face mask) or room-temperature oxygen (room temperature, 5 L\u002Fmin via face mask).\n\nThe primary outcome is the incidence of hypoxemia, defined as SpO₂ ≤ 90% lasting ≥ 5 seconds, within 10 minutes after initiation of the intervention. Secondary outcomes include severe hypoxemia (SpO₂ ≤ 85%), requirement for airway interventions, lowest SpO₂ value, PACU length of stay, postoperative shivering, and agitation. Safety outcomes include nasal discomfort, epistaxis, and device-related adverse events.",[69,30,70],"Hypoxemia","Anesthesia Recovery Period",[72,73,74,75,76,77],"Heated and Humidified Oxygen","General Anesthesia","PACU","Randomized Controlled Trial","Oxygen Therapy","Post-Anesthesia Care Unit","NOT_YET_RECRUITING","2026-08-18",{"date":44,"type":45},{"date":82,"type":22},"2026-09-01",{"date":84,"type":22},"2027-12-30",{"name":86,"class":52},"Second Affiliated Hospital of Xi'an Jiaotong University",8,{"id":89,"slug":90,"hasResults":12,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":98,"conditions":99,"keywords":106,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100648846","ct-volumetry-and-hepatic-vascular-deformation-mapping-to-predict-post-hepatectomy-liver-failure-100648846","NCT07727759","CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure","Beyond Size - Integrating CT Volumetry With Hepatic Vascular Deformation Mapping to Anticipate Post-Resection Congestion and Liver Failure","BEYOND-SIZE","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo major hepatic resection, defined as the removal of three or more Couinaud segments, at a participating center\n* Availability of a preoperative multiphasic contrast-enhanced CT of the liver of quality sufficient for central core-laboratory analysis\n* Willing and able to complete postoperative clinical and laboratory follow-up for at least 30 days\n* Written informed consent\n\nExclusion Criteria:\n\n* Minor hepatic resection (fewer than three Couinaud segments)\n* Significant pre-existing vascular anomaly or vascular pathology (for example, portal vein thrombosis)\n* Emergency hepatic resection for trauma\n* Preoperative imaging that fails central quality control\n* Incomplete follow-up data",{"count":97,"type":22},1070,"Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the future liver remnant (FLR) - cannot meet the body's metabolic needs. PHLF occurs after roughly 5% to 15% of major hepatectomies and is the leading cause of postoperative death.\n\nBefore surgery, surgeons routinely use CT scans to measure how much liver will remain (CT volumetry). Volume alone does not tell the whole story. After a large resection the remaining liver can rotate and shift into the empty space left behind, kinking or compressing the veins that drain it. The resulting congestion can make an apparently adequate remnant fail.\n\nThis prospective, multicenter, observational cohort study tests whether adding two elements to standard CT volumetry improves the preoperative prediction of liver failure:\n\n1. Hepatic vascular deformation mapping (VDM), a three-dimensional image-analysis technique that quantifies the geometry and displacement of the hepatic veins and the portal vein; and\n2. A set of simple, reproducible measurements that any radiologist can make on a standard CT scan (hepatic vein diameters, congestion index, spleen volume, liver attenuation, and the distances from the veins to the planned resection plane).\n\nConsecutive adults undergoing major hepatic resection (three or more Couinaud segments) at several tertiary hepatobiliary centers will be enrolled. The preoperative CT scans already performed as part of routine care are analyzed centrally by a core imaging laboratory. There is no additional imaging, no extra hospital visit, and no study-specific intervention: every patient receives standard surgical care. Participants are followed for at least 30 days after surgery to record liver failure (International Study Group of Liver Surgery criteria, operationalized by the \"50-50\" rule on postoperative day 5) and radiologic evidence of hepatic congestion.\n\nThree nested prediction models are compared - volumetry alone; volumetry plus VDM; and volumetry plus VDM plus the simple radiology parameters - and the best-performing model is converted into a practical risk score. Because the study runs across several centers, the model can be validated by leaving one center out at a time, which gives an honest estimate of how well it would perform at a new hospital. The goal is a generalizable, easy-to-use tool that tells surgeons, before the operation, which patients are genuinely at risk of post-hepatectomy liver failure.",[100,101,102,103,104,30,105],"Post-Hepatectomy Liver Failure","Liver Failure","Liver Neoplasms","Carcinoma, Hepatocellular","Liver Metastases","Hepatic Congestion",[107,108,109,110,111,112,113,114,115,116,117],"post-hepatectomy liver failure","CT volumetry","future liver remnant","vascular deformation mapping","hepatic venous congestion","major hepatectomy","clinical prediction model","ISGLS criteria","congestion index","hepatobiliary surgery","risk stratification","2026-08-17",{"date":79,"type":45},{"date":121,"type":45},"2026-08-15",{"date":123,"type":22},"2028-07-31",{"name":125,"class":52},"Minia University",3,{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":135,"targetDuration":137,"studyType":24,"phases":4,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":149},"100395790","early-ponv---a-registry-based-study-in-sweden-100395790","NCT04433676","Early PONV - a Registry Based Study in Sweden.","Risk of Early Postoperative Nausea and Vomiting (PONV) - a Study With Data From the Swedish Perioperative Register (SPOR).","SPOR-PONV","Inclusion Criteria:\n\n* Procedure under general or regional anaesthesia\n* Age \\>=18 years at the day of the procedure.\n\nExclusion Criteria:\n\n* No entry of the PONV-variable in the SPOR-registry",{"count":136,"type":22},1500000,"1 Day","The study is an registry study based on data from the Swedish Perioperative Registry (SPOR) during the years 2016-2022 with the aim to explore the risk for postoperative nausea and vomiting at the recovery unit (early PONV). The study will explore several cohorts (for example a specific procedure) on a national basis, report the risk for early PONV and identify associated factors.",[140,30],"Postoperative Nausea and Vomiting",{"date":42,"type":45},{"date":143,"type":45},"2016-01-01",{"date":145,"type":22},"2029-12-31",{"name":147,"class":148},"Jakob Wallden","OTHER_GOV",1,{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":64,"phases":161,"briefSummary":162,"conditions":163,"keywords":170,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":194,"completionDateStruct":195,"leadSponsor":197,"locationsCount":149},"100648262","hernia-sac-flap-coverage-of-mesh-in-bony-edged-ventral-hernia-repair-100648262","NCT07720154","Hernia Sac Flap Coverage of Mesh in Bony-Edged Ventral Hernia Repair","Sac-Flap Peritonealization of Mesh in Bony-Edged Ventral Hernias: A Randomized Controlled Trial","PERI-SAC","Inclusion Criteria:\n\n* Age 18 years or older.\n* Elective open repair planned for a complex ventral hernia (primary or incisional) in which at least one margin of the fascial defect is formed by bone - that is, a subxiphoid or costal-margin, suprapubic, or iliac or lumbar location - confirmed on cross-sectional imaging (CT or MRI) and at operation.\n* A hernial sac of sufficient quality and surface area to raise a pedicled flap adequate to cover the planned mesh, as judged at operation.\n* Planned retromuscular (sublay) synthetic mesh repair, with or without posterior component separation (transversus abdominis release).\n* Able to give written informed consent and to attend scheduled follow-up for 12 months.\n\nExclusion Criteria:\n\n* Emergency or urgent operation (incarceration with strangulation, obstruction, or perforation).\n* Active intra-abdominal infection, or a contaminated or dirty operative field (CDC wound class III-IV) at the time of randomization.\n* Planned use of biologic or composite intraperitoneal mesh, or a bridged (non-fascial-closure) repair as the primary plan.\n* Hernial sac absent, destroyed, densely scarred, or too small to raise a viable covering flap.\n* Concurrent bowel resection or stoma creation expected to alter the wound-contamination class.\n* ASA physical status V.\n* Life expectancy less than 12 months, or active malignancy under treatment with anticipated short survival.\n* Pregnancy.\n* Inability or unwillingness to provide informed consent or to comply with follow-up","75 Years",{"count":160,"type":22},180,[66],"This trial asks whether covering the inner, bowel-facing surface of a hernia mesh with a flap of the patient's own hernia sac improves healing after repair of a complex ventral (abdominal wall) hernia in which one edge of the defect is bone - for example hernias next to the breastbone and ribs, above the pubic bone, or at the iliac crest.\n\nIn these \"bony-edged\" hernias the mesh is both hardest to fix and hardest to cover. There is no fascia on the bony side for the surgeon to stitch the mesh to, and the lining layer of the abdomen cannot be closed underneath the mesh because the plane that carries it stops at the bone. The mesh may therefore be left in contact with the bowel, which can lead to dense adhesions, mesh erosion, chronic pain and, rarely, a fistula.\n\nNormally the hernia sac - the thin membrane that lines the hernia - is cut away and discarded. In this trial the surgeon instead preserves it as a living, blood-supplied flap, rotates it underneath the mesh, and stitches it in place as a new lining layer that separates the mesh from the bowel and covers the bony edge. The technique uses only the patient's own tissue: no extra mesh, no donor site and no added cost.\n\nOne hundred and eighty adults undergoing planned (non-emergency) open repair of a bony-edged complex ventral hernia will be randomly assigned in equal numbers to one of two groups: standard retromuscular (sublay) mesh repair with the added sac flap (90 participants), or standard retromuscular mesh repair alone, with the sac handled in the conventional way (90 participants). Every other step of the operation is the same in both groups.\n\nThe main question is whether the sac flap reduces the number of participants who develop any wound or mesh problem in the first 30 days after surgery. This is measured as a composite called a surgical site occurrence, which includes wound infection, seroma, haematoma, skin or soft-tissue death, wound breakdown, mesh exposure and fistula. The trial also compares complications needing a drainage or operative procedure, hernia recurrence at 12 months, overall complication severity, operating time, blood loss, hospital stay, readmission, reoperation, pain, quality of life and death.\n\nParticipants, ward and clinic staff, the doctors who assess the wounds, the radiologist who reads the follow-up scans and the trial statistician will not know which operation was performed; only the operating surgeon will. The group assignment is revealed only during the operation, after the surgeon has confirmed that the defect truly has a bony edge and that the sac is suitable for a flap. Participants are followed for 12 months.",[164,165,166,167,168,30,169],"Incisional Hernia","Abdominal Hernia","Complex Ventral Hernia","Surgical Site Infection","Seroma","Ventral Hernia",[171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191],"ventral hernia","incisional hernia","complex abdominal wall reconstruction","bony-edged hernia","subxiphoid hernia","suprapubic hernia","lumbar hernia","iliac crest hernia","hernial sac","sac flap","peritonealization","neo-peritoneum","autologous tissue coverage","retromuscular mesh","sublay mesh repair","transversus abdominis release","posterior component separation","surgical site occurrence","mesh-visceral interface","mesh erosion","hernia recurrence","2026-08-16",{"date":79,"type":45},{"date":121,"type":45},{"date":196,"type":22},"2028-08-15",{"name":125,"class":52},{"id":199,"slug":200,"hasResults":12,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":158,"enrollmentInfo":205,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":207,"conditions":208,"keywords":213,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":219,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":149},"100625855","postoperative-hypocalcemia-after-thyroidectomy-100625855","NCT07428057","Postoperative Hypocalcemia After Thyroidectomy","A Ten-Year Cohort Study of Clinical and Surgical Predictors for Hypocalcemia Post-Thyroidectomy","Inclusion Criteria:\n\n* Adult patients aged 18 years or older at time of surgery\n* Underwent thyroidectomy at Minia University Hospital\n* Availability of medical records with complete surgical and postoperative data\n* Documented serum calcium levels measured postoperatively\n* Minimum follow-up of 6 months postoperatively or documented outcome status\n\nExclusion Criteria:\n\n* Age less than 18 years at time of surgery\n* Preoperative hypocalcemia (serum calcium \\\u003C8.0 mg\u002FdL or ionized calcium \\\u003C1.0 mmol\u002FL)\n* Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism)\n* Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73m²)\n* Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease,short bowel syndrome)\n* Concurrent planned parathyroidectomy\n* History of neck irradiation\n* Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab,cinacalcet, chronic corticosteroids)\n* Incomplete medical records lacking essential data including surgical details, postoperative calcium levels,or follow-up data\n* Patients lost to follow-up before 6-month endpoint without documented outcome status",{"count":206,"type":22},600,"This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024). Postthyroidectomy hypocalcemia is one of the most common complications of thyroid surgery, affecting 20-50% of patients. The study aims to identify demographic, clinical, laboratory, and surgical factors associated with the development of both transient and permanent hypocalcemia. Results will inform risk stratification, patient counseling, and perioperative management strategies.",[209,210,211,212,30],"Thyroid Nodule","Thyroid Dysfunction","Hypocalcemia","Thyroid Cancer",[214,215,216,217,218],"Thyroidectomy","Postoperative hypocalcemia","Hypoparathyroidism","Parathyroid gland injury","Total thyroidectomy",{"date":79,"type":45},{"date":221,"type":45},"2026-03-04",{"date":223,"type":22},"2027-01-01",{"name":125,"class":52},{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":64,"phases":234,"briefSummary":235,"conditions":236,"keywords":239,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":149},"100652249","the-effect-of-acupressure-application-on-respiratory-performance-and-pain-levels-in-adult-patients-undergoing-cardiac-surgery-100652249","NCT07771751","The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery","The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 years and older.\n* Undergoing cardiac surgery for the first time.\n* Extubated and hemodynamically stable in the postoperative period.\n* A Glasgow Coma Scale (GCS) score of 15.\n* Absence of arterial or venous catheters, incisions, hematomas, ecchymoses, or any skin lesions\u002Fdeformities at the acupressure application sites.\n* No analgesic medication administered within the last four hours.\n* No known neuromuscular diseases that could affect respiratory muscle strength or performance.\n* Ability to speak Turkish and absence of any communication barriers.\n\nExclusion Criteria:\n\n* Development of postoperative complications (e.g., severe arrhythmia, need for re-intubation, active bleeding).\n* Receiving sedation in the intensive care unit.\n* Presence of chronic pain syndrome or regular use of opioids\u002Fanalgesics.\n* Known psychiatric disorders.",{"count":233,"type":22},114,[66],"The purpose of this randomized controlled trial is to evaluate the effect of acupressure on respiratory performance and pain levels in adult patients who have undergone open-heart surgery. Pulmonary complications and severe pain are common after cardiac surgery, often limiting the effectiveness of standard deep breathing exercises such as incentive spirometry. This study investigates whether applying acupressure-a non-invasive complementary therapy-can help manage postoperative pain and improve respiratory capacity. By potentially reducing pain without the respiratory side effects associated with pharmacological medications, acupressure may enable patients to perform their breathing exercises more effectively and support their overall recovery.",[237,238,30],"Postoperative Pain","Cardiac Surgery",[240,241,242,243,244],"Respiratory Performance","Pain Management","Nursing Care","acupressure","cardiac surgery","2026-08-14",{"date":79,"type":45},{"date":248,"type":22},"2026-09-21",{"date":250,"type":22},"2027-09-21",{"name":252,"class":52},"Fenerbahce University",{"id":254,"slug":255,"hasResults":12,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":12,"sex":61,"minAge":260,"maxAge":158,"enrollmentInfo":261,"targetDuration":263,"studyType":24,"phases":4,"briefSummary":264,"conditions":265,"keywords":268,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":149},"100533069","to-assess-the-impact-of-theeras-consensus-on-patients-with-endoscopic-pituitary-tumor-surgery-100533069","NCT06221020","To Assess the Impact of theERAS Consensus on Patients With Endoscopic Pituitary Tumor Surgery","To Assess the Impact of the Enhanced Recovery After Surgery (ERAS) Consensus on the Effectiveness and Prognosis of Patients With Endoscopic Pituitary Tumor Surgery","Inclusion Criteria:\n\n* Clinical diagnosis of pituitary tumors\n* To sign a written informed consent form\n\nExclusion Criteria:\n\n* Diagnosed with other malignant tumors\n* Severe infections, such as osteomyelitis, acute inflammation at the affected site, or open wounds at the treatment area\n* Pregnant women\n* Coagulation disorders or those taking anticoagulant medication\n* Other central nervous system disorders, alcohol addiction, other addictive drugs, or mental illness that may affect clinical assessment\n* Deemed unsuitable for surgical treatment or unable to comply with clinical evaluation upon assessment","20 Years",{"count":262,"type":22},70,"3 Months","The goal of this observational study is to evaluate the effectiveness and impact of Enhanced Recovery After Surgery (ERAS) on patients with pituitary gland tumors.",[266,267,30],"Enhanced Recovery After Surgery","Pituitary Tumor",[266,269,270,30],"Pituitary tumor","Anesthesia Safety","2026-08-13",{"date":118,"type":45},{"date":274,"type":45},"2023-12-12",{"date":276,"type":22},"2026-11-30",{"name":278,"class":52},"Chang Gung Memorial Hospital",{"id":280,"slug":281,"hasResults":12,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":12,"sex":61,"minAge":286,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":289,"conditions":290,"keywords":296,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":4},"100651477","erector-spinae-oxygen-saturation-and-aki-after-opcab-100651477","NCT07760129","Erector Spinae Oxygen Saturation and AKI After OPCAB","Erector Spinae Muscle Oxygen Saturation as an Early Predictor of Acute Kidney Injury in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery","Inclusion Criteria:\n\n1. Adults aged 19 years or older scheduled for elective off-pump coronary artery bypass (OPCAB) surgery.\n2. Able to receive a full explanation of the purpose and procedures of the study and to provide written informed consent voluntarily.\n3. Depth from the skin to the erector spinae muscle at the level of the left renal hilum, measured by ultrasonography in the operating room before anesthetic induction, of less than 2.0 cm, so that stable near-infrared spectroscopy measurement is considered feasible. Consenting patients who do not meet this criterion are not enrolled and are classified as screen failures.\n\nExclusion Criteria:\n\n1. Emergency surgery.\n2. Concomitant surgery performed by another department.\n3. Preoperative or postoperative cardiogenic shock, or need for mechanical circulatory support.\n4. Estimated glomerular filtration rate below 30 mL\u002Fmin\u002F1.73 m2.\n5. Previous kidney transplantation.\n6. Left renal disease or a solitary kidney.\n7. Body mass index above 30 kg\u002Fm2.\n8. Active bleeding or active infection.\n9. Inability to read and voluntarily consent to the informed consent document (for example, because of illiteracy, language barrier, or cognitive impairment).\n10. Refusal to participate in the study.","19 Years",{"count":288,"type":22},138,"Acute kidney injury (AKI) is a frequent and serious complication after cardiac surgery, including off-pump coronary artery bypass (OPCAB). Because AKI is diagnosed on the basis of serum creatinine, which rises 1 to 2 days after the actual renal insult, early detection and timely intervention remain difficult. Near-infrared spectroscopy (NIRS) allows non-invasive and continuous measurement of regional tissue oxygen saturation, but the effective penetration depth of commercially available devices is only approximately 2 to 2.5 cm. In most adults the renal cortex lies deeper than this, so the signal obtained from a flank sensor may originate largely from the abdominal wall musculature rather than from renal parenchyma. This limitation may explain the inconsistent association between renal regional oxygen saturation (renal rSO2) and AKI reported so far.\n\nThe erector spinae muscle at the level of the renal hilum lies within 2 cm of the skin in most patients and is supplied by the lumbar arteries and by vessels adjacent to the renal hilum. Erector spinae muscle regional oxygen saturation (ESrSO2) may therefore provide a technically more reliable NIRS signal that reflects perfusion of a vascular territory close to that of the kidney, particularly during the transient low cardiac output state induced by mechanical displacement of the heart for coronary anastomosis during OPCAB.\n\nThis single-center prospective observational cohort study will enroll 138 adult patients scheduled for elective OPCAB at Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea. ESrSO2 and renal rSO2 will be measured continuously with an INVOS oximeter from before anesthetic induction until the end of surgery, in addition to cerebral rSO2, which is part of standard care at the participating institution. The ESrSO2 and renal rSO2 channels will be physically masked on the monitor display during surgery, no alarms will be set for these two channels, and their values will not be used for any intraoperative clinical decision. The recorded data will be extracted after surgery using the INVOS Analytics Tool. Apart from placement of the additional NIRS sensors and a brief pre-induction ultrasound measurement of tissue depth, no study-specific procedure, laboratory test, or imaging study will be performed, and all anesthetic, surgical, and postoperative care will follow the standard institutional protocol.\n\nThe primary objective is to identify which ESrSO2-derived variable best predicts postoperative AKI, defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria within 7 days after surgery. The candidate variables are the baseline value, the intraoperative nadir, the area under the threshold (AUT), and the duration under the threshold below absolute values of 60%, 55%, and 50% and below 80% of the baseline value, calculated separately for the period before cardiac displacement and for the cardiac displacement period. Secondary objectives are to assess whether the selected ESrSO2 variable provides independent and incremental predictive information beyond a pre-specified baseline risk model, to compare the predictive performance of ESrSO2 with that of cerebral rSO2 and renal rSO2, and to evaluate the prediction of severe AKI (KDIGO stage 2 to 3) and persistent AKI (lasting 48 hours or longer).\n\nIf ESrSO2 proves to be a useful early marker of AKI, it could allow real-time, non-invasive identification of patients at high risk during surgery and provide a basis for future trials of renal protective strategies.",[291,292,293,30,294,295],"Acute Kidney Injury","Coronary Artery Disease","Coronary Artery Bypass, Off-Pump","Cardiac Surgical Procedures","Spectroscopy, Near-Infrared",[297,298,299,300,301,302,303,304],"rector spinae muscle regional oxygen saturation (ESrSO2)","near-infrared spectroscopy (NIRS)","regional oxygen saturation (rSO2","off-pump coronary artery bypass (OPCAB)","acute kidney injury (AKI)","KDIGO","area under the threshold (AUT)","tissue oximetry","2026-08-06",{"date":307,"type":45},"2026-08-12",{"date":309,"type":22},"2026-10-01",{"date":145,"type":22},{"name":312,"class":52},"Yonsei University",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":12,"sex":61,"minAge":320,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":323,"conditions":324,"keywords":328,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":149},"100650733","gnri-and-rectus-femoris-muscle-thickness-in-older-patients-undergoing-hip-fracture-surgery-100650733","NCT07751692","GNRI and Rectus Femoris Muscle Thickness in Older Patients Undergoing Hip Fracture Surgery","Prognostic Value of the Geriatric Nutritional Risk Index and Ultrasonographic Rectus Femoris Muscle Thickness in Older Patients Undergoing Hip Fracture Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 65 years or older\n* Scheduled to undergo surgical treatment for hip fracture\n* Provision of informed consent by the participant or, when applicable, a legally authorized representative\n\nExclusion Criteria:\n\n* Pathological fracture or fracture related to malignancy\n* Advanced neuromuscular disease\n* Active infection\n* Planned revision surgery\n* Lower limb amputation or severe deformity preventing rectus femoris muscle thickness measurement\n* Inability to obtain informed consent from the participant or a legally authorized representative","65 Years",{"count":322,"type":22},120,"This prospective observational study will evaluate whether nutritional risk and reduced muscle mass are associated with postoperative outcomes in adults aged 65 years or older undergoing surgery for hip fracture.\n\nNutritional risk will be assessed using the Geriatric Nutritional Risk Index (GNRI), which is calculated from routine preoperative serum albumin, body weight, and ideal body weight. Rectus femoris muscle thickness will be measured before surgery using a brief, noninvasive ultrasound examination of the non-fractured thigh.\n\nParticipants will receive routine clinical care, and no treatment or anesthesia method will be assigned by the study. Clinical information will be collected from hospital records, including postoperative length of hospital stay, surgical site infection, and mortality. Survival status will be evaluated at 30 and 90 days after surgery using hospital records and\u002For telephone follow-up.",[325,326,327,30],"Hip Fracture","Malnutrition","Sarcopenia",[329,330,331,332,333,334,167,335,336,337],"Geriatric Nutritional Risk Index","Rectus Femoris Muscle Thickness","Muscle Ultrasound","Geriatric Hip Fracture","Nutritional Risk","Postoperative Length of Stay","Prognostic Factors","30-Day Mortality","90-Day Mortality",{"date":339,"type":45},"2026-08-07",{"date":341,"type":22},"2026-08",{"date":343,"type":22},"2027-06",{"name":345,"class":52},"Fatih Sultan Mehmet Training and Research Hospital",{"id":347,"slug":348,"hasResults":12,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":12,"sex":61,"minAge":4,"maxAge":18,"enrollmentInfo":353,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":355,"conditions":356,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":366,"locationsCount":149},"100621821","a-multimodal-ai-prediction-model-for-complications-after-transcatheter-closure-of-perimembranous-vsd-in-children-100621821","NCT07375602","A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children","Multimodal Clinical Data Integration and Artificial Intelligence Modeling for Predicting Complications Following Pediatric Transcatheter Closure of Perimembranous Ventricular Septal Defect","Inclusion Criteria:\n\n* Age ≤ 18 years at the time of transcatheter procedure.\n* Diagnosis of perimembranous ventricular septal defect confirmed by echocardiography, and underwent transcatheter device closure at the study center.\n* Medical records sufficient to ascertain the primary outcome within the pre-specified follow-up window, and availability of minimum baseline clinical information required for model development\u002Fvalidation.\n\nExclusion Criteria:\n\n* Ventricular septal defects not classified as perimembranous on echocardiography, including muscular, outlet, or inlet VSDs, as well as multiple or complex VSDs involving more than one septal region.\n* Presence of complex congenital heart disease or associated structural abnormalities requiring concomitant surgical repair (e.g., tetralogy of Fallot).\n* Prior surgical VSD repair or prior transcatheter VSD closure.",{"count":354,"type":22},5249,"The goal of this observational study is to develop and validate a multimodal artificial intelligence prediction model for treatment-related complications in children with perimembranous ventricular septal defect (pmVSD) undergoing transcatheter device closure. The main question it aims to answer is: Can an AI model that integrates demographics, laboratory results, electronic health record text, echocardiography reports, chest radiographs, and electrocardiogram accurately predict the risk of complications at the individual patient level? Data will be retrospectively collected from routine clinical care records of pediatric patients who underwent transcatheter closure for pmVSD. Deep learning methods will be used to extract features from text and images to train and validate the prediction model.",[357,358,359,30],"Congenital Heart Disease (CHD)","Ventricular Septal Defects (VSD)","Cardiac Catheterization","2026-08-04",{"date":362,"type":45},"2026-08-05",{"date":364,"type":45},"2026-02-01",{"date":84,"type":22},{"name":367,"class":52},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine",{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":374,"eligibilityCriteria":375,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":64,"phases":378,"briefSummary":379,"conditions":380,"keywords":384,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":398,"completionDateStruct":399,"leadSponsor":401,"locationsCount":149},"100650133","comparing-suture-vs-combined-closure-strategies-for-large-blood-vessel-access-in-patients-undergoing-transcatheter-aortic-valve-implantation-tavi-100650133","NCT07743697","Comparing Suture vs. Combined Closure Strategies for Large Blood Vessel Access in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)","SEAL-TAVI - Suture vs combinEd Closure strAtegies in Large-bore Access After TAVI","SEAL-TAVI","Inclusion Criteria:\n\n* Patient is at least 18 years of age at the time of screening.\n* Patient is scheduled to undergo elective transcatheter aortic valve implantation (TAVI) via transfemoral arterial access.\n* Patient is deemed suitable for transfemoral TAVI and large-bore vascular access closure by the local Heart Team.\n* Patient (or legally authorized representative) provides written informed consent prior to initiating any study-related procedures.\n* Patient is willing and able to comply with all specified study procedures, follow-up visits, and clinical evaluations.\n\nExclusion Criteria:\n\n* Planned TAVI procedure via non-femoral arterial access (e.g., transapical, transaortic, subclavian\u002Faxillary, or carotid access).\n* Emergency or non-elective TAVI procedure.\n* Target main femoral artery vessel diameter, calcification, or tortuosity judged unsuitable for standard percutaneous large-bore vascular closure device deployment.\n* Known active, unresolved local or systemic infection at the planned vascular access site.\n* Known severe allergy or hypersensitivity to bovine tissue, collagen, or any component of the study closure devices (Perclose ProGlide\u002FProStyle or Angio-Seal) that cannot be adequately premedicated.\n* Severe bleeding diathesis, active major bleeding, or absolute contraindication to standard periprocedural anticoagulation or antiplatelet therapy.\n* Concurrent participation in another interventional clinical trial investigating cardiovascular devices or drugs that could confound study endpoints.\n* Patient is pregnant or breastfeeding.\n* Patient belongs to a vulnerable population (e.g., individuals deprived of liberty, under guardianship, or unable to give informed consent).",{"count":377,"type":22},705,[66],"The goal of this clinical trial is to compare two strategies for closing the main artery access site in adult patients undergoing transcatheter aortic valve implantation (TAVI) through a blood vessel in the leg (transfemoral access).\n\nThe main questions it aims to answer are:\n\nDoes using a single suture device lower the rate of access-related vascular complications compared to using a hybrid combination of a suture device and a plug-based closure device? How do the two closure strategies compare regarding bleeding complications, procedure time, and time to complete vessel sealing?\n\nResearchers will compare a single-suture closure strategy to a hybrid closure strategy (one suture plus one plug-based device) to see if using a single suture reduces vessel-related complications and improves patient safety after TAVI.\n\nParticipants will:\n\nUndergo standard pre-procedure screening and TAVI via the main artery in the leg as part of routine medical care.\n\nReceive an initial single-suture placement before the large TAVI delivery system is inserted.\n\nBe evaluated after sheath removal for initial bleeding control; qualifying participants will then be randomly assigned (1:1) to either receive no additional device (single suture group) or receive a plug-based closure device (hybrid group).\n\nHave their heart and access site monitored during hospitalization, including laboratory checks and imaging prior to discharge.\n\nComplete a 72-hour safety and complication evaluation.",[381,30,382,383],"Aortic Valve Stenosis","Vascular System Injuries","Hemorrhage",[374,385,386,387,388,389,390,391,392,393,394,395],"Transcatheter Aortic Valve Implantation","TAVI","Vascular Closure Device","Suture-Based Closure","Angio-Seal","ProGlide","ProStyle","Large-Bore Access","Vascular Complications","TAVR","Transcatheter Aortic Valve Replacement","2026-07-29",{"date":360,"type":45},{"date":309,"type":22},{"date":400,"type":22},"2028-09",{"name":402,"class":52},"University Hospital, Basel, Switzerland",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":410,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":412,"conditions":413,"keywords":416,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":149},"100649025","vascular-aging-and-acute-kidney-injury-after-cardiac-surgery-100649025","NCT07727772","Vascular Aging and Acute Kidney Injury After Cardiac Surgery","Multidimensional Assessment of Vascular Aging and Its Association With Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.\n* Patients who are able to provide written informed consent.\n* Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.\n\nExclusion Criteria:\n\n* Patients younger than 18 years.\n* Patients with preoperative end-stage renal disease or maintenance dialysis.\n* Patients who are unable to complete the study-specified vascular aging assessment.\n* Patients who decline participation or withdraw informed consent.",{"count":411,"type":22},472,"This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.",[414,30,415],"Acute Kidney Injury Cardiac Surgery","Vascular Aging",[417,418,419],"vascular aging","acute kidney injury","postoperative complications","2026-07-22",{"date":422,"type":45},"2026-07-27",{"date":424,"type":22},"2026-07-01",{"date":426,"type":22},"2027-12-28",{"name":428,"class":52},"Nanjing First Hospital, Nanjing Medical University",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":158,"enrollmentInfo":436,"targetDuration":438,"studyType":24,"phases":4,"briefSummary":439,"conditions":440,"keywords":445,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":453,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":149},"100648918","clinical-effects-of-intraoperative-heat-and-moisture-exchange-systems-during-thoracic-surgery-a-prospective-observational-cohort-study-100648918","NCT07729319","Clinical Effects of Intraoperative Heat and Moisture Exchange Systems During Thoracic Surgery: A Prospective Observational Cohort Study","Clinical Effects of Active Versus Passive Intraoperative Respiratory Gas Humidification During Video-Assisted Thoracoscopic Surgery: A Prospective Single-Center Observational Cohort Study","Inclusion Criteria:\n\n* Patients aged 18 to 75 years\n* Elective video-assisted thoracoscopic surgery (VATS)\n* Lung resection requiring general anesthesia\n* Planned one-lung ventilation\n* Written informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Pregnancy\n* Preoperative mechanical ventilation\n* Previous enrollment\n* Refusal to participate",{"count":437,"type":22},200,"7 Days","General anesthesia with endotracheal intubation bypasses the physiological warming and humidification functions of the upper airway, allowing cold and dry gases to reach the lower respiratory tract. This may impair mucociliary clearance, increase secretion viscosity, promote atelectasis, and contribute to postoperative pulmonary complications (PPCs).\n\nPatients undergoing thoracic surgery, particularly those requiring one-lung ventilation (OLV), are at increased risk for PPCs because of altered ventilation-perfusion matching, reduced functional residual capacity, and impaired secretion clearance. Although respiratory gas humidification is routinely used during anesthesia, evidence regarding the comparative clinical effects of active heated humidification (AHH) and passive heat and moisture exchangers (HMEs) during thoracic surgery remains limited.\n\nThis prospective observational cohort study aims to evaluate the association between intraoperative respiratory gas humidification methods and postoperative pulmonary complications and perioperative clinical outcomes in adult patients undergoing elective video-assisted thoracoscopic surgery (VATS).",[441,30,442,443,444],"Video Assisted Thoracic Surgery (VATS)","Pulmonary Complications in Surgical Patients","Humidification","Air Conditioning",[446,447,443,448,449,450,451,452,444],"VATS","Postoperative complications","Thoracic Surgery","Pulmonary Complications","One-Lung Ventilation","Heat and Moisture Exchanger","HME",{"date":422,"type":45},{"date":455,"type":22},"2026-07-25",{"date":457,"type":22},"2027-04",{"name":459,"class":52},"Marmara University",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":466,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":470,"conditions":471,"keywords":485,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":4},"100645943","quality-of-life-of-patients-who-have-undergone-bilateral-mastectomy-100645943","NCT07699913","Quality of Life of Patients Who Have Undergone Bilateral Mastectomy","Psychological Experience, Quality of Life, and Patient Satisfaction Following Bilateral Breast Reconstruction After Prophylactic or Therapeutic Mastectomy, Using the BREAST-Q Questionnaire.","RM BREAST Q","Inclusion Criteria:\n\n* Female sex\n* Age ≥ 18 years\n* Bilateral mastectomy\n* Breast reconstruction between January 1, 2015, and January 1, 2026\n* No objection to the study\n\nExclusion Criteria:\n\n* Individual under guardianship or curatorship, or deprived of liberty\n* Reconstruction not completed by January 1, 2026.",{"count":469,"type":22},115,"The investigators therefore aim to determine whether the type of mastectomy (preventive in a high-risk patient or therapeutic in a patient with a history of cancer), as well as the timing (immediate or delayed) and type of breast reconstruction, influence the quality of life and satisfaction of patients who have undergone bilateral mastectomy. The goal of this observational study is thus to measure and compare the quality of life of patients who have undergone bilateral mastectomy using the BREAST-Q questionnaire.",[472,473,474,475,476,477,478,479,480,30,481,482,483,484],"Surgery Date","Age","BMI","Height","Weight","Smoking Status","Hormone Therapy","Chemotherapy","Radiotherapy","Type of Reconstruction (Flap or Implant)","Timing of Reconstruction","Type of Mastectomy (Prophylactic or Therapeutic)","BRCA Mutation",[486,487,488],"Comparative","observational","retrospective","2026-07-13",{"date":491,"type":45},"2026-07-15",{"date":493,"type":22},"2026-07-10",{"date":495,"type":22},"2026-08-20",{"name":497,"class":52},"University Hospital, Grenoble",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":12,"sex":61,"minAge":506,"maxAge":4,"enrollmentInfo":507,"targetDuration":4,"studyType":64,"phases":508,"briefSummary":509,"conditions":510,"keywords":514,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":528,"leadSponsor":529,"locationsCount":126},"100646757","primary-versus-delayed-wound-closure-in-complicated-appendectomy-the-hiedi-yemen-trial-100646757","NCT07688109","Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)","A Comparative Study of Primary Versus Delayed Wound Closure Using the High-Efficiency Incision and Drainage With Irrigation (HIEDI) Technique to Minimize Surgical Site Infection (SSI) Risk in Patients Undergoing Complicated Appendectomy","HIEDI-Yemen","Inclusion Criteria:\n\n* Age 12 years and older\n* Intraoperative diagnosis of complicated appendicitis (perforation or gangrene)\n* Undergoing open appendectomy via McBurney or Rocky-Davis incision\n* Ability to provide written informed consent (patient or legal guardian for minors)\n* Availability for 30-day follow-up\n\nExclusion Criteria:\n\n* Generalized peritonitis requiring midline laparotomy\n* Immunocompromised status (e.g., chronic corticosteroid or immunosuppressive therapy, diagnosed HIV infection)\n* Poorly controlled diabetes mellitus (Hemoglobin A1c \\[HbA1c\\] greater than 8%)\n* Pregnancy\n* Concurrent malignancy\n* American Society of Anesthesiologists (ASA) physical status classification IV or V\n* Laparoscopic appendectomy","12 Years",{"count":437,"type":22},[66],"The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI) technique in patients undergoing open appendectomy for complicated appendicitis in Sana'a, Yemen.\n\nThe main questions it aims to answer are:\n\n* Does primary closure with HIEDI result in a non-inferior or lower incidence of Surgical Site Infection (SSI) at 30 days compared with delayed primary closure with HIEDI?\n* Does primary closure with HIEDI reduce length of hospital stay and improve the trajectory of objective wound healing compared with delayed primary closure with HIEDI?\n* What is the impact of each closure method on patient satisfaction and health-related quality of life?\n\nResearchers will compare the two groups to determine the optimal, evidence-based standard of care for wound management in complicated appendicitis within a resource-limited setting.\n\nParticipants will:\n\n* Undergo open appendectomy for intraoperatively confirmed complicated appendicitis (perforation or gangrene).\n* Receive standardized HIEDI wound decontamination (meticulous debridement and pulsatile irrigation with minimum 500 mL povidone-iodine 1:10 solution).\n* Be randomly allocated to either primary closure (all layers closed at surgery) or delayed primary closure (skin\u002Fsubcutaneous tissue left open and closed 3-5 days later).\n* Attend follow-up visits at days 7, 14, and 30 for wound assessment, infection surveillance, and outcome evaluation.",[511,512,30,513],"Appendicitis","Surgical Wound Infection","Wound Healing",[515,516,517,167,518,519,520,521,522,523],"Complicated appendicitis","Primary wound closure","Delayed primary closure","HIEDI technique","Wound decontamination","Appendectomy","Yemen","Randomized controlled trial","High-Efficiency Incision and Drainage with Irrigation","2026-07-02",{"date":526,"type":45},"2026-07-07",{"date":424,"type":22},{"date":276,"type":22},{"name":530,"class":52},"Sana'a University",{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":537,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":158,"enrollmentInfo":539,"targetDuration":4,"studyType":64,"phases":541,"briefSummary":542,"conditions":543,"keywords":547,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":149},"100641421","preoperative-fasting-and-the-gut-microbiome-before-hip-replacement-100641421","NCT07651462","Preoperative Fasting and the Gut Microbiome Before Hip Replacement","Preoperative Metabolic Optimization: Influence of Intermittent and Buchinger-Type Fasting on the Gut Microbiome, Immune Profile, and Postoperative Complications in Patients Undergoing Primary Total Hip Arthroplasty - A Randomized Controlled Trial","PreFAST-Hip","Inclusion Criteria:\n\n* Adults aged 18-75 years (inclusive)\n* Scheduled for elective primary total hip arthroplasty (THA)\n* Able and willing to provide written informed consent\n* Able to follow the 20-day preoperative fasting protocol independently at home (if randomized to the fasting arm) or willing to be randomized to either arm\n\nExclusion Criteria:\n\n* Resorption disorder due to bowel disease (e.g. inflammatory bowel disease, short-bowel syndrome, active celiac disease)\n* Antibiotic therapy within the last 2 months before baseline (T0)\n* Probiotic, prebiotic, or symbiotic supplementation within the last 2 months before baseline (T0)\n* Inability or unwillingness to provide informed consent\n* Severe comorbidity precluding fasting (e.g. ASA ≥ IV, advanced renal\u002Fhepatic impairment, eating disorder)\n* BMI \\\u003C 18.5 kg\u002Fm² (underweight)\n* Concurrent participation in another interventional drug or device trial\n* Pregnancy or breastfeeding",{"count":540,"type":22},130,[66],"Postoperative complications occur in 5-15% of patients undergoing elective primary total hip arthroplasty (THA), including periprosthetic joint infection (PJI), thrombosis, wound healing disorders, and metabolic dysregulation. The gut microbiome and the systemic immune profile have both been implicated as modifiable contributors to perioperative complication risk. Preoperative therapeutic fasting has been shown to remodel the gut microbiome, lower proinflammatory cytokines, and improve metabolic parameters.\n\nThis single-center, prospective, randomized, two-arm controlled trial at Charité - Universitätsmedizin Berlin investigates whether a structured 20-day preoperative fasting intervention (alternating cycles of the Buchinger Fastenbox and intermittent fasting) modulates two co-primary endpoints - plasma IL-8 (a central proinflammatory marker) and gut microbial alpha-diversity (Shannon index) - compared with standard preoperative care. Secondary endpoints include further immune markers (TNFα, IL-10, T-\u002FB-\u002FNK-cell subsets, activation\u002Fexhaustion markers, monocyte HLA-DR), microbiome composition and function, continuous glucose-monitoring and daily metabolic measures, patient-reported outcomes (HOOS, PROMIS-33, infection self-report), and clinical outcomes (postoperative complications per EBJIS criteria, length of stay).\n\nAdults aged 18-75 undergoing elective primary THA are stratified by metabolic status (metabolically healthy vs. metabolically unhealthy according to harmonized metabolic-syndrome criteria) and randomized 1:1 to the fasting intervention versus standard care. Stool and whole-blood samples are collected at baseline (Day -21), and at Day +7 post-operatively for shotgun-metagenomic sequencing and multiparameter flow cytometry, with additional cytokine blood samples at Day -1 and 6 h \u002F 24 h \u002F 72 h post-operatively. Continuous glucose monitoring is performed in all participants from Day -21 until surgery. Planned enrollment is 130 participants.",[544,545,30,512,546],"Hip Osteoarthritis","Arthroplasty, Replacement, Hip","Gastrointestinal Microbiome",[548,549,550,551,552,553,554,555,556],"Therapeutic fasting","Buchinger fasting","Intermittent fasting","Gut microbiome","Immunophenotyping","Continuous glucose monitoring","Total hip arthroplasty","Metabolic syndrome","Preoperative optimization","2026-06-17",{"date":559,"type":45},"2026-06-22",{"date":561,"type":45},"2025-07-01",{"date":563,"type":22},"2026-12-31",{"name":565,"class":52},"Charite University, Berlin, Germany",{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":571,"acronym":572,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":574,"minAge":18,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":64,"phases":577,"briefSummary":578,"conditions":579,"keywords":584,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":596,"completionDateStruct":598,"leadSponsor":600,"locationsCount":149},"100644334","timing-of-recruitment-maneuver-in-robotic-prostate-surgery-100644334","NCT07662642","Timing of Recruitment Maneuver in Robotic Prostate Surgery","Comparison of the Effects of Recruitment Maneuver Timing on Postoperative Pulmonary Complications in Patients Undergoing Robotic Prostate Surgery","ROBPROREC1","Inclusion Criteria:\n\n* Patients scheduled for elective robotic prostate surgery\n* Age 18 years or older\n* Body mass index between 18 and 35 kg\u002Fm²\n* No cognitive impairment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Emergency surgery\n* Preoperative oxygen requirement\n* Cognitive impairment\n* Refusal to participate in the study","MALE",{"count":576,"type":22},86,[66],"Robotic prostate surgery is commonly performed under general anesthesia with carbon dioxide pneumoperitoneum and steep Trendelenburg positioning. These conditions may reduce lung volumes, impair respiratory mechanics, and increase the risk of atelectasis and postoperative pulmonary complications. Recruitment maneuvers combined with individualized positive end-expiratory pressure may improve intraoperative oxygenation and lung compliance; however, the optimal timing of recruitment maneuver application in robotic prostate surgery remains unclear.\n\nThis prospective randomized study aims to compare the effects of recruitment maneuver timing on postoperative pulmonary complications in adult patients undergoing elective robotic prostate surgery. Participants will be randomized into two groups. In the Supine Recruitment Group, the recruitment maneuver will be performed before carbon dioxide insufflation while the patient is in the supine position, followed by individualized PEEP determination. In the Trendelenburg Recruitment Group, the recruitment maneuver will be performed after pneumoperitoneum and Trendelenburg positioning, followed by individualized PEEP determination. Patients will be evaluated for postoperative pulmonary complications up to postoperative 72 hours or until discharge, whichever occurs first.",[580,581,582,583,30],"Robotic Surgery","Urologic Surgical Procedures","Postoperative Pulmonary Complications (PPCs)","Pulmonary Atelectasis",[585,586,587,588,589,590,591,592],"Robotic prostate surgery","Recruitment maneuver","Pneumoperitoneum","Trendelenburg position","Positive end-expiratory pressure","Atelectasis","Postoperative pulmonary complications","General anesthesia","2026-06-16",{"date":595,"type":45},"2026-06-23",{"date":597,"type":45},"2026-05-09",{"date":599,"type":22},"2026-07-20",{"name":601,"class":52},"Ankara University",{"id":603,"slug":604,"hasResults":12,"nctId":605,"briefTitle":606,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":609,"targetDuration":4,"studyType":64,"phases":611,"briefSummary":612,"conditions":613,"keywords":617,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":624,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":149},"100641148","non-thermal-plasma-to-reduce-recurrence-in-chronic-subdural-hematoma-100641148","NCT07656818","Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma","Application of Non-Thermal Plasma in the Surgical Bed of Chronic Subdural Hematoma to Reduce the Post-Drainage Recurrence Rate: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults ≥ 18 years of age\n* Diagnosis of symptomatic chronic subdural hematoma (cSDH) requiring surgical drainage (burr hole drainage or craniotomy)\n* Ability to provide written informed consent (or consent from legal representative if patient is incapacitated)\n\nExclusion Criteria:\n\n* Pure acute or subacute subdural hematoma\n* Uncontrolled coagulopathy or bleeding disorder\n* History of intracranial aneurysm or prior cerebrovascular event with residual deficit\n* Presence of active intracranial metallic implants or electronic devices (e.g., programmable shunt, cardiac pacemaker, deep brain stimulator) in the head region\n* Pregnancy or lactation\n* Participation in another interventional clinical trial within 30 days prior to screening",{"count":610,"type":22},40,[66],"The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6 months. The main questions it aims to answer are:\n\n* Does NTP application significantly lower the radiological and clinical recurrence rate of cSDH compared to surgery alone?\n* Is NTP safe when applied to the subdural space and surgical wound bed?\n* Does NTP improve functional outcomes and time to hematoma resolution?\n\nParticipants will be randomly assigned to one of two groups:\n\n* Experimental group (n = 20): Standard burr hole drainage or craniotomy plus intraoperative NTP application over the exposed dura mater, the residual membrane, soft tissue layers, and the skin incision.\n* Control group (n = 20): Standard surgical drainage alone (no NTP).\n\nFollow-up includes clinical assessments and computed tomography (CT) scans at 1 week, 3 months, and 6 months post-surgery. The primary outcome is recurrence (symptomatic reaccumulation requiring re-intervention or ≥50% volume increase on CT).",[614,615,616,30],"Chronic Subdural Hematoma","Subdural Hematoma","Recurrence",[618,619,620,621,622,623],"Non-thermal plasma","Cold plasma","Chronic subdural hematoma","Neurosurgery","Recurrence prevention","Wound healing",{"date":625,"type":45},"2026-06-18",{"date":627,"type":45},"2026-03-02",{"date":629,"type":22},"2027-04-30",{"name":631,"class":52},"Benjamín Gonzalo Rodríguez Méndez",{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":637,"acronym":638,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":64,"phases":641,"briefSummary":642,"conditions":643,"keywords":646,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":652,"startDateStruct":653,"completionDateStruct":655,"leadSponsor":657,"locationsCount":149},"100633236","the-application-of-infrared-thermography-in-the-prediction-of-skin-healing-in-surgery-100633236","NCT07524062","The Application of Infrared Thermography in the Prediction of Skin Healing in Surgery","The Application of Infrared Thermography in the Prediction of Skin Healing in Surgery THERMS: THermography for Evaluation of Recovery and Monitoring of Surgical Wounds","THERMS","Inclusion Criteria:\n\n1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures\n2. Adult subjects (\\>18 years of age) at time of enrolment\n3. Patients undergoing a surgical excision under local anesthesia\n4. Indications of the excisions were skin lesions suspected to be malignant, skin lesions confirmed to be malignant via prior biopsy\n\nExclusion Criteria:\n\n1. Patient has history of pre-existing diabetes type I and II\n2. Patients with pre-existing chronic wound problems\n3. Patients with renal dysfunction,\n4. Patients with venous insufficiency confirmed via radiographic imaging\n5. Patients who received radiotherapy in the affected area in the past\n6. Patients with chronic steroid use in the past (\\> 3 months) or a immunosuppressant medication history\n7. Female who is pregnant",{"count":322,"type":22},[66],"This study investigates whether infrared thermography, a harmless and non-invasive thermal camera technique, can help monitor how surgical wounds heal after skin surgery. The goal is to detect wound problems earlier, such as infection or delayed healing, and to support doctors in making timely clinical decisions.",[513,512,30,644,645],"Skin Neoplasms","Skin Transplantation",[647,648,649,650,651],"Infrared thermography","Surgical wound healing","Dermatosurgery","Thermal imaging","Wound complications",{"date":625,"type":45},{"date":654,"type":45},"2026-06-15",{"date":656,"type":22},"2028-10",{"name":658,"class":52},"Universitaire Ziekenhuizen KU Leuven",{"id":660,"slug":661,"hasResults":12,"nctId":662,"briefTitle":663,"officialTitle":664,"acronym":665,"eligibilityCriteria":666,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":667,"targetDuration":4,"studyType":64,"phases":669,"briefSummary":670,"conditions":671,"keywords":674,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":682,"startDateStruct":683,"completionDateStruct":685,"leadSponsor":687,"locationsCount":689},"100617070","comparison-of-self-locking-versus-traditional-sutures-in-double-layer-laparoscopic-vaginal-vault-closure-after-hysterectomy-bi-sure-trial-100617070","NCT07313839","Comparison of Self-Locking Versus Traditional Sutures in Double-Layer Laparoscopic Vaginal Vault Closure After Hysterectomy (BI-SURE Trial)","Comparison Between Double-Layer Self-Locking and Traditional Sutures in Post-Hysterectomy Laparoscopic Colporrhaphy: A Multicenter Pragmatic Randomized Controlled Trial","BI-SURE","Inclusion Criteria:\n\n* Patients undergoing laparoscopic or robotically assisted hysterectomy for gynecologic malignant disease\n* Age ≥ 18 years\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Laparotomic or vaginal hysterectomy\n* Contraindication to laparoscopic vaginal vault closure",{"count":668,"type":22},310,[66],"Vaginal vault closure after laparoscopic or robotic hysterectomy may be associated with postoperative complications such as vaginal cuff dehiscence, infection, and bleeding. The optimal suture material and technique for laparoscopic colporrhaphy, particularly in patients undergoing surgery for gynecologic malignancies, remain controversial.\n\nThe BI-SURE trial is a multicenter, randomized controlled study designed to compare double-layer self-locking sutures versus double-layer traditional Polyglactin 910 sutures for laparoscopic vaginal vault closure after hysterectomy. The study aims to evaluate postoperative effectiveness and safety within three months after surgery.",[672,673,30],"Gynecologic Cancers","Vaginal Cuff Dehiscence",[675,676,677,678,679,680,681,447,522],"Laparoscopic hysterectomy","Vaginal vault closure","Colporrhaphy","Self-locking suture","Barbed suture","Polyglactin 910","Gynecologic oncology",{"date":557,"type":45},{"date":684,"type":45},"2025-10-07",{"date":686,"type":22},"2027-01",{"name":688,"class":52},"Azienda Ospedaliero-Universitaria di Parma",5,{"id":691,"slug":692,"hasResults":12,"nctId":693,"briefTitle":694,"officialTitle":695,"acronym":4,"eligibilityCriteria":696,"healthyVolunteers":12,"sex":61,"minAge":697,"maxAge":698,"enrollmentInfo":699,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":701,"conditions":702,"keywords":709,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":717,"lastUpdatePostDateStruct":718,"startDateStruct":719,"completionDateStruct":721,"leadSponsor":722,"locationsCount":4},"100642485","perioperative-respiratory-adverse-events-in-cleft-lip-and-palate-surgery-incidence-risk-factors-and-clinical-scoring-100642485","NCT07651904","Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring","Prospective Assessment of Perioperative Respiratory Adverse Events in Pediatric Patients Undergoing Cleft Lip and Palate Surgery: Predictive Risk Factors and the Role of Clinical Airway Scores","Inclusion Criteria:\n\n* Age 0-3 years (infants and toddlers)\n* Scheduled for elective cleft lip and\u002For palate repair surgery\n* General anesthesia planned\n* Written parental\u002Fguardian informed consent obtained\n\nExclusion Criteria:\n\n* Pre-existing respiratory failure or active tracheostomy\n* Emergency surgical procedures\n* Inability to obtain parental\u002Fguardian consent","0 Years","3 Years",{"count":700,"type":22},150,"Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population. These factors substantially increase the risk of perioperative respiratory adverse events (PRAEs), including laryngospasm, bronchospasm, desaturation, post-extubation stridor, and unanticipated re-intubation.\n\nThis prospective single-center observational cohort study aims to determine the true incidence of PRAEs in pediatric patients undergoing elective cleft lip and\u002For palate repair under general anesthesia, and to identify independent predictive risk factors using standardized airway assessment tools including the Han Mask Ventilation Score and the Intubation Difficulty Score (IDS). No interventions beyond routine clinical practice will be applied. All airway management decisions will remain at the discretion of the attending anesthesiologist.",[703,704,705,706,707,30,708],"Cleft Palate","Cleft Lip","Laryngospasm","Bronchospasm","Airway Obstruction","Difficult Intubation",[710,711,712,713,714,715,716],"cleft lip","cleft palate","pediatric anesthesia","perioperative respiratory adverse events","Han mask ventilation score","micrognathia","intubation difficulty score","2026-06-13",{"date":593,"type":45},{"date":720,"type":22},"2026-06-27",{"date":84,"type":22},{"name":723,"class":52},"Marmara University Pendik Training and Research Hospital",{"id":725,"slug":726,"hasResults":12,"nctId":727,"briefTitle":728,"officialTitle":729,"acronym":730,"eligibilityCriteria":731,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":732,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":734,"conditions":735,"keywords":737,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":740,"lastUpdatePostDateStruct":741,"startDateStruct":742,"completionDateStruct":744,"leadSponsor":746,"locationsCount":149},"100642751","wearable-device-based-early-warning-of-postoperative-complications-in-thoracic-surgery-100642751","NCT07646730","Wearable Device-Based Early Warning of Postoperative Complications in Thoracic Surgery","Development and Validation of a Wearable Device-Based Early Warning Model for Postoperative Complications in Thoracic Surgery: A Retrospective and Prospective Cohort Study","wearable","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Hospitalized in the Department of Thoracic Surgery of Tongji Hospital and scheduled to undergo thoracic surgery.\n3. Able to wear the study-designated wearable device after hospital admission and expected to continue wearing the device and\u002For uploading data within 30 days after discharge.\n\nExclusion Criteria:\n\n1. Patients or family members are unwilling to wear the wearable device or unable to meet the required wearing time.\n2. Severe or unstable psychiatric disease, such as severe depression or schizophrenia.\n3. Pregnancy or lactation.\n4. Allergy to the watch strap material or local skin conditions that prevent wearing the device.\n5. Unable to complete follow-up within 30 days after discharge.",{"count":733,"type":22},650,"After thoracic surgery, some patients may develop complications such as lung infection, abnormal heart rhythm, fluid around the lung, prolonged air leak, wound infection, emergency department visits, or hospital readmission. These problems may not be found early if monitoring is only done during routine vital sign checks or follow-up visits.\n\nThis study will evaluate whether data collected by a wearable device can help identify early warning signs of postoperative complications in patients undergoing thoracic surgery. The wearable device will collect information such as heart rate, oxygen level, skin temperature, physical activity, sleep, and wearing status.\n\nThe study includes two parts. First, the researchers will review previously collected wearable device and medical record data to develop an early warning model. Second, new patients undergoing thoracic surgery will wear the device from hospital admission until about 30 days after discharge. The model will then be tested to see how well it predicts complications that require medical intervention within 30 days after surgery.\n\nThe main goal is to evaluate how accurately the wearable device-based model can identify patients who develop postoperative complications and how early the model can provide a warning before the complication is clinically confirmed.",[30,448,736],"Perioperative Monitoring",[738,739,30,448],"Wearable Device","Early Warning Model","2026-06-12",{"date":654,"type":45},{"date":743,"type":45},"2025-12-16",{"date":745,"type":22},"2026-12-15",{"name":747,"class":52},"Tongji Hospital",{"id":749,"slug":750,"hasResults":12,"nctId":751,"briefTitle":752,"officialTitle":753,"acronym":4,"eligibilityCriteria":754,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":755,"enrollmentInfo":756,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":758,"conditions":759,"keywords":763,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":740,"lastUpdatePostDateStruct":771,"startDateStruct":772,"completionDateStruct":774,"leadSponsor":776,"locationsCount":778},"100618701","prediction-model-for-mins-after-major-hepatobiliary-surgery-100618701","NCT07335042","Prediction Model for MINS After Major Hepatobiliary Surgery","Development of an Interpretable Prediction Model for Myocardial Injury After Noncardiac Surgery in Patients Undergoing Major Hepatobiliary Surgery","Inclusion Criteria:\n\nAdults (18-85 yr, ASA physical status II-III) undergoing major hepatobiliary surgery were enrolled. Major surgery was defined as duration ≥ 3 h involving hepatectomy (≥ 3 segments) or biliary reconstruction necessitating ICU admission. Eligibility required paired perioperative high-sensitivity cardiac troponin T (hs-cTnT) data and comprehensive documentation of surgical covariates, including surgical approach (laparoscopic vs. open), resection nature (anatomic vs. non-anatomic), number of resected segments, tumor characteristics (size and location), and presence of cirrhosis.\n\nExclusion Criteria:\n\n(1) preoperative acute myocardial infarction, unstable angina, heart failure, or chronic kidney disease (estimated glomerular filtration rate \\\u003C 60 ml\u002F (min · 1.73 m2); (2) undocumented inflow occlusion strategy; or (3) non-imputable missing covariates.","85 Years",{"count":757,"type":22},1800,"This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.",[760,30,761,762],"Myocardial Injury After Noncardiac Surgery (MINS)","Liver Neoplasm","Hepatobiliary Diseases",[764,765,766,767,768,769,770],"MINS","Major Hepatobiliary Surgery","Hepatectomy","Hepatic Inflow Occlusion","Pringle Maneuver","Prediction Model","High-sensitivity Cardiac Troponin",{"date":654,"type":45},{"date":773,"type":45},"2026-01-14",{"date":775,"type":22},"2027-06-30",{"name":777,"class":52},"Beijing Tsinghua Chang Gung Hospital",6,{"id":780,"slug":781,"hasResults":12,"nctId":782,"briefTitle":783,"officialTitle":784,"acronym":785,"eligibilityCriteria":786,"healthyVolunteers":12,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":787,"targetDuration":4,"studyType":64,"phases":789,"briefSummary":790,"conditions":791,"keywords":802,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":807,"lastUpdatePostDateStruct":808,"startDateStruct":809,"completionDateStruct":811,"leadSponsor":813,"locationsCount":816},"100619934","post-market-study-of-the-signia-circular-stapler-with-tri-staple-technology-in-left-sided-colon-sigmoid-and-rectal-resections-100619934","NCT07351071","Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections","A Prospective, Multicenter, Single-arm, Post Market Study to Evaluate the Safety and Performance of the Signia™ Circular Stapler With Tri-Staple™ Technology in Elective Open or Minimally Invasive Left-sided Colon, Sigmoid, and Rectal Resections (SECURE)","SECURE","Preoperative Inclusion Criteria:\n\n1. Subject is competent and willing to provide documented informed consent to participate in this clinical study\n2. Subject is intended to undergo an elective left sided colon\u002Fcolorectal procedure where a creation of an anastomosis will be completed with the Signia™ circular stapler\n3. Subject is ≥ 18 years of age at time of consent\n\nPreoperative Exclusion Criteria:\n\n1. Subject is unable or unwilling to comply with the study requirements or follow-up schedule\n2. Subject with ASA classification ≥ IV\n3. Subject is pregnant (as determined by standard site practices)\n4. The procedure is an emergency procedure\n5. The procedure is a revision\u002Freoperation for the same indication\n6. The subject has a documented confounding medical condition which in the opinion of the investigator, will not be appropriate for the study, or the subject has an estimated life expectancy of less than 6 months\n7. Subject has participated or plans to participate in an investigational drug or device research study that would interfere with the results of this study\n8. Subject will undergo multiple synchronous colon resections\n9. Subject with a bleeding disorder or is undergoing anticoagulant treatment that has not been reversed (anticoagulant prophylaxis prescribed as part of the surgical protocol is allowed)\n10. Subject has undergone chemotherapy or received biologics within 6 weeks prior to the day of the procedure\n11. Subject has history of chronic corticosteroid use (used greater than 3 months within a year prior to the index procedure)\n12. Subject has chronic immunosuppression therapy (used greater than 3 months within a year prior to the index procedure)\n13. Any subject undergoing an ileal-anal pouch anastomosis surgery\n\nIntraoperative Exclusion Criteria\n\n1. Anastomosis not attempted with the Signia™ circular stapler\n2. Any subject for which the device is intended to be used outside the instructions for use (IFU)",{"count":788,"type":22},137,[66],"The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in patients undergoing left sided colon, sigmoid, or rectal resections in a post market setting.",[792,793,794,795,796,797,798,799,800,30,801],"Colorectal Anastomosis","Left-sided Colon Resection","Anastomotic Leak","Anastomotic Complication","Digestive System Diseases","Gastrointestinal Diseases","Colonic Diseases","Intestinal Diseases","Rectal Diseases","Anastomotic Leaks",[792,793,803,794,804,805,806],"Circular stapler","Rectal cancer","Low anterior resection","Powered stapler","2026-06-11",{"date":740,"type":45},{"date":810,"type":45},"2025-12-30",{"date":812,"type":22},"2027-02-28",{"name":814,"class":815},"Medtronic - MITG","INDUSTRY",9]