[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-nausea-and-vomiting-ponv\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-nausea-and-vomiting-ponv":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,54,84,119,154,181,217,239,271,298],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100652542","phase-4-sleep-quality---comparing-the-effect-of-ondansetron-or-dexamethasone-given-as-routine-prophylaxis-intraoperatively-to-prevent-post-operative-nausea-and-vomiting-scorpion-100652542",false,"NCT07777276","Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)","Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting","SCORPION","Inclusion Criteria:\n\n* Children aged 2 - 15 years,\n* Undergoing general anaesthesia for minor ambulatory surgery or procedures with a maximum of 1 overnight stay postoperatively\n* ASA I or III\n\nExclusion Criteria:\n\n* Currently taking regular dexamethasone or ondansetron\n* Currently taking regular steroids, including inhaled corticosteroids\n* Anaesthetic plan to give dual PONV prophylaxis\n* Known hypersensitivity to the active substance or to any of the excipients listed\n* Language barriers impeding data collection\n* Department for Child Protection and Family Support is involved in their care\n* Planned admissions to the Paediatric Intensive Care Unit (PICU)\n* Oncology patients\n* Severe developmental delay\n* ASA III or above\n* Significant cardiorespiratory conditions","ALL","2 Years","15 Years",{"count":21,"type":22},500,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Nausea and vomiting are common complications after anaesthesia, and anaesthetists routinely give medications to prevent them. Dexamethasone and ondansetron are the two most commonly used agents and have a long safety record. However, their effects on sleep, behaviour, and overall recovery are not well studied. Understanding these will guide future care. The aim of this study is to determine if dexamethasone or ondansetron given during an anaesthetic affect post-operative sleep, behaviour and recovery in children.\n\nPatients enrolled in the study will be randomised to receive either dexamethasone or ondansetron during their procedure. This randomisation will be blinded to patients, their families and their treating anaesthetist. Information about the patient's pain, recovery and sleep will be collected over 7 days post-operatively using online surveys.\n\nA subset of patients will also be asked to complete additional pre-operative non-invasive monitoring using an oximeter and an actigraph to measure their sleep quality before and after surgery. In addition to the postoperative surveys, these patients will be asked to wear the oximeter and actigraph for 3 nights before and immediatey after surgery. Patients who are admitted overnight postoperatively will also have additional transcutaneous carbon dioxide monitoring on the night of their surgery.",[28,29,30,31,32,33],"Postoperative Sleep Quality","Postoperative Behaviour","Postoperative Recovery in Children","Postoperative Nausea and Vomiting (PONV)","Paediatric Surgery","Anaesthesia",[35,36,37,38,39,40],"paediatric","surgery","postoperative nausea and vomiting","paediatric anaesthesia","sleep quality","postoperative recovery","NOT_YET_RECRUITING","2026-08-18",{"date":44,"type":45},"2026-08-20","ACTUAL",{"date":47,"type":22},"2026-08-17",{"date":49,"type":22},"2029-08-17",{"name":51,"class":52},"Telethon Kids Institute","OTHER",3,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":65,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100646524","efficacy-and-safety-between-tegileridine-and-sufentanil-in-laparoscopic-surgery-patients-at-high-risk-of-postoperative-nausea-and-vomiting-100646524","NCT07691086","Efficacy and Safety Between Tegileridine and Sufentanil in Laparoscopic Surgery Patients at High Risk of Postoperative Nausea and Vomiting","Efficacy and Safety Between Tegileridine and Sufentanil in Laparoscopic Surgery Patients at High Risk of Postoperative Nausea and Vomiting: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age: 18-75 years old ASA classification: I-III grade Received elective laparoscopic surgery (such as gynecological and general surgical laparoscopic surgeries) Apfel score ≥ 3 points Preoperative NRS pain score ≤ 3 points Did not use postoperative analgesic pump (PCA)\n\nExclusion Criteria:\n\n* BMI ≥ 30 kg\u002Fm² Allergic to opioids or study drugs History of chronic pain or long-term use of opioids Severe liver or kidney dysfunction Requires transfer to ICU after surgery Severe respiratory disease or SpO₂ \\\u003C 90% Pregnant or lactating women","18 Years","75 Years",{"count":64,"type":22},800,"2 Days","OBSERVATIONAL","Postoperative nausea and vomiting (PONV) is one of the most common and distressing perioperative adverse events in patients undergoing laparoscopic surgery.1 Although laparoscopic procedures are minimally invasive, PONV can still occur in 30%-60% of cases due to factors such as insufflation-induced stimulation, vagal nerve activation, and the use of perioperative opioids, with rates exceeding 70% in high-risk populations.2,3 PONV not only significantly reduces patient comfort and satisfaction but may also lead to wound dehiscence, electrolyte imbalances, aspiration, delayed oral intake, and reduced mobilization-thereby contradicting the principles of enhanced recovery after surgery (ERAS).3\n\nThe Apfel score is currently the most widely used and practical clinical tool for assessing PONV risk.4 Patients scoring ≥3 on the Apfel scale are considered at high risk for PONV, and guidelines recommend multimodal analgesia and multi-route preventive strategies to minimize opioid-related adverse effects.4\n\nTegileridine fumarate injection (Tegileridine, trade name: Aisute) is a novel μ-opioid receptor-biased agonist.5 Unlike traditional opioids, tegileridine primarily activates G protein-coupled signaling pathways to exert analgesic effects while minimizing activation of the β-arrestin-2 pathway, which is closely associated with adverse reactions such as respiratory depression and nausea\u002Fvomiting.5,6 Previous clinical studies have shown that tegileridine provides effective pain relief for moderate to severe postoperative pain, with a potentially lower incidence of PONV compared to conventional opioids.\n\nHowever, clinical evidence regarding the effectiveness and safety of a single intravenous dose of tegileridine administered at the end of surgery for pain transition in Apfel high-risk patients undergoing laparoscopic surgery remains limited. Therefore, it is necessary to systematically evaluate this analgesic strategy in real-world clinical settings to provide robust evidence-based support for clinical practice.8\n\nThis study aims to assess, in patients undergoing laparoscopic surgery with an Apfel score ≥3, the following outcomes of a single intravenous administration of tegileridine fumarate at the end of surgery: 1) analgesic efficacy; 2) incidence and severity of PONV within 24 hours postoperatively; and 3) occurrence of other perioperative adverse events, including pruritus, respiratory depression, and dizziness. The findings will provide clinical guidance for postoperative pain management and prevention of adverse events in high-risk PONV patients undergoing laparoscopic surgery.",[31,69,70],"Enhanced Recovery After Surgery","Laparoscopic Surgery",[72,73,74],"enhanced recovery after surgery","Postoperative nausea and vomiting (PONV)","laparoscopic surgery","2026-07-06",{"date":77,"type":45},"2026-07-08",{"date":79,"type":22},"2026-06-15",{"date":81,"type":22},"2027-06-30",{"name":83,"class":52},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100643344","transauricular-vagus-nerve-stimulation-frequencies-for-postoperative-pain-100643344","NCT07633444","Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain","Effects of Different Frequencies of Transauricular Vagus Nerve Stimulation on Postoperative Pain: A Randomized, Double-Blind, Sham-Controlled Trial With Preoperative and Postoperative Sessions","TVNS-PAIN","Inclusion Criteria:\n\n* Adults aged 18 to 59 years.\n* Undergoing elective abdominal or urologic surgery.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* History of neurological disorders.\n* History of psychiatric disorders.\n* Inability to understand study procedures.\n* Pregnancy.\n* Cognitive impairment.\n* Communication difficulties that interfere with study assessments.\n* Auricular dermatitis or skin lesions at the stimulation site.\n* Pre-existing cardiac arrhythmia.\n* Chronic opioid use.\n* Implanted electronic medical devices, including pacemakers.","59 Years",{"count":94,"type":22},174,[96],"NA","The goal of this clinical trial is to learn whether different frequencies of transauricular vagus nerve stimulation (tVNS) can reduce postoperative pain and opioid consumption in adults undergoing abdominal or urologic surgery. It will also evaluate the effects of tVNS on recovery quality, autonomic function, and treatment safety. The main questions it aims to answer are:\n\nDoes transauricular vagus nerve stimulation reduce postoperative opioid consumption during the first 24 hours after surgery? Do different stimulation frequencies (high-frequency and low-frequency tVNS) produce different effects on postoperative pain and autonomic responses? Is transauricular vagus nerve stimulation safe and well tolerated in surgical patients?\n\nResearchers will compare high-frequency tVNS, low-frequency tVNS, and sham stimulation (inactive stimulation) to determine their effects on postoperative pain and opioid requirements.\n\nParticipants will:\n\nBe randomly assigned to receive high-frequency tVNS, low-frequency tVNS, or sham stimulation.\n\nReceive two 30-minute stimulation sessions, one before anesthesia and one after surgery in the post-anesthesia care unit.\n\nUndergo assessments of postoperative pain, opioid consumption, need for rescue analgesics, postoperative nausea and vomiting, heart rate changes, and quality of recovery.\n\nBe monitored for adverse events related to the intervention during the study period.\n\nA total of 174 participants will be enrolled in this single-center, randomized, double-blind, sham-controlled clinical trial.",[99,31,100],"Postoperative Pain","Opioid Consumption, Postoperative",[99,102,103,104,105,106,107],"Transauricular Vagus Nerve Stimulation","tVNS","Neuromodulation","Opioid Consumption","Pain Management","Randomized Controlled Trial","RECRUITING","2026-06-07",{"date":111,"type":45},"2026-06-10",{"date":113,"type":22},"2026-06-01",{"date":115,"type":22},"2026-12-04",{"name":117,"class":52},"Federal University of Bahia",1,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":126,"sex":17,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":131,"briefSummary":132,"conditions":133,"keywords":137,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":153},"100634074","the-effect-of-paedfusor-tci-eleveld-tci-and-sevoflurane-anesthesia-on-postoperative-awakening-agitation-in-pediatric-patients-100634074","NCT07534956","The Effect of Paedfusor TCI, Eleveld TCI, and Sevoflurane Anesthesia on Postoperative Awakening Agitation in Pediatric Patients","Investigation of the Effects of Two Different TCI (Target Controlled Infusion) Models (Paedfusor and Eleveld) and Inhalation Anesthesia on Postoperative Awakening Agitation\u002FDelirium in Pediatric Patients","Inclusion Criteria:\n\n* Children aged 3-10 years\n* Children weighing over 10 kg\n* American Society of Anesthesiologists (ASA) physical condition classification I-II\n* Those who will undergo planned urogenital surgery under general anesthesia\n* Those who have obtained written informed consent from their parents or legal guardians\n\nExclusion Criteria:\n\n* Patients assessed as ASA III or higher\n* Known neurological or psychiatric disorders\n* Developmental delay or cognitive impairment\n* Use of sedatives or psychoactive drugs\n* Allergy or contraindication to the study drugs (propofol or sevoflurane)\n* History of previous adverse reactions to anesthesia\n* Patients requiring emergency surgery\n* Significant liver, kidney, or cardiovascular disease\n* Patients whose parents or legal guardians have not given consent",true,"3 Years","10 Years",{"count":130,"type":22},150,[96],"Emergence delirium is a common complication in pediatric patients undergoing general anesthesia. The aim of this study is to investigate the incidence of postoperative awakening delirium and agitation in pediatric patients aged 3-10 years (ASA I-II) using two different target-controlled infusion (TCI) methods (Paedfusor and Eleveld) for TIVA, compared to inhalation anesthesia. This study will examine the effect of two different TCI models on postoperative awakening agitation\u002Fdelirium by comparing them with each other and with inhalation anesthesia.",[134,135,136,31],"Emergence Delirium in Pediatric Anesthesia","Pediatric Anesthesia","Postoperative Agitations in Pediatric Patients",[138,139,140,141,142,143],"pediatric anesthesia","paedfusor","eleveld","target controlled infusion","sevoflurane","postoperative agitation","2026-04-11",{"date":146,"type":45},"2026-04-16",{"date":148,"type":45},"2026-01-13",{"date":150,"type":22},"2027-11-30",{"name":152,"class":52},"Marmara University Pendik Training and Research Hospital",2,{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":162,"conditions":163,"keywords":168,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":118},"100630499","quality-improvement-project-to-reduce-preoperative-fasting-times-before-elective-procedures-100630499","NCT07488468","Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures","Inclusion Criteria:\n\n* All patients elective surgery or intervention requiring with anesthesiology care general anesthesia, regional anesthesia, sedation, or anesthesiology stand-by\n\nExclusion Criteria:\n\n* Already sedated, intubated, and mechanically ventilated patients",{"count":161,"type":22},1000,"This single-center quality improvement project evaluates preoperative fasting times before elective procedures requiring anesthesiology care. The project aims to reduce prolonged fasting for clear fluids by implementing a local standard operating procedure (SOP) allowing patients to drink clear liquids until being called to the operating room (\"drink until called\"), supported by staff education and fasting instruction cards. Fasting times and selected perioperative outcomes will be assessed before and after implementation.",[164,165,31,166,167],"Preoperative Fasting","Perioperative Patient Comfort \u002F Quality of Care","Postoperative Pulmonary Complications","Delirium",[169,170,171],"Preoperative fasting","clear liquids","quality improvement","2026-03-17",{"date":174,"type":45},"2026-03-23",{"date":176,"type":45},"2026-01-30",{"date":178,"type":22},"2026-07-30",{"name":180,"class":52},"University of Giessen",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":188,"minAge":61,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":23,"phases":192,"briefSummary":193,"conditions":194,"keywords":199,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":118},"100626825","restrictive-vs-liberal-intraoperative-fluid-strategy-and-postoperative-outcomes-after-elective-cesarean-section-100626825","NCT07440667","Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section","A Prospective Randomized Controlled Trial Comparing Restrictive and Liberal Intraoperative Fluid Strategies on Postoperative Nausea and Vomiting and Gastrointestinal Recovery After Elective Cesarean Section Under Spinal Anesthesia","Inclusion Criteria:\n\n* Female patients aged 18-45 years\n* ASA physical status II\n* Scheduled for elective cesarean section under spinal anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean section\n* Preeclampsia or eclampsia\n* Known cardiac failure\n* Known renal failure\n* Known hepatic failure\n* Coagulopathy\n* Contraindication to spinal anesthesia\n* Conversion to general anesthesia\n* Major technical complications during spinal anesthesia\n* Refusal to participate","FEMALE","45 Years",{"count":191,"type":22},160,[96],"Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery. Although intraoperative fluid administration is routinely used to prevent spinal-induced hypotension, the optimal fluid strategy remains unclear. Both restrictive and liberal fluid approaches may influence maternal hemodynamics and postoperative outcomes through different physiological mechanisms.\n\nThis prospective, single-center, randomized controlled trial aims to compare restrictive (≤3 mL\u002Fkg\u002Fh) and liberal (\\>3 mL\u002Fkg\u002Fh) intraoperative crystalloid fluid strategies in patients undergoing elective cesarean section under spinal anesthesia. The primary outcome is the incidence of PONV within the first 24 hours postoperatively. Secondary outcomes include postdural puncture headache (PDPH), time to first flatus, hypotension frequency, and vasopressor requirements.",[195,31,196,197,198],"Cesarean Section","Postdural Puncture Headache (PDPH)","Postoperative Ileus","Gastrointestinal Recovery",[195,200,201,202,203,204,205,198,206,207],"Spinal Anesthesia","Intraoperative Fluid Therapy","Restrictive Fluid Strategy","Liberal Fluid Strategy","Postoperative Nausea and Vomiting","Postdural Puncture Headache","Hypotension","Vasopressor Use","2026-03-07",{"date":210,"type":45},"2026-03-10",{"date":212,"type":45},"2026-03-04",{"date":214,"type":22},"2027-01-30",{"name":216,"class":52},"Nigde Omer Halisdemir University",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":188,"minAge":61,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":4},"100620654","phase-4-granisetron-combined-with-dexamethasone-or-metoclopramide-for-ponv-prevention-after-laparoscopic-cholecystectomy-100620654","NCT07360431","Granisetron Combined With Dexamethasone or Metoclopramide for PONV Prevention After Laparoscopic Cholecystectomy","Preoperative Granisetron in Combination With Dexamethasone or Metoclopramide for Prevention of Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n\\- 1- Adult female. 2- (ASA I-II), aged 18-60 years. 3- Non smoker. 4- Scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n\n5- Use of intraoperative opioid analgesics.\n\nExclusion Criteria:\n\n* 1- History of hypersensitivity to study drugs. 2- Chronic antiemetic. 3- Antidepressant use. 4- Gastrointestinal disease. 5- Pregnancy\u002Flactation. 6- Severe hepatic\u002Frenal dysfunction","60 Years",{"count":226,"type":22},102,[25],"Postoperative nausea and vomiting (PONV) remain common and distressing complications following laparoscopic cholecystectomy, particularly in female patients. This randomized interventional study aims to evaluate the effectiveness of preoperative granisetron when combined with either dexamethasone or metoclopramide in preventing PONV. The study compares the incidence and severity of nausea and vomiting, as well as the need for rescue antiemetic therapy, among female patients undergoing laparoscopic cholecystectomy under general anesthesia.",[31],"2026-01-16",{"date":232,"type":45},"2026-01-22",{"date":234,"type":22},"2026-03",{"date":236,"type":22},"2027-10",{"name":238,"class":52},"Assiut University",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":246,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":254,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":118},"100617191","chewing-gum-flavors-to-reduce-postoperative-nausea-and-vomiting-after-pipac-100617191","NCT07315412","Chewing Gum Flavors to Reduce Postoperative Nausea and Vomiting After PIPAC","Comparative Effectiveness of Ginger-Mint and Cinnamon-Flavored Gum in Preventing Nausea and Vomiting Following Pressurized Intraperitoneal Aerosol Chemotherapy","Inclusion Criteria:\n\n* Adults aged 18 years or older undergoing Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).\n* Able to communicate, understand study instructions, and provide written informed consent.\n* No known allergy or intolerance to ginger, mint, or cinnamon.\n* Able and willing to chew gum for 15 minutes.\n* Apfel risk score ≥3 for postoperative nausea and vomiting.\n\nExclusion Criteria:\n\n* Postoperative complications requiring intensive care or reoperation.\n* Need for rescue antiemetic medication within the first 2 postoperative hours.\n* History of psychiatric disorder, neurological disease, or cognitive impairment affecting participation.\n* Anatomical or functional limitation preventing chewing (e.g., full dentures, jaw restriction, oral surgery).\n* Known phenylketonuria or metabolic intolerance to chewing gum ingredients.\n* Active chemotherapy, radiotherapy, or immunosuppressive therapy affecting gastrointestinal function.","80 Years",{"count":248,"type":22},75,[96],"This randomized controlled clinical trial aims to evaluate the effectiveness of chewing gum with different natural flavors in reducing postoperative nausea and vomiting (PONV) following Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Adult patients undergoing PIPAC will be randomly assigned to one of three groups: (1) ginger-mint flavored gum, (2) cinnamon flavored gum, or (3) control group with standard postoperative care only. Participants in the intervention arms will chew one piece of gum for 15 minutes in the post-anesthesia care unit (PACU). Nausea intensity (Numeric Rating Scale, 0-10) and the presence of vomiting or retching will be assessed at baseline and every 15 minutes for 2 hours.\n\nThe study hypothesizes that ginger-mint and cinnamon flavored chewing gums, both plant-based and certified vegan, will be effective, non-pharmacological, and safe methods to reduce nausea and vomiting after PIPAC. This research may contribute to enhanced postoperative comfort and faster recovery by supporting the principles of Enhanced Recovery After Surgery (ERAS).",[31,252,253],"Peritoneal Metastases From Colorectal Cancer","Intraperitoneal Chemotherapy",[255,256,257,258,259,260,261],"Chewing gum","ginger","cinnamon","postoperative neusea","vomiting","eras","supportive care","2025-12-23",{"date":264,"type":45},"2026-01-02",{"date":266,"type":22},"2025-12-10",{"date":268,"type":22},"2027-05-30",{"name":270,"class":52},"Fenerbahce University",{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":17,"minAge":278,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":282,"conditions":283,"keywords":285,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":293,"leadSponsor":295,"locationsCount":118},"100604326","inflammatory-biomarkers-as-predictors-of-ponv-following-pediatric-orchiopexy-100604326","NCT07148063","Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy","Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy","Inclusion Criteria:\n\n* Patients aged between 1 and 8 years\n* Patients with ASA physical status I-II\n* Patients scheduled for elective orchiopexy\n* Obtained written informed consent from parents\u002Fguardians\n\nExclusion Criteria:\n\n* Patients younger than 1 year or older than 8 years\n* Patients with ASA physical status III or higher\n* Presence of acute infection signs\n* History of previous nausea or vomiting","1 Year","8 Years",{"count":281,"type":22},170,"Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).\n\nRecent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators.\n\nThis prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.",[135,31,284],"Inflammatory Biomarkers",[286,287,31,288],"Pediatric anesthesia","Orchiopexy","Inflammatory biomarkers","2025-09-08",{"date":291,"type":45},"2025-09-09",{"date":289,"type":45},{"date":294,"type":22},"2026-03-27",{"name":296,"class":297},"Diskapi Yildirim Beyazit Education and Research Hospital","OTHER_GOV",{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":310,"conditions":311,"keywords":316,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":4},"100568804","phase-4-effect-of-timing-of-dexamethasone-during-induction-on-postoperative-outcomes-100568804","NCT06685991","Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes","Effect of Timing of Dexamethasone Administration During Induction on Postoperative Outcomes: A Triple-Blinded Randomized Controlled Trial","TIDE","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective non cardiac surgery requiring general anesthesia\n* surgery last at least 90 minutes\n* scare of more than 5 cm Able to provide informed consent Eligible for dexamethasone administration as part of routine perioperative care\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to dexamethasone or related corticosteroids\n* History of uncontrolled diabetes mellitus or significant blood glucose management issues, as dexamethasone may affect glucose levels\n* Severe cardiovascular instability or hemodynamic issues contraindicating study participation\n* Patients receiving immunosuppressive therapy or with conditions affecting the immune system, as corticosteroids may alter immune responses\n* Pregnancy or breastfeeding, due to potential risks to the fetus or infant\n* Current or recent (within 30 days) use of other glucocorticoids, which may interfere with study outcomes\n* Patients with psychiatric or cognitive conditions that impair their ability to consent or adhere to study protocols\n* Lack of informed consent","70 Years",{"count":308,"type":22},300,[25],"This study aims to investigate how the timing of dexamethasone administration during anesthesia induction affects patient outcomes after surgery. Dexamethasone is commonly used to reduce nausea and inflammation during and after surgery. However, it is not yet known if administering dexamethasone at different times during induction (before, during, or after specific anesthetic drugs) leads to better recovery and fewer postoperative complications.\n\nParticipants will be randomly assigned to one of three groups: one group will receive dexamethasone before fentanyl, another after the muscle relaxant, and a third group will not receive dexamethasone. This approach will help us understand if the timing of dexamethasone affects patient outcomes such as nausea, pain, and recovery quality. The study is triple-blinded, meaning that the participants, care providers, and investigators will not know which group the participants are in, to ensure unbiased results.",[31,99,312,313,314,315],"Inflammatory Response to Wounding","Hyperglycemia Drug Induced","Hypotension on Induction","Timing of Dexamethasone Administration",[317,318,319,320,321,322,323],"Dexamethasone","Timing of Administration","Anesthesia Induction","Randomized Controlled Trial (RCT)","Triple-Blinded Study","Induction Protocol","Postoperative outcomes","2024-11-10",{"date":326,"type":45},"2024-11-13",{"date":328,"type":22},"2024-12-01",{"date":330,"type":22},"2026-01-31",{"name":332,"class":52},"AABDI Mohammed"]