[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-pain":31},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,332,0,25,[9,46,76,115,143,165,193,223,246,271,301,321,340,362,386,410,442,471,497,526,548,568,592,617,638],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100652717","intrathecal-morphine-versus-intrathecal-dexmedetomidine-compared-to-placebo-for-postoperative-pain-relief-after-spine-fixation-surgeries-100652717",false,"NCT07777627","Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries","Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries: A Randomized Double-Blinded Study","Inclusion Criteria:\n\n* Aged between 21 and 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) Physical Status I or II.\n* Scheduled for elective lumbar spine fixation surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients' refusal.\n* Decompensated hepatic or renal or cardiac disease.\n* Coagulation disorder.\n* Pregnancy and lactation.\n* Body mass index above 30 kg\u002Fm2.\n* Severe pulmonary disorders.\n* Patients on opioid, alcohol or allergy to any of the study drugs.","ALL","21 Years","60 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to compare the efficacy of intrathecal morphine and intrathecal dexmedetomidine in reducing pain following lumbar spine fixation surgeries.",[28,29,30,31,32],"Intrathecal Morphine","Intrathecal Dexmedetomidine","Placebo","Postoperative Pain","Spine Fixation Surgeries","RECRUITING","2026-08-17",{"date":36,"type":37},"2026-08-20","ACTUAL",{"date":39,"type":37},"2026-07-01",{"date":41,"type":22},"2028-07-01",{"name":43,"class":44},"Tanta University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100652634","recto-intercostal-fascial-plane-and-external-oblique-intercostal-blocks-for-pain-in-laparoscopic-cholecystectomyin-laparoscopic-cholecystectomy-100652634","NCT07777172","Recto-Intercostal Fascial Plane and External Oblique Intercostal Blocks for Pain in Laparoscopic Cholecystectomyin Laparoscopic Cholecystectomy","Does the Addition of Recto-Intercostal Fascial Plane Block to External Oblique Intercostal Plane Block Improve the Quality of Postoperative Analgesia in Laparoscopic Cholecystectomy? A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 75 years\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Patients scheduled for elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics\n* Infection at the procedure\u002Finjection site\n* Severe coagulopathy or use of anticoagulants\n* Chronic opioid consumption or history of neuropathic pain","18 Years","75 Years",{"count":21,"type":22},[25],"Laparoscopic cholecystectomy is a common surgical procedure that can cause significant postoperative pain, particularly originating from trocar insertion sites. Regional anesthesia techniques are frequently used as part of multimodal analgesia to improve patient comfort.\n\nThis randomized controlled trial aims to evaluate the efficacy of adding a recto-intercostal fascial plane block (RIFPB) to an external oblique intercostal plane block (EOIPB). Patients scheduled for elective laparoscopic cholecystectomy will be randomly assigned to receive either an EOIPB alone or a combination of EOIPB and RIFPB. The primary objective is to determine if the combined block approach provides superior postoperative analgesia, evaluated by compared to the EOIPB alone.",[31,59],"Cholecystectomy, Laparoscopic",[61,62,63,64,65,66],"External Oblique Intercostal Plane Block","Recto-Intercostal Fascial Plane Block","Fascial Plane Block","Regional Anesthesia","Postoperative Analgesia","Multimodal Analgesia","NOT_YET_RECRUITING",{"date":36,"type":37},{"date":70,"type":22},"2026-08-25",{"date":72,"type":22},"2027-03-15",{"name":74,"class":75},"Ankara Etlik City Hospital","OTHER_GOV",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":45},"100651986","impact-of-video-based-patient-education-on-physician-trust-pain-and-anxiety-in-laparoscopic-cholecystectomy-100651986","NCT07767344","Impact of Video-Based Patient Education on Physician Trust, Pain, and Anxiety in Laparoscopic Cholecystectomy","The Effect of Video-Based Preoperative Patient Education on Physician Trust, Postoperative Pain, and Anxiety Levels in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial","VITAP","Inclusion Criteria:\n\n* 18-65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Psychiatric disease\n* Anticoagulant use or coagulopathy\n* Allergy to local anesthetic\n* Infection at the block site\n* Thoracic deformity\n* Inability to comprehend pain or anxiety assessment scales.","65 Years",{"count":86,"type":22},62,[25],"This prospective, randomized, single-center, single-blind study aims to evaluate the effects of video-based preoperative education on physician trust, postoperative pain, anxiety, and opioid consumption in patients undergoing elective laparoscopic cholecystectomy under general anesthesia. Sixty-two ASA I-II patients aged 18-65 years will be randomized into two groups: standard verbal information alone or verbal information plus a standardized educational video regarding ultrasound-guided transversus abdominis plane (TAP) block. All patients will receive standardized general anesthesia, multimodal analgesia, and bilateral TAP block. The primary outcome will be physician trust assessed at postoperative 24 hours using the Trust in Physician Scale. Secondary outcomes include preoperative anxiety measured with the Amsterdam Preoperative Anxiety and Information Scale (APAIS), postoperative pain scores, opioid consumption, rescue analgesic requirement, and postoperative nausea and vomiting incidence. The study hypothesizes that video-based education will improve physician trust and perioperative patient-centered outcomes.",[31,90,91,92,64,93],"Laparoscopic Cholecystectomy Surgery","Preoperative Anxiety","Trust in Healthcare System","Transversus Abdominis Plane Block (TAP Block)",[95,96,97,98,99,100,101,102,103,104,105],"Laparoscopic cholecystectomy","TAP block","Video-based education","Preoperative education","Trust in Physician Scale","APAIS","Preoperative anxiety","Postoperative pain","Multimodal analgesia","Patient-centered outcomes","Randomized controlled trial","2026-08-16",{"date":108,"type":37},"2026-08-18",{"date":110,"type":37},"2026-08-12",{"date":112,"type":22},"2026-10-13",{"name":114,"class":75},"Sanliurfa Education and Research Hospital",{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":123,"minAge":53,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":23,"phases":127,"briefSummary":128,"conditions":129,"keywords":132,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":45},"100621369","effects-of-mobilization-and-caffeine-after-cesarean-100621369","NCT07369726","Effects of Mobilization and Caffeine After Cesarean","The Effect of Early Post-Cesarean Mobilization and Caffeine Consumption on Bowel Motility, Pain, and Psychological Well-being: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Being between 18 and 35 years of age,\n2. Women who underwent cesarean delivery under spinal anesthesia,\n3. Having a post-cesarean pain level of 4 or higher,\n4. Being able to understand and write Turkish and communicate effectively with researchers.\n\nExclusion Criteria:\n\n1. Women who underwent emergency cesarean delivery,\n2. Those with pregnancy complications (preeclampsia, placenta previa, etc.),\n3. Those with a history of chronic gastrointestinal disease (e.g., irritable bowel syndrome, Crohn's disease, ulcerative colitis),\n4. Those with sensitivity or allergy to caffeine,\n5. Those with a history of chronic pain syndrome or dependence on analgesics,\n6. Regular coffee drinkers (≥2 cups per day),\n7. Intraoperative complications such as bowel or bladder injury,\n\ni) Those who cannot comply with the study protocol or complete the follow-up process.\n\nRemoval Criteria:\n\n1. Participants are excluded from the study under the following conditions:\n2. During surgery If complications occur (e.g., bladder or bowel injury, excessive bleeding),\n3. Postoperative complications requiring admission to the intensive care unit (ICU) for the mother or newborn,\n4. Development of severe postoperative nausea, vomiting, or intolerance to oral intake,\n5. Inability to consume or refusal to consume coffee according to the study protocol,\n6. Withdrawal of consent by the participant at any point during the study,\n7. Failure to comply with surgical procedures or loss of follow-up,\n8. Development of medical conditions during follow-up that may affect study results (e.g., acute infections, neurological disorders).",true,"FEMALE","35 Years",{"count":126,"type":22},60,[25],"This study Maims to assess bowel motility, pain and psychological well-being in women in the post-cesarean period by mobilizing them early and encouraging them to consume coffee.",[130,31,131],"Gastrointestinal Motility","Psychological Well-Being",[133,134,131,135],"gastrointestinal motility","postoperatif pain","Early Ambulation",{"date":108,"type":37},{"date":138,"type":37},"2025-11-25",{"date":140,"type":22},"2026-09-01",{"name":142,"class":44},"KTO Karatay University",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":122,"sex":123,"minAge":53,"maxAge":124,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":164,"locationsCount":45},"100618260","post-caesarean-pranayama-and-pain-100618260","NCT07329309","Post-Caesarean Pranayama and Pain","The Effect of Post-Caesarean Section Pranayama Breathing Exercises on Pain and Postpartum Comfort: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Undergone a caesarean section under spinal anaesthesia\n* Reported a post-operative pain level of at least 4 on the Numerical Rating Scale (NRS)\n* Knowledge of Turkish\n* Ability to communicate effectively with the research team\n* Volunteer to participate in the study and provide written consent\n\nExclusion Criteria:\n\n* Having given birth by emergency caesarean section\n* Presence of pregnancy complications (e.g. pre-eclampsia, gestational diabetes, placenta praevia)\n* History of chronic pain or analgesic dependence\n* Requirement for admission to the intensive care unit in the early postoperative period\n* Need for additional surgical intervention\n* Development of significant intraoperative or postoperative complications\n* Refusal to exercise or intolerance to exercise\n* Failure to comply with study procedures\n* Withdrawal of consent\n* Incomplete follow-up\n* Development of a new medical condition during the study that could affect the results",{"count":151,"type":22},100,[25],"This study aims to investigate the effect of pranayama breathing exercises on postoperative pain and postpartum comfort levels in women following caesarean section, with the objective of providing important evidence for the integration of non-pharmacological methods into postpartum care.",[31],[156,157,158,159],"caesarean section","pain","pranayama","comfort",{"date":108,"type":37},{"date":162,"type":37},"2026-02-05",{"date":112,"type":22},{"name":142,"class":44},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":179,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":45},"100652249","the-effect-of-acupressure-application-on-respiratory-performance-and-pain-levels-in-adult-patients-undergoing-cardiac-surgery-100652249","NCT07771751","The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery","The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 years and older.\n* Undergoing cardiac surgery for the first time.\n* Extubated and hemodynamically stable in the postoperative period.\n* A Glasgow Coma Scale (GCS) score of 15.\n* Absence of arterial or venous catheters, incisions, hematomas, ecchymoses, or any skin lesions\u002Fdeformities at the acupressure application sites.\n* No analgesic medication administered within the last four hours.\n* No known neuromuscular diseases that could affect respiratory muscle strength or performance.\n* Ability to speak Turkish and absence of any communication barriers.\n\nExclusion Criteria:\n\n* Development of postoperative complications (e.g., severe arrhythmia, need for re-intubation, active bleeding).\n* Receiving sedation in the intensive care unit.\n* Presence of chronic pain syndrome or regular use of opioids\u002Fanalgesics.\n* Known psychiatric disorders.",{"count":173,"type":22},114,[25],"The purpose of this randomized controlled trial is to evaluate the effect of acupressure on respiratory performance and pain levels in adult patients who have undergone open-heart surgery. Pulmonary complications and severe pain are common after cardiac surgery, often limiting the effectiveness of standard deep breathing exercises such as incentive spirometry. This study investigates whether applying acupressure-a non-invasive complementary therapy-can help manage postoperative pain and improve respiratory capacity. By potentially reducing pain without the respiratory side effects associated with pharmacological medications, acupressure may enable patients to perform their breathing exercises more effectively and support their overall recovery.",[31,177,178],"Cardiac Surgery","Postoperative Complications",[180,181,182,183,184],"Respiratory Performance","Pain Management","Nursing Care","acupressure","cardiac surgery","2026-08-14",{"date":108,"type":37},{"date":188,"type":22},"2026-09-21",{"date":190,"type":22},"2027-09-21",{"name":192,"class":44},"Fenerbahce University",{"id":194,"slug":195,"hasResults":12,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":122,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":203,"conditions":204,"keywords":206,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":45},"100652134","aromatherapy-and-its-impact-on-preoperative-anxiety-postoperative-pain-and-patient-experience-100652134","NCT07771205","Aromatherapy and Its Impact on Preoperative Anxiety, Postoperative Pain, and Patient Experience","Aromatherapy and Its Impact on Preoperative Anxiety, Postoperative Pain, and Patient Experience: A Randomized Control Trial","Inclusion Criteria:\n\n* Able to speak, read, understand, and write in English or Spanish\n* Undergoing a surgical procedure under general anesthesia\n* Able to provide informed consent independently\n\nExclusion Criteria:\n\n* Cataract and other ocular surgeries\n* Allergies to aromatherapy ingredients\n* Chronic pain management\n* Olfactory deficits",{"count":201,"type":22},286,[25],"Aromatherapy's Impact on Preoperative Anxiety, Postoperative Pain, and Patient Experience\n\nIntroduction:\n\nSurgery often results in increased levels of anxiety and postoperative pain. Postoperative pain relief is typically treated with opioids. However, evidence shows that treatment with opioids alone is often insufficient to provide adequate levels of pain relief and can contribute to the growing opioid crisis. Alternative pain management strategies that combine narcotic medication with complementary therapies can improve comfort as well as decrease preoperative anxiety. Aromatherapy is an evidence-based complementary therapy used to decrease preoperative anxiety and postoperative pain that has been underutilized in ambulatory surgical centers. This study aimed to evaluate the impact Aromatherapy has as an anxiety and pain management strategy. Subsequently, evidence also supports that improving the patient experience can lead to better surgical outcomes.\n\nStudy Aim:\n\nThis study will examine the effect that aromatherapy has on preoperative anxiety, postoperative pain and patient experience\n\nStudy Question(s):\n\nIn perioperative patients at Kaiser Stockton Ambulatory Surgery Unit, how does aromatherapy, compared with standard practice, affect preoperative anxiety?\n\nIn perioperative patients at Kaiser Stockton Ambulatory Surgery Unit, how does aromatherapy, compared with standard practice, affect postoperative pain?\n\nIn perioperative patients at Kaiser Stockton Ambulatory Surgery Unit, how does aromatherapy, compared with standard practice, affect patient experience?\n\nStudy Method: Prospective Experimental Randomized Control Clinical Trial\n\nStudy Duration: 18 months\n\nStudy Process: The participants will be recruited through their Pre-surgery interview, at which time a brief explanation will be given on aromatherapy, its potential to reduce preoperative anxiety and postoperative pain, and increase the patient experience. The study design and protocol will also be described. Should the participants elect to participate in this study, they will be randomly assigned using a computer program. Upon arrival for surgery, informed consent will be obtained. Anxiety and pain will be assessed for pre- and post- intervention and just before transferring to the operating room (OR). Upon arrival to the Post-Anesthesia Care Unit (PACU), pain will be assessed in 15-minute intervals until discharge. Anxiety will be reassessed at discharge. Experience will be assessed 2 weeks after discharge.\n\nData Analysis:\n\nA one-way Multivariate Analysis of Variance (MANOVA) will be used to assess the impact of aromatherapy on pain, anxiety, and satisfaction.\n\nConclusions:\n\nThis study aims to add to the body of knowledge of how the incorporation of aromatherapy can impact patient outcomes.",[31,91,205],"Patient Experience",[101,207,208,157,209,210,211,212,213,214,215],"surgery","anxiety","postoperative pain","ambulatory","experience","patient experience","aromatherapy","complementary alternative medicine","nurse-led",{"date":108,"type":37},{"date":218,"type":37},"2026-07-07",{"date":220,"type":22},"2028-01",{"name":222,"class":44},"Kaiser Permanente",{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":229,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":236,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":45},"100652191","deep-subgluteal-block-vs-peng-combined-with-lfcn-block-for-analgesia-after-hip-arthroplasty-100652191","NCT07770932","Deep Subgluteal Block vs PENG Combined With LFCN Block for Analgesia After Hip Arthroplasty","Comparison of Deep Subgluteal Block and Pericapsular Nerve Group Block Combined With Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia After Hip Arthroplasty: A Randomized Prospective Study","DSG-PENG","Inclusion Criteria:\n\n* Patients scheduled for elective total or partial hip arthroplasty under general anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Aged between 18 and 80 years\n* Able to understand the study procedures, give voluntary written informed consent, and operate a patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Patient refusal or inability to provide informed consent\n* Pre-existing peripheral neuropathy, cognitive impairment, or psychiatric disorders\n* History of significant severe renal or hepatic failure\n* Allergy or hypersensitivity to amide-type local anesthetics or opioids\n* Infection, severe anatomic distortion, or previous surgery at the proposed block injection sites\n* History of substance abuse or chronic opioid use (defined as daily opioid use for \\> 3 months prior to surgery)","80 Years",{"count":126,"type":22},[25],"This randomized, prospective study aims to compare the clinical efficacy of ultrasound-guided Deep Subgluteal Block (DSGB) versus Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve (LFCN) block for postoperative analgesia management in patients undergoing hip arthroplasty.\n\nA total of 60 patients scheduled for hip arthroplasty under general anesthesia will be randomly allocated into two equal groups of 30: Group DSG and Group PENG+LFCN. Total local anesthetic volume (30 mL) and active drug dose (75 mg bupivacaine) will be standardized across both groups to ensure rigorous blinding and high methodological quality.\n\nThe primary outcome of the study is to compare total postoperative opioid (fentanyl) consumption within the first 24 hours. Secondary outcomes include postoperative pain scores evaluated via the Numerical Rating Scale (NRS) at rest and during movement, the presence and degree of quadriceps motor block, and opioid-related adverse effects (e.g., nausea, vomiting, pruritus).",[31],[237],"Deep Subgluteal Block PENG Block Lateral Femoral Cutaneous Nerve Block Hip Arthroplasty Nerve Block Opioid Consumption","2026-08-13",{"date":108,"type":37},{"date":241,"type":22},"2026-08-01",{"date":243,"type":22},"2027-01-30",{"name":245,"class":44},"Medipol University",{"id":247,"slug":248,"hasResults":12,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":12,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":254,"targetDuration":4,"studyType":23,"phases":256,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":264,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":45},"100651586","ficb-for-hip-fracture-pain-in-elderly-100651586","NCT07762846","FICB for Hip Fracture Pain in Elderly","The Early Intervention of Fascia Iliaca Compartment Block (FICB) as Pain Management for Elderly Patients With Hip Fracture to Improve Postoperative Rehabilitation: A Prospective Randomized Controlled Study","FICB-PREP","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Diagnosis of unilateral hip fracture (including femoral neck fracture or intertrochanteric fracture) confirmed by any imaging modality (X-ray, CT, or MRI)\n* Scheduled for hip fracture surgery under general anesthesia with endotracheal intubation (including total hip arthroplasty, hemiarthroplasty, intertrochanteric intramedullary nail fixation, closed reduction and internal fixation, etc.)\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Able to provide written informed consent personally or via a legally authorized representative\n* Able to communicate normally in Chinese\n\nExclusion Criteria:\n\n* Known allergy to ropivacaine, bupivacaine, or liposomal bupivacaine\n* Presence of any contraindication to nerve block, including but not limited to: nerve injury, coagulopathy, severe infection at the injection site, exudate at the injection site, etc.\n* Pre-existing psychiatric or neurological disorders, including but not limited to: depression, severe central nervous system depression, Parkinson's disease, basal ganglia lesions, schizophrenia, epilepsy, Alzheimer's disease, myasthenia gravis\n* Pre-existing severe cardiac, pulmonary, hepatic, or renal dysfunction, including but not limited to: history of heart failure, requiring dialysis, etc.\n* Inability to communicate preoperatively (e.g., coma, dementia)\n* Preoperative pain score \\\u003C 4 on Visual Analog Scale (VAS) or chronic\u002Fold hip fracture\n* Currently participating in another interventional clinical trial\n* Any other condition that, in the opinion of the investigator, would preclude evaluation of the therapeutic response or make it unlikely that the patient will complete the expected treatment course and follow-up",{"count":255,"type":22},144,[25],"Hip fracture is a common injury in elderly patients, often requiring surgical treatment. However, these patients frequently experience severe postoperative pain, which can delay mobility and recovery, and increase the risk of complications such as delirium, pneumonia, and prolonged hospital stay.\n\nThe fascia iliaca compartment block (FICB) is a regional anesthesia technique that has been shown to provide effective pain relief for hip fracture patients. This study aims to investigate whether early administration of FICB, performed upon hospital admission before surgery, can improve postoperative rehabilitation outcomes in elderly patients with hip fracture.\n\nThis is a prospective, randomized, controlled study. A total of 144 elderly patients with hip fracture will be randomly assigned to either the FICB group or the control group. The FICB group will receive ultrasound-guided FICB after being admitted to the orthopaedic ward, while the control group will receive standard analgesic care once inside the operating room.\n\nThe primary outcome measure is Quality of Recovery-15 score (QoR-15 score) 24 hours post-surgery. Secondary outcomes include: QoR-15 score at 48 hours postoperatively, NRS scores and sleep duration and quality scores at preoperative and various postoperative time points, total perioperative consumption of opioids and other analgesic drugs, extubation time and emergence agitation during anesthesia recovery period, incidence of delirium from postoperative period to before discharge, length of hospital stay, and overall satisfaction score with pain management.\n\nThe hypothesis of this study is that early FICB intervention, compared to standard care, will lead to better pain control, earlier mobilization, shorter hospital stay, and improved overall postoperative recovery in elderly patients with hip fracture.",[259,31,260,261,262,263],"Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures)","QoR-15","Fascia Iliaca Block","Recovery of Function (G11.427.698.620)","Elderly",{"date":238,"type":37},{"date":266,"type":22},"2026-08",{"date":268,"type":22},"2027-12",{"name":270,"class":44},"RenJi Hospital",{"id":272,"slug":273,"hasResults":12,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":277,"eligibilityCriteria":278,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":285,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":294,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":4},"100651576","speng-block-versus-suprascapular-and-axillary-nerve-blocks-for-pain-after-shoulder-arthroscopy-100651576","NCT07762417","SPENG Block Versus Suprascapular and Axillary Nerve Blocks for Pain After Shoulder Arthroscopy","Analgesic Efficacy of the Shoulder Posterior Pericapsular Nerve Group Block Versus Combined Posterior Suprascapular and Axillary Nerve Blocks for Shoulder Arthroscopy: A Randomized, Blinded, Non-Inferiority Trial","SPENG-RCT","Inclusion Criteria:\n\n* Age 18 to 70 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled to undergo elective shoulder arthroscopy under general anesthesia\n* Able to understand the Numeric Rating Scale for pain assessment\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics used in the study\n* Infection at the planned block injection site\n* Coagulopathy or ongoing anticoagulant therapy that cannot be appropriately interrupted for peripheral nerve block\n* Pre-existing neurological deficit affecting the operative upper extremity\n* Moderate or severe pulmonary disease\n* Known diaphragmatic dysfunction\n* Chronic opioid use\n* Chronic pain syndrome\n* Body mass index greater than 35 kg\u002Fm²\n* Pregnancy or breastfeeding\n* Inability to understand or reliably report Numeric Rating Scale pain scores\n* Inadequate sonographic window preventing safe performance of the allocated block technique before randomization","70 Years",{"count":126,"type":22},[25],"This prospective, randomized, patient- and assessor-blinded, single-center non-inferiority trial will compare the analgesic efficacy of the Shoulder Posterior Pericapsular Nerve Group (SPENG) block with combined posterior suprascapular and axillary nerve blocks in adults undergoing elective shoulder arthroscopy under general anesthesia. Both groups will receive the same total volume and concentration of local anesthetic. The primary outcome will be the highest resting Numeric Rating Scale pain score recorded during the first 24 postoperative hours. Secondary outcomes will include block performance time, sensory block success in suprascapular and axillary nerve territories, opioid consumption, time to rescue analgesia, motor function, diaphragmatic function, postoperative recovery quality, patient satisfaction, and block-related complications.",[31,284],"Shoulder Arthroscopy",[286,287,288,289,290,291,292,293],"Diaphragm-sparing block","Postoperative analgesia","Regional anesthesia","Axillary nerve block","Suprascapular nerve block","Shoulder arthroscopy","Shoulder Posterior Pericapsular Nerve Group block","SPENG block",{"date":185,"type":37},{"date":296,"type":22},"2026-11-01",{"date":298,"type":22},"2027-06-15",{"name":300,"class":75},"Izmir City Hospital",{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":122,"sex":123,"minAge":53,"maxAge":84,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":45},"100553251","phase-2-intravenous-oxytocin-for-post-operative-pain-after-minimally-invasive-hysterectomy-100553251","NCT06483659","Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy","Inclusion Criteria:\n\n* Ages 18-65 years old\n* ASA category 1-3\n* Scheduled to undergo minimally invasive hysterectomy\n* No documented allergy to oxytocin\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) group 4 or greater\n* Age \\>65 years old\n* Additional surgical procedures including but not limited to minor laparotomy, omentectomy, cystectomy, vaginectomy, and\u002For ablation of endometriosis.\n* Active opioid prescription of the equivalent of oxycodone \\>10 mg \u002Fday\n* Opioid use disorder, including patients in treatment receiving naltrexone or Suboxone (Buprenorphine-naloxone)\n* Allergies to any study medication: acetaminophen, celecoxib, ketorolac, fentanyl, hydromorphone, or oxycodone.\n* Epidural\u002FRegional anesthesia for intra-operative or post-operative pain.\n* Inability to understand the questionnaires\n* Intra-operative and post-operative exclusion: Procedure converted to open or extension of primary surgery, Intra-operative EBL \\>500 ml., Placement of epidural catheter or regional anesthesia at PACU for pain management, Hospitalization of the patient due to surgical or anesthetic complications",{"count":308,"type":22},152,[310],"PHASE2","This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.",[31],"2026-08-11",{"date":238,"type":37},{"date":316,"type":37},"2025-06-01",{"date":318,"type":22},"2028-06-30",{"name":320,"class":44},"Brigham and Women's Hospital",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":328,"targetDuration":4,"studyType":23,"phases":329,"briefSummary":330,"conditions":331,"keywords":332,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":336,"completionDateStruct":337,"leadSponsor":338,"locationsCount":45},"100651840","pcdd-generation-1-oral-liquid-acetaminophen-delivery-evaluation-100651840","NCT07765238","PCDD Generation 1 Oral Liquid Acetaminophen Delivery Evaluation","Evaluation of the Patient-Controlled Dispenser & Deactivator (PCDD) Generation 1 System for Oral Liquid Acetaminophen Delivery","Inclusion Criteria:\n\nParticipants\n\n* Admitted to the participating orthopedic service for elective total shoulder replacement\n* Received a preoperative brachial plexus block\n* English speaking - as on-site study members are only fluent in English\n* Able to independently use the PCDD system and follow basic operating instructions\n\nNurses\n\n* Registered nurse employed at Yale New Haven Hospital.\n* Provides clinical care to an enrolled study participant during the participant's hospitalization.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\nParticipants\n\n* Patient refusal to participate\n* Pregnancy: all child bearing age patients will receive a urine screening test on the day of surgery and this result will be documented in the EMR epic. This is an elective procedure and the surgery will almost always be cancelled in the case of positive pregnancy test. In the extremely rare event the care proceeds, we will exclude the patient from the study. Emergency surgery\n* Cognitive impairment preventing informed consent or independent use of the device\n* Chronic pain requiring ongoing pain management or home opioid use\n* Substance use disorder\n* Failed preoperative brachial plexus block, defined as significant postoperative pain in the PACU requiring early escalation of analgesic management\n\nNurses\n\n* Declines or is unwilling to provide informed consent.",{"count":126,"type":22},[25],"This prospective randomized pilot study evaluates the feasibility, acceptability, and preliminary efficacy of the Patient-Controlled Dispenser and Deactivator (PCDD) Generation 1 system for patient-controlled oral liquid acetaminophen administration in postoperative total shoulder replacement inpatients compared with standard nurse-administered oral acetaminophen delivery.",[181,31],[333],"total shoulder replacement surgery","2026-08-10",{"date":185,"type":37},{"date":266,"type":22},{"date":268,"type":22},{"name":339,"class":44},"Yale University",{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":352,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":356,"startDateStruct":357,"completionDateStruct":358,"leadSponsor":360,"locationsCount":45},"100651685","comparison-of-paravertebral-versus-epidural-block-for-post-thoracotomy-pain-control-100651685","NCT07763249","Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control","Comparison Between Paravertebral Block and Epidural Block for the Management of Postoperative Pain in Patients Undergoing Thoracotomy and One-Lung Ventilation: A Prospective Non-inferiority Study.","Inclusion Criteria:\n\n* Patients aged 18 years or older;\n* Elective thoracic surgeries requiring open thoracotomy;\n* American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n* Pregnancy or lactation;\n* Urgent or emergency surgeries;\n* Contraindications to epidural catheter insertion or neuraxial anesthesia;\n* Infection at the proposed block site;\n* Patient refusal to undergo the study blocks;\n* Video-assisted thoracic surgeries;\n* Anticipated need for invasive mechanical ventilation in the postoperative period;\n* Chronic opioid use (daily use for more than 3 months of ≥10 mg oral morphine equivalent);\n* Severe vertebral deformities or previous thoracic spine surgery that prevent safe performance of the blocks;\n* Known allergy to local anesthetics, opioids, or study medications;\n* Body mass index \\> 35 kg\u002Fm²;\n* Advanced liver or kidney failure (Child-Pugh C or estimated glomerular filtration rate \\\u003C 50 mL\u002Fmin\u002F1.73 m²);\n* Severe cognitive impairment that prevents understanding of instructions or pain assessment.",{"count":348,"type":22},80,[25],"This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients undergoing elective open thoracotomy with one-lung ventilation. The primary outcome is the mean pain intensity at rest assessed by the Numeric Verbal Scale (NVS 0-10) during the first 48 hours after surgery. A total of 80 participants will be randomized 1:1 at Hospital de Clínicas de Porto Alegre, Brazil. The study aims to determine whether BPV provides non-inferior analgesia compared to BPD, with a potential advantage of less hemodynamic interference and better postoperative mobilization.",[31],[31,353,354,355,64],"Thoracotomy","Acute Pain","Thoracic Surgery",{"date":238,"type":37},{"date":140,"type":22},{"date":359,"type":22},"2028-07-31",{"name":361,"class":44},"Hospital de Clinicas de Porto Alegre",{"id":363,"slug":364,"hasResults":12,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":12,"sex":123,"minAge":53,"maxAge":84,"enrollmentInfo":369,"targetDuration":4,"studyType":23,"phases":370,"briefSummary":371,"conditions":372,"keywords":377,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":382,"leadSponsor":384,"locationsCount":4},"100651579","single-vs-multiple-injection-intertransverse-process-block-in-breast-cancer-surgery-100651579","NCT07763756","Single vs Multiple Injection Intertransverse Process Block in Breast Cancer Surgery","Comparison of Single-Injection and Multiple-Injection Intertransverse Process Block for Postoperative Analgesia in Breast Cancer Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* ASA physical status I-III\n* Scheduled for elective breast cancer surgery\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* Ability to understand and use the patient-controlled analgesia (PCA) device\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Allergy to local anesthetics\n* Infection at the injection site\n* Coagulopathy or ongoing anticoagulant therapy\n* Chronic opioid use or opioid dependence\n* Severe hepatic or renal insufficiency\n* Pregnancy or breastfeeding\n* Cognitive impairment or inability to communicate pain scores\n* Body mass index (BMI) \\\u003C18 or \\>35 kg\u002Fm²",{"count":126,"type":22},[25],"This randomized clinical trial aims to evaluate and compare the analgesic efficacy of single Intertransverse Process Block (ITP) and multiple Intertransverse Process Block (ITP) in patients undergoing Breast Cancer Surgery. The primary outcome is Visual Analog Scale (VAS) during the first 24 hours after surgery. Secondary outcomes include total opioid consumption, requirement for rescue analgesia, block performance time, block-related and systemic side effects (hematoma, pneumothorax, local anesthetic toxicity, vascular puncture, infection), Patient satisfaction assessed using a Likert scale, quality of recovery assessed using the QoR-15 questionnaire.",[373,31,374,375,376],"Breast Cancer","Mastectomy","Regional Anaesthesia","Intertransverse Process Block",[378,376],"ITP","2026-08-09",{"date":238,"type":37},{"date":296,"type":22},{"date":383,"type":22},"2027-09-01",{"name":385,"class":44},"Antalya City Hospital",{"id":387,"slug":388,"hasResults":12,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":392,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":393,"targetDuration":4,"studyType":23,"phases":395,"briefSummary":397,"conditions":398,"keywords":401,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":405,"completionDateStruct":406,"leadSponsor":408,"locationsCount":45},"100642566","phase-4-fascia-iliaca-block-using-liposomal-bupivacaine-for-analgesia-after-hip-fracture-surgery-100642566","NCT07643792","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery: a Randomized Trial","Inclusion Criteria:\n\n* Aged ≥ 18 years.\n* Scheduled to undergo hip replacement surgery.\n* Agree to receive regional nerve block and postoperative patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Inability to communicate due to visual, auditory, language, or other reasons before surgery.\n* Chronic opioid dependence and long-term use of various types of analgesics (for more than 3 months).\n* Severe coagulation abnormalities (International Normalized Ratio \\> 1.7, activated partial thromboplastin time exceeding the normal value by more than 4 seconds, platelet count \\\u003C 80 × 10⁹\u002FL), trauma or infection at the intended puncture site, or severe low back pain.\n* Preoperative severe renal insufficiency (serum creatinine \\> 442 μmol\u002FL or requiring renal replacement therapy), hepatic insufficiency (Child-Pugh class C), or ASA physical status \\> IV.\n* Known allergy to local anesthetics.\n* Any other condition that the investigator or attending physician deems unsuitable for participation in the study.",{"count":394,"type":22},148,[396],"PHASE4","Patients after hip surgery often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (such as plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia, decrease opioid consumption, and improve postoperative recovery quality within 72 hours in older patients after hip fracture surgery.",[261,399,31,400],"Liposomal Bupivacaine","Hip Surgery",[261,399,31,402],"Hip surgery","2026-08-08",{"date":313,"type":37},{"date":266,"type":22},{"date":407,"type":22},"2028-08",{"name":409,"class":44},"Peking University First Hospital",{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":17,"minAge":417,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":422,"conditions":423,"keywords":428,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":4},"100651526","phase-4-topical-magnesium-sulfate-versus-peritonsillar-bupivacaine-for-post-tonsillectomy-pain-relief-in-children-100651526","NCT07760207","Topical Magnesium Sulfate Versus Peritonsillar Bupivacaine for Post-Tonsillectomy Pain Relief in Children","Topical Magnesium Sulfate Versus Peritonsillar Bupivacaine Infiltration for Post-Tonsillectomy Analgesia: A Prospective, Randomized Trial","Inclusion Criteria:\n\n* Pediatric patients aged 8-15 years undergoing elective tonsillectomy.\n\nExclusion Criteria:\n\n* Patients younger than 8 years or older than 15 years.\n* Known allergy to magnesium sulfate or bupivacaine.\n* Pre-existing neurological disorders (for example, neuromuscular diseases, epilepsy) that could affect pain perception or magnesium metabolism.\n* Pre-existing cognitive impairment or developmental delay affecting pain assessment.\n* Chronic pain syndromes or regular use of analgesics.\n* Coagulopathy or bleeding disorders.","8 Years","15 Years",{"count":420,"type":22},40,[396],"Tonsillectomy (tonsil removal) is a very common surgery for children, but it often causes significant throat and ear pain afterward. Doctors usually inject a numbing medicine, such as bupivacaine, into the area around the tonsils to help control this pain. However, these injections require needles, which can cause swelling, distort tissue, and slightly increase the risk of bleeding or infection, and the pain relief typically only lasts for about 4 to 6 hours.\n\nThis study is investigating a needle-free alternative to see if it provides effective pain relief. The researchers are testing a medication called magnesium sulfate, which blocks certain pain receptors and can be applied directly to the surgical site using a soaked gauze pad instead of a needle injection.\n\nThe main goal of this clinical trial is to compare how well topical magnesium sulfate relieves pain compared to standard bupivacaine injections in children undergoing tonsillectomy.\n\nThe study will include 40 children between the ages of 8 and 15 years old. During the surgery, while under general anesthesia, half of the children will receive the topical magnesium sulfate pad applied to the surgical area for 5 minutes, and the other half will receive the standard bupivacaine injection. After the surgery, researchers will measure the children's pain levels using visual pain scales featuring faces and numbers. They will also track how much extra pain medication the children need, how well their surgical wounds heal, and if they experience any adverse effects.",[424,425,31,426,427],"Post-tonsillectomy Pain","Tonsillectomy","Tonsillectomy Distress Syndrome","Odynophagia",[425,429,430,431,432,433],"Magnesium Sulfate","Bupivacaine","Analgesia","Pediatric","Peritonsillar Infiltration","2026-08-07",{"date":110,"type":37},{"date":437,"type":22},"2026-09",{"date":439,"type":22},"2027-10",{"name":441,"class":44},"Assiut University",{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":450,"targetDuration":4,"studyType":23,"phases":452,"briefSummary":453,"conditions":454,"keywords":457,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":45},"100651502","parasternal-intercostal-plane-catheter-for-pain-control-after-cabg-surgery-100651502","NCT07759570","Parasternal Intercostal Plane Catheter for Pain Control After CABG Surgery","The Effect of Superficial Parasternal Intercostal Plane Catheter Analgesia Following Sternotomy in Coronary Artery Bypass Surgery on Postoperative Pain: A Prospective Randomized Controlled Trial","PIP-PAIN","Inclusion Criteria:\n\n\\- Adult patients with coronary artery disease scheduled for coronary artery bypass graft surgery\n\nExclusion Criteria:\n\n* Under 18 years of age\n* ASA (American Society of Anesthesiologists) Class V patients\n* Non-elective emergency cases\n* Patient refusal to participate in the study\n* Language barrier\n* Patients who have previously undergone sternotomy\n* History of significant psychiatric disorders\n* Patients with known long-term opioid use\n* Patients with potential contraindications to nerve blocks (bleeding diathesis, infection, and allergy to local anesthetics)\n* Patients with an ejection fraction \\\u003C40%\n* Patients with right ventricular systolic dysfunction (patients with TAPSE \\\u003C1.8 cm)\n* Patients with a left atrial diameter \\>4 cm\n* Patients with severe valvular heart disease\n* Patients undergoing concomitant valvular heart surgery\n* Patients with a history of atrial flutter and\u002For atrial fibrillation",{"count":451,"type":22},56,[25],"Coronary artery bypass graft (CABG) surgery performed via sternotomy (incision of the breastbone) can cause severe pain after surgery; this can slow recovery and increase the need for opioid pain relievers. This study investigates whether placing a catheter to deliver a local anesthetic to the superficial parasternal intercostal plane reduces pain following this type of heart surgery. Patients undergoing CABG via sternotomy will be randomly assigned to either the catheter-based analgesia group or the standard pain management group. The researchers will compare postoperative pain levels and analgesic medication requirements between the two groups to determine whether this technique improves postoperative pain control.",[455,456,31],"Bypass Surgery","Arrythmia",[458,459,460,461,462],"parasternal block","postoperative analgesia","cardiovascular surgery","arrhythmia","regional anesthesia","2026-08-06",{"date":110,"type":37},{"date":466,"type":22},"2026-08-30",{"date":468,"type":22},"2026-11-15",{"name":470,"class":44},"Koc University Hospital",{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":477,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":478,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":484,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":490,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":45},"100634470","serratus-posterior-superior-intercostal-plane-block-versus-intrathecal-morphine-in-vats-100634470","NCT07540104","Serratus Posterior Superior Intercostal Plane Block Versus Intrathecal Morphine in VATS","Comparison of the Effects of Serratus Posterior Superior Intercostal Plane Block and Intrathecal Morphine on Postoperative Acute Pain in Patients Undergoing Video-assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* American Society of Anesthesiologists physical status I to III\n* Scheduled for elective video-assisted thoracoscopic surgery, including wedge resection, segmentectomy, or lobectomy\n\nExclusion Criteria:\n\n* Refusal to participate\n* Pregnancy\n* Morbid obesity (body mass index greater than 40 kg per square meter)\n* Allergy to study medications\n* Neuropsychiatric disorders, cognitive impairment, or inability to communicate\n* History of substance abuse\n* Active systemic infection or infection at the planned injection site\n* Severe cardiac, respiratory, hepatic, renal, or endocrine disease.\n* Chronic pain syndrome or ongoing chronic pain treatment\n* Emergency surgery or previous ipsilateral VATS or thoracotomy\n* Preoperative opioid use: ≥15 mg oral morphine equivalents\u002Fday for ≥30 days within the previous 3 months.\n* Anticipated need for postoperative mechanical ventilation.\n* Contraindications to neuraxial or peripheral regional anesthesia, including anticoagulant therapy, coagulopathy, infection, or relevant anatomical abnormalities.",{"count":126,"type":22},[25],"This study aims to compare the analgesic effects of the serratus posterior superior intercostal plane block and intrathecal morphine in patients undergoing video-assisted thoracoscopic surgery.\n\nThis is a prospective, randomized, controlled, single-center clinical trial including adult patients undergoing elective thoracoscopic surgery. Participants will be randomly assigned to receive either a serratus posterior superior intercostal plane block or intrathecal morphine before general anesthesia.\n\nThe primary outcome is cumulative opioid consumption during the first 24 postoperative hours, expressed as intravenous morphine milligram equivalents. Secondary outcomes include pain scores, time to first analgesic request, quality of recovery, and postoperative complications.\n\nThe study aims to determine whether these two techniques differ in their effectiveness for postoperative pain management.",[482,31,483],"Thoracic Anesthesia","Video Assisted Thoracic Surgery (VATS)",[485,486,487,488,489],"Thoracic Surgery, Video-Assisted","Analgesia, Postoperative","Morphine","Injections, Spinal","Nerve Block",{"date":334,"type":37},{"date":492,"type":37},"2026-04-15",{"date":494,"type":22},"2026-09-15",{"name":496,"class":44},"Ondokuz Mayıs University",{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":17,"minAge":504,"maxAge":84,"enrollmentInfo":505,"targetDuration":4,"studyType":23,"phases":507,"briefSummary":509,"conditions":510,"keywords":511,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":45},"100624222","phase-1-psilocybin-after-trauma-surgery-for-pain-100624222","NCT07406828","Psilocybin After Trauma Surgery for Pain","Single Dose Psilocybin for a Post-surgical Trauma Inpatient Population for Pain, Mood, and Opioid Use Disorder","Inclusion Criteria:\n\n1. ≥ 25 years old and ≤65 years old\n2. Inpatient\n3. English-speaking\n4. History of opioid use disorder as diagnosed by DSM-V\n5. Able to swallow capsules.\n6. Patients are able to be enrolled and receive psilocybin within 3 days (72 hours) of surgery (time point 0 for this three-day window begins after patient arrival in the ICU) after a trauma surgery. Psilocybin will be administered in the morning to allow for the 8-hour monitoring period.\n\nExclusion Criteria:\n\n1. Pregnancy. Women of child-bearing potential need to have a negative pregnancy test result at screening and baseline.\n2. Sexually active male participants and\u002For their female partners and female participants of child-bearing potential need to be on adequate and effective method of contraception (diaphragm, male condom, combined pill, copper IUD, levonorgestrel IUS, etonogestrel implant).for one week following study drug administration.\n3. Breastfeeding\n4. Patients receiving concurrent ketamine therapy or who have received ketamine therapy during the trauma admission.\n5. UDS screen on admission (if obtained) positive for alcohol, opioids other than prescribed for pain or maintenance opioids for OUD, or other substances of abuse\n6. History of psychedelic substance use in the preceding 5 years\n7. History (or active) cardiovascular disease (non-optimized coronary vascular disease, stable or unstable angina, new onset EKG abnormalities, congenital long QT syndrome, cardiac trauma involving surgical repair or CABG within 1 year)\n8. Screening blood pressure SBP \\>140 mmHg or DBP \\> 90 mmHg on three separate occasions\n9. Head trauma, traumatic brain injury, or concussion.\n10. Tachycardia defined as HR \\> 100, averaged over the previous 12 hours, excluding intra-operative care)\n11. History of dementia\n12. History of pre-existing neurological conditions (including TIA, stroke, epilepsy, MS, ALS, Guillain-Barre, Parkinson's)\n13. Patients on SSRIs, TCAs, MAO-Is, lithium, or other serotonergic medications, antipsychotics. Prohibited medications need to be discontinued at least 30 days prior to psilocybin dosing.\n14. Patients that received intra-operative intravenous methadone dosing \\> 20 mg.\n15. On vasopressors\n16. Hepatic impairment, mild to moderate, with Child-Pugh score ≥ 7\n17. Nicotine dependence, which would prevent the patient from staying in their room for the duration of the 8-hour psilocybin study period.\n18. On sedating IV infusions (propofol, ketamine, fentanyl, benzodiazepine, dexmedetomidine)\n19. History of suicidal or homicidal ideations within the last year\n20. History of seizure disorder\n21. Requiring restraints or active sitter\n22. Patients with a history of poorly controlled anxiety (GAD7 score of 10 or more), poorly controlled depression (PHQ9 score of 15 or more), panic disorder, paranoia, PTSD, bipolar disorder, any primary psychotic disorder like schizophrenia, schizoaffective disorder, or antisocial personality disorder; personal or first- or second-degree relative history of psychotic or bipolar I or II disorder\n23. History of Hallucinogen Use Disorder or Hallucinogen Persisting Perception Disorder (per DSM-V)\n24. Unable to consent (intubated\u002Fsedated)\n25. Intellectual disability\n26. Additional or anticipated surgeries within 7248 hrs of psilocybin administration\n27. Discharge from hospital pending within 24 hrs of psilocybin administration\n28. Any allergy to psilocybin or other inert substances in the product","25 Years",{"count":506,"type":22},70,[508],"PHASE1","The goal of this clinical trial is to evaluate whether a single dose of psilocybin is feasible and safe for adults with opioid use disorder (OUD) who are recovering from trauma surgery. The main questions it aims to answer are:\n\n1. Is a single psilocybin dose feasible to administer during postoperative hospitalization?\n2. Is psilocybin safe in this patient population?\n3. How does psilocybin affect postoperative pain, opioid use, anxiety, and depression after hospital discharge?\n\nParticipants will:\n\nReceive one oral dose of psilocybin during their postoperative inpatient stay Complete assessments of pain, mood, and opioid use during recovery",[181,31],[512,513,514,515,207,516,517],"psilocybin","postoperative trauma","opioid","opioid use prevention","mushrooms","opioid adverse events","2026-08-05",{"date":463,"type":37},{"date":521,"type":22},"2027-12-31",{"date":523,"type":22},"2029-08",{"name":525,"class":44},"Trent Emerick",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":532,"eligibilityCriteria":533,"healthyVolunteers":12,"sex":123,"minAge":53,"maxAge":84,"enrollmentInfo":534,"targetDuration":4,"studyType":23,"phases":535,"briefSummary":536,"conditions":537,"keywords":539,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":541,"lastUpdatePostDateStruct":542,"startDateStruct":543,"completionDateStruct":544,"leadSponsor":546,"locationsCount":45},"100644956","spsip-block-versus-esp-block-for-chronic-pain-after-unilateral-breast-surgery-100644956","NCT07674836","SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery","Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block for the Prevention of Chronic Postoperative Pain After Unilateral Breast Surgery: A Prospective, Randomized, Assessor-Blinded Trial","SPES-CPSP","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* ASA physical status I-III\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* Scheduled for elective unilateral breast surgery (mastectomy with or without sentinel lymph node biopsy)\n* Ability to understand and provide written informed consent\n\nExclusion Criteria:\n\n* Infection at the site of block application\n* Known allergy to local anesthetics\n* Coagulopathy or anticoagulant therapy\n* Chronic opioid use\n* Pregnancy\n* Inability to communicate or cooperate\n* Refusal to participate\n* Failed block\n* Requirement of additional intraoperative analgesia outside the study protocol\n* Development of serious intraoperative complications",{"count":21,"type":22},[25],"This prospective, randomized, assessor-blinded study will compare serratus posterior superior intercostal plane block and erector spinae plane block in adult female patients undergoing unilateral breast surgery. The primary outcome is chronic postoperative pain at 3 months, assessed using the Brief Pain Inventory-Short Form.",[31,538],"Opioid Use",[540,538],"Post Operative Pain","2026-08-04",{"date":463,"type":37},{"date":39,"type":37},{"date":545,"type":22},"2026-12-01",{"name":547,"class":75},"Engin Çetin",{"id":549,"slug":550,"hasResults":12,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":12,"sex":17,"minAge":555,"maxAge":4,"enrollmentInfo":556,"targetDuration":4,"studyType":23,"phases":558,"briefSummary":559,"conditions":560,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":564,"completionDateStruct":565,"leadSponsor":566,"locationsCount":4},"100650825","local-anesthetic-infiltration-for-pain-control-after-orthopedic-wide-excision-100650825","NCT07753629","Local Anesthetic Infiltration for Pain Control After Orthopedic Wide Excision","Analgesic Effect of Subcutaneous Local Infiltration Anesthesia Before Skin Closure on Postoperative Pain in Patients Undergoing Orthopedic Wide Excision: A Prospective Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Scheduled to undergo elective orthopedic wide excision surgery under general anesthesia\n* American Society of Anesthesiologists (ASA) Physical Status Classification 1, 2, or 3\n* Age 19 years or older\n\nExclusion Criteria:\n\n* Unwilling to provide informed consent\n* History of allergy to local anesthetics\n* History of chronic pain\n* Use of opioid analgesics within 24 hours before surgery\n* Active infection at the surgical site","19 Years",{"count":557,"type":22},58,[25],"This study evaluates whether injecting a local anesthetic mixture (ropivacaine, morphine, ketorolac, and epinephrine) under the skin at the incision site before wound closure reduces pain after orthopedic wide excision surgery for bone or soft tissue tumors. Participants will be randomly assigned to receive either the local anesthetic mixture or a saline control injection. Neither participants nor the study team assessing outcomes will know which treatment was given. The main goal is to determine whether this injection reduces the amount of opioid pain medication needed during the first 24 hours after surgery. The study will also assess pain scores, nausea and vomiting, and quality of recovery.",[561,31],"Wide Excision","2026-08-03",{"date":434,"type":37},{"date":434,"type":22},{"date":359,"type":22},{"name":567,"class":44},"Seoul National University Hospital",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":574,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":84,"enrollmentInfo":576,"targetDuration":4,"studyType":577,"phases":4,"briefSummary":578,"conditions":579,"keywords":581,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":585,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":45},"100650587","comparison-of-tlip-block-and-qip-block-for-postoperative-analgesia-after-lumbar-spine-surgery-100650587","NCT07750418","Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine Surgery","Comparison of the Efficacy of Classic Thoracolumbar Interfascial Plane (TLIP) Block and Quadratus Lumborum-Iliac Plane (QIP) Block for Postoperative Analgesia in Patients Undergoing Lumbar Vertebral Surgery: A Prospective Observational Study","TLIP-QIP","Inclusion Criteria:\n\n* Aged 18-65 years\n* ASA physical status I-II\n* Undergoing elective lumbar discectomy at up to two spinal levels under general anesthesia\n* Receiving classic TLIP block or QIP block for postoperative analgesia as part of routine clinical practice\n\nExclusion Criteria:\n\n* Hypersensitivity or allergy to study medications\n* Coagulopathy\n* Infection at the injection site\n* Severe neurological deficit\n* Chronic opioid use\n* Advanced hepatic or renal failure\n* Obesity (BMI \\>35 kg\u002Fm2)\n* Pregnancy\n* ASA physical status III-IV\n* Mental retardation\n* Inability to provide informed consent",{"count":126,"type":22},"OBSERVATIONAL","This study compares two regional anesthesia techniques used for pain control after lumbar spine surgery: the classic thoracolumbar interfascial plane (TLIP) block and the quadratus lumborum-iliac plane (QIP) block. Patients between 18 and 65 years of age who undergo elective lumbar discectomy (up to two spinal levels) will be observed based on which block their treating anesthesiologist chooses to use as part of routine clinical practice. No randomization or additional intervention beyond standard care will be performed. Researchers will record the total amount of opioid pain medication used in the first 24 hours after surgery, the time until the first request for pain medication, pain scores at several time points after surgery (0, 1, 2, 4, 8, 12, and 24 hours), and any side effects (such as nausea, vomiting, or sedation) or complications related to the block. The aim is to compare the effectiveness and safety of these two techniques in reducing pain and opioid use after lumbar spine surgery.",[580,31],"Lumbar Disc Herniation",[582,583,584,65],"Thoracolumbar Interfascial Plane Block","Quadratus Lumborum Block","Lumbar Discectomy",{"date":463,"type":37},{"date":587,"type":22},"2026-08-15",{"date":589,"type":22},"2026-12-31",{"name":591,"class":44},"Vezirköprü State Hospital",{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":19,"enrollmentInfo":598,"targetDuration":4,"studyType":23,"phases":600,"briefSummary":601,"conditions":602,"keywords":603,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":612,"completionDateStruct":613,"leadSponsor":615,"locationsCount":45},"100650410","effect-of-local-anesthetic-infiltration-for-postoperative-pain-control-in-laparoscopic-abdominal-surgery-a-prospective-randomized-study-100650410","NCT07747584","Effect of Local Anesthetic Infiltration for Postoperative Pain Control in Laparoscopic Abdominal Surgery: A Prospective Randomized Study","Inclusion Criteria:\n\nAdults aged 18 to 60 years. Scheduled for elective laparoscopic abdominal surgery (e.g., cholecystectomy, appendectomy, or hernia repair).\n\nAmerican Society of Anesthesiologists (ASA) physical status I or II. Able to understand and use the Visual Analog Scale (VAS) for pain assessment. Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\nIntraoperative conversion to open laparotomy. Known allergy, hypersensitivity, or contraindication to bupivacaine or other amide local anesthetics.\n\nPregnancy or breastfeeding. History of chronic pain syndromes or regular use of opioid or non-opioid analgesics before surgery.\n\nHistory of substance abuse or severe psychiatric disorders that may affect pain perception.\n\nLocal skin infection at the planned trocar insertion sites.",{"count":599,"type":22},166,[25],"Brief Summary\n\nPostoperative pain remains a common problem after laparoscopic abdominal surgery despite the minimally invasive nature of these procedures. Pain mainly arises from the trocar insertion sites, tissue manipulation, and the effects of pneumoperitoneum. Although systemic analgesics are routinely used, they may not provide adequate pain relief and can be associated with adverse effects.\n\nThis prospective randomized controlled trial aims to evaluate whether pre-incisional infiltration of bupivacaine at laparoscopic trocar insertion sites reduces postoperative pain compared with standard care without local anesthetic infiltration. A total of 166 adult patients undergoing elective laparoscopic abdominal surgery will be randomly assigned to receive either local bupivacaine infiltration before skin incision or no local anesthetic infiltration. All participants will receive the same standard perioperative care and postoperative analgesic regimen.\n\nThe primary outcome is postoperative pain intensity measured using the Visual Analog Scale (VAS) during the first 24 hours after surgery. Secondary outcomes include the time to first rescue analgesic, total opioid consumption within the first 24 hours, and overall postoperative pain control. The results of this study may help determine whether local bupivacaine infiltration is an effective, simple, and low-cost addition to multimodal analgesia for patients undergoing laparoscopic abdominal surgery.",[31],[31,604,605,430,606,607,66,608,609],"Laparoscopic Surgery","Laparoscopic Abdominal Surgery","Local Anesthetic Infiltration","Trocar Site Infiltration","Visual Analog Scale","Opioid Consumption","2026-07-31",{"date":518,"type":37},{"date":266,"type":22},{"date":614,"type":22},"2027-01",{"name":616,"class":44},"Allied Hospital Faisalabad",{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":623,"enrollmentInfo":624,"targetDuration":4,"studyType":23,"phases":626,"briefSummary":627,"conditions":628,"keywords":630,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":636,"locationsCount":45},"100503268","rectus-sheath-block-in-cardiac-surgery-100503268","NCT05833048","Rectus Sheath Block in Cardiac Surgery","Inclusion Criteria:\n\n* In order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n  1. Adults 18-85 years old\n  2. Scheduled to undergo cardiac procedures involving chest tubes\n  3. Male or female\n\nExclusion Criteria:\n\n* An individual who meets any of the following criteria will be excluded from participation in this study:\n\n  1. ASA class V\n  2. Urgent or emergent surgery\n  3. Contraindications to administration of local anesthesia (e.g. local anesthetic allergy)\n  4. History of substance abuse or chronic opioid use\n  5. Patient refusal or inability to consent","85 Years",{"count":625,"type":22},75,[25],"This is a prospective, randomized study. The purpose of this study is to evaluate the effect of post-surgical pain control of a type of peripheral nerve block, Rectus Sheath Block.\n\n1. Does the rectus sheath block decrease opioid consumption postoperatively after cardiac surgery?\n2. Does the rectus sheath block decrease VAS pain scores postoperatively after cardiac surgery? Study participants will be assigned to receive either rectus sheath block or no block.",[629,31],"Cardiac Disease",[184,462],"2026-07-30",{"date":610,"type":37},{"date":634,"type":37},"2024-07-29",{"date":589,"type":22},{"name":637,"class":44},"Icahn School of Medicine at Mount Sinai",{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":4,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":123,"minAge":53,"maxAge":231,"enrollmentInfo":645,"targetDuration":4,"studyType":23,"phases":646,"briefSummary":647,"conditions":648,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":45},"100648160","quadroiliac-plane-block-for-analgesia-after-renal-transplantation-100648160","NCT07716566","Quadroiliac Plane Block for Analgesia After Renal Transplantation","Analgesic Efficacy of Ultrasound-Guided Quadroiliac Plane Block Versus Surgical Wound Infiltration in Patients Undergoing Renal Transplantation: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* American Society of Anesthesiologists physical status I-III\n* Scheduled to undergo renal transplantation surgery\n* Ability to understand the study procedures and postoperative assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Known allergy to bupivacaine or other amide-type local anesthetics\n* Infection at the planned injection site\n* Coagulopathy or anticoagulant therapy associated with an unacceptable bleeding risk for regional anesthesia\n* Sepsis\n* Severe spinal deformity or anatomical abnormality preventing performance of the quadroiliac plane block\n* Inability to cooperate or communicate reliably\n* Cognitive impairment or intellectual disability preventing informed consent or reliable outcome assessment\n* Altered level of consciousness\n* Breastfeeding\n* Refusal to participate",{"count":126,"type":22},[25],"Renal transplantation is a major abdominal surgical procedure that may cause moderate to severe postoperative pain. Opioids are commonly used as part of multimodal analgesia; however, opioid-related adverse effects such as sedation, respiratory depression, nausea, vomiting, and constipation may delay recovery and mobilization.\n\nThe quadroiliac plane block is an ultrasound-guided interfascial plane block performed near the attachment of the quadratus lumborum muscle to the iliac crest. The technique may provide analgesia over a broad lower abdominal area and may reduce postoperative opioid requirements.\n\nThis prospective, randomized, double-blind, controlled clinical trial will compare an ultrasound-guided unilateral quadroiliac plane block with surgical wound infiltration in adult patients undergoing renal transplantation. Participants will be randomly assigned to receive either a quadroiliac plane block with 40 mL of 0.25% bupivacaine or surgical wound infiltration with 10 mL of 0.25% bupivacaine.\n\nAll participants will receive standardized multimodal analgesia and intravenous patient-controlled analgesia with tramadol. The primary objective is to compare cumulative tramadol consumption during the first 24 hours after surgery. Postoperative pain scores, dermatomal sensory distribution, motor block, nausea, vomiting, sedation, and quality of recovery will also be evaluated.",[31],"2026-07-29",{"date":631,"type":37},{"date":652,"type":22},"2026-07-20",{"date":654,"type":22},"2027-07-21",{"name":656,"class":44},"Kanuni Sultan Suleyman Training and Research Hospital"]