[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-sore-throat\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-sore-throat":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,76,98,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100650242","testing-two-doses-of-nebulized-ketamine-for-postoperative-sore-throat-100650242",false,"NCT07746115","Testing Two Doses of Nebulized Ketamine for Postoperative Sore Throat","Optimizing Nebulized Ketamine for Postoperative Sore Throat Relief: A Placebo-Controlled Randomized Trial","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Scheduled for elective surgery under general anesthesia requiring endotracheal intubation.\n* Able to provide written informed consent.\n* Willing to comply with all study procedures and follow-up assessments.\n\nExclusion Criteria:\n\n* Known hypersensitivity or allergy to ketamine.\n* Pre-existing sore throat, hoarseness, or significant upper airway pathology.\n* Current upper respiratory tract infection.\n* Anticipated difficult airway or more than one intubation attempt.\n* Surgery involving the upper airway, oral cavity, pharynx, larynx, or maxillofacial region.\n* Severe cardiovascular disease or uncontrolled hypertension.\n* Severe respiratory disease.\n* Pregnancy or breastfeeding.\n* History of psychiatric illness or psychosis.\n* Chronic opioid use or regular use of analgesic or anti-inflammatory medications.\n* Inability to communicate postoperative symptoms or complete study assessments.","ALL","18 Years","65 Years",{"count":20,"type":21},195,"ESTIMATED","INTERVENTIONAL",[24],"NA","Postoperative sore throat (POST) is one of the most common complications following general anesthesia with endotracheal intubation, affecting patient comfort, delaying recovery, and reducing overall satisfaction with perioperative care. Although POST is usually self-limiting, its high incidence makes it an important target for preventive interventions.\n\nNebulized ketamine has emerged as a promising non-invasive strategy for reducing POST because of its local analgesic and anti-inflammatory effects mediated through N-methyl-D-aspartate (NMDA) receptor antagonism. Previous randomized trials and systematic reviews have demonstrated that nebulized ketamine can reduce both the incidence and severity of POST compared with placebo. However, most published studies have evaluated a single 50-mg dose, and the minimum effective dose remains uncertain.\n\nThis prospective, randomized, placebo-controlled, double-blind clinical trial aims to compare the efficacy and safety of two preoperative doses of nebulized ketamine (25 mg and 50 mg) with placebo in adult patients undergoing elective surgery under general anesthesia with endotracheal intubation. Participants aged 18-65 years with American Society of Anesthesiologists (ASA) physical status I or II will be randomly assigned in a 1:1:1 ratio to receive nebulized ketamine 25 mg, nebulized ketamine 50 mg, or nebulized normal saline 15 minutes before induction of anesthesia.\n\nThe primary outcome is the incidence of postoperative sore throat assessed at 2, 4, 6, 12, and 24 hours after surgery using a standardized four-point grading scale. Secondary outcomes include the severity of POST, postoperative pain intensity measured using the Visual Analog Scale (VAS), patient satisfaction, need for rescue analgesia, sedation assessed using the Ramsay Sedation Scale, and the incidence of adverse effects, including nausea, dizziness, and hallucinations.\n\nThe study hypothesizes that a lower dose of nebulized ketamine (25 mg) will provide comparable protection against postoperative sore throat to the conventional 50-mg dose while minimizing dose-related adverse effects. Identifying the minimum effective dose may improve the safety profile, optimize perioperative patient comfort, and support evidence-based recommendations for preventing postoperative sore throat after endotracheal intubation.",[27],"Postoperative Sore Throat","NOT_YET_RECRUITING","2026-08-04",{"date":31,"type":32},"2026-08-05","ACTUAL",{"date":34,"type":21},"2026-08-15",{"date":36,"type":21},"2027-03-01",{"name":38,"class":39},"Aswan University Hospital","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":49,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100626832","low-flow-sevoflurane-and-desflurane-anesthesia-in-laparoscopic-cholecystectomy-100626832","NCT07440758","Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy","The Effect of Low-Flow Sevoflurane and Low-Flow Desflurane Anesthesia on Postoperative Sore Throat in Laparoscopic Cholecystectomy Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Aged between 18 and 65 years\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with a recent history of upper respiratory tract infection\n* Patients with a recent history of sore throat\n* Patients with chronic cough\n* Patients with a history of previous neck or tracheal surgery\n* Patients with predictors of difficult intubation\n* Patients with a history of difficult intubation\n* Obese patients (BMI \\> 35 kg\u002Fm²)\n* Patients with chronic respiratory diseases (asthma, COPD)\n* Pregnancy\n* Use of dexamethasone\n* Patients with hepatic impairment\n* Patients with allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide\n* Patients with known allergy to halogenated anesthetic agents\n* Patients with a history of malignant hyperthermia\n* Patients with mental disorders or those unable to provide reliable assessment",{"count":48,"type":21},70,[24],"Several studies have demonstrated that inhalational anesthetic agents such as desflurane and sevoflurane may cause varying degrees of postoperative sore throat, hoarseness, and cough in orotracheally intubated patients. However, data evaluating these outcomes under low-flow anesthesia conditions remain limited and insufficient.\n\nThis single-center, prospective, randomized controlled study will be conducted in patients aged 18-65 years, classified as American Society of Anesthesiologists (ASA) physical status I-II, who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent to participate in the study.\n\nThe primary objective of the study is to compare the effects of low-flow desflurane and low-flow sevoflurane anesthesia on the incidence and severity of postoperative sore throat.\n\nThe secondary outcomes include the evaluation of postoperative hoarseness and cough, the incidence of postoperative nausea and vomiting (PONV), and the total consumption of inhalational anesthetic agents.",[52,27],"Laparoscopic Cholecystectomy",[54,55,56,57,58,59,60,61,62,63,64],"Postoperative sore throat","Low-flow anesthesia","Sevoflurane","Desflurane","Laparoscopic cholecystectomy","General anesthesia","Orotracheal intubation","Endotracheal cuff pressure","Postoperative complications","Postoperative nausea and vomiting","PONV","RECRUITING","2026-08-03",{"date":31,"type":32},{"date":69,"type":32},"2026-03-20",{"date":71,"type":21},"2026-07-30",{"name":73,"class":74},"Kayseri City Hospital","OTHER_GOV",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100622239","comparison-of-nebulized-ketamine-with-nebulized-magnesium-sulfate-for-the-prevention-of-postoperative-sore-throat-100622239","NCT07381036","Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat","Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat in Adult Surgical Patients Undergoing General Anesthesia: Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years old.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Elective surgery requiring GA with endotracheal intubation.\n\n  \\- Exclusion Criteria:\n* Surgery involves the oral cavity, nasopharynx, larynx, and neck regions.\n* Surgery requires prone position.\n* Surgery lasted more than 3 hours.\n* History of preoperative sore throat, common cold.\n* Anticipated difficult airway.\n* Any known allergies to study drugs.\n* Recent non-steroidal anti-inflammatory drugs use.\n* Pregnancy.",true,{"count":85,"type":21},150,[24],"The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST.\n\n* Primary outcome\n\n  • To compare the incidence of POST method.\n* Secondary outcomes\n\n  * Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative.\n  * The hemodynamics recording (HR, BP, MBP, pre and post nebulization)\n  * Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)",[27],"2026-01-30",{"date":91,"type":32},"2026-02-03",{"date":93,"type":21},"2026-02-01",{"date":95,"type":21},"2026-09-01",{"name":97,"class":39},"Sohag University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":105,"minAge":17,"maxAge":18,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":115,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":75},"100619209","effect-of-cuff-pressure-assessment-methods-on-postoperative-complications-in-breast-surgery-100619209","NCT07341646","Effect of Cuff Pressure Assessment Methods on Postoperative Complications in Breast Surgery","The Effect of Endotracheal Tube Cuff Pressure Assessment Methods on Postoperative Complications in Patients Undergoing Elective Breast Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female patients aged 18 to 65 years.\n* Patients classified as American Society of Anesthesiologists (ASA) physical status I, II, or III.\n* Patients scheduled for elective breast surgery requiring general anesthesia and endotracheal intubation.\n* Patients who provide voluntary written informed consent to participate.\n\nExclusion Criteria:\n\n* Patients with a history of Chronic Obstructive Pulmonary Disease (COPD) or an asthma attack within the last 6 months.\n* Presence of preoperative sore throat, hoarseness, or cough.\n* Patients with predicted difficult intubation or those who are difficult to intubate.\n* Patients with communication difficulties that prevent accurate assessment of symptoms.\n* Patients whose surgery duration exceeds 3 hours.\n* Patients older than 65 years.","FEMALE",{"count":107,"type":21},90,[24],"Endotracheal intubation is a standard procedure used to secure the airway during general anesthesia. A key component of the breathing tube is the \"cuff,\" a balloon-like device that is inflated to seal the airway and prevent aspiration. However, if the pressure within this cuff is too high, it can restrict blood flow to the tracheal lining, leading to complications such as postoperative sore throat, hoarseness, and difficulty swallowing (dysphagia).\n\nCurrently, there are various methods to monitor and adjust this pressure. In many clinical practices, the pressure is adjusted subjectively or checked only once at the beginning of the surgery. These methods may allow pressure to exceed safe limits (typically 20-30 cmH₂O) or fluctuate during the procedure, potentially causing tissue irritation. This randomized controlled trial aims to compare three different methods of assessing and maintaining endotracheal tube cuff pressure to determine which is most effective at reducing postoperative complications. The study focuses on women undergoing elective breast surgery, a group chosen because the surgery typically lasts 1-3 hours and does not involve major changes in head and neck position, allowing for a clear assessment of the cuff pressure methods.\n\nParticipants will be randomly assigned to one of three groups:\n\n* Continuous Monitoring Group: Cuff pressure is monitored continuously using a pressure indicator and maintained within the 20-30 cmH₂O range throughout the surgery.\n* Manometer Group: Cuff pressure is measured and set to 20-30 cmH₂O using a manual manometer once, immediately after intubation.\n* Control Group (Minimal Occlusive Volume): The cuff is inflated with the minimum amount of air required to prevent an air leak, without using a pressure gauge.\n\nResearchers will assess patients for sore throat, cough, hoarseness, and swallowing difficulties at 0, 1, 12, and 24 hours after surgery to identify the safest and most comfortable method for airway management.",[111,27,112,113,114],"Airway Complications","Hoarseness","Dysphagia","Cough Severity",[116,117,118,27,111,119],"Continuous Cuff Pressure Monitoring","Manometer","Endotracheal Tube Cuff Pressure","Intubation Safety","2026-01-14",{"date":122,"type":32},"2026-01-15",{"date":124,"type":21},"2026-03-01",{"date":126,"type":21},"2027-06-01",{"name":128,"class":39},"Izmir Katip Celebi University",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":138,"phases":4,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":4},"100599725","establishment-of-prediction-model-for-postoperative-sore-throat-100599725","NCT07088224","Establishment of Prediction Model for Postoperative Sore Throat","Analysis of Risk Factors and Establishment of Prediction Model for Postoperative Sore Throat After Thyroid Surgery Under General Anesthesia","Inclusion Criteria:\n\nAge ≥ 18 years； Undergoing thyroid surgery under general anesthesia, including both open and endoscopic procedures； Complete postoperative follow-up records available (minimum 48 hours)； Accessible and complete surgical and anesthesia records； Provision of written informed consent by the patient or their legally authorized representative；\n\nExclusion Criteria:\n\nFailed tracheal intubation or need for emergency tracheotomy during surgery； Reoperation required due to postoperative complications such as bleeding or nerve injury； Severe cardiopulmonary disease (ASA physical status ≥ IV) or long-term use of corticosteroids； Incomplete clinical data；",{"count":137,"type":21},375,"OBSERVATIONAL","This observational study aims to identify the risk factors associated with postoperative sore throat (POST) and to develop a clinical prediction model for patients undergoing thyroid surgery under general anesthesia. Despite improvements in surgical and anesthetic techniques, POST remains one of the most common complications following thyroidectomy, with an incidence of up to 80%. POST can significantly impact patient comfort, swallowing function, nutritional intake, and recovery quality, leading to prolonged hospitalization and increased healthcare costs.\n\nThe etiology of POST is multifactorial, involving intubation-related factors (e.g., endotracheal tube size, cuff pressure), surgery-related factors (e.g., duration of surgery, neck hyperextension), and patient-related factors (e.g., age, sex, smoking history, pre-existing throat symptoms). However, large-scale, systematic studies in the Chinese population remain limited.\n\nWith the increasing adoption of Enhanced Recovery After Surgery (ERAS) principles, the accurate identification of modifiable risk factors and early prediction of POST risk are essential for targeted preventive strategies and improved perioperative management. Recent advancements in machine learning and statistical modeling allow for the development of personalized, multifactorial risk assessment tools.\n\nIn this study, clinical data from patients undergoing thyroid surgery at Nanjing First Hospital will be collected and analyzed. The primary goal is to identify key preoperative and intraoperative predictors of POST and to establish a multivariable nomogram-based prediction model. Internal validation using bootstrap methods will be performed to evaluate the model's discrimination, calibration, and clinical utility, ultimately supporting evidence-based interventions to improve postoperative outcomes and patient satisfaction.",[27],"2025-07-20",{"date":143,"type":32},"2025-07-28",{"date":145,"type":21},"2025-08-01",{"date":147,"type":21},"2026-07-31",{"name":149,"class":39},"Nanjing First Hospital, Nanjing Medical University"]