[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-wound-healing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-wound-healing":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100649323","accuracy-and-healing-outcomes-of-endodontic-surgery-using-a-static-surgical-guide-100649323",false,"NCT07734987","Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide.","Evaluation of the Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide: A Prospective Longitudinal Cohort Clinical Trial.","Inclusion Criteria:\n\n1. Patient is aged 16 years or older.\n2. Patient possesses a healthy or stable systemic physical status classification (ASA I or II).\n3. Presence of at least one permanent tooth displaying a distinct clinical indication for apical endodontic surgery.\n4. The estimated post-resection crown-to-root ratio of the target tooth remains \\\u003C= 1.\n5. The periapical radiolucency features a well-defined maximum radiographic dimension of \\>= 5 mm on CBCT.\n6. The target tooth has no history of previous surgical root-end resection procedures.\n7. The lesion does not directly involve or impinge upon hazardous adjacent anatomical structures (e.g., the inferior alveolar nerve canal, the maxillary sinus floor, or the mental foramen).\n8. The presence of at least three stable, non-mobile permanent teeth within the same dental arch to serve as reliable anchor units to support the surgical template.\n9. Patient is fully capable and willing to provide signed written informed consent.\n\nExclusion Criteria:\n\n1. Women who are currently pregnant or breastfeeding.\n2. History of known allergy or systemic hypersensitivity to amide local anesthetics, epinephrine co-agents, or any structural resins and bioceramic materials utilized in this protocol.\n3. Extensive metal restorations, crowns, or massive fixed partial dentures adjacent to the target site that generate severe radiographic scattering artifacts, compromising CBCT measurement quality.\n4. Target tooth displays clinical evidence of a vertical root fracture, non-restorable structural crown destruction, or advanced localized periodontitis.\n5. Massive periapical pathology requiring a root-end resection length exceeding 3 mm, or necessitating excessive mechanical field widening beyond the template boundaries to achieve surgical curettage.\n6. Inadequate stability, rocking, or poor fit of the printed surgical guide during the intraoral verification phase.\n7. Patient demonstrates non-compliance or is unable to return for scheduled longitudinal follow-ups and imaging appointments.","ALL","16 Years",{"count":19,"type":20},11,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to evaluate the surgical accuracy and healing outcomes of endodontic surgery performed with the assistance of a 3D-printed static surgical guide in patients requiring apicoectomy.\n\nThe main questions it aims to answer are:\n\n1. What is the level of positional and angular accuracy of the actual root-end resection compared to the virtual planning when utilizing a static surgical guide?\n2. What are the postoperative pain and swelling levels reported by patients at 1, 3, and 7 days after undergoing guided endodontic surgery?\n3. What are the clinical success rates and CBCT-based radiographic healing outcomes at 6 months postoperatively?\n\nParticipants will:\n\n* Undergo a preoperative digital workflow combining CBCT data and intraoral surface scans to design a customized static surgical guide.\n* Undergo targeted endodontic surgery where a 4.5-mm trephine bur is guided through the static template to perform the osteotomy and a 3-mm root-end resection in a single step.\n* Receive retrograde root-end cavity preparation via ultrasonic tips and root-end filling using calcium aluminosilicate bioceramic paste (Well-Root PT).\n* Complete self-evaluation forms regarding pain and swelling on postoperative days 1, 3, and 7.\n* Return for follow-up examinations at 1 week (for suture removal) and at 6 months for definitive clinical evaluations, as well as follow-up multi-planar CBCT imaging to evaluate both periapical bone healing and surgical accuracy via superimposition with the baseline preoperative plan.",[26,27,28,29],"Periapical Periodontitis","Periradicular Lesion","Endodontic Treatment Failure","Postoperative Wound Healing",[31],"Static surgical guide, Endodontic surgery, Apicoectomy, Cone Beam Computed Tomography, Trephine bur, Well-Root PT, Structural accuracy, Bone healing outcomes","RECRUITING","2026-07-24",{"date":35,"type":36},"2026-07-29","ACTUAL",{"date":38,"type":20},"2026-07-01",{"date":40,"type":20},"2027-09",{"name":42,"class":43},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":44},"100622649","wound-healing-and-bacterial-adherence-with-triclosan-coated-sutures-after-mandibular-impacted-third-molar-surgery-100622649","NCT07386366","Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery","Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 35 years.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees.\n* No use of topical or systemic antibiotics for at least 4 weeks before surgery.\n* Able and willing to provide written informed consent.\n* No active infection associated with the mandibular third molar at the time of enrollment.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study.\n* Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar.\n* Participant withdraws consent or does not agree to continue participation.\n* Unable to attend scheduled follow-up visits.\n* Difference in surgical extraction time between the two procedures is 12 minutes or more.\n* Suture loss\u002Floosening before completion of the final assessment time point.",true,"18 Years","35 Years",{"count":56,"type":20},14,[23],"The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years.\n\nThe main questions it aims to answer are:\n\n1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n\nParticipants will:\n\n* Have surgery to remove two similar lower impacted wisdom teeth (one on each side)\n* Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random\n* Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.",[60,29],"Impacted Mandibular Third Molar",[62,63,64,65,66,67,68,69],"Triclosan-coated suture","Polyglactin 910","Impacted third molar surgery","Mandibular third molar","Oral surgery","Postoperative wound healing","Bacterial adhesion","Antibacterial suture","2026-07-19",{"date":72,"type":36},"2026-07-21",{"date":74,"type":36},"2025-10-07",{"date":76,"type":20},"2026-07",{"name":42,"class":43}]