[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"predictive-learning-models\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:predictive-learning-models":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100647843","development-of-a-prediction-score-for-the-occurrence-of-death-or-lung-transplantation-in-patients-with-emphysema-secondary-to-alpha-1-anti-tripsin-deficiency-100647843",false,"NCT07715617","Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency","FLARE","1. Inclusion criteria:\n\n   * diagnosed between 2010 and 2025\n   * in the pulmonology department\n   * diagnosis of emphysema and COPD secondary to alpha-1 antitrypsin deficiency ZZ, Znull, ZMalton, Z and rare mutations,\n   * emphysema according to the initial thoracic CT scan (+\u002F- 12 months after diagnosis).\n2. Exclusion criteria:\n\n   * Age \\\u003C18 years\n   * Patient opposed to the use of their data for research purposes\n   * Patient deprived of liberty by judicial decision\n   * Patient not affiliated with a social security scheme\n   * no CT scan available\n   * no lung function test available the year around CT scan","ALL","18 Years",{"count":19,"type":20},230,"ESTIMATED","OBSERVATIONAL","Emphysema linked to alpha-1-antitrypsin deficiency (DAAT): towards a better prediction of risks Emphysema caused by alpha-1-antitrypsin deficiency (DAAT) is a rare genetic disorder that can lead to serious complications, such as the need for a lung transplant or death, affecting up to 15% of patients. The only specific treatment available is a weekly infusion of alpha-1-antitrypsin (IV-AAT), an expensive and burdensome therapy.\n\nCurrently, there is no reliable model to predict the course of the disease in these patients. Our study, conducted in several French hospitals, aims to develop a prediction tool combining clinical, biological, functional data and advanced medical image analysis (lung CT). This model will make it possible to identify the most at-risk patients, in order to better adapt their care, anticipate transplant needs and avoid unnecessary treatments for low-risk patients.\n\nUltimately, this approach could also improve access to care for patients who need it most, while optimizing health system resources.",[24,25,26,27,28,29],"Alpha-1-antitrypsin Deficiency","Emphysema","Artificial Intelligence (AI)","Predictive Learning Models","Mortality Prediction","Lung Transplantation","RECRUITING","2026-07-15",{"date":33,"type":34},"2026-07-20","ACTUAL",{"date":36,"type":34},"2026-02-16",{"date":38,"type":20},"2031-03-16",{"name":40,"class":41},"University Hospital, Bordeaux","OTHER",4]