[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prenatal-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prenatal-stress":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100649681","perinatal-autism-genetics-and-epigenetics-study-100649681",false,"NCT07738003","Perinatal Autism Genetics and Epigenetics Study","Perinatal Experience and Epigenetic Change in Autism: Discovering Modifiable Pathways for Intervention","PAGES","Inclusion Criteria:\n\nA. Criteria for Pregnant Women:\n\n1. Pregnant women in their 1st or 2nd trimester of a singleton pregnancy.\n2. Age 18 to 50 years\n3. Currently use a smart phone\n\nB. ASD Group at age 18 to 27 months\n\n1. M-CHAT score \\>= 4 or POSI score \\>= 3\n2. Child has subsequently clinically confirmed diagnosis of ASD, based on ADOS\u002FTAP testing and\u002For other clinical evaluation\n\nC. Developmental Delay (DD) Group at age 18 to 27-months\n\n1. Developmental screening score on SWYC in the \"at risk\" range.\n2. Child has subsequently clinically confirmed developmental delay on clinical evaluation and\u002For self-report measure\n\nD. Typically Developing (TD) Group at age 18 to 27 months - None\n\nExclusion Criteria:\n\nA. Criteria for Pregnant Women:\n\n1. Non-English speaking mother\n2. History of severe mental illness in the past year, resulting in inpatient admission\n\nB. All children\n\n1. \\\u003C35 weeks gestational age at birth\n2. History of serious neonatal complications requiring NICU admission for one week or more\n3. Known genetic or syndromic condition (e.g. Down Syndrome, etc.) that impacts learning and brain development\n4. Hearing impairment\n\nC. ASD Group at age 18 to 27 months\n\n\\- None\n\nD. Developmental Delay (DD) Group at age 18 to 27 months\n\n1. Screen positive for ASD (M-CHAT \\>= 4 AND POSI \\>= 3)\n2. First-degree relative who has been diagnosed with ASD\n\nE. Typically Developing (TD) Group at age 18 to 27 months\n\n1. Screen positive for ASD (M-CHAT \\>= 4 AND POSI \\>= 3)\n2. Developmental screening\u002Fassessment score in the \"at risk\" range.\n3. First-degree relative who has been diagnosed with ASD",true,"ALL","0 Years","50 Years",{"count":22,"type":23},7200,"ESTIMATED","OBSERVATIONAL","The University of Iowa's Center for Disabilities and Development is researching how pregnancy, early childhood experiences, and genetic factors influence child development, with a focus on autism spectrum disorder (ASD). Pregnant women are invited to participate in a study that tracks their pregnancy and child's early development, through simple, at-home activities using a cell phone. Participants complete short questionnaires, join an online interview, and videotape their baby's play after birth. They are also sent a kit to swab their baby's mouth to collect cheek cells for genetic testing. The study will explore whether stress and early social experience lead to genetic changes associated with autism or other developmental conditions.",[27,28,29,30],"Autism Disorders and Maternal Stress","Development Delay","Prenatal Stress","Social Behavior",[32,33,34,35,36],"autism","epigenetics","prenatal stress","social experience","developmental delay","RECRUITING","2026-07-31",{"date":40,"type":41},"2026-08-03","ACTUAL",{"date":43,"type":41},"2026-05-12",{"date":45,"type":23},"2030-05",{"name":47,"class":48},"University of Iowa","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":49},"100624860","the-effect-of-mindfulness-based-childbirth-education-on-fear-of-birth-prenatal-stress-and-childbirth-self-efficacy-100624860","NCT07415122","The Effect of Mindfulness-Based Childbirth Education on Fear of Birth, Prenatal Stress, and Childbirth Self-Efficacy","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n\n  * Gestational age between 28 and 38 weeks\n  * Primiparous (first pregnancy)\n  * Able to understand and speak Turkish\n  * No communication problems that would hinder participation\n  * No high-risk pregnancy as determined by a physician\n  * Able to read and write\n  * Willing to participate in the study and providing informed consent\n\nExclusion Criteria:\n\n* • Pregnant women with high-risk pregnancies (history of antepartum bleeding, intrauterine growth restriction, placenta previa, membrane rupture, preeclampsia, hypertension, diabetes, or other medical conditions, fetal anomalies, or any contraindication to normal vaginal delivery, substance or alcohol dependence)\n\n  * pregnant women with a diagnosed psychiatric illness or who have undergone psychotherapy or medication treatment in the last six months,\n  * pregnant women who have previously participated in childbirth preparation classes,\n  * pregnant women with experience in yoga and meditation before or during pregnancy,\n  * pregnant women with chronic illnesses,\n  * pregnant women who are foreign nationals.","FEMALE","18 Years",{"count":59,"type":23},80,"INTERVENTIONAL",[62],"NA","This randomized controlled trial aims to evaluate the effect of mindfulness practices integrated into childbirth preparation education on fear of childbirth, prenatal stress, and childbirth self-efficacy in pregnant women.Participants will be randomly assigned either to the childbirth education group with mindfulness practices or to the standard childbirth education\u002Fcontrol group. Results will be evaluated using the prenatal self-assessment childbirth fear subscale, the perceived stress scale before childbirth, and the self-efficacy scale during labor before and after intervention.This study aims to provide evidence on whether mindfulness practices in childbirth preparation classes affect pregnant women's fear of childbirth, prenatal stress, and childbirth self-efficacy.",[29,65,66],"Childbirth Self-efficacy","Fear of Childbirth",[68,69,70,71,72,73],"Mindfulness","Childbirth Preparation Education","Pregnancy","Midwifery","Randomized Controlled Trial","Maternal Mental Health","NOT_YET_RECRUITING","2026-02-16",{"date":77,"type":41},"2026-02-18",{"date":79,"type":23},"2026-02-01",{"date":81,"type":23},"2026-07-15",{"name":83,"class":48},"Ondokuz Mayıs University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":17,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":60,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":49},"100567070","laughter-yogas-impact-on-traumatic-childbirth-preparation-100567070","NCT06663397","Laughter Yoga's Impact on Traumatic Childbirth Preparation","The Effects Of Laughter Yoga-Supported Childbirth Preparation Training On Traumatic Birth Perception, Fear Of Birth, Prenatal Depression, And Attachment: A Randomized Controlled Study","Inclusion Criteria:\n\n* Women aged 18 years and older.\n* Pregnant individuals between 20-26 weeks of gestation (Childbirth preparation training should begin by the 20th week of pregnancy according to the recommendations of the Turkish Ministry of Health, and since the training is planned to last 4 weeks, participants will be recruited before entering the third trimester).\n* First-time pregnancies.\n* Individuals who understand, speak, and can read and write in Turkish.\n* Women who consent to participate in the study.\n\nExclusion Criteria:\n\n* Women with high-risk pregnancies (such as placenta previa, history of antepartum bleeding, ruptured membranes, preeclampsia, hypertension, diabetes, or other medical conditions, intrauterine growth restriction, multiple pregnancies, fetal anomalies, or any contraindications for normal vaginal delivery, substance or alcohol dependence, chronic illnesses, etc.).\n* Individuals diagnosed with psychiatric disorders.\n* Those who have received psychotherapy or medication within the last six months prior to the study.\n* Pregnant women with prior training or experience in cognitive awareness-based or mind-body methods.",{"count":92,"type":23},68,[62],"This study will be conducted as a single-center, parallel-group, randomized controlled intervention trial to determine the effects of birth preparation training supported by laughter yoga on the perception of traumatic birth, fear of birth, prenatal depression, and attachment in primiparous women. The research population will consist of pregnant women who attend the Pregnancy Clinic of the Department of Obstetrics and Gynecology at Cebeci Medical Faculty, Ankara University. The study will involve two groups: the first group will receive birth preparation training supported by laughter yoga, while the second group will receive standard birth preparation training. A total of 68 pregnant women, 34 in each group, are planned to participate in the study. Data will be collected using the Introductory Information Form, Traumatic Birth Perception Scale, Prenatal Self-Assessment Scale Fear of Birth Subscale, Edinburgh Depression Scale, and Prenatal Attachment Inventory. These instruments will be administered to the participants three times: before the training, immediately after the training, and one month later. The research data will be analyzed using the Statistical Package for Social Sciences (SPSS) version 24. Descriptive statistics (number, percentage, mean, standard deviation, minimum, and maximum values) will be used for data analysis. Independent samples t-test will be employed for comparisons between two independent groups, paired samples t-test will be used for repeated measures, one-way ANOVA will be used for comparisons among more than two groups, and Pearson correlation analysis will be applied for the relationship between two quantitative variables.\n\nWhen data do not follow a normal distribution, the Mann-Whitney U test will be used for comparisons between two independent groups, the Wilcoxon signed-rank test will be used for repeated measures, the Kruskal-Wallis test will be used for comparisons among more than two groups, and Spearman correlation analysis will be used for the relationship between two quantitative variables. The reliability of the scales used in the study will be determined using Cronbach's alpha coefficient. Statistical significance will be set at p \\< 0.05.",[96,29,97],"Maternal Distress","Pregnancy Related",[99,66,100,101,102,103],"Perception of Traumatic Birth","Prenatal Depression","Prenatal Attachment","Laughter Yoga","Childbirth Preparation Training","2024-10-27",{"date":106,"type":41},"2024-10-29",{"date":108,"type":23},"2024-12-30",{"date":110,"type":23},"2026-03-31",{"name":112,"class":48},"Ankara University"]