[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prf\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prf":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100648182","the-effect-of-using-different-scaffolds-in-retreated-teeth-on-the-clinical-and-radiological-success-of-regenerative-endodontic-treatment-100648182",false,"NCT07721051","The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment","Inclusion Criteria:\n\n* Patients aged 16-40 who are systemically healthy\n* Patients who have a permanent tooth with a single root canal and fully developed root that requires retreatment\n* Patients who may or may not have periapical radiolucency\n\nExclusion Criteria:\n\n* Patients who require antibiotic prophylaxis\n* Patients with systemic conditions such as diabetes or hematological disorders\n* Patients who have taken antibiotics, anti-inflammatory medications, and\u002For antidepressants within the past three weeks\n* Patients who are pregnant or suspect they may be pregnant during treatment\n* Patients with heavy plaque and tartar buildup on their teeth\n* Patients with redness and bleeding of the gums\n* Patients with severe gingivitis, generalized periodontitis, or a periodontal pocket depth of more than 3 mm\n* Patients with internal or external root resorption\n* Patients for whom complete isolation with a rubber dam cannot be achieved\n* Patients with an open, immature root apex\n* Patients with horizontal or vertical fractures\n* Patients with teeth having multiple roots or root canals","ALL","16 Years","40 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.\n\nParticipants will be randomly assigned to one of four groups based on the scaffold used: induced blood clot, injectable platelet-rich fibrin (i-PRF), advanced platelet-rich fibrin (A-PRF), or advanced platelet-rich fibrin plus (A-PRF+). All participants will receive the same root canal disinfection and restorative procedures, with the scaffold type differing between the groups.\n\nParticipants will be evaluated clinically and radiographically at 3, 6, and 12 months after treatment. The study will compare the groups in terms of the resolution of clinical signs and symptoms and changes observed on radiographic and cone-beam computed tomography images.",[24,25,26,27,28,29,30],"Endodontics","Regenerative Endodontic Procedures","PRF","i-PRF","Retreatment","A-PRF","A-PRF Plus",[32,33,29,34,27],"Regenerative endodontic procedures","retreatment","A-PRF plus","NOT_YET_RECRUITING","2026-07-19",{"date":38,"type":39},"2026-07-22","ACTUAL",{"date":41,"type":20},"2026-10-01",{"date":43,"type":20},"2028-03-01",{"name":45,"class":46},"Kırıkkale University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":15,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100641906","evaluation-of-multilayered-prf-in-comparison-with-connective-tissue-graft-by-sohn-ponchos-technique-on-peri-implant-mucosal-enhancement-in-the-esthetic-zone-100641906","NCT07649239","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone. A Randomized Clinical Trial","-Inclusion Criteria: Patients with single bounded missing tooth in the esthetic zone Patients in the age group of 21-65 years Patients having good oral hygiene (mean plaque score of \\\u003C 25%) and with stable periodontal status.\n\n-Exclusion Criteria: Smokers patients Patients with poor maintenance of oral hygiene, as determined by a mean plaque score of ≥ 25% despite efforts by the clinician to improve oral hygiene maintenance.\n\nPatients with medically compromised conditions like uncontrolled diabetes mellitus or any systemic diseases that may result in compromised hard and soft tissue healing.",true,"20 Years","70 Years",{"count":58,"type":20},26,"INTERVENTIONAL",[61],"NA","An effective biological seal is crucial for protecting and supporting dental implants, particularly in the anterior region for the desired esthetic outcome.PRF membrane and CTG has been utilized to improve peri-implant soft tissue thickness and increase the width of keratinized tissue around dental implants. The stability of the PRF membrane is maintained by securing it with the healing abutment of the implant. While a few longitudinal studies have assessed the benefits of using PRF membrane with Sohn's Poncho technique in the posterior region, its effectiveness in the anterior region of the mouth remains to be evaluated.",[64,65,66,67,26],"Soft Tissue","Peri-Implant Health","Soft Tissue Augmentation at Dental Implants","Connective Tissue Graft","RECRUITING","2026-06-12",{"date":71,"type":39},"2026-06-16",{"date":73,"type":39},"2026-01-10",{"date":75,"type":20},"2027-02-01",{"name":77,"class":46},"Gulf Medical University",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":26,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":15,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":59,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":78},"100547327","topical-application-of-prf-before-radiation-therapy-100547327","NCT06406530","Topical Application of PRF Before Radiation Therapy","Topical Application of PRF in Tooth Extraction Sockets Before Radiation Therapy for Head and Neck Cancer","Inclusion Criteria:\n\n* Head and neck cancer with planed radiation therapy\n* Bilateral tooth extraction\n* Similar tooth size\n* Atraumatic tooth extractions without flap surgery\n* Patients age above 18y of age\n\nExclusion Criteria:\n\n* Prior radiation therapy in the head and neck area\n* Prior and current therapy with bisphosphonates or equivalent modern biologics\n* Patients during pregnancy or breastfeeding","18 Years","99 Years",{"count":89,"type":20},34,[61],"The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket.\n\nSecondary aim is to monitore the effect on the pain perception.",[26],[26,94,95,96,97,98],"wound healing","dentistry","oral surgery","radiation therapy","cancer","2025-04-08",{"date":101,"type":39},"2025-04-11",{"date":103,"type":39},"2023-12-01",{"date":105,"type":20},"2025-09-01",{"name":107,"class":46},"University of Giessen"]