[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prophylactic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prophylactic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100647722","prophylactic-anticoagulation-for-central-venous-line-insertion-in-critically-ill-children-100647722",false,"NCT07710482","Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children","Prophylactic Anticoagulation Versus Standard Care at Central Venous Line Insertion in Critically Ill Children: A Randomized Controlled Study","Inclusion Criteria:\n\n* All Children requiring a newly placed central venous line (peripherally inserted central catheter \\[PICC\\], or non-tunneled central venous catheter) for clinical care.\n\nExclusion Criteria:\n\n* Known major congenital bleeding diathesis or platelet count \\\u003C50,000\u002FµL at time of insertion.\n* Already on therapeutic anticoagulation for another indication.\n* Known heparin allergy or history of heparin-induced thrombocytopenia.\n* Use of dialysis catheters (study focuses on standard CVCs\u002FPICCs).","ALL","1 Month","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026 to Mars 2027.\n\nAim of the study will be:\n\n1. Compare the incidence of clinically significant catheter-related complications (catheter occlusion requiring intervention or catheter-related thrombosis) within 14 days after CVL insertion between children receiving prophylactic anticoagulation and those receiving standard care.\n2. Compare time-to- first catheter occlusion.\n3. Compare rate of catheter-related bloodstream infection (CLABSI) within 30 days.\n4. Compare number of catheter manipulations and unplanned catheter removals.\n5. Compare major and minor bleeding events.\n6. Assess catheter dwell time and need for thrombolysis or therapeutic anticoagulation.",[27,28],"Prophylactic","Anticoagulation",[27,28,30,31,32,33,34,35,36,37,38,39],"Central","venous","line","Insertion","critically","ill","childern","Randomized","Controlled","Study","NOT_YET_RECRUITING","2026-07-16",{"date":43,"type":44},"2026-07-20","ACTUAL",{"date":46,"type":21},"2026-08-01",{"date":48,"type":21},"2027-08-31",{"name":50,"class":51},"Menoufia University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":60,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100465197","does-additional-use-of-preoperative-azithromycin-decrease-posthysterectomy-infections-100465197","NCT05337566","Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections","Infections After Hysterectomy - a Placebo-controlled Study Comparing the Prophylactic Use of Azithromycin and Cefuroxime With Single Cefuroxime","Inclusion Criteria:\n\n* Women undergoing hysterectomy for benign indication in University Hospitals (Helsinki University Hospital, Turku University Hospital, Tampere University Hospital, Oulu University Hospital and Kuopio University Hospital) who have not any contraindications for azithromycin or cefuroxime.\n\nExclusion Criteria:\n\n* Inability to understand the study protocol.\n* Allergy for either cefuroxime or azithromycin.\n* Congenital or acquired prolonged Q-T-corrected interval. All the participants will be asked about arrhythmias and whether they have congenital arrhythmias in the family,\n* Electrocardiogram will be checked for all the participants.\n* Use of medicines that may prolong Q-T-corrected interval (class Ia arrhythmia medications, quinidine, procainamide, and class III arrhythmia medications dofetilide, amiodarone and sotalol).\n* Use of selective serotonin reuptake inhibitor medication and prolonged Q-T-corrected interval.","FEMALE",{"count":62,"type":21},2278,[24],"During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%. By reducing post-hysterectomy infections, it is possible to reduce individual burden of disease in addition to the direct and indirect financial costs. This study primary aim is to assess if prophylactic preoperative use of azithromycin in addition to generally used cefuroxime decreases post-hysterectomy infections as compared to cefuroxime only prophylaxis during 30 days after hysterectomy. Secondary aim is to assess if there is change in post-hysterectomy superficial infections, urinary tract infections, or post-operative fever between the cohorts and to report possible side-effects of the used antibiotics. In addition, the study finds out a possible role of bacterial vaginosis and microbiome n post-hysterectomy infections.",[66,67,68,27],"Infection Post Op","Hysterectomy","Antibiotics",[70],"postoperative, infection, hysterectomy, antibiotics","RECRUITING","2024-08-19",{"date":74,"type":44},"2024-08-21",{"date":76,"type":44},"2022-09-05",{"date":78,"type":21},"2030-12",{"name":80,"class":51},"Helsinki University Central Hospital",6]