[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pseudoexfoliation-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pseudoexfoliation-syndrome":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,67,96,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100648464","corneal-biomechanics-and-surgically-induced-astigmatism-in-pseudoexfoliation-syndrome-100648464",false,"NCT07722247","Corneal Biomechanics and Surgically Induced Astigmatism in Pseudoexfoliation Syndrome","Influence of Corneal Biomechanics on Surgically Induced Astigmatism After Cataract Surgery in Patients With Pseudoexfoliation Syndrome","Inclusion Criteria:\n\n* Adults aged 50-85 years\n* Age-related cataract scheduled for standard phacoemulsification cataract surgery with intraocular lens implantation\n* Presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group)\n* Ability to provide written informed consent\n* Willingness to attend all scheduled postoperative follow-up visits\n\nExclusion Criteria:\n\n* Previous ocular surgery in the study eye\n* Corneal diseases or abnormalities that may affect corneal biomechanical measurements or keratometry\n* Glaucoma and ocular hypertension\n* Ocular trauma or active ocular inflammation","ALL","50 Years","85 Years",{"count":20,"type":21},70,"ESTIMATED","OBSERVATIONAL","This prospective study aims to evaluate the influence of corneal biomechanical properties on surgically induced astigmatism following standard phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome compared with patients without pseudoexfoliation. Corneal hysteresis (CH), corneal resistance factor (CRF) and corneal astigmatism will be measured before surgery and at postoperative follow-up visits. The relationship between changes in corneal biomechanics and surgically induced astigmatism will be analyzed.",[25,26,27],"Pseudoexfoliation Syndrome","Cataract","Astigmatism",[29,30,31,32,33,34],"corneal biomechanics","corneal hysteresis","corneal resistence factor","cataract surgery","pseudoexfoliation syndrome","surgically induced astigmatism","RECRUITING","2026-08-17",{"date":38,"type":39},"2026-08-18","ACTUAL",{"date":41,"type":39},"2026-07-20",{"date":43,"type":21},"2026-10",{"name":45,"class":46},"Kata Culina","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":66,"locationsCount":47},"100648309","influence-of-cataract-surgery-on-corneal-biomechanical-properties-in-patients-with-pseudoexfoliation-syndrome-100648309","NCT07719101","Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome","The Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* adults aged 50 years and older\n* presence of age-related cataract requiring phacoemulsification cataract surgery\n* presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group)\n* ability and willingness to provide written consent\n\nExclusion Criteria:\n\n* previous ocular surgery,\n* corneal disease,\n* glaucoma or ocular hypertension,\n* dry eye disease (Schirmer test \\\u003C10 mm, tear break-up time \\\u003C5 seconds or positive fluorescein staining),\n* high refractive error (myopia \\> -6.00 D or hyperopia \\> +5.00 D),\n* unilateral pseudoexfoliation when the eye scheduled for surgery showed Adults no signs of PEX,\n* intraoperative or postoperative complications,\n* any ocular disease that could influence corneal biomechanics",{"count":20,"type":21},"Pseudoexfoliation syndrome is associated with alterations in the biomechanical properties of the cornea. This prospective observational cohort study aims to evaluate changes in corneal biomechanical properties after standard phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome compared with patients without pseudoexfoliation syndrome. Corneal hysteresis (CH) and corneal resistance factor (CRF) will be measured using the Ocular Response Analyzer before surgery and at postoperative day 1, day 7, and day 30. The study will enroll patients undergoing routine cataract surgery to compare postoperative changes in CH and CRF between the pseudoexfoliation and control groups.",[25,26],[29,30,59,33,32],"corneal resistance factor","NOT_YET_RECRUITING","2026-07-21",{"date":63,"type":39},"2026-07-23",{"date":41,"type":21},{"date":43,"type":21},{"name":45,"class":46},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":16,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":47},"100572304","corneal-biomechanics-optical-properties-and-anterior-segment-structural-features-in-patients-with-pseudoexfoliation-100572304","NCT06731530","Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation","A Comparative Study of Anterior Segment Structural Features, Biomechanical Behaviour and Optical Properties of the Cornea in Patients With and Without Pseudoexfoliation Syndrome.","CorPEX","Inclusion Criteria:\n\n* age 60-80 years.\n* unilateral or bilateral pseudophakia (cataract surgery undergone at Papageorgiou General Hospital, Thessaloniki, Greece).\n* open anterior chamber angle (grade \\> 2, van Herick method).\n\nExclusion Criteria:\n\n* History of intraocular surgery other than uncomplicated cataract surgery (phakoemulsification).\n* Cataract surgery within the last 3 months.\n* History of ocular trauma.\n* Use of contact lenses.\n* Corneal pathology.\n* Use of anti-VEGF medications.\n* History of uveitis or active uveitis.\n* Hypertension (IOP \\> 21 mmHg) or glaucoma.\n* Myopia or hyperopia greater than 3 diopters.\n* Astigmatism greater than 1.5 diopters.\n* Posterior capsular opacification grade 2, 3, or 4 based on the EPCO grading scale.\n* Tear break-up time \\\u003C10 sec",true,"60 Years","80 Years",{"count":79,"type":21},86,"The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.",[25,82,83],"Biomechanical Parameters","Corneal Densitometry",[33,85,86],"biomechanical parameters","corneal transparency","2024-12-24",{"date":89,"type":39},"2024-12-27",{"date":91,"type":39},"2024-12-13",{"date":93,"type":21},"2025-05",{"name":95,"class":46},"Aristotle University Of Thessaloniki",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100561334","the-correlation-between-pupil-size-and-retinal-nerve-fibers-changes-in-pseudoexfoliation-syndrome-100561334","NCT06588816","The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome.","Inclusion Criteria:\n\n* All patients with pseudoexfoliation syndrome.\n\nExclusion Criteria:\n\n* previous ocular surgery or ocular trauma affecting the pupil. Any systemic or neurologic disease affecting the pupil",{"count":103,"type":21},33,"To study the possible correlation between pupillary diameter before and after dilation with intraocular pressure, lens stability and glaucomatous damage (represented by optic disc changes using cup to disc ratio and OCT changes in retinal nerve fiber layer and ganglion cell complex) in each eye of the same patient with PEX.",[25],[107,108,109,110,33],"pupil","pseudoexfoliation","pupil dilation","pupil size","2024-09-06",{"date":113,"type":39},"2024-09-19",{"date":115,"type":21},"2024-12",{"date":117,"type":21},"2027-03",{"name":119,"class":46},"Assiut University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":130,"phases":131,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":47},"100520206","outcome-of-two-surgical-methods-for-iolimplantation-in-eyes-with-pseudoexfoliation-syndrome-100520206","NCT06053554","Outcome of Two Surgical Methods for IOLImplantation in Eyes With Pseudoexfoliation Syndrome","Outcome of Two Surgical Methods for IOLImplantation in Eyes With Pseudoexfoliation Syndrome: Lens in the Bag-technique Versus Lens in the Ciliary Sulcus With Optic Capture Technique","Inclusion Criteria:\n\n* Age 60 - 100\n* Necessity for bilateral cataract surgery with pseudoexfoliation syndrome\n* willing to give informed consent and follow-up the duration of study\n\nExclusion Criteria:\n\n* Endstage glaucoma\n* Christalline lens sub\u002F luxation\n* active inflammatory diseases of the eye","100 Years",{"count":129,"type":21},120,"INTERVENTIONAL",[132],"NA","The aim of this study is to compare the surgical outcomes of the two IOL implantation methods for eyes with cataract and PEX in a single-center and with highly experienced surgeons. The goal is to acquire relevant information regarding these two IOL implantation techniques, which will help surgeons to decide which approach to choose, ultimately resulting in a benefit for patients with PEX syndrome who require cataract surgery.\n\nThe main questions are:\n\nIs there a difference in lens tilt and decentration between the both methods. Is there a difference in the frequency and amount of capsular phimosis between the both methods.",[135,25],"Age Related Cataracts",[137,138,139,140,141],"Femtolaser","Sulcus-IOL","Anterior segment","Lens tilt and decentration","Capsular phimoses","2023-10-20",{"date":144,"type":39},"2023-10-24",{"date":146,"type":39},"2023-09-18",{"date":148,"type":21},"2030-08",{"name":150,"class":46},"Medical University of Vienna"]