[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulmonary-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulmonary-ventilation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,38,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100651111","accuracy-of-3d-electrical-impedance-tomography-for-assessing-lung-ventilation-100651111",false,"NCT07756086","Accuracy of 3D Electrical Impedance Tomography for Assessing Lung Ventilation","Accuracy of Three-Dimensional Electrical Impedance Tomography for Assessing Dynamic Regional Lung Ventilation Validated by Four-Dimensional CT: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 years or older.\n* Healthy volunteers or patients in the intensive care unit for whom CT imaging is considered necessary based on the treating physician's clinical judgment.\n* Able to cooperate with or undergo simultaneous 4D-CT and 3D-EIT monitoring.\n* Able to provide written informed consent personally or through a legally authorized representative, as applicable.\n\nExclusion Criteria:\n\n* Unable to tolerate or having a contraindication to 4D-CT examination, including pregnancy or severe respiratory distress.\n* Extensive chest skin injury or infection, or any condition preventing placement of the EIT electrode belt.\n* Body size or chest deformity that may substantially limit the quality of EIT or CT data, including chest circumference outside the compatible range of the EIT device.\n* Presence of an implanted electronic device that may interfere with EIT signals, such as a cardiac pacemaker.\n* Unable to complete simultaneous 4D-CT and 3D-EIT monitoring because of significant motion, persistent coughing, poor cooperation, or other technical or clinical reasons.\n* Any other condition that, in the investigator's judgment, makes the individual unsuitable for participation in the study.",true,"ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","This prospective observational study will evaluate how accurately three-dimensional electrical impedance tomography (3D-EIT) measures the distribution of air in the lungs during breathing when compared with four-dimensional computed tomography (4D-CT).\n\n3D-EIT is a noninvasive, radiation-free imaging method that measures changes in electrical impedance across the chest and can provide continuous information about regional lung ventilation. In this study, 4D-CT will be used as the reference method because it can provide detailed images of changes in the lungs throughout the breathing cycle.\n\nApproximately 50 adults, including healthy volunteers and hospitalized patients who are able to undergo both examinations, will be enrolled at a single center. EIT and CT data will be collected at the same time during stable breathing. Researchers will compare the two methods to determine how closely their measurements of ventilation in different lung regions agree. The study will also explore whether EIT can detect changes in regional ventilation under different breathing conditions.\n\nThe study will not use the research EIT results to make clinical treatment decisions. The findings may support the future use of EIT as a noninvasive, radiation-free method for monitoring regional lung ventilation.",[25],"Pulmonary Ventilation","NOT_YET_RECRUITING","2026-08-04",{"date":29,"type":30},"2026-08-10","ACTUAL",{"date":32,"type":21},"2026-09-01",{"date":34,"type":21},"2027-07-01",{"name":36,"class":37},"Shanghai Zhongshan Hospital","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":46,"minAge":18,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100599049","eit-evaluation-of-pulmonary-ventilation-with-different-ropivacaine-concentrations-in-intercostal-nerve-blockade-100599049","NCT07079436","EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade","Electrical Impedance Tomography (EIT) to Evaluate the Effect of Different Concentrations of Ropivacaine on Pulmonary Ventilation Function During Intercostal Nerve Blockade","EIT","Inclusion Criteria:\n\n* Patients scheduled for elective breast quadrantectomy;\n* Aged 18-80 years;\n* American Society of Anesthesiologists (ASA) physical status I-II;\n* Body mass index (BMI) \\\u003C35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Contraindications for nerve block: infection at the puncture site, local anesthetic allergy, coagulation dysfunction or bleeding risk;\n* Patients with unilateral diaphragmatic paralysis;\n* Patients with severe ventilatory or gas exchange dysfunction;\n* Complicated with acute or chronic pulmonary and bronchial diseases, sleep apnea syndrome;\n* Mental disorders;\n* Patients who refuse to participate;\n* Patients whom the researchers consider unsuitable for the clinical trial, with reasons to be specified.","FEMALE","80 Years",{"count":49,"type":21},72,"INTERVENTIONAL",[52],"NA","This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery. Researchers will use a non-invasive imaging technique called electrical impedance tomography (EIT) to monitor lung ventilation in real time.\n\nWhy is this study being done? Intercostal nerve block is a common anesthesia method for breast surgeries, but the ideal strength of ropivacaine that balances effective pain relief with safety for lung function is not fully clear. EIT can help measure how each drug strength affects breathing by showing changes in lung airflow.\n\nWhat will happen in the study? Participants: 72 adults scheduled for breast quadrantectomy, aged 18-80, will be randomly assigned to receive one of three ropivacaine strengths (0.25%, 0.375%, or 0.5%) during intercostal nerve block.\n\nProcedures: After anesthesia, EIT will monitor lung ventilation before and after the block. Researchers will measure:\n\nHow much each lung side contributes to breathing during quiet and deep breaths. How quickly the anesthesia works, pain levels during surgery, and any side effects (like difficulty breathing or allergic reactions).\n\nWho can join? Adults having elective breast quadrantectomy. ASA physical status I-II (generally healthy to mildly ill). BMI \\\u003C35 kg\u002Fm². No history of nerve block allergies, breathing problems, or certain lung diseases.\n\nWhat are the possible benefits? The study may help doctors choose the best ropivacaine strength to ensure good pain control while minimizing risks to lung function, especially for same-day surgery patients.\n\nWhat are the risks? Potential risks include rare side effects from the anesthetic (like allergic reactions or low blood pressure) or temporary breathing changes, which will be closely monitored.\n\nHow is the study designed? This is a double-blind, randomized trial (neither patients nor doctors know which drug strength is used) at Fudan University Shanghai Cancer Center.",[55,25,56,57,58],"Intercostal Nerve Block","Anesthesia, Local","Breast Neoplasms","Surgical Procedures, Operative",[60,55,61,62,63,57],"Ropivacaine","Pulmonary Ventilation Function","Electrical Impedance Tomography","Anesthetic Concentration","2025-07-22",{"date":66,"type":30},"2025-07-23",{"date":68,"type":21},"2025-08-10",{"date":70,"type":21},"2025-12-31",{"name":72,"class":37},"Fudan University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":96,"locationsCount":4},"100575579","evaluation-of-chest-wall-motion-symmetry-during-ventilation-in-healthy-subjects-by-optoelectronic-plethysmography-100575579","NCT06774118","Evaluation of Chest Wall Motion Symmetry During Ventilation in Healthy Subjects by Optoelectronic Plethysmography","EVAST","Inclusion Criteria:\n\n* aged between 10 and 70\n* with no prior major cardiopulmonary surgical, traumatic or medical history\n* agreeing to participate in the study\n\nExclusion Criteria:\n\n* A major medical cardiopulmonary history, or a history of surgery or trauma to the thorax, abdomen or spine.\n* A major medical cardiopulmonary history included any pathology requiring hospital treatment or allopathic therapy lasting more than 3 months.\n* Active smoker\n* Protected by law (guardianship, curatorship, safeguard of justice)\n* Refusing to take part in the study","10 Years","70 Years",{"count":83,"type":21},100,"Pulmonary ventilation is the only macroscopically observable breathing step. The ventilatory mechanism has been extensively studied and knowledge of its operation is now well established. The thoraco-abdominal couple is generally considered as a homogeneous functional unit. The anatomical organization of the trunk is not symmetrical. The right lung receives 55% of the volume of air mobilized, the heart is usually lateralized to the left and exerts a mechanical stress on the left lung, the thoracic diaphragm is asymmetrical. The densities of the subdiaphragmatic viscera vary greatly between hollow organs (stomach, colon) and full organs (liver rate).\n\nConventional spirometry, the gold-standard reference method in ventilatory analysis, allows to measure the quantities of air mobilized at inspiration and expiration. This quantitative method does not provide information on the kinematics of the different areas of the thorax and abdomen involved during breathing.\n\nOptoelectronic plethysmography (OEP) is a non-invasive technique for the analysis of the 3D motion of passive markers placed on the surface of the subject's chest, abdomen and back. This technique, validated as a reliable alternative to conventional spirometry, allows the combination of quantitative measurements of respiratory volumes with qualitative measurements of thoraco-abdominal kinematics. The OEP has the specificity of allowing to choose a segmentation of the trunk to analyze the kinematics of the different identified zones. The most commonly used method in research is segmentation into three compartments (pulmonary thoracic, abdominal and abdominal thoracic).\n\nThe OEP studies also suggested the use of segmentation in relation to the median plane of the body to compare the symmetry of the three compartments described above. This 6-compartment segmentation was rarely used in respiratory analysis to assess interventions such as surgery of pulmonary rehabilitation protocols. To our knowledge, there is no study in healthy subjects to assess the level of symmetry of pulmonary ventilation. This type of study is a fundamental preliminary step to be able to subsequently study the symmetry of the ventilatory kinematics in the case of pathologies giving deformities of the thorax, spine and abdomen (scoliosis for example).",[25],[87,88,89],"breathing symmetry","optoelectronic plethysmography","pulmonary ventilation","2025-01-08",{"date":92,"type":30},"2025-01-14",{"date":94,"type":21},"2025-02-01",{"date":70,"type":21},{"name":97,"class":37},"Université de Reims Champagne-Ardenne"]