[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulp-necrosis-apical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulp-necrosis-apical-periodontitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100638402","early-phase-1-the-effect-of-different-intra-canal-medications-on-postoperative-pain-100638402",false,"NCT07603934","The Effect of Different Intra-canal Medications on Postoperative Pain","Evaluation of Postoperative Pain After Using Ibuprofen, Nitrofurantoin, or Calcium Hydroxide as Intracanal Medicaments in Root Canal Treatment of Necrotic Mandibular Posterior Teeth. A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients with necrotic pulps.\n2. Adult, healthy patients, older than 18 years old\n3. Males and females.\n4. Patient with the ability to understand and use pain scales.\n5. Patient who accepts enroll to the study.\n\nExclusion Criteria:\n\n1. Patients' allergies or any other contraindication to any of the medications used.\n2. Pregnant and lactating females.\n3. Patients have been taking pain medication 12 hours earlier.\n4. Patients who have more than one symptomatic mandibular tooth in the same quadrant.\n5. Patients with contributory medical history (ASA\\>II).",true,"ALL","18 Years","40 Years",{"count":21,"type":22},111,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth\n\nResearch question\u002Fhypothesis:\n\nIn patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and\u002For severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications.\n\nThe study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.",[28],"Pulp Necrosis, Apical Periodontitis",[30],"Necrotic Pulp","RECRUITING","2026-07-20",{"date":34,"type":35},"2026-07-21","ACTUAL",{"date":37,"type":35},"2025-12-15",{"date":39,"type":22},"2027-03-15",{"name":41,"class":42},"Cairo University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100646803","comparing-amla-emblica-officinalis-and-3-sodium-hypochlorite-against-enterococcus-faecalis-in-root-canal-treatment-a-randomized-controlled-trial-100646803","NCT07688005","Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment: A Randomized Controlled Trial","\"Comparative Antibacterial Evaluation of Emblica Officinalis and 3% Sodium Hypochlorite, Against Enterococcus Faecalis, as Root Canal Irrigants in Non-surgical Root Canal Treatment of Mature Single Rooted Anterior Teeth - A Randomized Controlled Trial.\"","Inclusion Criteria:\n\n* Co-operative patients of both sexes aged between 18-50 years\n* Patients belonging to ASA classification I and II (mild to moderate systemic disease).\n* Permanent mature single-rooted and single canal teeth.\n* Patients with pulp necrosis \u002F apical periodontitis (primary endodontic infection with periapical radiolucency) will be included.\n* Adequate crown structure.\n* Probing level \\\u003C\u002F= 3mm\n* Patients not taking antibiotics for the last two weeks (pragmatic approach).\n\nExclusion Criteria:\n\n* ●Patients with ASA Classification III, IV, V and VI or any other congenital disease.\n\n  * Patient with liver failure and patient on blood thinning medication will be excluded.\n  * Teeth with Multiple roots and canals.\n  * Teeth with calcified pulp chamber.\n  * Teeth with previous endodontic therapy performed.\n  * Aberrant anatomy.\n  * Teeth associated with vertical root fracture and coronal perforation.\n  * Patient taking antibiotics in the last two weeks.","50 Years",{"count":53,"type":22},66,[55],"NA","Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment. One bacterium, Enterococcus faecalis, is commonly found in persistent root canal infections. The goal of root canal treatment is to remove these bacteria and prevent the infection from returning. Along with cleaning the canal using dental instruments, dentists use disinfecting solutions (called irrigants) to kill remaining bacteria.\n\nThe most commonly used irrigant is 3% sodium hypochlorite. Although it is effective at killing bacteria, it can irritate tissues, cause allergic reactions, has an unpleasant smell and taste, and may weaken the tooth. Because of these disadvantages, researchers are exploring safer natural alternatives. Amla (Emblica officinalis) is a medicinal plant known for its antibacterial, anti-inflammatory, and pain-relieving properties. This study aims to compare amla with 3% sodium hypochlorite to determine how well each reduces Enterococcus faecalis during root canal treatment and whether they produce similar clinical outcomes.\n\nThe study will include 66 patients aged 14-50 years who require root canal treatment for an infected single-rooted front tooth. Participants will be randomly assigned to one of two groups: one will receive 3% sodium hypochlorite, and the other will receive amla as the root canal irrigant. Bacterial samples will be collected before treatment, immediately after cleaning the canal, and one week later. The number of bacteria will be measured and compared between the two groups. The researchers will also assess pain, tenderness, and other signs of healing after treatment. The findings will help determine whether amla is a safe and effective natural alternative to the standard root canal irrigant.",[28],[59,60],"Enterococcus faecalis Root Canal Treatment Sodium Hypochlorite Emblica officinalis (Amla) Root Canal Irrigants","Colony-Forming Units (CFU\u002FmL)","NOT_YET_RECRUITING","2026-06-30",{"date":64,"type":35},"2026-07-07",{"date":66,"type":22},"2026-07-01",{"date":68,"type":22},"2026-09-01",{"name":70,"class":42},"Postgraduate Medical Institute, Lahore"]