[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulse-oximetry-accuracy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulse-oximetry-accuracy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100653822","local-warming-to-improve-pulse-oximetry-accuracy-in-critically-ill-patients-100653822",false,"NCT07792304","Local Warming to Improve Pulse Oximetry Accuracy in Critically Ill Patients","Effect of Local Warming on Pulse Oximetry Accuracy in Critically Ill Patients With Low Peripheral Perfusion: A Multicenter Randomized Controlled Trial","PULSEWARM","Inclusion Criteria:\n\n* Age 18 years or older.\n* Admitted to an intensive care unit.\n* Receiving invasive mechanical ventilation via endotracheal tube or tracheostomy.\n* Existing arterial catheter placed for a clinical indication.\n* Objectively verified low peripheral perfusion, defined as finger perfusion index (PFI) \\\u003C1.0 at screening.\n* Stable baseline pulse oximetry signal permitting calculation of the SpO2-SaO2 difference.\n* Clinical condition considered sufficiently stable to allow study measurements without interfering with ongoing treatment.\n\nExclusion Criteria:\n\n* Absence of a stable baseline pulse oximetry signal on all available sensors, preventing calculation of the SpO2-SaO2 difference.\n* Skin injury, burn, infection, or other local skin condition of the hand or forearm that prevents safe application of the warming pad or pulse oximetry sensor.\n* Clinical instability for which the treating physician considers study participation likely to interfere with acute treatment or patient safety.\n* Known hypersensitivity to materials used in the warming pad or sensors.\n* Participation in another ongoing interventional study that could affect the primary outcome.","ALL","18 Years",{"count":20,"type":21},240,"ESTIMATED","INTERVENTIONAL",[24],"NA","Pulse oximeters are widely used in intensive care to continuously estimate the oxygen level in the blood. However, pulse oximeter measurements may be less accurate when blood flow to the fingers is poor, which is common in critically ill patients.\n\nThis study will investigate whether warming the hand and lower part of the forearm can improve the accuracy of pulse oximeter measurements in mechanically ventilated adult intensive care patients with low blood flow to the fingers.\n\nParticipants will be randomly assigned to either a local warming strategy or usual care without warming. In the warming group, the hand and lower forearm will be warmed for 15 minutes to a target temperature of 41-42°C. Pulse oximeter measurements will be compared with oxygen saturation measured from an arterial blood sample before and after the intervention.\n\nThe main objective is to determine whether local warming reduces the difference between pulse oximeter oxygen saturation (SpO₂) and arterial oxygen saturation (SaO₂) 15 minutes after the start of the assigned strategy. The study will also assess whether any improvement persists at 60 minutes, how peripheral blood flow changes during 4 hours of follow-up, whether repeat warming is effective when blood flow decreases again, and whether the effect differs according to skin phototype. Safety related to the warming intervention will also be evaluated.",[27,28,29],"Critical Illness","Low Peripheral Perfusion","Pulse Oximetry Accuracy",[31,32,33,34,35,36,37,38,39,40],"Pulse oximetry Oxygen saturation","SpO₂","SaO₂","Peripheral perfusion Perfusion index","Skin pigmentation","Local warming","Fitzpatrick skin phototype","Critically ill patients","Arterial blood gas","Mechanical ventilation","NOT_YET_RECRUITING","2026-09-22",{"date":44,"type":45},"2026-09-25","ACTUAL",{"date":47,"type":21},"2026-10-01",{"date":49,"type":21},"2028-12-01",{"name":51,"class":52},"Vastra Gotaland Region","OTHER_GOV",4]