[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quality-of-life\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quality-of-life":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,388,0,25,[9,53,79,114,139,166,202,229,264,298,323,354,376,410,446,473,499,532,565,588,614,637,661,683,702],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100648034","mindfulness-based-education-for-women-with-polycystic-ovary-syndrome-100648034",false,"NCT07718217","Mindfulness-Based Education For Women With Polycystic Ovary Syndrome","The Effect Of Mindfulness-Based Education For Women With Polycystic Ovary Syndrome On Menstrual Symptoms, Stress, And Quality of Life: A Randomized Controlled Study","Inclusion Criteria:\n\n* Self-identify as female.\n* Be of reproductive age (18-49 years).\n* Have a confirmed diagnosis of Polycystic Ovary Syndrome (PCOS) based on the Rotterdam criteria.\n* Be able to read, understand, and communicate in Turkish.\n* Have access to the internet and a device capable of participating in online education sessions.\n\n  * Be willing to attend the four-week online education program and complete all study assessments.\n  * Provide written informed consent before participation.\n\nExclusion Criteria:\n\n* Currently pregnant or breastfeeding.\n* Having a severe psychiatric disorder or cognitive impairment that may interfere with participation.\n* Having a serious chronic medical condition that could affect study outcomes or prevent participation in the intervention.\n* Currently participating in another interventional research study.\n* Having previously received structured mindfulness training or participated in a mindfulness-based program during the study period.\n* Being unable to attend the online education sessions or complete the study assessments.\n* Declining or withdrawing informed consent at any stage of the study.",true,"FEMALE","18 Years","49 Years",{"count":22,"type":23},78,"ESTIMATED","INTERVENTIONAL",[26],"NA","Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the disease's pathophysiology remains unclear. This has hindered the diagnosis of the disease and the appropriate treatment for millions of individuals. The long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease. Women with PCOS may experience menstrual symptoms, increased stress, and difficulties in managing the physical and emotional effects of the condition. Supportive approaches that improve symptom management and quality of life may be beneficial in addition to routine care.\n\nThe aim of this randomized controlled study is to evaluate the effect of mindfulness-based PCOS education on menstrual symptoms, stress levels, and quality of life in women with PCOS. The study will examine whether a structured mindfulness-based education program can support women in managing PCOS-related symptoms and improving their overall well-being.\n\nWomen diagnosed with PCOS who meet the study eligibility criteria will be invited to participate. Participants will be randomly assigned to either the intervention group or the control group. Participants in the intervention group will receive a mindfulness-based PCOS education program, while those in the control group will receive routine care without it.\n\nResearchers will assess participants' menstrual symptoms, stress levels, and quality of life using validated measurement tools before and after the intervention. The findings of this study will provide information about the potential role of mindfulness-based education as a supportive approach in the management of PCOS and may contribute to the development of patient-centered education programs for women with PCOS.",[29,30,31,32],"Polycystic Ovary Syndrome (PCOS)","Menstrual Symptoms","Stress","Quality of Life",[34,35,36,37,30,38,39,32],"Polycystic Ovary Syndrome","PCOS","Mindfulness-Based Education","Mindfulness","Menstrual Pain","PCOS-Specific Quality of Life","RECRUITING","2026-08-19",{"date":43,"type":44},"2026-08-21","ACTUAL",{"date":46,"type":44},"2026-07-20",{"date":48,"type":23},"2026-12",{"name":50,"class":51},"Aydin Adnan Menderes University","OTHER",1,{"id":54,"slug":55,"hasResults":12,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100652844","tension-type-headache-and-its-association-100652844","NCT07779655","Tension-type Headache and Its Association","Tension-type Headache and Its Association With Smartphone Use,Sleep Quality and Quality of Life","Inclusion Criteria:\n\n* Adults aged 18-60 years\n* Attending the outpatient clinics at Assiut University Hospitals during the study period\n* Able to understand the study questionnaires and provide informed consent\n* No severe psychiatric illness or cognitive impairment interfering with questionnaire completion\n* No serious medical illness that may affect participation\n\nExclusion Criteria:\n\n* History of major neurological diseases (e.g., stroke, epilepsy, brain tumors)\n* History of secondary headache disorders\n* History of migraine or other primary headache disorders according to ICHD-3 criteria\n* Refusal to participate","ALL","60 Years",{"count":63,"type":23},199,"OBSERVATIONAL","To estimate the prevalence of tension-type headache among adults attending the outpatient clinics at Assiut University Hospitals, and to assess its association with smartphone use, sleep quality, and quality of life.",[67,68,69,32],"Tension-Type Headache","Sleep Disturbance","Smartphone Addiction","NOT_YET_RECRUITING","2026-08-18",{"date":43,"type":44},{"date":74,"type":23},"2026-08-10",{"date":76,"type":23},"2028-08-10",{"name":78,"class":51},"Assiut University",{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":17,"sex":60,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":90,"conditions":91,"keywords":96,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":52},"100652087","ai-based-personalized-exercise-prescription-through-mobile-health-on-physical-activity-and-health-outcomes-in-older-adults-a-feasibility-study-100652087","NCT07768670","AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Artificial Intelligence-based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Inclusion Criteria:\n\n* Be aged 65 years or older.\n* Own a smartphone (Android or iOS) compatible with study applications.\n* Have reliable access to the internet or Wi-Fi.\n* Demonstrate basic digital literacy sufficient to operate a smartphone (e.g., ability to open applications, navigate simple interfaces, and follow on-screen instructions), with or without initial guidance from the research staff.\n* Be able to safely engage in physical activity, as determined by the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) or physician approval if indicated.\n* Report engaging in less than 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Be able to communicate in English sufficiently to complete study procedures and assessments.\n\nExclusion Criteria:\n\n* Are younger than 65 years of age.\n* Do not own a compatible smartphone (Android or iOS) or do not have reliable internet\u002FWi-Fi access.\n* Are deemed unable to safely participate in physical activity based on the screening process (including PAR-Q+, STEADI, and research staff assessment), or do not obtain required physician clearance when indicated.\n* Currently meet or exceed 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Are unable to communicate in English sufficiently to understand study procedures, provide informed consent, or complete study-related assessments.\n* Have any medical, physical, or cognitive condition that, in the judgment of the research team, would make participation unsafe or prevent completion of study procedures.","65 Years",{"count":88,"type":23},20,[26],"The purpose of this research is to investigate the feasibility, acceptability, appropriateness, and preliminary efficacy of a wearable and artificial intelligence-driven mobile application-based exercise prescription grounded in self-determination theory (SDT) and behavioral change techniques (BCTs) among older adults. As no data exists on the feasibility of AI-driven exercise programs grounded in SDT and multiple BCTs specifically for older adults, this will be a pioneering study to explore the feasibility of wearable and AI-driven exercise program protocols and the rates of acceptance and appropriateness of the exercise prescription intervention among older adults. In addition, this study will test the preliminary efficacy of the intervention on physical activity (PA), mental health, and quality of life. This study follows the National Institute of Health (NIH) stage model, and it represents stage 1b of the NIH stage model, which emphasizes the feasibility and actionable processes for delivering a new health intervention. Specifically, this study will: 1.Evaluate the research protocol feasibility of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs (of goal setting, self-monitoring, graded task, and demonstration) on older adults over 8 weeks 2. Evaluate the acceptability and appropriateness of a wearable, AI-driven, mobile application-based exercise prescription grounded in SDT and BCTs among older adults over 8 weeks. 3. Evaluate the preliminary impact of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs on older adult PA (steps per day and daily duration of light PA and Moderate-vigorous PA), sedentary time, sleep, mental health (depression and anxiety), and quality of life.",[92,93,94,95,32],"Feasibility Studies","Physical Activity","Mental Health (Depression)","Anxiety",[97,98,99,100,101,102,103,104,105],"AI-based intervention","mobile health technology","wearable","fitness app","feasibility study","study acceptability and appropriateness","older adult","age 65 years","60 years",{"date":107,"type":44},"2026-08-20",{"date":109,"type":23},"2026-10-01",{"date":111,"type":23},"2026-12-31",{"name":113,"class":51},"The University of Tennessee, Knoxville",{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":17,"sex":60,"minAge":19,"maxAge":86,"enrollmentInfo":122,"targetDuration":4,"studyType":24,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":52},"100601585","pain-intervention-with-needling-pilot-of-integrated-neuromodulation-techniques-100601585","NCT07112404","Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques","PINPOINT Study: Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques","PINPOINT","Inclusion Criteria:\n\n* Both males and females between the ages of 18 and 65 will be included in this study.\n\nPhase 1 Inclusion criteria\n\n\\- Healthy adults who report no pain for more than 1 day in the past 3 months in their lumbar region. Lumbar region will include posterior lumber musculature, lumbar spine, sacroiliac pain, or superior gluteal area pain.\n\nPhase 2 Inclusion criteria\n\n* Adults experiencing chronic low back pain. Chronic low back pain will be identified as having pain the lumbar region for at least 3 months. The pain may be constant or episodic in nature.\n* Participants will be included if they experience pain at least 75% of the days in the past 3 months. All pain levels will be included. Lumbar region will include posterior lumber musculature, lumbar spine, sacroiliac pain, or superior gluteal area pain.\n\nExclusion Criteria:\n\n* Individuals who are currently seeking any form of medical treatment for lumbar conditions beyond routine physician follow-up appointments in order to avoid confounding variables, regardless of pain-free status. These may include, but are not limited to, seeking treatment from a chiropractor, acupuncturist, or massage therapist or medical procedures such as injections into the lumbar region for pain.\n* Additionally, those with previous lumbar surgeries or those with previous major injuries to the lumbar spine that may have resulted in structural abnormalities that may compromise needle placement will be excluded. If surgical procedures did not alter structural alignment, then it will be allowed. For example, an approved procedure may include discectomy or nerve ablation, while a not approved procedure would include a lumbar fusion or scoliosis rod placement.\n* Additionally, if a person is experiencing radicular symptoms from a back injury, despite not feeling the symptoms in the lumbar region, will not be considered. Radicular symptoms will be defined as those present past the knee and\u002For electrical in nature. Individuals with neurological conditions or those who need the services of another due to cognitive deficits will not be considered for this study.\n* Furthermore, as this study relies on an intact sensory system, participants with conditions that may affect sensory processing (e.g., peripheral neuropathy, skin conditions, or circulatory disorders) will be excluded through careful screening.\n\nAdditional exclusion criteria\n\n* Will include the following conditions identified as contraindications for dry needling: those with impaired sensitivity, taking anticoagulants, a compromised immune system, a local or systemic infection, an active tumor, history of lymph node removal, history of autoimmune disease, allergy to metals such as nickel or chromium, history of cosmetic procedures in the area, pregnant individuals, or osteoporosis.\n* Non-English-speaking subjects will be excluded from the study due to the need to understand any communication while dry-needling procedures are taking place.",{"count":123,"type":23},42,[26],"The study will be conducted on site in Galveston, Texas, United States. Study-related assessments and procedures will be performed at the designated clinical study site by qualified study personnel in accordance with the study protocol and applicable regulatory requirements.\n\nThe study's purpose is to determine the effects of three different dry needling sessions on pain and quality of life for those with chronic low back pain. Dry needling is a therapeutic procedure in which a very thin, monofilament needle is inserted through the skin to reach a target tissue like a muscle to help reduce pain, improve muscle activation, and increase blood flow. Dry needling has also been shown to improve nervous system function.",[127,128,129,32],"Pain","Back Pain","Lower Back Pain","2026-08-13",{"date":132,"type":44},"2026-08-17",{"date":134,"type":44},"2025-10-23",{"date":136,"type":23},"2027-09",{"name":138,"class":51},"The University of Texas Medical Branch, Galveston",{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":24,"phases":148,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":158,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":52},"100551039","developing-a-smartphone-application-to-support-veteran-opioid-use-disorder-treatment-100551039","NCT06454903","Developing a Smartphone Application to Support Veteran Opioid Use Disorder Treatment","Developing a Smartphone Application to Support the Functional Needs of Veterans in Medication Treatment for Opioid Use Disorder","Inclusion Criteria:\n\n-For the Phase 3, Stage 1b RCT The investigators will be recruiting Veterans engaged in MOUD who also demonstrate deficits in psychosocial functioning (N = 40, n = 20 per condition).\n\nEligible Veterans in must have:\n\n* a current Opioid Use Disorder (OUD) diagnosis\n* active Medication treatment for OUD (MOUD) prescription for buprenorphine or methadone\n* have a Veterans Rand 12 (VR-12) Physical Component Scale (PCS) or Mental Component Scale (MCS) that is \\\u003C1SD below the normed mean for their respective sex-assigned-at-birth (Selim et al., 2008).\n\nExclusion Criteria:\n\nParticipants may not:\n\n* have untreated major psychiatric disorders (e.g., psychotic disorders)\n* current (i.e., past-month) suicidal\u002Fhomicidal ideation with intent (i.e., a positive C-SSRS)\n* cognitive\u002Fmedical impairments precluding meaningful participation (via clinician determination based on participant's behavior and\u002For chart review)",{"count":147,"type":23},75,[26],"Opioid Use Disorder (OUD) is a complex, chronic condition affecting nearly 70,000 Veterans who can experience significantly reduced quality of life (e.g., poorer social, occupational, and health-related functioning). VA clinics providing Medication treatment for OUD (MOUD); e.g., buprenorphine, methadone), the 1st-line treatment for OUD, often face challenges in also attempting to treat Veteran functional needs, which may require them to extend beyond their available resources to provide support. There is an urgent need for functionally impactful and accessible treatments for Veterans in MOUD.\n\nAcceptance and Commitment Therapy (ACT) is a well-suited framework to support the functioning of Veterans in MOUD with over 20 years of research support. However, the traditional practice ACT requires a trained clinician to provide weekly, hour-long therapy sessions (typically for 12-16 weeks) and may be too burdensome for MOUD clinics to use alongside standard care.\n\nFortunately, emerging research suggests that mobile health interventions (MHIs; e.g., smartphone apps) can overcome many of these pragmatic barriers. MHIs can efficiently deliver functionally-focused treatments focused on Veteran functioning in \"real-world\" settings, through minimally burdensome and accessible formats. Currently however, no MHI's targeting functioning exist for Veterans in MOUD.\n\nThe proposed study will address this gap by developing and evaluating an early prototype of a targeted smartphone app designed to enhance the functional outcomes of Veterans receiving MOUD called \"ACT to RECOVER\" (Acceptance and Commitment Therapy to Reach Empowerment through Commitment, Openness, and Valuing Experiences in Recovery).\n\nThe study will occur in 3 phases:\n\nPhase 1: Development. Develop content for ACT to RECOVER using Veteran (n=10) and provider feedback (n=10).\n\nPhase 2: Iterative Usability Assessment. Conduct field testing (3 rounds, n=4-5 per round) to refine ACT to RECOVER format, acceptability, and usability.\n\nPhase 3: Pilot ACT to RECOVER in a Stage 1b Randomized Controlled Trial (RCT). Conduct a pilot trial to compare ACT to RECOVER (n=20) to a smartphone-based symptom monitoring control group (n=20).\n\n* (3a) Evaluate the acceptability and feasibility of each condition's app and study procedures.\n* (3b) Explore changes in functional (e.g., values-based living, quality of life) and clinical outcomes (e.g., illicit opioid use) which will be key outcomes in future efficacy testing.",[151,152,32],"Opioid-Related Disorders","Psychosocial Functioning",[151,152,32,154,155,156,157],"Mobile Applications","Smartphone Apps","Acceptance and Commitment Therapy","User-Centered Design",{"date":132,"type":44},{"date":160,"type":44},"2025-04-02",{"date":162,"type":23},"2029-10-31",{"name":164,"class":165},"VA Office of Research and Development","FED",{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":17,"sex":60,"minAge":86,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":24,"phases":175,"briefSummary":176,"conditions":177,"keywords":181,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":201},"100651870","virtual-nature-versus-guided-imagery-for-anxiety-and-well-being-in-hospitalized-older-adults-100651870","NCT07765355","Virtual Nature Versus Guided Imagery for Anxiety and Well-Being in Hospitalized Older Adults","Bottom-Up Virtual Nature Versus Top-Down Guided Imagery in Hospitalized Older Adults: A Randomized Parallel-Group Clinical Trial","Inclusion Criteria:\n\n* Aged 65 years or older\n* Receiving inpatient hospital care, with at least two weeks of hospitalisation at the time of enrolment\n* Montreal Cognitive Assessment (Hungarian version) score of 18 or above, with education correction\n* Physically able to safely wear a head-mounted virtual reality display\n* Adequate corrected or uncorrected vision and hearing\n* Able to communicate in Hungarian\n* Stable psychiatric and cardiovascular condition, as determined from medical history and in consultation with the treating physician\n* Able to provide independent written informed consent\n\nExclusion Criteria:\n\n* Epilepsy with recurrent seizures, or photosensitivity\n* Neurological condition associated with increased risk during virtual reality use, including Meniere's disease and significant carotid stenosis\n* Active psychosis, hallucinations, or severe depression with psychotic features\n* Open wound or skin lesion on the face, chronic neck pain, or spinal condition preventing safe use of the head-mounted display\n* Severe uncorrectable sensory impairment\n* Unstable psychotropic medication during the preceding eight weeks\n* Regular use of analgesic or psychotropic medication that may substantially affect perception of the experience\n* Active alcohol or substance use disorder within the past year\n* Refusal or inability to provide informed consent\n\nEnrolment is deferred, rather than excluded, in the presence of active delirium or infectious illness, until the condition resolves.",{"count":174,"type":23},60,[26],"Long hospital stays can be difficult for older adults. Being confined to a ward, with limited mobility and little access to the outdoors, may contribute to anxiety, low mood, and reduced well-being. Contact with nature is known to support relaxation and emotional recovery, but hospitalized patients often cannot go outside.\n\nThis study compares two ways of bringing a nature experience to patients who are staying in hospital. In the first approach, participants wear a virtual reality headset and watch 360-degree videos filmed in real natural settings near Budapest: a meadow, a stream, and a mountain. The nature scene reaches them through their eyes and ears. In the second approach, participants listen to a short recorded audio guide and picture the same three nature scenes in their own minds, with their eyes closed. Here the nature scene is created by their own imagination.\n\nBoth approaches use exactly the same nature themes. The only difference is how the experience reaches the person: from the outside through the senses, or from the inside through imagination. The study asks whether these two routes have different effects, and whether they can be told apart by measuring heart rate variability, which reflects how the body's automatic nervous system responds.\n\nParticipants are adults aged 65 or older who have been in hospital for at least two weeks. After joining the study, each participant is first observed for two weeks while receiving only their usual hospital care. This period serves as their own comparison. They are then assigned by chance to one of the two approaches and take part in three sessions over two weeks. Questionnaires and brief cognitive tests are completed at three points: when joining, before the sessions begin, and after the sessions end.\n\nThe main question is whether anxiety symptoms decrease more during the session period than during the preceding period of usual care. The study also looks at mood, attention and memory, well-being, and resilience.",[95,178,32,179,180],"Hospitalization","Psychological Distress","Depression",[182,183,184,185,186,187,188,189,190,191,192],"virtual reality","guided imagery","nature exposure","heart rate variability","hospitalized older adults","top-down processing","bottom-up processing","RMSSD","geriatrics","Katathym Imaginative Psychotherapy","symbol therapy",{"date":194,"type":44},"2026-08-14",{"date":196,"type":44},"2025-06-01",{"date":198,"type":23},"2027-01",{"name":200,"class":51},"Semmelweis University",2,{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":24,"phases":212,"briefSummary":213,"conditions":214,"keywords":216,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":52},"100651141","effects-of-extracorporeal-shockwave-therapy-versus-dry-needling-on-jumpers-knee-100651141","NCT07756918","Effects of Extracorporeal Shockwave Therapy Versus Dry Needling on Jumpers Knee","Effects of Extracorporeal Shockwave Therapy Versus Dry Needling on Pain, Knee Function and Quality of Life in Jumpers Knee","Inclusion Criteria:\n\n* Participants of either gender between the age of 18-35 years with a confirmed diagnosis of jumper's knee for more than 1 month.\n* Confirmed diagnosis of jumper's knee for more than 1 month.\n* Pain NPRS (Numeric Pain Rating Scale) score greater than 4 at the first evaluation.\n\nExclusion Criteria:\n\n* Surgery around the knee joint within the last 6 months.\n* Chronic knee joint disease.\n* Knee pain management with corticosteroid injections in the last 3 months.\n* Trauma history\n* Systemic illness","35 Years",{"count":211,"type":23},48,[26],"The study is randomized and single-blinded. Ethical approval is taken from ethical committee of Riphah International University, Lahore. Participants who meet the inclusion criteria will be enrolled and allocated in group A \\& B through sealed envelope method by Non-probability Convenient random sampling technique. Subjects in Group A will receive Shock wave therapy. Group B will receive Dry needing.",[127,32,215],"Jumper's Knee",[217,218,219,220],"dry needling","extra-corporeal shock wave therapy","pain","jumper knee",{"date":222,"type":44},"2026-08-11",{"date":224,"type":44},"2025-10-15",{"date":226,"type":23},"2026-08-30",{"name":228,"class":51},"Riphah International University",{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":12,"sex":60,"minAge":61,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":24,"phases":239,"briefSummary":240,"conditions":241,"keywords":247,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":263},"100651606","effectiveness-and-costs-of-pressure-ulcer-treatment-and-the-quality-of-life-of-patients-with-pressure-ulcers-receiving-home-based-and-institutional-care-100651606","NCT07763106","Effectiveness and Costs of Pressure Ulcer Treatment and the Quality of Life of Patients With Pressure Ulcers Receiving Home-Based and Institutional Care","Comparative Assessment of the Effectiveness and Costs of Pressure Ulcer Treatment and the Quality of Life of Patients With Pressure Ulcers Receiving Home-Based and Institutional Care","Inclusion Criteria:\n\n* Women and men aged 60 to 90 years,\n* stage II-IV pressure ulcers in the lumbar-sacral area of the trunk, pelvic girdle, and lower limbs,\n* high risk of pressure ulcers (above 15 points on the Waterlow scale),\n* daily functional ability below 40 points on the Barthel scale,\n* consent from the patient or legal guardian\u002Fcaregiver to participate in the study.\n\nExclusion Criteria:\n\n* General contraindications (acute inflammatory conditions and febrile illnesses, venous thrombosis, cachexia),\n* pressure ulcers requiring surgical treatment (black necrosis, inflammation of bones and soft tissues),\n* tunneling pressure ulcers showing signs of acute inflammation,\n* pressure ulcers showing signs of infection (causing fever, swelling, pain, and unpleasant odor),\n* pressure ulcers with a surface area of less than 0.5 cm2,\n* pressure ulcers occurring on the lower legs or feet in patients with acute and chronic venous insufficiency and diabetes,\n* multiple pressure ulcers (\\>2),\n* malignant tumors,\n* decompensated diabetes,\n* end-stage chronic heart failure,\n* end-stage renal disease,\n* mental illness.","90 Years",{"count":238,"type":23},80,[26],"A study aimed at comparing the effectiveness of treatment, costs, and quality of life of patients with pressure ulcers in home care and institutional care.\n\nEighty individuals aged 60-90 years with stage II-IV pressure ulcers can participate in the study.\n\nParticipants will be assessed for factors such as health status, independence, mood, and quality of life.\n\nThe study will allow for better tailoring care to patients' needs. Other benefits of participating in the study is that the participants will receive a detailed assessment of their health, nutrition, quality of life, as well as support in managing their pressure ulcers. They will receive regular care and medical evaluations, which may positively impact their health and well-being.\n\nRefusing to participate in this study will not affect the patients treatment in any way.\n\nPlease ask if there is anything that is unclear or if you would like additional information.\n\nTaking part in this study is entirely voluntary.",[242,243,32,244,245,246],"Pressure Ulcer (PU)","Pressure Ulcers, Bedsores, Decubitus Ulcer","INSTITUTIONAL CARE","Wound Closure","Wound Care",[248,249,250,251,252,253,254],"Pressure Ulcer","Quality of life","Home-Based","Institutional Care","wound care","wound closure","wound treatment","2026-08-09",{"date":130,"type":44},{"date":258,"type":23},"2026-09-01",{"date":260,"type":23},"2027-12-31",{"name":262,"class":51},"The Jerzy Kukuczka Academy of Physical Education in Katowice",3,{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":86,"enrollmentInfo":272,"targetDuration":4,"studyType":24,"phases":273,"briefSummary":274,"conditions":275,"keywords":280,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":52},"100651050","cancog-pilot-trial-of-cognitive-rehabilitation-for-cancer-survivors-100651050","NCT07755839","CanCOG®: Pilot Trial of Cognitive Rehabilitation for Cancer Survivors","CanCOG® - Cognitive Rehabilitation in Cancer: A Protocol for a Multicenter Pilot Randomized Controlled Trial With Non-central Nervous System Cancer Survivors","CanCOG®","Inclusion Criteria:\n\n* Adults aged 18 to 65 years whose native language is European Portuguese;\n* Diagnosis of cancer not involving the central nervous system (non-CNS cancer);\n* Disease stage I to III;\n* Completion of primary cancer treatment at least 6 months and no more than 5 years prior to enrollment (with the exception of ongoing hormone therapy and immunotherapy);\n* Score \\\u003C 51 on the Perceived Cognitive Abilities subscale of the FACT-Cog v3. Stable psychiatric and neurological medication regimen for at least 3 months prior to enrollment;\n* Educational level equal to or higher than the 3rd year of primary education;\n* Ability to read and write in Portuguese and provide informed consent to participate.\n\nExclusion Criteria:\n\n* Diagnosis of current severe psychiatric disorders (e.g., schizophrenia, psychosis, bipolar disorder, major depressive disorder, or attention-deficit\u002Fhyperactivity disorder);\n* Diagnosis of communication disorders;\n* Diagnosis of neurodevelopmental disorders or other severe medical conditions (e.g., history of stroke, encephalitis, dementia or neurodegenerative disease, epilepsy, or traumatic brain injury);\n* Presence of metastases or other tumors;\n* History of substance abuse (alcohol or drugs);\n* Current or prior participation in another cognitive rehabilitation intervention.",{"count":174,"type":23},[26],"Cancer-related cognitive impairment (CRCI) affects a large proportion of non-central nervous system cancer survivors and can negatively impact cognitive functioning and daily life. Cognitive rehabilitation has shown promising results in addressing these difficulties. The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and preliminary efficacy of the CanCOG®- Cognitive Rehabilitation in Cancer program in Portuguese adult cancer survivors with CRCI.\n\nAdult non-central nervous system cancer survivors (n=60) will be randomly assigned to receive either the CanCOG® intervention or treatment as usual.\n\nCanCOG® is a structured cognitive rehabilitation program designed to help cancer survivors manage cognitive difficulties through cognitive training exercises, psychoeducation, and compensatory strategy training. The program consists of six weekly sessions of 1 hour and 30 minutes each, delivered over six consecutive weeks. Sessions are administered in person in small groups (3-9 participants) and are led by a trained professional.\n\nThe main focus of the study is to assess feasibility outcomes, including recruitment, retention, adherence to the intervention, and completion of study assessments, as well as acceptability and participant satisfaction.\n\nThe study will also explore preliminary effects of the intervention on cognitive functioning (both perceived and objective), symptoms of anxiety and depression, and quality of life. Participants will complete assessments at baseline (2 weeks after the intervention), 2 weeks after the intervention, and at 3- and 6-month follow-ups. Some participants (10-15) will also take part in interviews to provide feedback on their experience with the program.",[276,277,278,279,32],"Cancer-related Cognitive Impairment","Cancer-related Cognitive Dysfunction","Cancer-related Cognitive Difficulties","Depression and Anxiety Symptoms",[281,282,283,284,285,286,287,288,289],"cancer","cancer survivors","cognitive rehabilitation","cognition","non-pharmacological interventions","RCT","Pilot study","crci","cancer-related cognitive impairment","2026-08-07",{"date":74,"type":44},{"date":293,"type":23},"2026-09",{"date":295,"type":23},"2028-05",{"name":297,"class":51},"Aveiro University",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":12,"sex":60,"minAge":306,"maxAge":307,"enrollmentInfo":308,"targetDuration":4,"studyType":24,"phases":310,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":52},"100467584","quality-of-life-and-quality-of-sleep-studies-in-children-with-home-care-ventilation-in-the-west-of-france-100467584","NCT05368662","Quality of Life and Quality of Sleep Studies in Children With Home Care Ventilation in the West of France","Quality of Life and Quality of Sleep Studies in Children With Home Care Ventilation in Two Regions of France Pays de Loire and Bretagne","EQuaViSE","Inclusion Criteria:\n\n* Child aged 6 months to 17 years treated with non-invasive ventilation at home for at least 1 month\n* Follow-up in one of the five centers participating in the study (Angers, Nantes, Le Mans, Rennes and Brest)\n* Informed consent form signed by both parents, or holder of parental authority, for the participation of their child\n* To be affiliated or beneficiary of social security\n\nExclusion Criteria:\n\n* Parents with poor command of the French language, implying not being able to complete the various questionnaires\n* Refusal of the child to participate in the study","6 Months","17 Years",{"count":309,"type":23},160,[26],"Home ventilation in children, invasive or non invasiv,e is an interesting treatment for different disease which cause chronic respiratory impairement. The aim of this treatment is to support alveolar hypoventilation. Concerned diseases are : neuro-muscular disease, upper airways pathologies, whest wall or lung pathologies, central control ventilation disease. Prevalence of home children ventilation is in augmentation in France. The last national study in 2021 about infants show a prevalence of 9.3\u002F100 000. Advantages with home children ventilation in addition of improvement of survey, it can observe improvement of quality of life and improvement of the quality of their sleep. Quality of life is a thematic less studying. Last studies show an impairment of quality of life in all thematics compare to children with no disease but also with infants whith chronic diseases. This study were about few numbers of patients. The aim of this study is to evaluate the quality of life and the quality of sleep in children with home ventilation to complete the actual littérature to improve the respiratory care of this population.",[32,313],"Non Invasive Ventilation","2026-08-06",{"date":290,"type":44},{"date":317,"type":44},"2022-11-11",{"date":319,"type":23},"2026-12-14",{"name":321,"class":322},"University Hospital, Angers","OTHER_GOV",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":60,"minAge":86,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":24,"phases":332,"briefSummary":333,"conditions":334,"keywords":341,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":52},"100585459","geriatric-trauma-care-program-for-living-alone-older-adults-with-injuries-100585459","NCT06902636","Geriatric Trauma Care Program for Living Alone Older Adults With Injuries","Patient Experience of Older Adults Living Alone With Injuries and Long-Term Effects of Geriatric Trauma Care Program for Living Alone Older Adults With Injuries","Inclusion Criteria:\n\n1. willing to join this study for three months\n2. with limb injuries\n3. living alone in a household\n4. aged 65 years old or older\n5. independent before a traumatic injury\n6. having a smartphone.\n\nExclusion Criteria:\n\n1. with an ISS greater than 16 (severe injuries)\n2. having cognitive impairments\n3. diagnosed with psychiatric illness",{"count":331,"type":23},90,[26],"To examine the long-term effects of the Geriatric Trauma Care Program (GTCP) regarding pain, functional disability, depression, loneliness, and health-related quality of life among older adults with traumatic injuries who live alone.",[335,336,337,127,338,339,32,340],"Limb Injury","Older Adults","Geriatric","Geriatric Depression","Barthel Index","Loneliness",[342,343,344,345],"Limb injury","geriatric trauma","older adults","loneliness","2026-08-04",{"date":314,"type":44},{"date":349,"type":44},"2025-03-27",{"date":351,"type":23},"2026-10-31",{"name":353,"class":51},"Kaohsiung Medical University",{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":18,"minAge":361,"maxAge":362,"enrollmentInfo":363,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":365,"conditions":366,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":369,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":52},"100438485","quality-of-recovery-after-childbirth-100438485","NCT04989894","Quality of Recovery After Childbirth","Investigating the Quality of Recovery After Childbirth","Inclusion Criteria:\n\n* Aged 21-50 years old;\n* Able to read and understand written Chinese;\n* Primiparous and having singleton pregnancy;\n* Delivered via spontaneous vaginal delivery, or elective cesarean delivery;\n* ≥38 gestational week.\n\nExclusion Criteria:\n\n* Failed neuraxial analgesia in those receiving elective cesarean delivery;\n* General anaesthesia;\n* Intrapartum cesarean delivery;\n* Women whose infants have died;\n* Mother or baby requiring ICU after delivery;\n* Assisted\u002F operative vaginal delivery.","21 Years","50 Years",{"count":364,"type":23},122,"In this proposed study, the investigators hope to assess the quality of recovery after delivery in a local population that would take into account physiological and psychological parameters to better understand the recovery process after delivery. The investigators will identify risk factors, especially those that are modifiable and associated with a poorer ObsQoR score and hence a poor quality of recovery after delivery. This data may then be used to educate women and manage expectations in the postpartum period, and help develop potential therapeutic interventions.",[32,367,368],"Childbirth","Maternal Health",{"date":290,"type":44},{"date":371,"type":44},"2021-12-20",{"date":373,"type":23},"2027-12",{"name":375,"class":322},"KK Women's and Children's Hospital",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":384,"minAge":385,"maxAge":307,"enrollmentInfo":386,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":388,"conditions":389,"keywords":396,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":52},"100549884","study-of-the-quality-of-life-in-school-aged-children-with-posterior-urethral-valves-100549884","NCT06439862","Study of the Quality of Life in School Aged-children With Posterior Urethral Valves","Quality of Life in School Aged-children With Posterior Urethral Valves","QUALIVUP","Inclusion Criteria:\n\n* Male patients and their parents\u002Frelatives\n* Aged 6 to 17 years old\n* Treated for PUV in their first year of life between 2006 and 2018\n* Managed in the Femme-Mère-Enfant Hospital in Lyon\n\nExclusion Criteria:\n\n* Children with pre-existing severe cognitive and physical disability (physician's rating) from other condition\n* Children enable to complete QoL questionnaire due to mental or communication impairment","MALE","6 Years",{"count":387,"type":23},300,"Posterior urethral valves (PUV) are the most common congenital obstructive lesion of the urethra, affecting from 1 per 3000 to 1 per 8000 live births. Valve ablation usually resolves the obstruction in PUV but patients still may suffer of deterioration in renal and urinary functions.\n\nRenal insufficiency is the most feared long-term complication. Up to 50 % of the patients will develop chronic kidney disease (CKD), and up to 20 % will develop end-stage renal disease (ESRD) and ultimately will require kidney transplantation. PUV is the first urological cause of ESRD. Progression towards CKD depends on febrile urinary tract infections (UTIs), severity of a vesicoureteral reflux and bladder dysfunction.\n\nBladder dysfunction is due to an overactive and small poorly compliant bladder during infancy. Detrusor overactivity usually decreases in childhood and bladder capacity increases. The most common symptom of this bladder dysfunction is urinary incontinence. 60 % of children are continent at the age of 5 years old and 90 % at 10 years old. In case of persistent bladder dysfunction, medical treatment (anticholinergics, alpha-blockers) may be introduced, or even intermittent catheterizations.\n\nCurrent scientific literature has very few studies on quality of life (QoL) in patients with PUV, mostly in adult patients and very small cohorts. Men treated for PUV in childhood had a good quality of life compared to the normative population, except for sleeping, eating and sexual activity. It seemed that the more severe the urological and nephrological functions were, the lower the QoL was. Children were only asked about intermittent urinary catheterization, and family point of view has never been collected. However, QoL and long-term evolution represent the first concerns of parents-to-be in prenatal counseling, or after diagnosis in an infant with PUV.\n\nHence, the aim of the study is to investigate the quality of life in school-aged children who had been treated for PUV in their first year of life, as measured by the Pediatric Quality of Life Inventory Version 4.0 (PedsQL 4.0).",[32,390,391,392,393,394,395],"Posterior Urethral Valve","Renal Insufficiency","Chronic Renal Disease","End Stage Renal Disease","Bladder Dysfunction","Urinary Incontinence",[249,397,398,399,400],"Posterior Urethral Valves","Children","Adolescents","Family","2026-08-03",{"date":403,"type":44},"2026-08-05",{"date":405,"type":44},"2024-08-20",{"date":407,"type":23},"2028-08",{"name":409,"class":51},"Hospices Civils de Lyon",{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":17,"sex":18,"minAge":209,"maxAge":86,"enrollmentInfo":417,"targetDuration":4,"studyType":24,"phases":419,"briefSummary":420,"conditions":421,"keywords":433,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":52},"100649918","dietary-supplements-and-middle-aged-women-collagen--omega-100649918","NCT07740967","Dietary Supplements and Middle Aged Women (Collagen & Omega)","The Effects of Dietary Supplements on Health and Wellbeing in Middle Aged Women","Inclusion Criteria:\n\n* Female\n* Age 35 - 65 years old\n* Healthy, free from known disease\n* Non-smoker\n* BMI of 18 - 30 kg\u002Fm2 of\n* Classified as either recreationally physically active (meet the WHO guidelines for physical activity of completing at least 150-300 min moderate-intensity activity or 75-150 min of vigorous-intensity activity a week, plus muscle-strengthening activities 2 or more days a week) OR classified as sedentary (do not meet minimum activity guidelines but do occasional and\u002For incidental physical activity (e.g., walking to work, household activities))\n\nExclusion Criteria:\n\n* Currently have a musculoskeletal injury or diagnosed condition (e.g., cardiovascular disease, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder)\n* Regularly taking prescription medication initiated in the last 3 months or unstable\n* Have initiated hormone replacement therapy within the last 3 months and\u002For currently unstable\n* BMI not between 18-30 kg\u002Fm2\n* Allergy to ingredients in supplements or standardized breakfasts\n* Pregnant or breastfeeding, or any other contraindications to consuming study supplements\n* Lost more than 10% of body mass in past 6 months or plan on trying to lose body mass during trial period\n* Currently consuming the supplements being investigated and unwilling to stop taking them\n* Any known cognitive or visual impairments limiting ability to perform cognitive tests\n* Unwilling to maintain current diet and physical activity levels or exercise and activity levels above recreationally active (e.g., athlete)",{"count":418,"type":23},34,[26],"This study will examine the effects of combining different types of dietary supplements on various aspects of health and wellbeing in middle aged women. The main outcomes of the trial will be aspects of health and wellbeing that middle aged women report as increasingly problematic, such as joint pain, fatigue, sleep, and changes in body composition, strength, and inflammation. Participants will consume the supplement(s) or placebo for 8 weeks, and outcome measures will be assessed before and after supplementation.",[422,423,424,425,426,427,428,32,429,430,431,432],"Cognition","Inflammation Biomarkers","Bone Metabolism Biomarkers","Fatigue Symptom","Sleep","Body Composition Changes","Joint Pain","Gastrointestinal Comfort","Blood Pressure and Augmentation Index","Muscle Strength","Fatty Acid Blood Profile",[434,435,436,437],"Collagen peptides","Middle aged women","Joint pain","Dietary supplements","2026-07-31",{"date":401,"type":44},{"date":441,"type":44},"2026-05-01",{"date":443,"type":23},"2028-08-01",{"name":445,"class":51},"Loughborough University",{"id":447,"slug":448,"hasResults":12,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":452,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":454,"enrollmentInfo":455,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":457,"conditions":458,"keywords":462,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":466,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":471,"locationsCount":52},"100614501","evolution-of-insomnia-during-the-first-year-in-patients-newly-diagnosed-with-cancer-100614501","NCT07280416","Evolution of Insomnia During the First Year in Patients Newly Diagnosed With Cancer","Evolution of Insomnia During the First Year in Patients Newly Diagnosed With Cancer: a Longitudinal Study and Analysis of Associated Factors.","INDICA","Inclusion Criteria:\n\n* Confirmed diagnosis of metastatic or non-metastatic cancer,\n* Cancer treated with intravenous chemotherapy and\u002For immunotherapy administered intravenously or subcutaneously,\n* Age ≥ 18 years,\n* Ability to read and understand French,\n* Patient covered by a social security system,\n* Signed informed consent.\n\nExclusion Criteria:\n\n* SCI questionnaire score \\\u003C16\n* Diagnosed or controlled sleep disorders\n* Presence of severe cognitive disorders (e.g., Alzheimer's disease) or major psychiatric disorders (e.g., psychosis), as noted in the medical record, observed at recruitment, or reported by the patient\n* Patient in an emergency situation, or subject to a legal protection measure (guardianship, curatorship, or judicial protection) and unable to provide consent","80 Years",{"count":456,"type":23},260,"The diagnosis of cancer can be a major trigger for new sleep problems, especially insomnia, in people who did not have sleep issues before. Insomnia may appear early in the care pathway and can continue over time, often interacting with other physical or emotional symptoms.\n\nThe main goal of this preliminary study is to describe how insomnia develops during the first months after a cancer diagnosis in patients who had no sleep problems at the time of diagnosis. This will be done through regular follow-up over time.\n\nA secondary aim is to identify the factors that may contribute to the onset or persistence of insomnia, such as the cancer treatments patients receive, as well as any medical or non-medical therapies used to manage sleep difficulties.\n\nThe study will also look at whether patients who develop sleep problems are referred to psychologists trained in specific therapies for insomnia, and how well they follow and adhere to these treatments.",[459,460,127,461,32],"Cancer","Insomnia","Depression Anxiety Disorder",[281,463,219,464,465],"insomnia","Depresion Anxiety disorder","longitudinal",{"date":401,"type":44},{"date":468,"type":44},"2025-12-16",{"date":470,"type":23},"2028-11-01",{"name":472,"class":51},"Centre Hospitalier Emile Roux",{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":479,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":481,"enrollmentInfo":482,"targetDuration":4,"studyType":24,"phases":484,"briefSummary":485,"conditions":486,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":201},"100631922","nurse-led-intervention-on-self-care-adherence-and-quality-of-life-100631922","NCT07506980","Nurse Led Intervention on Self Care Adherence and Quality of Life","Effect of Nurse-led Intervention on Self-care Adherence and Quality of Life Among Patients Undergoing Hemodialysis.","Selfcare","Inclusion Criteria:\n\nAge 18-69 years. Have interdialytic weight gain more than or equal to 1.5 kg. In dialysis treatment twice a week for the last 3 months. Provide consent in verbal and written form Having a mobile phone to use on one's own or with family members.\n\nExclusion Criteria: Self-reported hearing difficulty and visual difficulty.Cognitive problems such as memory loss, language difficulties, and forgetfulness. Having heart problems like dysrhythmia, ventricular heart disease, or reduced ejection fraction requires oxygen at the time of dialysis.","69 Years",{"count":483,"type":23},112,[26],"Background: Hemodialysis is the most common treatment modality in patients with chronic kidney disease. The majority of people with dialysis have a below-average quality of life. Adherence to diet and fluid intake, engagement in physical activity, and feeling blue and anxious will all affect quality of life. Nurses play a key role in patient education and behavioral support. Nurse-led interventions, especially educational programs (laptop-based), combined with reminders and educational materials, may improve patients' knowledge, adherence to treatment, and improvement in quality of life.\n\nMethodology The study will adopt the quantitative research design .The study will be conducted in a single private tertiary care center. First, the day and shift were randomized, and participants belonging to the particular day and shift will be considered as Group A and Group B. After this, the eligibility criteria will be assessed, and the baseline assessment will be done. A convenient sampling technique will be used to select the study sample. The sample will be a minimum of 56 in each arm. Therefore, altogether there will be at least 112 participants. One group will receive nurse-led interventions (Group A), and the control group (Group B) will receive usual routine care.\n\nNurse-led intervention comprises 4 laptop-based educational and counseling sessions, 4-6 telephone reminders, and the distribution of the booklet on self-care. All four sessions will be conducted by the specialist nurse or nurse with at least one year of working experience in a dialysis unit. Each session will be conducted once every one to two weeks. The primary outcome will be self-care adherence. The self-care adherence will be measured by direct assessment of clinical parameters (interdialytic weight gain) of adherence and subjectively through face-to-face interviews. Patients' medical records will be reviewed. The secondary outcome will be the quality of life score. An independent assessor (enumerator) will measure the outcome at T1 and T2, which will be done at 4 months (T1) and 6 months (T2) from the baseline.\n\nAnalysis will be done through the Stata software version 14. Descriptive statistics like frequency, percentage, mean±sd, median, inter quartile range are based on the nature of the data. Similarly, inferential statistics such t t-test and linear regression analysis will be used to find out the difference in mean score between two groups. The findings will be considered statistically significant at level p\\\u003C0.05 at 95% CI.\n\nThe strength of this study will be the inclusion of both clinical and subjective parameters of adherence and assessment of quality of life. Use of a qualitative approach in explaining the factors, like appropriateness of the education and counselling session, along with the facilitators and barriers to adherence, will further help to modify the interventions. If the method is found to be effective, this will be an effective measure to improve quality of life cost-effectively. This can be continued on a regular basis in the same center and can be utilized in others, too.",[487,488,489,32,490],"Nurse Led Interventions","Patients on Hemodialysis","Self Care","Interdialytic Weight Gain","2026-07-29",{"date":438,"type":44},{"date":494,"type":44},"2026-03-30",{"date":496,"type":23},"2026-11-30",{"name":498,"class":51},"Kathmandu University School of Medical Sciences",{"id":500,"slug":501,"hasResults":12,"nctId":502,"briefTitle":503,"officialTitle":504,"acronym":4,"eligibilityCriteria":505,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":506,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":507,"conditions":508,"keywords":515,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":52},"100649752","retrospective-observational-study-of-oral-complications-and-quality-of-life-in-head-and-neck-cancer-patients-treated-with-radiotherapy-or-chemoradiotherapy-100649752","NCT07739771","Retrospective Observational Study of Oral Complications and Quality of Life in Head and Neck Cancer Patients Treated With Radiotherapy or Chemoradiotherapy.","Retrospective Evaluation of Severe Oral Mucositis Incidence, Time to Onset and Functional Impact in Quality of Life in Head and Neck Cancer Radiated and Chemo-radiated Patients. Part of the Stop Oral Mucositis Project (STOPOMP)","Inclusion Criteria:\n\n* Adults (≥18 years) diagnosed with head and neck cancer\n* Treated with radiotherapy or chemoradiotherapy, with or without surgery and\u002For immunotherapy, according to tumor type and stage, between 2019 and 2023\n* With available medical records documenting clinical assessments of oral mucositis during at least the radiotherapy\u002FCRT treatment period, and that had used the oral mucosa topical measures\n\nExclusion Criteria:\n\n* Patients with missing or insufficient clinical records required for the study\n* Patients with concomitant malignancies undergoing active treatment at the same time.",{"count":174,"type":23},"Head and Neck cancer patients receiving radiation therapy (with or without chemotherapy) suffer several oral complications, such as oral mucositis, which impairs quality of life of patients during radiotherapy and in the post-treatment follow-up period. The use of topical agents to protect oral mucosa against radiation-induced toxicity is part of the routine clinical practice. Among these products, the use of mouthwashes and\u002For gels are extensively used in the Centro Oncológico Clara Campal - Hospital HM Sanchinarro. Once such product is a proprietary formulation based on natural ingredients such as olive oil, betaine, and xylitol (Mucosa Innovations S.L.).",[509,32,510,127,511,512,513,514],"Oral Mucositis","Mucositis","Speech","Saliva","Radiation Toxicity","Chemotherapeutic Toxicity",[509,516,517,127,518,519,520,521,522],"Cancer Therapy Toxic Effect","Cancer Support","Ulcers","Treatment Interruptions","Oral Mucosa","Radiotherapy","Chemotherapy","2026-07-28",{"date":438,"type":44},{"date":526,"type":23},"2026-08",{"date":528,"type":23},"2026-10",{"name":530,"class":531},"Mucosa Innovations, S.L.","INDUSTRY",{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":18,"minAge":539,"maxAge":540,"enrollmentInfo":541,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":543,"conditions":544,"keywords":554,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":564,"locationsCount":52},"100649631","retrospective-cohort-study-of-symptoms-and-quality-of-life-in-women-with-genitourinary-syndrome-of-menopause-100649631","NCT07737782","Retrospective Cohort Study of Symptoms and Quality of Life in Women With Genitourinary Syndrome of Menopause.","Retrospective Observational Study in a Cohort of Postmenopausal Women With Genitourinary Syndrome of Menopause (GSM): Characterization of Symptoms and Impact on Quality of Life.","Inclusion Criteria:\n\nPatients included in this retrospective data evaluation must have met all of the following criteria:\n\n* Postmenopausal women (defined as at least 12 consecutive months of amenorrhea)\n* Present at least one symptom of GSM documented in the medical record\n* Evidence in the medical record that the patient had perceived the GSM symptom(s) as having an impact on her quality of life.\n* Documentation in the medical record that the patient had initiated treatment with XCM INTIM, together with follow-up clinical data including an assessment performed at least 8 weeks after treatment initiation.\n* Patients that had attended at the Department of Obstetrics and Gynecology of Hospital Universitario La Luz between January 2022 and April 2026, regardless of whether they had participated in another study during this period.\n\nExclusion Criteria:\n\nPatients will be excluded from the study if any of the following conditions were present:\n\n* Use of topical vulvovaginal hormonal products within 4 weeks prior to initiation of XCM INTIM treatment.\n* Use of systemic estrogen therapy within 8 weeks prior to initiation of XCM INTIM treatment.\n* Presence of relevant gynecological and\u002For urinary conditions that could have interfered with the assessment of symptoms attributed to GSM, including but not limited to active vulvovaginal and\u002For urinary tract infections, significant vulvar lesions, active gynecological malignancies, severe stress urinary incontinence (Sandvik score ≥ 8), pelvic organ prolapse stage III or higher (POP-Q), or any other condition considered by the investigator to be a significant confounding factor.\n* Previous radiotherapy involving the pelvic and\u002For genital region.\n* Previous laser and\u002For radiofrequency treatment in the pelvic region.\n* Medical records containing insufficient information for analysis of the primary study variables.","40 Years","75 Years",{"count":542,"type":23},100,"The goal of this clinical trial is to retrospectively identify the most prevalent symptoms of genitourinary syndrome of menopause (GSM) among postmenopausal women and to evaluate their impact on quality of life. Moreover, based on data collected from medical records and\u002For patient-reported questionnaires, if available data enable it, it will be assessed whether treatment with the topical vulvovaginal gel XCM INTIM for a minimum of 8 weeks results in changes in symptom severity and in the impact of these symptoms across different quality-of-life domains.",[545,546,547,32,548,549,550,551,552,553],"Vulvar Atrophy","Vulvovaginal Signs and Symptoms","Genitourinary Syndrome of Menopause (GSM)","Menopause Related Conditions","Dyspareunia","Urinary Incontinence, Urgency-frequency","Sexual Function","Women´s Health","Vaginal Dryness",[555,546,556,32,557,552,558],"Genitourinary Syndrome of Menopause","Patient Reported Outcome Measures","Day-to-Day Impact of Vaginal Ageing","Real World Data",{"date":560,"type":44},"2026-07-30",{"date":562,"type":23},"2026-07",{"date":293,"type":23},{"name":530,"class":531},{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":454,"enrollmentInfo":572,"targetDuration":4,"studyType":24,"phases":573,"briefSummary":574,"conditions":575,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":581,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":586,"locationsCount":52},"100468520","sacral-neuromodulation-for-neurogenic-lower-urinary-tract-bowel-and-sexual-dysfunction-100468520","NCT05380856","Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction","Sacral Neuromodulation for Patients With Multiple Sclerosis With Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction. A Multicenter Double-blind, Placebo-controlled Randomized Clinical Trial.","Inclusion Criteria:\n\n* Refractory neurogenic lower urinary tract dysfunction (nLUTD) defined by visual analogue scale on treatment satisfaction ranging from 0 to 100 (100 means maximal satisfaction with the current treatment). All patients indicating satisfaction less than 50 are considered non-responders\u002Fhaving refractory overactive bladder (OAB) to current treatment\n* No effect of medical treatment defined by antimuscarinics, beta3-agonist and alpha-blocker.\n* Patients having refractory nLUTD who intend to try SNM for relief of their symptoms\n* Expanded Disability Status Scale (EDSS) \\\u003C 5 and no progression of neurological disease within 6 months\n* Written informed consent\n* Able to understand the information given about the project\n\nExclusion Criteria:\n\n* EDSS \\> 5, neurological disease with severe progression within the last 6 months and\u002For unable to manage the electronic devices\n* Age \\\u003C 18 years\n* Any other urological pathology but nLUTD\n* Bladder Pain Syndrome\u002FInterstitial cystitis\n* Any other intestinal or gynecological pathology but neurological conditional symptoms\n* Current pelvic malignancy or clinically significant pelvic mass\n* Previous pelvis radiotherapy\n* Bladder injections with botulinum neurotoxin type A within 6 months before inclusion in trial\n* Unable to manage the electronic devices\n* Inability to give an informed consent",{"count":174,"type":23},[26],"A multi-center double-blinded placebo-controlled randomized clinical trial.\n\nThe patients will be randomized into two groups.\n\nTo investigate the efficacy of SNM to improve the key bladder diary variables compared to placebo (i.e. sham) for patients with MS having refractory neurogenic lower urinary tract dysfunction (NLUTD).\n\nAfter first step SNM-procedure and a 3-4 weeks test period patients with more than 50% improvement in the key bladder diary variables will have the IPG implanted. After a month of optimization patients will into two groups: IPG ON or IPG OFF.\n\nPeriod of randomization: four months. Number anticipated to be included: 60 patients",[576,577,578,579,580,32],"Neurogenic Dysfunction of the Urinary Bladder","Multiple Sclerosis","Sacral Neuromodulation","Bowel Dysfunction","Sexual Dysfunction",{"date":491,"type":44},{"date":583,"type":44},"2023-09-26",{"date":585,"type":23},"2027-03-01",{"name":587,"class":51},"Odense University Hospital",{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":12,"sex":60,"minAge":539,"maxAge":595,"enrollmentInfo":596,"targetDuration":4,"studyType":24,"phases":598,"briefSummary":599,"conditions":600,"keywords":603,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":609,"completionDateStruct":611,"leadSponsor":612,"locationsCount":52},"100649715","mind-body-pilates-vs-pressure-biofeedback-for-chronic-non-specific-low-back-pain-100649715","NCT07738965","Mind-Body Pilates vs Pressure Biofeedback for Chronic Non-Specific Low Back Pain","Effects of Mind-Body Pilates Versus Pressure Biofeedback on Pain,Core Strength and Quality of Life in Chronic Non-Specific Low Back Pain","Inclusion Criteria:\n\n* Age 40-55 years.\n* Diagnosed with chronic non-specific low back pain (pain lasting ≥12 weeks).\n* Numeric Rating Scale (NRS) pain score ≥3.\n* Able to understand study procedures and provide written informed consent.\n* Able to participate in the exercise program and attend treatment sessions.\n\nExclusion Criteria:\n\n* History of lumbar spine surgery within the past 12 months.\n* Serious spinal pathology (fracture, tumor, infection, inflammatory disease).\n* Neurological deficits or radiculopathy requiring surgical management.\n* Pregnancy.\n* Participation in a structured Pilates or core stabilization program within the previous 6 months.\n* Any medical condition that prevents safe participation in exercise.","55 Years",{"count":597,"type":23},66,[26],"Chronic Non-Specific Low Back Pain means pain in the lower back that lasts for more than 3 months and does not have a serious cause like a fracture, infection, or nerve damage. It is very common and affects many people at some point in their lives.\n\nThis type of back pain usually happens because the muscles that support your spine become weak or do not work properly. It can also be linked to poor posture, sitting too long, lack of exercise, stress, or anxiety. Over time, this can lead to stiffness, reduced movement, and difficulty doing daily activities.\n\nTreatment mainly focuses on exercise and staying active. Simple physiotherapy treatments like stretching, strengthening, and heat therapy can help reduce pain, but they may not fully improve the deeper muscles that support your back.\n\nTwo helpful exercise approaches are:\n\nMind-Body Pilates: This involves slow, controlled movements with proper breathing. It helps improve posture, strengthen core muscles, and reduce stress.\n\nPressure Biofeedback Training: This uses a small device to help you learn how to correctly activate deep abdominal muscles that support your spine.\n\nBoth methods can reduce pain and improve movement. Pilates focuses on whole-body control and relaxation, while biofeedback training focuses more on activating specific muscles.\n\nIn simple terms, regular exercise, good posture, and learning how to properly use your core muscles are key to managing long-term back pain and improving your quality of life.",[601,127,602,32],"Chronic Non Specific Low Back Pain","Core Strength",[604,605,606],"Mind-Body Pilates","pressure biofeedback","chronic Non specific low back pain","2026-07-27",{"date":438,"type":44},{"date":610,"type":23},"2026-07-01",{"date":496,"type":23},{"name":613,"class":51},"Lahore University of Biological and Applied Sciences",{"id":615,"slug":616,"hasResults":12,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":620,"eligibilityCriteria":621,"healthyVolunteers":17,"sex":384,"minAge":19,"maxAge":539,"enrollmentInfo":622,"targetDuration":4,"studyType":24,"phases":623,"briefSummary":626,"conditions":627,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":631,"completionDateStruct":633,"leadSponsor":635,"locationsCount":52},"100635460","phase-2-cbd-supplementation-in-brazilian-jiu-jitsu-athletes-100635460","NCT07552974","CBD Supplementation in Brazilian Jiu-Jitsu Athletes","Evaluation of the Effects of Isolated Cannabidiol (CBD) on Inflammation, Pain, Sleep and Quality of Life in Brazilian Jiu-Jitsu Athletes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","CBD-BJJ-RCT","Inclusion Criteria:\n\n* Age between 18 and 40 years;\n* Minimum 2 years of BJJ practice;\n* Training at least 3 times per week;\n* Free from injuries that prevent training or competition;\n* No current or recent cannabis use;\n* Signed Informed Consent Form (ICF).\n\nExclusion Criteria:\n\n* History of hepatic, renal, or cardiovascular diseases;\n* Use of medications that may interact with CBD (e.g., anticoagulants);\n* Allergy or known hypersensitivity to cannabinoids;\n* Pregnancy or planning to become pregnant;\n* Participation in another clinical study within the last 30 days.",{"count":542,"type":23},[624,625],"PHASE2","PHASE3","Brazilian Jiu-Jitsu (BJJ) is a high-intensity martial art that imposes significant physical and physiological demands on practitioners, including rigorous training and frequent competitions, which can result in chronic inflammation, delayed-onset muscle soreness (DOMS), sleep disturbances, and reduced quality of life. Effective recovery strategies are essential to optimize athletic performance and longevity in the sport.\n\nCannabidiol (CBD), a non-psychotomimetic phytocannabinoid derived from Cannabis sativa, has emerged as a promising therapeutic agent due to its anti-inflammatory, analgesic, anxiolytic, and neuroprotective properties.\n\nPreclinical studies indicate that CBD modulates inflammatory pathways, such as inhibition of NF-κB and NLRP3, thereby reducing pro-inflammatory cytokines such as IL-6, TNF-α, IL-8, and IL-1β, while increasing the anti-inflammatory cytokine IL-10.\n\nIn clinical contexts, CBD has shown potential to attenuate DOMS and improve sleep without the adverse effects associated with non-steroidal anti-inflammatory drugs (NSAIDs). However, evidence in BJJ athletes remains limited, with gaps in the translation of preclinical findings to healthy athletic populations.\n\nThe prevalence of injuries in combat sports can reach 28%, with contusions and sprains being common and further exacerbating inflammation and pain. Although approximately 23.4% of athletes report cannabis use, there is a lack of randomized controlled trials (RCTs) specifically for BJJ evaluating isolated CBD at standardized doses.\n\nFurthermore, concerns regarding hepatotoxicity, monitored through enzymes such as AST and ALT, require rigorous safety evaluation.\n\nThis protocol describes an RCT to investigate the effects of 200 mg\u002Fday of isolated CBD for 12 weeks in BJJ athletes, focusing on sensitive inflammatory markers (IL-6 as the primary pro-inflammatory marker and IL-10 as the anti-inflammatory marker), pain, sleep, and quality of life.\n\nThe study aims to address gaps identified in systematic reviews and provide an evidence-based foundation for future recommendations.",[628,127,426,32],"Pro and Anti Inflamatory Cytokines","2026-07-24",{"date":607,"type":44},{"date":632,"type":23},"2027-01-01",{"date":634,"type":23},"2027-07-31",{"name":636,"class":51},"Associação Pan-Americana Multidisciplinar de Endocanabinologia",{"id":638,"slug":639,"hasResults":12,"nctId":640,"briefTitle":641,"officialTitle":642,"acronym":643,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":645,"enrollmentInfo":646,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":654,"startDateStruct":655,"completionDateStruct":657,"leadSponsor":658,"locationsCount":660},"100589500","effect-of-alcohol-sclerotherapy-on-pelvic-pain-and-quality-of-life-in-women-with-ovarian-endometriosis-100589500","NCT06955221","Effect of Alcohol Sclerotherapy on Pelvic Pain and Quality of Life in Women With Ovarian Endometriosis","Effect of US-guided Alcohol Sclerotherapy for Endometriomas on Pelvic Pain and Quality of Life","ESCOMA","Inclusion Criteria:\n\n* Female sex\n* Age ≥18 and ≤45 years\n* Ultrasound suspicion of unilocular endometrioma or with a thin septum less than 3 mm\n* Size between 30-100 mm, persistent for at least 3-6 months since diagnosis\n* Ca125 marker \\\u003C300 UI\u002FmL and HE4 \\\u003C 70 pM\n* Signed informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>45 years\n* History of ovarian or uterine cancer\n* Endometrioma size \\\u003C30 mm or \\>100 mm\n* Indication for surgical treatment of the endometrioma due to suspected severe extra-ovarian endometriosis or any other cause\n* Ultrasound suspicion of dermoid cysts, anechoic cysts, or cysts with high risk of malignancy\n* Ca125 \\>300 UI\u002FmL\n* HE4 \\>70 pM\n* Pregnant women\n* Patients who do not wish to participate in the study or who are mentally incapacitated","45 Years",{"count":647,"type":23},288,[26],"The goal of this clinical trial is to evaluate whether ultrasound-guided alcohol sclerotherapy can improve pelvic pain and quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas, compared to expectant management.\n\nThe main questions it aims to answer are:\n\n1. \\- Does sclerotherapy significantly reduce pelvic pain compared to expectant management?\n2. \\- Does sclerotherapy improve quality of life as measured by the EHP-5 score?\n\nResearchers will compare the sclerotherapy group to the expectant management group to determine whether the intervention leads to greater improvement in pain and quality of life.\n\nParticipants will:\n\n* Be randomly assigned to one of two groups: (1) Sclerotherapy group: undergo ultrasound-guided puncture and alcohol sclerotherapy; (2) Control group: expectant management\n* Complete quality of life and pain assessments at baseline and after 6 months\n* Provide blood and urine samples for biomarker analysis (e.g., cortisol, IL-6, hsCRP, catecholamines)\n* Undergo ovarian reserve assessments (AMH, antral follicle count)\n* Be followed for adverse events, recurrence, fertility outcomes, and treatment-related costs\n\nThe study will follow an intention-to-treat and per-protocol analysis approach.",[651,652,32,653],"Endometrioma","Ultrasound Therapy; Complications","Pelvic Pain",{"date":607,"type":44},{"date":656,"type":44},"2025-01-01",{"date":260,"type":23},{"name":659,"class":51},"Hospital Universitari de Bellvitge",28,{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":12,"sex":60,"minAge":595,"maxAge":4,"enrollmentInfo":668,"targetDuration":4,"studyType":24,"phases":670,"briefSummary":671,"conditions":672,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":675,"lastUpdatePostDateStruct":676,"startDateStruct":677,"completionDateStruct":679,"leadSponsor":681,"locationsCount":52},"100649473","a-community-based-solution-for-nocturia-integrating-digital-technology-and-behavioral-interventions-100649473","NCT07734207","A Community-based Solution for Nocturia: Integrating Digital Technology and Behavioral Interventions","A Novel Community-based Solution for Nocturia: Integrating Digital Technology and Multi-strategy Interventions","Inclusion Criteria:\n\n1. Baseline nocturia frequency ≥ 2 times\u002Fnight (confirmed by subjective report or simplified questionnaire).\n2. Ability to operate LINE on a smartphone or have a caregiver assist with completing the electronic urinary diary.\n\nExclusion Criteria:\n\n1. Acute urinary tract infection\n2. Uncontrolled heart failure\n3. Serum sodium \\\u003C 130 mEq\u002FL\n4. Underwent urological surgery within the past three months\n5. Major psychiatric or neurological disorder in an active phase, (GDS-15\\>5)\n6. Participation in other clinical trials related to nocturia",{"count":669,"type":23},50,[26],"Nocturia is a prevalent and distressing condition among older adults in Taiwan, significantly impacting sleep quality, mental health, and fall risks. This pilot study evaluates a novel community-based management model that integrates digital health technology with behavioral therapy. Participants aged 55 years or older experiencing nocturia (≥2 voids\u002Fnight) will be cluster-randomized into an intervention group or a control group.\n\nThe intervention group will utilize a voiding diary and a non-contact home uroflowmetry (HUFM) device to track voiding patterns and receive real-time feedback. This data-driven approach is combined with personalized lifestyle guidance (e.g., fluid restriction and leg elevation) and psychiatric screening for sleep and mood disorders. The primary objective is to evaluate the reduction in nocturnal voids and improve quality of life, while exploring the potential to reduce dependence on medications.",[673,674,32],"Nocturia","Sleep Disturbanc","2026-07-23",{"date":491,"type":44},{"date":678,"type":44},"2026-04-08",{"date":680,"type":23},"2027-03-31",{"name":682,"class":51},"National Taiwan University Hospital",{"id":684,"slug":685,"hasResults":12,"nctId":686,"briefTitle":687,"officialTitle":415,"acronym":4,"eligibilityCriteria":688,"healthyVolunteers":17,"sex":18,"minAge":209,"maxAge":86,"enrollmentInfo":689,"targetDuration":4,"studyType":24,"phases":691,"briefSummary":420,"conditions":692,"keywords":694,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":697,"lastUpdatePostDateStruct":698,"startDateStruct":699,"completionDateStruct":700,"leadSponsor":701,"locationsCount":52},"100649225","dietary-supplements-and-middle-aged-women-creatine-100649225","NCT07729930","Dietary Supplements and Middle Aged Women (Creatine)","Inclusion Criteria:\n\n* Female\n* Aged 35-65 years old\n* Healthy, free from known disease\n* Non-smoker\n* BMI 18-30 kg\u002Fm2\n* Classified as recreationally active (meet the WHO guidelines for physical activity: complete at least 150-300 minutes of moderate intensity activity or 75-150 minutes of vigorous intensity activity a week, plus muscle strengthening activities 2 or more days a week) OR sedentary (do not meet the minimum activity guidelines but do occasional and\u002For incidental physical activity, e.g., walking to work, household activities).\n\nExclusion Criteria:\n\n* Currently have a musculoskeletal injury or diagnosed condition (CVD, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder)\n* Regularly taking prescription medication initiated in the last 3 months or unstable\n* Have initiated hormone replacement therapy within the last 3 months or unstable\n* Have an allergy to ingredients in the supplements or standardised breakfast\n* Pregnant or breastfeeding, or any other contradictions to consuming the study supplements\n* Lost more than 10% of body mass in the past 6 months or plan on trying to lose body mass during trial period\n* Currently consuming the supplements being investigated and unwilling to stop\n* Any known cognitive or visual impairments limiting ability to perform cognitive tests\n* Unwilling to maintain current diet and physical activity levels and report any change in health status",{"count":690,"type":23},38,[26],[422,431,425,430,427,426,429,32,428,423,424,693],"Menopause Symptoms",[695,435,696,437],"Creatine","Cognitive function","2026-07-21",{"date":523,"type":44},{"date":441,"type":44},{"date":470,"type":23},{"name":445,"class":51},{"id":703,"slug":704,"hasResults":12,"nctId":705,"briefTitle":706,"officialTitle":707,"acronym":4,"eligibilityCriteria":708,"healthyVolunteers":12,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":709,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":710,"conditions":711,"keywords":715,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":725,"lastUpdatePostDateStruct":726,"startDateStruct":727,"completionDateStruct":729,"leadSponsor":731,"locationsCount":52},"100636635","changes-in-oral-health-related-quality-of-life-ohrqol-during-full-arch-implant-treatment-100636635","NCT07568249","Changes in Oral Health-related Quality of Life (OHRQoL) During Full Arch Implant Treatment","Changes in Oral Health-related Quality of Life ( OHRQoL) Full Arch Implant Treatment: A Prospective Study","Inclusion Criteria:\n\nAdults aged 18 years or older. Patients requiring full-arch implant-supported rehabilitation of the maxilla and\u002For mandible.\n\nPatients with indication for immediate full-arch implant-supported rehabilitation using 4, 6, or 8 implants per arch, according to anatomical and clinical conditions.\n\nPatients able to understand the study procedures and complete patient-reported outcome questionnaires Patients willing to provide written informed consent.\n\nExclusion Criteria:\n\nPatients with medical contraindications for implant surgery. Patients unable to provide informed consent. Patients unable to complete the study questionnaires Patients with uncontrolled systemic conditions that may contraindicate implant therapy.\n\nPatients unable or unwilling to attend the planned follow-up visits. Patients receiving partial-arch implant rehabilitation only.",{"count":542,"type":23},"Full-arch implant-supported fixed dental prostheses are a widely accepted treatment for edentulous patients, with high long-term implant survival rates. However, further research is needed on longer-term patient satisfaction and on the psychosocial impact of this treatment on patients' daily life and functioning. Assessing patient-reported outcomes - oral health-related quality of life (OHRQoL) and patient satisfaction - allows the impact of full-arch rehabilitation on patients to be evaluated.",[712,32,713,714],"Edentulous Mouth","Tooth Loss","Oral Health Quality of Life (OHQoL) Was Assessed",[716,717,718,719,720,721,722,723,724],"dental implant","oral health","outcome studies","oral quality of life","OHIP-14","Implant-supported prosthesis","quality of life","oral health quality of life","PIDAQ-PT","2026-07-19",{"date":697,"type":44},{"date":728,"type":44},"2025-11-01",{"date":730,"type":23},"2028-10-01",{"name":732,"class":51},"Implantology Institute"]