[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rapid-sequence-induction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rapid-sequence-induction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100648512","comparison-of-high-flow-nasal-cannula-and-tight-face-mask-for-maintaining-oxygenation-during-rapid-sequence-induction-100648512",false,"NCT07723430","Comparison of High-Flow Nasal Cannula and Tight Face Mask for Maintaining Oxygenation During Rapid Sequence Induction","Comparison of the Effectiveness of High-Flow Oxygen Cannula Versus Tight Face Mask in Maintaining Oxygenation During Rapid Sequence Induction","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients requiring rapid sequence induction (RSI) for endotracheal intubation in the operating room, emergency department, or intensive care unit.\n* Patients in whom both high-flow nasal cannula (HFNC) and tight face mask preoxygenation are technically feasible.\n* Patients (or their legally authorized representatives, when applicable) able to provide written informed consent.\n\nExclusion Criteria:\n\n* Patients requiring immediate crash intubation without sufficient time for preoxygenation.\n* Patients with facial deformities, upper airway obstruction, or other conditions preventing the use of either HFNC or a tight face mask.\n* Known contraindications or hypersensitivity to medications used for rapid sequence induction.\n* Pregnant women.\n* Patients younger than 18 years of age.\n* Patients with do-not-intubate (DNI) orders.\n* Patients already intubated or mechanically ventilated before enrollment.\n* Patients who underwent endotracheal intubation within the previous 24 hours.","ALL","18 Years",{"count":19,"type":20},290,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective randomized controlled trial aims to compare the effectiveness of High-Flow Nasal Cannula (HFNC) versus Tight Face Mask (TFM) in maintaining oxygenation during rapid sequence induction (RSI) for endotracheal intubation in adult patients. Participants will be randomly assigned in a 1:1 ratio to receive either HFNC or TFM for preoxygenation before induction of anesthesia. The primary outcome is the lowest peripheral oxygen saturation (SpO₂) recorded from induction until successful endotracheal intubation. Secondary outcomes include the incidence of oxygen desaturation (\\\u003C90%), duration of apnea, duration of laryngoscopy, intubation time, number of intubation attempts, and peri-intubation complications. The study will determine whether HFNC provides superior oxygenation compared with conventional face mask preoxygenation during RSI and may contribute to improving airway management protocols and patient safety.",[26,27,28,29],"Hypoxemia","Airway Management","Endotracheal Intubation","Rapid Sequence Induction","NOT_YET_RECRUITING","2026-07-22",{"date":33,"type":34},"2026-07-23","ACTUAL",{"date":36,"type":20},"2026-08-01",{"date":38,"type":20},"2027-02-20",{"name":40,"class":41},"Khyber Teaching Hospital","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100572427","phase-3-best-hypnotic-drug-choice-for-rapid-sequence-induction-in-the-operating-room-100572427","NCT06733129","Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room","Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room: a 3-arm Randomized Trial","HYPNOTIKS","Inclusion Criteria:\n\n* age between 18 - 80 years' old\n* female\\* and male\n\n  * ≥ 1 risk factor of aspiration of gastric contents defined as\n  * preoperative fasting period of less than 6 hours,\n  * occlusive syndrome, functional ileus, vomiting episode within the last 12 hours,\n  * orthopaedic trauma within the last 12 hours,\n  * medical history of symptomatic gastroesophageal reflux or hiatus, hernia or gastroparesis or dysautonomia or gastroesophageal surgery with sphincter dysfunction)\n* patient requiring orotracheal intubation during general anaesthesia in the operating room.\n* patient or his\u002Fher next of kin written informed consent or emergency procedure\n* failure to discontinue GLP1 analogue as recommended (exenatide, liraglutide, albiglutide, taspoglutide, lixisenatide)\n\nExclusion Criteria:\n\n* predicted impossible tracheal intubation (≥ 1 of the following criteria: patient with known intubation complications, Mallampati score IV, Thyromental Distance ≤ 4.0 cm, Mouth Opening \\\u003C 3 cm, Sternomental Distance \\\u003C 12.5 cm, significant modification of the airway due to congenital, cancer, trauma or burning lesions (non-exhaustive list)) \\[30\\]\n* preoperative arterial hypotension (MAP \\\u003C 65 mmHg or under catecholamine)\n* preoperative respiratory distress syndrome (SpO2 \\\u003C 90% in room air)\n* contraindications to the use of ketamine and\u002For propofol and\u002For NMB:\n\n  * allergy to the active substance or to one of the excipients or to soy or peanuts,\n  * porphyria\n  * intracranial hypertension\n  * uncontrolled arterial hypertension (systolic arterial pressure \\> 180 mmHg)\n  * personal or family history of known malignant hyperthermia, congenital muscular dystrophy, myasthenia, a known congenital deficit in plasma pseudocholinesterase\n* pregnancy or breast-feeding woman\n* patients under court protection or guardianship\n* absence of insurance covering health costs","80 Years",{"count":52,"type":20},1218,[54],"PHASE3","The best hypnotic choice to optimize the balance between good intubation condition quality and hemodynamic stability during RSI performed in the operating theatre remained to be investigated.\n\nTherefore, a randomized study evaluating the efficacy of propofol, ketamine, and a combination of both is appropriate. So, we designed the HyPnotiKs randomized controlled study to investigate the efficacy of these hypnotic drugs in patients undergoing RSI in the operating theatre. The primary endpoint will be the successful tracheal intubation at the first attempt without major arterial hypotension event.",[29],[58,59,60,61,62,63,64],"Rapid sequence induction","Full stomach patient","hypotension","propofol","ketamine","ketofol","general anesthesia","RECRUITING","2025-11-24",{"date":68,"type":34},"2025-12-02",{"date":70,"type":34},"2025-04-14",{"date":72,"type":20},"2027-04-30",{"name":74,"class":41},"Nantes University Hospital",20]