[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rebound-intracranial-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rebound-intracranial-hypertension":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100648597","onsd-trajectory-in-rebound-ich-100648597",false,"NCT07722702","ONSD Trajectory in Rebound ICH","Optic Nerve Sheath Diameter Trajectory During Osmotherapy Weaning as a Predictor of Rebound Intracranial Hypertension in Traumatic Brain Injury","ONSD\u002F INH","Inclusion Criteria:\n\n* Adults (≥18 years) with blunt traumatic brain injury admission GCS ≤12\n* (or GCS 13-15 with CT signs of elevated ICP including midline shift ≥5 mm, effaced cisterns, or significant cerebral edema)\n* clinical decision to initiate 20% mannitol osmotherapy\n\nExclusion Criteria:\n\n* Ocular conditions precluding ONSD measurement (glaucoma, prior ocular surgery,\n* globe or optic nerve trauma,\n* periorbital edema, orbital masses, optic nerve sheath cysts);\n* planned decompressive surgery or evacuation of mass lesion within 48 hours; limitation of life-sustaining therapy; pregnancy; contraindications to mannitol (baseline sodium \\>155 mEq\u002FL, osmolality \\>320 mOsm\u002Fkg, eGFR \\\u003C30 mL\u002Fmin); penetrating TBI; or concurrent spinal cord injury with shock.","ALL","18 Years","80 Years",{"count":21,"type":22},100,"ESTIMATED","6 Weeks","OBSERVATIONAL","The goal of this prospective observational study is to determine whether the trajectory of optic nerve sheath diameter (ONSD) after osmotherapy weaning can predict rebound intracranial hypertension in adult patients with traumatic brain injury requiring osmotherapy for elevated intracranial pressure. The main questions it aims to answer are:\n\nDoes the trajectory of ONSD during osmotherapy weaning predict the development of rebound intracranial hypertension? What is the diagnostic accuracy of serial ONSD measurements for the early detection of rebound intracranial hypertension? Researchers will compare patients who develop rebound intracranial hypertension with those who do not to determine whether changes in ONSD trajectory differ significantly between the two groups.\n\nParticipants will:\n\nUndergo serial bedside ocular ultrasound examinations for ONSD measurement at predefined time points after osmotherapy weaning.\n\nReceive standard clinical management for traumatic brain injury according to institutional protocols; no additional therapeutic intervention will be administered.\n\nUndergo routine neurological assessments, laboratory investigations, and neuroimaging as clinically indicated.\n\nBe followed for the occurrence of rebound intracranial hypertension and relevant clinical outcomes during their ICU stay",[27,28,29],"Traumatic Brain Injury","Rebound Intracranial Hypertension","Cerebral Edema",[31,32,33,34],"ONSD","Osmotherapy","Rebound ICH","Cerebral edema","NOT_YET_RECRUITING","2026-07-19",{"date":38,"type":39},"2026-07-23","ACTUAL",{"date":41,"type":22},"2026-09-01",{"date":43,"type":22},"2027-10-01",{"name":45,"class":46},"Benha University","OTHER"]