[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rectal-neuroendocrine-tumor\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rectal-neuroendocrine-tumor":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100651374","underwater-endoscopic-mucosal-resection-versus-endoscopic-submucosal-dissection-for-the-treatment-of-small-rectal-neuroendocrine-tumors-100651374",false,"NCT07759960","Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors","Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors: A Prospective, Multicenter, Non-inferiority Trial","Inclusion Criteria:\n\n1. Age from 18 to 75 years;\n2. With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy;\n3. With tumor size ≤10 mm assessed by colonoscopy or EUS;\n4. Plan to receive UEMR or ESD treatment and provide written informed consent.\n\nExclusion Criteria:\n\n1. Unable to tolerate ESD or UEMR as assessed by the research team;\n2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation;\n3. Rectal NET with lymph node metastasis or distant metastasis;\n4. Received resection of rectal neuroendocrine tumor by other surgical procedures;\n5. Multiple rectal neuroendocrine tumors;\n6. Vulnerable groups such as pregnant women or patients with mental disorders;\n7. Poor compliance, unable to cooperate with treatment.","ALL","18 Years","75 Years",{"count":20,"type":21},174,"ESTIMATED","INTERVENTIONAL",[24],"NA","Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.",[27],"Rectal Neuroendocrine Tumor","RECRUITING","2026-08-09",{"date":31,"type":32},"2026-08-12","ACTUAL",{"date":34,"type":32},"2026-04-14",{"date":36,"type":21},"2029-12",{"name":38,"class":39},"Nanfang Hospital, Southern Medical University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":4},"100585399","endoscopic-resection-for-small-rectal-neuroendocrine-tumors-100585399","NCT06901856","Endoscopic Resection for Small Rectal Neuroendocrine Tumors","Modified Cap-assisted Endoscopic Mucosal Resection and Modified Endoscopic Mucosal Resection with a Ligation Device for Small Rectal Neuroendocrine Tumors Less Than 1 Cm: a Muticenter Randomized Noninferiority Trial","Inclusion Criteria:\n\n1. Age from 18 to 80 years;\n2. With a high suspicion or evidence of rectal NET assessed using EUS or colonoscopy;\n3. With tumor size ≤10 mm assessed by colonoscopy;\n4. Plan to receive mEMR-C or mEMR-L treatment and provide written informed consent;\n\nExclusion Criteria:\n\n1. Unable to tolerate mEMR-L or mEMR-C as assessed by the research team of each center;\n2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation;\n3. Rectal NET with lymph node metastasis or distant metastasis;\n4. Received resection of rectal neuroendocrine tumor by other surgical procedures;\n5. Multiple rectal neuroendocrine tumors;\n6. Vulnerable groups such as pregnant women or patients with mental disorders;\n7. Poor compliance, unable to cooperate with treatment.","80 Years",{"count":50,"type":21},120,[24],"According to clinical practice and relevant retrospective research data, both modified cap-assisted endoscopic mucosal resection (mEMR-C) and endoscopic mucosal resection with a ligation device(ESMR-L) were reported to be effective for the treatment of small rectal neuroendocrine tumors (NETs) . However, there is a lack of multicenter prospective studies to evaluate the advantages and disadvantages of mEMR-C and mEMR-L. mEMR-C is the modified ESMR-L without submucosal injection.",[27],"NOT_YET_RECRUITING","2025-03-24",{"date":57,"type":32},"2025-03-30",{"date":59,"type":21},"2025-03",{"date":61,"type":21},"2027-10",{"name":63,"class":39},"Guangdong Provincial People's Hospital",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":45,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100472233","endoscopic-resection-for-small-rectal-neuroendocrine-tumors-100472233","NCT05429216","Modified Cap-assisted Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection for Small Rectal Neuroendocrine Tumors Less Than 1 cm: a Muticenter Randomized Noninferiority Trial","Inclusion Criteria:\n\n1. Age from 18 to 75 years;\n2. With a high suspicion or evidence of rectal NET assessed using EUS or colonoscopy;\n3. With tumor size ≤10 mm assessed by colonoscopy;\n4. Plan to receive mEMR-C or ESD treatment and provide written informed consent;\n\nExclusion Criteria:\n\n1. Unable to tolerate ESD or MEMR-C as assessed by the research team of each center;\n2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation;\n3. Rectal NET with lymph node metastasis or distant metastasis;\n4. Received resection of rectal neuroendocrine tumor by other surgical procedures;\n5. Multiple rectal neuroendocrine tumors;\n6. Vulnerable groups such as pregnant women or patients with mental disorders;\n7. Poor compliance, unable to cooperate with treatment.",{"count":71,"type":21},102,[24],"In previous single center study, both modified cap-assisted endoscopic mucosal resection (mEMR-C) and endoscopic submucosal dissection (ESD) were reported to be effective for the treatment of small rectal neuroendocrine tumors (NETs) and mEMR-C was inferior to ESD for the treatment of small rectal NETs (≤10 mm), as it has shorter operation times and lower hospitalization costs. However, a multicenter randomized controlled trial is needed to prove the universality and generality of these findings.",[27],"2022-06-27",{"date":77,"type":32},"2022-07-01",{"date":79,"type":21},"2022-06",{"date":81,"type":21},"2026-12",{"name":38,"class":39}]