[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-failure":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,85,0,25,[9,48,89,113,142,176,199,222,251,274,298,334,357,378,399,430,455,490,515,544,574,604,628,653,677],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100651824","epidural-spinal-cord-stimulation-for-respiratory-recovery-in-brain-injury-100651824",false,"NCT07766681","Epidural Spinal Cord Stimulation for Respiratory Recovery in Brain Injury","An Exploratory Clinical Trial of Epidural Spinal Cord Stimulation for Respiratory Recovery in Patients With Brain Injury","BREATH","Inclusion Criteria:\n\n* Age 18 to 74 years. Body mass index less than 30 kg\u002Fm². Imaging-confirmed stroke or traumatic brain injury. Glasgow Coma Scale score of 3 to 8, with relatively stable vital signs. Requirement for invasive mechanical ventilation through an oral or nasal endotracheal tube or tracheostomy for at least 24 hours.\n\nWritten informed consent provided by the participant's legally authorized representative; if the participant regains decision-making capacity, continued participation will be reconfirmed with the participant.\n\nWillingness and ability of the participant or legally authorized representative to comply with the study intervention and follow-up procedures.\n\nExclusion Criteria:\n\n* Suspected or confirmed infection at the planned electrode implantation site, severe uncontrolled systemic infection, known metal allergy relevant to the implanted device, or uncontrolled intracranial hypertension.\n\nRespiratory failure primarily attributable to severe pneumonia, pulmonary contusion, pneumothorax, hemothorax, chronic obstructive pulmonary disease with respiratory failure, severe asthma, or a requirement for home oxygen therapy within the previous 6 months.\n\nNew York Heart Association class III or IV heart failure or presence of an implanted cardiac pacemaker.\n\nSevere hepatic dysfunction, including Child-Pugh class C, severe renal dysfunction with estimated glomerular filtration rate ≤30 mL\u002Fmin\u002F1.73 m², or dialysis dependence.\n\nStatus epilepticus or active convulsions. Cervical spinal cord injury, other spinal cord injury, major chest wall deformity, myasthenia, or respiratory dysfunction primarily caused by brainstem injury.\n\nSevere psychiatric or pre-existing neurological or cognitive disorders that would interfere with study evaluation or completion, including amyotrophic lateral sclerosis, dementia, Parkinson disease, Huntington disease, or another clinically significant central nervous system disorder unrelated to the index brain injury.\n\nExpected survival of 72 hours or less, or a decision to withhold endotracheal intubation, cardiopulmonary resuscitation, or other life-sustaining treatment.\n\nPregnancy or breastfeeding. Any other condition that, in the investigator's judgment, may place the participant at unacceptable risk or interfere with completion of the study.","ALL","18 Years","74 Years",{"count":22,"type":23},10,"ESTIMATED","INTERVENTIONAL",[26],"NA","Patients with severe brain injury may develop impaired respiratory drive, diaphragm dysfunction, prolonged mechanical ventilation, and difficulty recovering spontaneous breathing. Epidural spinal cord stimulation may activate preserved spinal respiratory circuits and improve respiratory muscle activity. This prospective, single-center, non-randomized, single-arm exploratory study will enroll 10 patients with stroke or traumatic brain injury who have impaired consciousness and require invasive mechanical ventilation. Participants will undergo epidural spinal cord stimulation in addition to standard clinical care. Diaphragmatic electrical activity, respiratory function, diaphragm ultrasound findings, diaphragm electromyography, duration of mechanical ventilation, pulmonary infection, length of stay, mortality, safety events, and 6-month neurological outcome will be assessed. The study aims to evaluate the safety and preliminary efficacy of epidural spinal cord stimulation for improving respiratory function after brain injury.",[29,30],"Brain Injuries","Respiratory Failure",[32,33,34],"Epidural spinal cord stimulation","Respiratory failure","Diaphragmatic electrical activity","NOT_YET_RECRUITING","2026-08-09",{"date":38,"type":39},"2026-08-14","ACTUAL",{"date":41,"type":23},"2026-08-05",{"date":43,"type":23},"2028-12-31",{"name":45,"class":46},"Zhongda Hospital","OTHER",3,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100637740","brain-blood-flow-and-cerebral-autoregulation-monitoring-in-critically-ill-children-100637740","NCT07613918","Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children","Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study","Inclusion Criteria:\n\n* Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English\n* Mechanically ventilated (Endotracheal tube)\n* Indwelling arterial catheter\n* Current patient in the American Family Children's Hospital PICU.\n* 1 day to 17.5 years of age\n\nExclusion Criteria:\n\n* Subjects with a known or obvious anatomic barrier preventing safe application of the transcranial Doppler probe (e.g., cranial dressings, cranial fixation hardware, ventricular access devices positioned over insonation sites, or bilateral craniectomies)\n* Patient with known chronic hypertension\n* Admission FSS score \\> 16\n* Tracheostomized patient\n* The designated sub-investigator (Dr. Talal Al Hendawi) and PI (Dr. Neil Munjal) are unavailable to perform the Transcranial Doppler scan at the time of eligibility. All study scans are performed by either Dr. Al Hendawi or Dr.Munjal to ensure standardization and data integrity. Therefore, if they are unavailable (e.g., due to clinical service, leave, or other scheduling constraints), the patient will not be enrolled in the study.\n* Not suitable for study participation due to other reasons at the discretion of the investigators","1 Day","17 Years",{"count":58,"type":23},125,"OBSERVATIONAL","This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.",[62,63,30,64,65],"Critical Illness","Pediatric Critical Illness","Traumatic Brain Injury","Cardiac Arrest",[67,68,69,70,71,72,73,74,75,76,77,78],"PICU","infant","Transcranial Doppler Assessment","Cerebral Autoregulation","Blood Flow Velocity","children","mechanical ventilation","neurocritical care","pulsatility index","Mean flow index","neonate","pediatric critical care","2026-07-29",{"date":81,"type":39},"2026-07-30",{"date":83,"type":23},"2026-08",{"date":85,"type":23},"2028-05",{"name":87,"class":46},"University of Wisconsin, Madison",1,{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":12,"sex":18,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":24,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100598131","impact-of-biphasic-cuirass-ventilation-compared-to-non-invasive-ventilation-in-high-risk-extubations-100598131","NCT07067502","Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations","Impact of Biphasic Cuirass Ventilation Compared to Non-Invasive Ventilation in High Risk Extubations","Inclusion Criteria:\n\n* High risk extubation patients in the Medical Intensive care units who are being thought to be placed on non invasive ventilator post extubation.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>80\n* Pregnant\n* Inmate\u002FPrisoner\n* Chest wall defects\n* BMI \\>50\n* History of Diaphragmatic paralysis\n* History of Neuromuscular disease\n* Contraindication to study device (open chest wound, flail chest, complex thoracic surgeries in the past)","19 Years","80 Years",{"count":99,"type":23},50,[26],"subjects on mechanical ventilator who are about to be extubated to Non invasive ventilation because the physician thinks they are high risk for failure will be approached and consented for our study. Once randomized they will either be on the standard of care Non invasive arm or the intervention arm which would mean they are placed on the Biphasic cuirass ventilation.",[30,103],"Extubation Failure","2026-07-27",{"date":106,"type":39},"2026-07-28",{"date":108,"type":23},"2026-10-01",{"date":110,"type":23},"2027-07-30",{"name":112,"class":46},"University of Missouri-Columbia",{"id":114,"slug":115,"hasResults":12,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":24,"phases":123,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":141},"100648618","epidural-spinal-cord-stimulation-for-respiratory-recovery-in-cervical-sci-100648618","NCT07722130","Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI","An Exploratory Clinical Trial of Cervical Epidural Spinal Cord Stimulation for Respiratory Recovery in Patients With Cervical Spinal Cord Injury","Inclusion Criteria:\n\n1. Age between 18 and 75 years, with BMI \\\u003C30 kg\u002Fm².\n2. Cervical SCI involving levels C1-C5 for at least 2 weeks.\n3. Respiratory failure defined by one or more of the following:\n\n   * Peripheral oxygen saturation \\\u003C90% on room air;\n   * Arterial oxygen tension (PaO₂) \\\u003C60 mmHg;\n   * Respiratory acidosis (PaCO₂ \\>45 mmHg with pH \\\u003C7.35);\n   * Requirement for mechanical ventilation.\n4. Maximum inspiratory pressure (MIP) \\>-15 cmH₂O.\n5. Judged by the treating physician to be unable to tolerate continuous ventilator weaning for ≥48 hours due to SCI.\n6. Written informed consent provided by the participant or legally authorized representative.\n\nExclusion Criteria:\n\n1. Active infection at the planned electrode implantation site, severe systemic infection, or existing implanted neurostimulation devices.\n2. Respiratory failure primarily caused by severe pneumonia, pulmonary contusion, pneumothorax, hemothorax, chronic obstructive pulmonary disease, or requirement for home oxygen therapy within the previous 6 months.\n3. New York Heart Association (NYHA) class III or IV heart failure or implanted cardiac pacemaker.\n4. Severe hepatic or renal dysfunction (Child-Pugh class C liver disease or estimated glomerular filtration rate ≤30 mL\u002Fmin\u002F1.73 m²) or dialysis dependence.\n5. Generalized seizures, traumatic brain injury, intracranial hypertension, intracranial aneurysm with Glasgow Coma Scale score ≤12, or neuromuscular disorders affecting respiratory function.\n6. Expected survival \\\u003C72 hours or refusal of life-sustaining treatment.\n7. Pregnancy or breastfeeding.\n8. Any other condition considered by the investigator to make study participation inappropriate.","75 Years",{"count":122,"type":23},20,[26],"This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure. Participants receive ESCES plus standard care; electrodes are implanted at C3-C5 with daily individualized stimulation. Primary outcomes: Edi peak, change of Edi peak and frequency. Secondary: tidal volume, maximal inspiratory pressure, NVE, NME, diaphragm ultrasound, cough strength, 90-day ventilator-free days, ICU stay, and survival. This is the first systematic ESCES study for SCI-related respiratory failure, aiming to provide preliminary safety\u002Fefficacy data for future RCTs.",[126,30],"Spinal Cord Injury Cervical",[128,129,130,131],"respiratory failure","spinal cord injury","epidural spinal cord electrical stimulation","diaphragm electrical activity","RECRUITING","2026-07-18",{"date":135,"type":39},"2026-07-23",{"date":137,"type":39},"2026-06-01",{"date":139,"type":23},"2029-03-31",{"name":45,"class":46},2,{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":18,"minAge":150,"maxAge":55,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":152,"briefSummary":153,"conditions":154,"keywords":162,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":88},"100625192","supraglottic-airway-for-resuscitation-in-preemies-100625192","NCT07419438","Supraglottic Airway for Resuscitation in Preemies","Supraglottic Airway Interface for Positive Pressure Ventilation During Delivery Room Resuscitation of Premature Infants: A Pilot Feasibility Trial","SUPREEMIE","Inclusion Criteria:\n\n* Gestational age 29 0\u002F7 to 33 6\u002F7 weeks at birth\n* Estimated fetal weight \\>\u002F= 1000 grams at birth\n* Clinical decision to initiate PPV\n* Parental informed consent\n\nExclusion Criteria:\n\n* Major anomalies or aneuploidy\n* Palliative care planned or considered\n* Not resuscitated in the infant resuscitation room","0 Days",{"count":122,"type":23},[26],"The goal of this single-arm intervention trial is to learn whether using a supraglottic airway (SA) as the primary interface for positive pressure ventilation (PPV) is feasible during delivery room resuscitation of premature infants. This study will be conducted in premature infants born between 29 0\u002F7 and 33 6\u002F7 weeks' gestation who require PPV at birth.\n\nThe main question it aims to answer is: Is it feasible to use a supraglottic airway as the primary interface to provide effective PPV during delivery room resuscitation in 29 0\u002F7 to 33 6\u002F7 weeks' gestation premature infants?\n\nParticipants will (1)Be screened prenatally and have informed consent obtained from the birth parent prior to delivery; (2)Be rescreened for eligibility on the day of delivery before receiving the study intervention; (3)Receive PPV using a supraglottic airway as the primary ventilation interface if resuscitation is required at birth; and (4)Have clinical and procedural data collected during delivery room resuscitation and for up to 24 hours after birth.",[30,155,156,157,158,159,160,161],"Premature Neonates","Delivery Room Resuscitation","Positive Pressure Ventilation","Neonatal Resuscitation","Supraglottic Airway","Laryngeal Mask","Laryngeal Mask Airways",[33,163,156,164,165,159,166,161],"Premature neonates","Positive pressure ventilation","Neonatal resuscitation","laryngeal mask","2026-07-13",{"date":169,"type":39},"2026-07-14",{"date":171,"type":39},"2026-03-13",{"date":173,"type":23},"2026-10",{"name":175,"class":46},"University of Pennsylvania",{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":24,"phases":184,"briefSummary":185,"conditions":186,"keywords":189,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":88},"100645481","mechanical-ventilator-adjustments-and-patient-dyspnea-100645481","NCT07701850","Mechanical Ventilator Adjustments and Patient Dyspnea","The Influence of Standard Ventilator Setting Adjustments on Dyspnea Experienced in Awake Mechanically-ventilated Patients: A Pilot Study","Inclusion Criteria:\n\n* Admitted to a participating ICU at BIDMC\n* Requiring mechanical ventilation\n* Awake by both of the following criteria\n* RASS -2 to +2\\*\n* CAM-ICU negative‡\n* Able to communicate\u002Fanswer dyspnea questionnaire\n\n  * RASS (Richmond Agitation-Sedation Scale) is a validated scale commonly used in the ICU to assess patient's level of sedation and agitation. It ranges from -5 to +4. While -5 means an unarousable coma, +4 means violent patient with immediate self danger. The scale from -2 to +2 ranges from light sedation to agitated.\n\n    * CAM-ICU (Confusion Assessment Method) is an ICU validated scale used to assess the presence of delirium. A negative CAM-ICU scale has good positive and negative predictive value to diagnose or exclude delirium.\n\nPhysicians and nurses are trained to evaluate patients using both scales\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old\n* Comfort measures only\n* Hemodynamic instability (MAP \\\u003C 65 mmHg) or increasing requirement of vasopressor\n* PEEP \\> 10 cmH2O\n* FiO2 \\> 0.6\n* Current Prone position\n* Current Pneumothorax\n* Bronchopleural fistula\n* Neuromuscular conditions that impair responding to the dyspnea scale or expression\n* Dementia\n* Prisoners\n* Pregnant women\n* Patients intubated and ventilated for less than 12 hours during the current ventilation episode\n* pH \\\u003C 7.20 or \\> 7.55\n* Presence of chest tube\n* Status post thoracotomy\n* Treating clinician refusal",{"count":122,"type":23},[26],"In the past 5 years, there are increasing data suggesting that patients treated with mechanical ventilation experience shortness of breath, despite appropriate sedation. This adverse experience is believed to contribute to the finding that up to 25% of patients who survive severe respiratory diseases experience mental health problems including post traumatic distress syndrome (PTSD). The purpose of this study is to evaluate if\u002Fhow sequential changes in the delivery of mechanical ventilation affect shortness of breath sensation in awake patients requiring mechanical ventilation. Improving the knowledge of the impact of the patient-ventilator interaction on shortness of breath sensation may lead to strategies to improve the comfort of non-sedated and sedated ventilated patients, and thereby reduce mental health sequelae in survivors of acute severe respiratory diseases The investigators hypothesize that current ventilator strategies, particularly reduced tidal volume (size of breath given by the ventilator) utilized in managing patients with severe respiratory diseases, contribute to shortness of breath in patients with increased drive to breathe. In this setting, some safe ventilator changes may improve or worsen the shortness of breath sensation in awake patients on mechanical ventilation.",[30,187,188],"Dyspnea During Mechanical Ventilation","Mechanical Ventilation",[128,73,190],"dyspnea","2026-07-08",{"date":169,"type":39},{"date":194,"type":23},"2026-09-01",{"date":196,"type":23},"2027-07-01",{"name":198,"class":46},"Beth Israel Deaconess Medical Center",{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":120,"enrollmentInfo":206,"targetDuration":4,"studyType":24,"phases":208,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":88},"100616550","real-time-algorithm-driven-ventilation-feedback-to-improve-lung-protective-ventilation-in-patients-with-ards-realvent-study-100616550","NCT07307066","Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)","REALVENT","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Receiving invasive mechanical ventilation via endotracheal intubation at the time of screening\n* Initiation of invasive mechanical ventilation within the past 24 hours\n* PaO₂\u002FFiO₂ ≤ 200 mmHg on PEEP ≥ 8 cmH₂O or, if arterial blood gas is unavailable: SpO₂\u002FFiO₂ ≤ 235 with SpO₂ ≤ 97%\n* Chest imaging (chest X-ray or CT) showing bilateral pulmonary infiltrates not fully explained by pleural effusions, lobar collapse, or pulmonary nodules\n* Respiratory failure not fully explained by cardiac failure or fluid overload\n* Expected to require invasive mechanical ventilation for ≥ 72 hours after enrollment\n\nExclusion Criteria:\n\n* Receipt of extracorporeal membrane oxygenation (ECMO) or high-frequency oscillatory ventilation at screening\n* Brain death or anticipated withdrawal of life-sustaining treatment within 72 hours\n* Pregnancy\n* Known neuromuscular disease affecting spontaneous respiratory effort\n* Prisoners or individuals unable to provide informed consent or surrogate consent\n* Simultaneous enrollment in another interventional ICU study\n* Lack of digital infrastructure for real-time ventilator waveform acquisition",{"count":207,"type":23},208,[26],"The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive mechanical ventilation. This multicentre randomised controlled trial will compare real-time respiratory waveform monitoring with automated feedback against standard ICU care. The primary endpoint is the LPV achievement rate over the first 72 hours.",[211,212,30,62],"ARDS (Acute Respiratory Distress Syndrome)","VILI (Ventilator-induced Lung Injury)","2026-06-29",{"date":215,"type":39},"2026-07-01",{"date":217,"type":39},"2025-12-30",{"date":219,"type":23},"2027-02-28",{"name":221,"class":46},"Peking Union Medical College Hospital",{"id":223,"slug":224,"hasResults":12,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":24,"phases":232,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":250},"100521200","phase-3-precision-ventilation-vs-standard-care-for-acute-respiratory-distress-syndrome-100521200","NCT06066502","Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome","PREcision VENTilation to Attenuate Ventilator-Induced Lung Injury: A Phase 3 Multicenter Randomized Clinical Trial","PREVENT VILI","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Ventilator-dependent ARDS, with all of the following (a-e):\n\n   1. Invasive ventilation with positive end-expiratory pressure (PEEP) ≥ 8 cm H2O or FiO2 ≥ 0.5\n   2. Hypoxemia as characterized by: • If arterial blood gas (ABG) available: the partial pressure of oxygen in the arterial blood (PaO2)\u002FFiO2 ≤ 300 mm Hg, or, • if ABG not available OR overt clinical deterioration in oxygenation since last ABG: SpO2\u002FFiO2 ≤ 316 with SpO2 ≤ 97% (both conditions) on two representative assessments between 1 to 6 hours apart. • If patient is positioned prone or receiving inhaled pulmonary vasodilator at time of screening:\n\n      Qualifying PaO2\u002FFiO2 or SpO2\u002FFiO2 (as defined above) that was recorded within the 6 hours immediately prior to initiating either of these therapies may be used for eligibility determination. • If PEEP has been increased by \\> 5 cm H2O within the last 12 hours immediately prior to screening:\n\n      Qualifying PaO2\u002FFiO2 or SpO2\u002FFiO2 (as defined above) prior to PEEP increase may be used for eligibility determination if recorded within this 12-hour window.\n   3. Bilateral lung opacities on chest imaging not fully explained by effusions, lobar collapse, or nodules\n   4. Respiratory failure not fully explained by heart failure or fluid overload\n   5. Onset within 1 week of clinical insult or new\u002Fworsening symptoms\n3. Early in ARDS course\n\n   * Full criteria for ARDS (#2 above) first met within previous 3 days\n   * Current invasive ventilation episode not more than 4 days duration\n   * Current severe hypoxemic episode (receipt of invasive ventilation, noninvasive ventilation, or high-flow nasal cannula) not more than 10 days duration\n\nExclusion Criteria:\n\n1. Esophageal manometry already in use clinically\n2. Severe brain injury: including suspected elevated intracranial pressure, cerebral edema, or Glasgow coma score (GCS) ≤ 8 directly caused by severe brain injury (e.g., ischemia or hemorrhage)\n3. Gross barotrauma or chest tube inserted to treat barotrauma (note: chest tube inserted strictly for drainage of pleural effusion is not an exclusion)\n4. Esophageal pathology that, in judgement of the site investigator, significantly increases risk of esophageal catheter placement, including high-risk esophageal varices, recent oropharyngeal or gastroesophageal surgery; or past esophagectomy\n5. Ongoing severe coagulopathy (platelet \\\u003C 5000\u002FμL or INR \\> 4)\n6. Extracorporeal membrane oxygenation (ECMO) or CO2 removal (ECCO2R)\n7. Neuromuscular disease that impairs spontaneous breathing (including but not limited to amyotrophic lateral sclerosis, Guillain-Barré syndrome, spinal cord injury at C5 or above)\n8. Any of the following severe chronic lung diseases: cystic fibrosis, acute bronchiectasis exacerbation, acute exacerbation of a chronic interstitial lung disease (ILD), chronic pulmonary hypertension (PH) on PH-targeted vasoactive medication, or lung transplant\n9. End-stage chronic cirrhosis with Child-Pugh Class C (Section 12.3)\n10. ICU admission for burn injury\n11. Current ICU stay \\> 2 weeks or acute care hospital stay \\> 4 weeks\n12. Moribund patient not expected to survive 24 hours as assessed by the study physician; if cardiopulmonary resuscitation (CPR) was provided, assessment for moribund status must occur at least 6 hours after CPR was completed\n13. Current limitation on life-sustaining care (other than do-not-resuscitate), or expectation by clinical team that a limitation on life-sustained care will be adopted within next 24 hours.\n14. Treating clinician refusal or unwilling to use protocol-specified ventilator settings\u002Fmodes\n15. Prisoner\n16. Previous enrollment in this trial",{"count":231,"type":23},1100,[233],"PHASE3","The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS). Participants will be ventilated according to one of two different strategies. The main question the study hopes to answer is whether the personalized ventilation strategy helps improve survival.",[236,30],"Acute Respiratory Distress Syndrome",[238,239,240,241,73,242],"critical care","critical illness","esophageal manometry","transpulmonary pressure","lung stress","2026-06-25",{"date":213,"type":39},{"date":246,"type":39},"2024-06-24",{"date":248,"type":23},"2030-12-31",{"name":198,"class":46},33,{"id":252,"slug":253,"hasResults":12,"nctId":254,"briefTitle":255,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":258,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":24,"phases":261,"briefSummary":262,"conditions":263,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":88},"100542369","improving-psychological-outcomes-for-acute-respiratory-failure-survivors-using-a-self-management-intervention-100542369","NCT06341972","Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention","SMARA","Inclusion Criteria:\n\n* ≥18 years old\n* English speaking and not aphasic\n* ARF with mechanical ventilation via endotracheal tube \\> 24 hours\n* Expected hospital stay of \\>7 days at time of eligibility\n* Alert (ie, Richmond Agitation Sedation Scale sedation score = -1, 0, or 1)\n* Not delirious (ie, negative Confusion Assessment Method -ICU score)\n* Presence of anxiety symptoms (Visual Analog Scale-Anxiety score ≥50)\\*\\*\n\nExclusion Criteria:\n\n* Pre-existing cognitive impairment (AD-8 score ≥2)\n* History of major psychiatric illness (i.e., psychotic disorder, bi-polar disorder, suicide attempt in past 24 months, pervasive developmental disorder, active substance use disorder)\n* Declines or incapable of informed consent\n* Anticipated discharge to hospice, primary focus on palliative care, or \\>90% probability of in-hospital death",true,{"count":260,"type":23},60,[26],"A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant.\n\nThe goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and potential benefit of an evidence-based psychological intervention for anxiety and associated outcomes for ICU patients.\n\nThe main question\\[s\\] it aims to answer are:\n\n* Is this intervention feasible and acceptable in ARF patients?\n* Is this intervention in the ICU and hospital associated with reduced anxiety symptoms?\n\nParticipants will participate in a cognitive behavioral therapy informed self-management intervention aimed to reduce anxiety symptoms. Researchers will compare the intervention group to patients who receive usual care to see if the intervention reduces symptoms at the the conclusion of the intervention and at 3 months follow-up.",[30,264,62],"Anxiety","2026-06-18",{"date":267,"type":39},"2026-06-22",{"date":269,"type":39},"2024-05-31",{"date":271,"type":23},"2028-09-01",{"name":273,"class":46},"Johns Hopkins University",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":280,"eligibilityCriteria":281,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":283,"conditions":284,"keywords":287,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":88},"100632836","heart-rate-variability-as-a-marker-for-titrating-high-flow-nasal-cannula-therapy-100632836","NCT07518862","Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy","Heart Rate Variability as a Marker for Titrating High Flow Nasal Cannula Therapy in Patients With Respiratory Failure","VARIATION","Inclusion Criteria:\n\n* Age \\> 18\n* Currently receiving High-Flow Nasal Cannula Therapy\n\nExclusion Criteria:\n\n* FiO2 ≥ 90%\n* Pacemaker rhythm or presence of atrial fibrillation\n* Post-cardiac surgery patients\n* Contra-indications to electrical impedance tomography (EIT) and\u002For electrocardiogram (ECG) (active implantable medical device, burns, thoracic wounds limiting electrode placement)\n* Non-English-speaking",{"count":122,"type":23},"High-flow nasal cannula is a type of non-invasive respiratory support that helps patients breathe more comfortably. Because the flow is high, it can deliver more oxygen to the lungs and make breathing easier by reducing the effort needed to breathe. However, the best strategy to determine the best oxygen flow rate remains uncertain. Reducing flow rates prematurely can increase work of breathing and prolong ICU stay, while unnecessary prolongation can increase costs. Currently, evidence to guide titration is limited.\n\nHeart rate variability is the natural variation in the time between each heartbeat. Heart rate variability reflects the level of autonomic nervous system activity in response to stress. The autonomic nervous system is the part of the nervous system that automatically controls how heart rate speeds up and slows down. When heart rate variability is higher, it indicates that the system is able to adjust to changes in the body, including stress. However, when heart rate variability is low, it indicates that the system is constrained and in a state of stress.\n\nThe VARIATION study is designed to characterize how heart rate variability goal of this observational study is to learn whether heart rate variability can serve as a marker of the appropriateness of high flow nasal cannula flow support during flow titration in patients with respiratory failure. The main question it aims to answer is:\n\nDoes heart rate variability change before other conventional respiratory signs when there are changes in respiratory function due to inadequate flow rate?\n\nParticipants already on high flow nasal cannula as part of their regular medical care will:\n\n1. Undergo a stepwise decrease in high flow nasal cannula flow rate.\n2. Be recorded continuously with electrocardiogram and electrical impedance tomography.",[30,285,286],"Heart Rate Variability (HRV)","High Flow Nasal Cannula",[288,289],"Electrocardiogram (ECG)","Electrical Impedance Tomography (EIT)","2026-06-16",{"date":265,"type":39},{"date":293,"type":39},"2026-05-26",{"date":295,"type":23},"2026-12",{"name":297,"class":46},"University Health Network, Toronto",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":258,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":308,"conditions":309,"keywords":314,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":88},"100602123","icu-background-early-awareness-for-critical-deterioration-100602123","NCT07119411","ICU Background Early Awareness for Critical deterioratiON","ICU Background Early Awareness for Critical deterioratiON (BEACON)","BEACON","Inclusion Criteria:\n\n* admission to intensive care unit\n\nExclusion Criteria:\n\n* age \\\u003C 18 years\n* presence of documented refused general consent form (at database closure)\n* admission for the sole purpose of dying\u002Forgan donation or evaluation of such",{"count":307,"type":23},1962,"The study will compare ICU sub-units, those with additional support of a clinician awareness system, ICU Beacon, and those receiving the standard of care. The win-ratio composite outcome will be assessed by comparing patients by study group and stratified by APACHE score at admission.",[30,310,311,312,313],"Circulatory Failure","Mortality","Organ Dysfunction","Organ Failure, Multiple",[315,128,316,317,318,319,320,321,322,323,324],"icu","circulatory failure","early warning system","prevention","prediction","risk prediction","organ failure","multi-organ failure","win-ratio","ICU Beacon","2026-06-12",{"date":327,"type":39},"2026-06-15",{"date":329,"type":39},"2025-12-01",{"date":331,"type":23},"2027-11-01",{"name":333,"class":46},"ETH Zurich",{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":338,"acronym":339,"eligibilityCriteria":340,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":341,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":88},"100380679","investigating-health-related-quality-of-life-in-patients-with-chronic-respiratory-failure-100380679","NCT04236726","Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure","CRF-QoL","Inclusion Criteria:\n\nDiagnosed with chronic respiratory failure receiving any of:\n\n* Non-invasive ventilation\n* Prolonged mechanical ventilation\n* Mechanical insufflation-exsufflation therapy\n\nExclusion Criteria:\n\n* Aged \\\u003C18\n* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol",{"count":342,"type":23},200,"To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.",[345,30,346,347],"Chronic Obstructive Pulmonary Disease","Neuromuscular Diseases","Ventilatory Failure","2026-06-03",{"date":350,"type":39},"2026-06-04",{"date":352,"type":39},"2019-12-19",{"date":354,"type":23},"2026-12-31",{"name":356,"class":46},"Guy's and St Thomas' NHS Foundation Trust",{"id":358,"slug":359,"hasResults":12,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":363,"eligibilityCriteria":364,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":365,"targetDuration":4,"studyType":24,"phases":366,"briefSummary":367,"conditions":368,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":88},"100567655","a-trial-comparing-high-flow-nasal-cannula-versus-noninvasive-ventilation-on-reintubation-and-post-extubation-respiratory-failure-in-high-risk-patients-with-systolic-heart-failure-100567655","NCT06671015","A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure","A Prospective Randomized Controlled Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure","EXTUBATE-HF","Inclusion Criteria:\n\n* The patient is a male or non-pregnant female greater than or equal to 18 years of age\n* The patient is ventilated for greater than 24 hours\n* The patient has a systolic left ventricular dysfunction defined as an ejection fraction less than or equal to 40%\n* The patient, or legally authorized representative, has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent, approved by the appropriate Institutional Review Board (IRB) or Ethics Committee (EC).\n\nExclusion Criteria:\n\n* Patients actively being treated for a COPD exacerbation or known hypercapnia (PaCO2\\>45) on last Arterial Blood Gas (ABG)\n* Patients agitated or uncooperative state\n* Patients with do-not-resuscitate orders\n* Patients presenting with tracheostomies or anatomical abnormalities interfering with mask fit\n* Patients are prisoners\n* Patient self-extubates\n* Patients with pre-existing NIV prescription (e.g., obstructive sleep apnea, neuromuscular disorders, advanced COPD)",{"count":99,"type":23},[26],"This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical ventilation (IMV) and are admitted to either the cardiac intensive care unit (CICU) or medical ICU (MICU) will be included.\n\nSubjects meeting eligibility criteria will be randomized 1:1 to one of the two treatment groups:\n\n* Intervention: Extubation to high-flow nasal cannula (HFNC)\n* Control: Extubation to non-invasive ventilation (NIV)",[369,30],"Systolic Heart Failure",{"date":371,"type":39},"2026-05-28",{"date":373,"type":39},"2025-10-04",{"date":375,"type":23},"2027-02",{"name":377,"class":46},"Yale University",{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":384,"eligibilityCriteria":385,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":386,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":88},"100633112","benefit-of-sleep-quality-monitoring-by-eeg-in-icu-100633112","NCT07522450","Benefit of Sleep Quality Monitoring by EEG in ICU","Benefit of the Sleep Quality Assessment Using Electroencephalographic Monitoring in Critically Ill Patients","REVASOM","Inclusion Criteria:\n\n* Adults\n* Acute respiratory failure with non-invasive ventilation or high-flow oxygenotherapy hospitalized in critical care unit\n* Conscious\n* Insurance coverage\n* Consent to participate\n\nExclusion Criteria:\n\n* pregnancy\n* cutaneous lesion on the scalp\n* guardianship",{"count":387,"type":23},47,"The goal of this observational study is to learn about the benefit of monitoring sleep quality using EEG in patients hospitalized in critical care unit for acute respiratory failure. The main question it aims to answer is:\n\n• Does EEG monitoring improve sleep quality assessment in critically ill patients with acute respiratory failure compared to nurse sleep quality assessment? Participants hospitalized in critical care unit for acute respiratory failure will have their sleep quality assessed by both EEG monitoring and nurse evaluation during their stay in critical care unit.",[30],"2026-05-12",{"date":392,"type":39},"2026-05-15",{"date":394,"type":39},"2026-03-04",{"date":396,"type":23},"2027-03-20",{"name":398,"class":46},"University Hospital, Rouen",{"id":400,"slug":401,"hasResults":12,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":405,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":407,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":409,"conditions":410,"keywords":415,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":88},"100611983","evaluation-and-optimization-of-telephone-triage-using-artificial-intelligence-ai-models-for-the-detection-of-demands-for-time-dependent-pathology-at-the-emergency-and-urgent-care-coordination-center-ccue-100611983","NCT07247669","Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).","Proyecto \"trIAje\": evaluación y optimización Del Triaje telefónico Mediante Modelos de Inteligencia Artificial (IA) Para la detección de Demandas Por patología Tiempo-dependiente en el Centro Coordinador de Urgencias y Emergencias (CCUE).","TrIAje Project","Inclusion Criteria:\n\nTelephone calls recorded with codes A36 + A58 (unconsciousness\u002Fcardiorespiratory arrest), A16 (respiratory distress), A23 (non-traumatic chest pain) and A54 (stroke).\n\nExclusion Criteria:\n\n* Demands with relevant information about the patient or the event incomplete or absent.",{"count":408,"type":23},5000000,"Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day. Each call needs to be assessed based on the information given over the phone to determine how serious the case is. The reasons for calling range from minor health issues to life-threatening emergencies like cardiac arrest (CPA).\n\nThis project focuses on improving telephone triage for four key emergency situations that often indicate severe or life-threatening conditions:\n\nUnconsciousness \u002F Cardiac arrest Difficulty breathing Chest pain (non-traumatic, possible heart-related issues) Stroke symptoms Our goal is to make telephone triage more accurate and efficient by using advanced Artificial Intelligence (AI) techniques, including Machine Learning (ML) and Natural Language Processing (NLP). These tools will help CCUE operators make better and faster decisions, ensuring that patients receive the right care as quickly as possible.\n\nHow it will be done:\n\nThe investigators will analyze anonymized historical call data from the emergency coordination system (CCR) and digital clinical records (HCDM). This includes:\n\nStructured data: Predefined fields, such as answers to standard triage questions.\n\nUnstructured data: Free-text notes and other information recorded during the call.\n\nA hybrid AI approach will be used, combining:\n\nTraditional AI methods (supervised learning and deep learning) to classify cases.\n\nGenerative AI techniques (advanced language models) to extract useful insights from free-text data.\n\nBuilding the Best Prediction Model\n\nTo find the most effective AI model, we will test different machine learning techniques, including:\n\nDecision Trees Random Forests Support Vector Machines (SVM) XGBoost Ensemble methods Neural Networks We will also analyze which questions and variables are the most important in predicting the severity of a case. Based on this, we will suggest improvements to the current triage questions to enhance accuracy.\n\nMeasuring Success\n\nWe will evaluate the AI model using key performance metrics, including:\n\nAccuracy (overall correctness) Sensitivity (ability to detect real emergencies) Specificity (ability to avoid false alarms) False Positive \\& False Negative Rates (how often the system makes mistakes) Likelihood Ratios (how well the system distinguishes between urgent and non-urgent cases) F1-Score \\& ROC Curve (overall performance indicators) Why This Matters This project will assess how effective the current telephone triage system is and develop a new AI-powered model to improve it. The goal is to help emergency operators quickly identify the most serious cases, reducing response times and improving patient outcomes. In the future, the investigators aim to integrate this improved AI model into the CCUE system to enhance emergency response across Andalusia.",[411,412,30,413,414],"Chest Pain","Stroke Acute","Cardiac Arrest (CA)","Coma",[416,417,418,419,420,421],"Emergency Medical Communication Center","Triage Telephone","Emergency Medical Services","Priority","Machine Learning","Artificial Intelligence",{"date":423,"type":39},"2026-05-13",{"date":425,"type":39},"2025-03-01",{"date":427,"type":23},"2027-12-31",{"name":429,"class":46},"Centro de Emergencias Sanitarias 061 Andalucía",{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":436,"targetDuration":4,"studyType":24,"phases":438,"briefSummary":439,"conditions":440,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":88},"100554594","optimizing-care-in-critically-ill-at-uchealth-by-liberalizing-the-target-o2-in-mechanically-ventilated-icu-patients-100554594","NCT06501118","Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients","Inclusion Criteria:\n\n* Admission to ICU and requiring invasive mechanical ventilation\n\nExclusion Criteria:\n\n* Transferred patients from outside the UCHealth system\\*:\n* Patients with pre-existing disease that requires chronic use of positive pressure ventilation delivered through a tracheostomy\\*:\n* Pregnant women:\n* Prisoners\n* Patients receiving mechanical ventilation for less than twelve hours",{"count":437,"type":23},3600,[26],"A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen saturation target range.",[30,441,442,443,444,445],"Acute Hypoxemic Respiratory Failure","Acute Hypoxic Respiratory Failure","Hypoxemia","Hypoxia","Hypoxic Respiratory Failure","2026-05-04",{"date":448,"type":39},"2026-05-08",{"date":450,"type":39},"2024-09-01",{"date":452,"type":23},"2026-07-31",{"name":454,"class":46},"University of Colorado, Denver",{"id":456,"slug":457,"hasResults":12,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":461,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":463,"enrollmentInfo":464,"targetDuration":466,"studyType":59,"phases":4,"briefSummary":467,"conditions":468,"keywords":475,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":489},"100600524","a-new-tool-for-extubation-readiness-in-mechanically-ventilated-patients-readiness-for-extubation-score-100600524","NCT07098611","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)","REXs","Inclusion Criteria:\n\n\\- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit.\n\nExclusion Criteria:\n\n* Patients without legal guardian consent.\n* Tracheostomized patients.\n* Patients enrolled in other studies.\n* Individuals with diaphragmatic pacers.\n* Pregnant patients.","89 Years",{"count":465,"type":23},470,"6 Weeks","Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.",[469,470,30,471,103,472,473,474],"Ventilator Weaning","Respiration, Artificial","Extubation Readiness","Extubation Succeeded","Intensive Care Patients Invasively Ventilated","Weaning Invasive Mechanical Ventilation",[73,476,477,478,319,479],"extubation","weaning","readiness","score","2026-04-29",{"date":482,"type":39},"2026-05-05",{"date":484,"type":39},"2025-06-15",{"date":486,"type":23},"2026-12-30",{"name":488,"class":46},"Medipol University",7,{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":496,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":498,"targetDuration":4,"studyType":24,"phases":499,"briefSummary":500,"conditions":501,"keywords":503,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":509,"completionDateStruct":511,"leadSponsor":513,"locationsCount":88},"100621605","eit-guided-respiratory-physiotherapy-for-prolonged-mechanical-ventilation-pmv-100621605","NCT07372794","EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)","Electrical Impedance Tomography-Guided Respiratory Physiotherapy for Liberation From Prolonged Mechanical Ventilation: A Multicenter Randomized Controlled Trial","PMV","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Invasive mechanical ventilation for ≥ 21 consecutive days.\n* Clinically stable and eligible for respiratory physiotherapy as determined by the treating team.\n* Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment.\n* Written informed consent obtained from the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* Contraindications to electrical impedance tomography .\n* Hemodynamic instability requiring high-dose vasoactive support.\n* Severe hypoxemia refractory to optimization.\n* Unstable fractures or other contraindications to mobilization or positioning.\n* Pregnancy.\n* Expected death within 48 hours.",{"count":342,"type":23},[26],"Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies.\n\nThis multicenter randomized controlled trial aims to evaluate whether EIT-guided respiratory physiotherapy improves ventilator-free days at day 28 compared with conventional respiratory physiotherapy in adult patients with PMV.\n\nRespiratory physiotherapy consists of airway clearance, chest physiotherapy techniques, breathing pattern optimization, and therapeutic positioning. In the EIT-guided group, real-time EIT imaging is used to individualize physiotherapy strategies based on predefined ventilation distribution indicators, while the control group receives standardized physiotherapy according to institutional protocols without EIT guidance.\n\nSecondary outcomes include successful liberation from mechanical ventilation, diaphragm ultrasound parameters, EIT-derived ventilation distribution indices (exploratory mechanistic outcomes), ICU Mobility Scale, healthcare resource utilization, and safety outcomes.",[502,30,62],"Prolonged Mechanical Ventilation",[504,502,505,469,506],"Electrical Impedance Tomography","Respiratory Physiotherapy","Ventilator-Free Days","2026-04-28",{"date":446,"type":39},{"date":510,"type":39},"2026-02-16",{"date":512,"type":23},"2026-12-15",{"name":514,"class":46},"Capital Medical University",{"id":516,"slug":517,"hasResults":12,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":4,"eligibilityCriteria":521,"healthyVolunteers":12,"sex":18,"minAge":522,"maxAge":4,"enrollmentInfo":523,"targetDuration":4,"studyType":24,"phases":525,"briefSummary":526,"conditions":527,"keywords":528,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":88},"100550970","effects-of-pbmt-smf-in-mechanically-ventilated-patients-100550970","NCT06454006","Effects of PBMT-sMF in Mechanically Ventilated Patients","Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in Reducing the Number of Days in the Intensive Care Unit (ICU) for Adult Patients Requiring Mechanical Ventilation","Inclusion Criteria:\n\n* Legally authorized representative signed informed consent;\n* Male or female aged 21 years or older;\n* On mechanical ventilation through orotracheal intubation for no more than 72 hours prior to study enrollment or pending mechanical ventilation through orotracheal intubation;\n* Predicted to remain on mechanical ventilation for at least 48 hours (≥48 hours) from the time of study enrollment\n\nExclusion Criteria:\n\n* Mechanical ventilation initiated longer than 72 hours prior to anticipated enrollment;\n* Body Mass Index (BMI) \\> 40 kg\u002Fm²;\n* Fever of 100.4°C or higher;\n* Situated in the prone position for 24 hours or longer during mechanical ventilation;\n* Prognosis of mortality within 72 hours, per the patient's physician;\n* Hypersensitivity to light;\n* Use of non-invasive ventilation, Continuous Positive Airway Pressure (CPAP) and\u002For Bilevel Positive Airway Pressure (BiPAP) device for ≥ 50% of the time over the preceding 6 months;\n* Tracheostomy;\n* Any one or more of the following present on both sides of the neck (bilaterally) at the intended treatment site(s): internal jugular (IJ) venous cannulation; incisions, significant bruising; burn(s); notable skin irritation\u002Frash, or other skin condition that may place the subject at risk from harm from the device treatment;\n* Fracture, external or internal hemorrhage, or at risk of hemorrhage following acute trauma or fracture, or known or potential acute occult bleeding (e.g., gastric ulcer, intestine) in the intended treatment areas;\n* Metallic device implants or body penetrating metallic devices in the upper body\u002Fneck area whose location may interfere with the study device treatment administration. E.g., extracorporeal membrane oxygenation (ECMO) cannula;\n* Non-removable electrical\u002Felectronic device in the upper body\u002Fneck area that may interfere with the study device treatment administration, e.g., -implanted pacemaker or cardiac defibrillator;\n* Cardiogenic or septic shock with ongoing severe hemodynamic instability (according to the American College of Chest Physicians definition (that cannot be stabilized within the 48 hours enrollment period);\n* Conditions that may limit ultrasonographic assessment of diaphragmatic thickness, e.g., occluding chest drain, pleural effusion, pulmonary consolidation of the lower lobe(s);\n* Current cancer of any type;\n* Pregnancy;\n* Any comorbidity, co-existing condition or illness, or other factor that in the opinion of the study investigator may render the subject unsuitable for participation in the study;\n* Admission to the ICU within the last 12 months due to respiratory distress\u002Ffailure;\n* Two or more admissions to the ICU within the prior 12 months for any reason;\n* Current participation in another clinical study.","21 Years",{"count":524,"type":23},112,[26],"The goal of this clinical trial is to evaluate the effectiveness of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) in adult patients who require mechanical ventilation. The main questions it aims to answer are:\n\n(i) Does PBMT-sMF lower the length of stay in the intensive care unit (ICU) for mechanically ventilated patients? (ii) Does PBMT-sMF increase the diaphragm thickness in mechanically ventilated patients in the ICU?\n\nResearches will compare active PBMT-sMF plus standard of care to a placebo PBMT-sMF plus standard of care to see if active PBMT-sMF works to prevent or retard disuse atrophy of the diaphragm during mechanical ventilation.",[30],[529,530,531,532,533,534],"Mechanical ventilation","Photobiomodulation therapy","LLLT","Static magnetic field","Diaphragm","Intensive care unit","2026-04-20",{"date":537,"type":39},"2026-04-23",{"date":539,"type":39},"2024-07-31",{"date":541,"type":23},"2027-06",{"name":543,"class":46},"University of Nove de Julho",{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":550,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":552,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":554,"conditions":555,"keywords":556,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":88},"100634212","comparison-of-the-efficacy-and-safety-of-ciprofol-versus-propofol-for-sedation-in-icu-patients-undergoing-non-invasive-ventilation-100634212","NCT07536750","Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation","Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation: A Multicenter Retrospective Cohort Study","CALM-ICU","Inclusion Criteria Age:\n\n* Age ≥18 years\n* Admitted to the intensive care unit (ICU) between January 1, 2022 and July 30, 2024\n* Received intravenous sedation with either ciprofol or propofol during ICU stay\n* Total duration of ciprofol or propofol administration ≥2 hours\n* Sedation initiated while the patient was not receiving invasive mechanical ventilation\n* Receiving non-invasive respiratory support or oxygen therapy at the time sedation was started, including noninvasive ventilation (NIV), high-flow nasal cannula (HFNC), nasal cannula, or face mask oxygen therapy\n* Availability of complete electronic medical records including sedation assessment using the Richmond Agitation-Sedation Scale (RASS)\n* Availability of continuous vital sign monitoring records including respiratory rate, oxygen saturation, blood pressure, and heart rate\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Pregnancy or breastfeeding\n* Use of other primary sedative agents during the observation period, including midazolam or dexmedetomidine\n* Total exposure time to ciprofol or propofol \\\u003C2 hours\n* Known allergy or hypersensitivity to ciprofol, propofol, or their formulation components\n* Initiation of invasive mechanical ventilation before sedation\n* Missing key clinical data required for outcome evaluation, including sedation score, vital signs, or drug administration records\n* Participation in other interventional clinical trials that may interfere with outcome assessment\n* Severe visual or hearing impairment preventing accurate sedation assessment\n* Coma or conditions that prevent reliable evaluation using the Richmond Agitation-Sedation Scale (RASS)\n* Any condition that the investigators consider inappropriate for inclusion in the study",{"count":553,"type":23},1680,"Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation (NIV), or conventional oxygen therapy. Anxiety, agitation, dyspnea, and poor tolerance of respiratory support may compromise treatment adherence and increase the risk of respiratory deterioration and endotracheal intubation. Appropriate sedation may improve patient comfort, facilitate respiratory support, and reduce complications. However, sedation in non-mechanically ventilated ICU patients remains challenging because excessive sedation may lead to respiratory depression or hemodynamic instability.\n\nPropofol is commonly used for ICU sedation because of its rapid onset and controllable depth of sedation. Nevertheless, propofol is associated with several adverse effects, including respiratory depression, hypotension, and injection pain, which may limit its use in patients without invasive mechanical ventilation.\n\nCiprofol is a novel short-acting intravenous sedative that acts as a gamma-aminobutyric acid type A (GABA-A) receptor agonist and is structurally related to propofol. Previous studies have demonstrated that ciprofol has rapid onset, predictable sedation, less injection pain, and a potentially lower incidence of respiratory depression and hemodynamic instability compared with propofol. Clinical studies have shown favorable safety and efficacy profiles of ciprofol in procedural sedation, anesthesia induction, and sedation in mechanically ventilated ICU patients. However, evidence regarding its use in ICU patients receiving non-mechanical ventilation is still limited.\n\nThis study aims to compare the effectiveness and safety of ciprofol versus propofol for sedation in adult ICU patients who are not receiving invasive mechanical ventilation. The study will be conducted as a multicenter retrospective cohort study involving approximately 30 tertiary hospitals in China. Adult ICU patients treated between January 1, 2022 and July 30, 2024 who received intravenous sedation with either ciprofol or propofol while receiving non-invasive respiratory support (including NIV, HFNC, or conventional oxygen therapy) will be included.\n\nThe primary outcomes are sedation success rate and the incidence of respiratory depression. Sedation success is defined as maintaining the Richmond Agitation-Sedation Scale (RASS) within the target range of -2 to +1 for at least two consecutive hours without discontinuation of the sedation regimen or switching to another sedative. Respiratory depression will be defined based on predefined criteria including severe hypoxemia, markedly reduced respiratory rate, abnormal end-tidal carbon dioxide levels, or apnea.\n\nSecondary outcomes include endotracheal intubation rate during the sedation period, ICU length of stay, ICU mortality, and the requirement for vasoactive agents. Propensity score matching and multivariable statistical models will be used to adjust for baseline differences and potential confounders between treatment groups.\n\nThis real-world study aims to provide evidence regarding the clinical effectiveness and respiratory safety of ciprofol compared with propofol for sedation in ICU patients without invasive mechanical ventilation. The findings may help optimize sedation strategies in critically ill patients receiving non-invasive respiratory support and provide evidence to support future prospective clinical trials.",[30,62],[557,558,559,560,561,562,563,564],"Ciprofol","Propofol","ICU Sedation","Noninvasive Ventilation","High-Flow Nasal Cannula","Respiratory Depression","Sedation Safety","Critical Care","2026-04-15",{"date":567,"type":39},"2026-04-17",{"date":569,"type":39},"2025-11-24",{"date":571,"type":23},"2026-06-30",{"name":573,"class":46},"Nanfang Hospital, Southern Medical University",{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":581,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":583,"conditions":584,"keywords":589,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":602,"locationsCount":4},"100634623","bedside-lung-ultrasound-to-monitor-lung-recruitment-in-obese-patients-100634623","NCT07542093","Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients","Use of Bedside Lung Ultrasound to Monitor Lung Recruitment Maneuvers During Mechanical Ventilation in Obese Patients","Inclusion Criteria:\n\n* Adult patients aged \\>18 years\n* BMI ≥ 33 kg\u002Fm² (morbid obesity)\n* Intubated and receiving invasive mechanical ventilation for any indication (elective surgery, respiratory failure, post-operative ICU admission)\n* Expected duration of mechanical ventilation ≥ 6 hours\n* Hemodynamically stable at enrollment: Mean Arterial Pressure (MAP) ≥ 65 mmHg without escalating vasopressor support\n* SpO₂ ≥ 85% on current ventilator settings\n* Written informed consent obtained from patient or legal guardian\n\nExclusion Criteria:\n\n* Known or suspected pneumothorax or bullous emphysema (contraindication to recruitment maneuvers)\n* Severe hemodynamic instability: MAP \\\u003C 60 mmHg or requiring high-dose vasopressors (norepinephrine \\> 0.3 mcg\u002Fkg\u002Fmin)\n* Active bronchopleural fistula\n* Recent thoracic or cardiac surgery (within 48 hours) where high airway pressures are contraindicated\n* Raised intracranial pressure (ICP) or known severe traumatic brain injury\n* Confirmed ARDS with PaO₂\u002FFiO₂ ratio \\\u003C 100 mmHg (severe ARDS, where recruitment strategy differs significantly)\n* Chest wall deformity or subcutaneous emphysema that precludes reliable lung ultrasound assessment\n* Refusal of consent",{"count":582,"type":23},45,"Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse. This happens because the extra weight of the chest and abdomen presses on the lungs, reducing their capacity and making it difficult to maintain adequate oxygen levels. To address this, doctors often perform a standard lung recruitment maneuver, which involves temporarily increasing the air pressure from the ventilator to gently pop open the collapsed lung areas. However, standard bedside monitoring tools make it difficult to see exactly how well the different regions of the lungs are reopening.\n\nThis prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time.\n\nDuring the study, researchers will use a standardized 12-zone ultrasound scan to examine the lungs of mechanically ventilated adult patients (BMI ≥ 33 kg\u002Fm²) before, during, and after a step-by-step lung recruitment maneuver. By calculating a \"Total Lung Ultrasound Score,\" the medical team can directly visualize and measure the transition from collapsed tissue to normal, aerated lung tissue. Furthermore, the ultrasound will be used during a step-down pressure phase to help identify the patient's \"optimal PEEP\" (Positive End-Expiratory Pressure), which is the exact customized pressure needed to keep the lungs open after the maneuver is complete, thereby improving oxygenation and minimizing the risk of lung injury.",[585,586,30,587,588],"Morbid Obesity","Obesity","Atelectasis","Ventilator-Induced Lung Injury (VILI)",[590,591,592,188,593,594,595],"Lung Ultrasound (LUS)","Lung Ultrasound Score","Lung Recruitment Maneuvers (LRM)","Positive End-Expiratory Pressure (PEEP)","Optimal PEEP","Decremental PEEP Titration","2026-04-14",{"date":598,"type":39},"2026-04-21",{"date":600,"type":23},"2026-05",{"date":541,"type":23},{"name":603,"class":46},"Assiut University",{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":611,"targetDuration":4,"studyType":24,"phases":613,"briefSummary":614,"conditions":615,"keywords":616,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":620,"lastUpdatePostDateStruct":621,"startDateStruct":623,"completionDateStruct":625,"leadSponsor":626,"locationsCount":88},"100633020","noninvasive-technique-and-high-flow-nasal-oxygen-in-respiratory-failure-100633020","NCT07521254","Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure","Different Modalities of Combined Noninvasive Ventilation With High Flow Nasal Oxygen Versus Noninvasive Ventilation Alone in Acute Respiratory Failure","Inclusion Criteria:\n\n* Age ≥18 year of both sexes. • Diagnosed with Acute Respiratory Failure (ARF) defined as the combination of a PaO2\u002FFiO2 ratio \\\u003C 300 after 15 minutes of conventional oxygen delivered through a face mask, with a FiO2 at least of 50% and respiratory rate \\> 30 breaths\u002Fmin.\n\nExclusion Criteria:\n\n* Chronic respiratory disease\n\n  * Cardiogenic pulmonary edema\n  * Life-threatening arrythmias\n  * Hemodynamic instability requiring vasopressors\n  * Facial abnormalities preventing NIV or HFNC application\n  * Glasgow coma score of ≤ 12 points (Teasdale et al. 1974)\n  * Agitated patients characterized by RASS score (Richmond Agitation Sedation Scale) ≥ +2\n  * Patients who needed immediate endotracheal intubation\n  * Pregnant patients",{"count":612,"type":23},75,[26],"After obtaining Institutional Ethical Committee approval of Faculty of Medicine, Minia University and written informed consent from patients or first- degree relatives, this prospective randomized non-blind comparative study will be conducted in adult intensive care unit (ICU) of Anesthesia, Intensive Care and Pain management department Minia university hospital over a period from September 2025 to April 2026. This study is designed to compare the effectiveness of two protocols of sequential use of High Flow Nasal Cannula (HFNC) and noninvasive ventilation (NIV) versus NIV alone in patients with Acute Respiratory failure (ARF) admitted to the intensive care unit (ICU). The study will include 75 patients of both sexes, classified as ASA class Ⅰ-ⅠⅠⅠ, divided into three groups with 25 patients in each group.",[30],[617,618,33,619],"Noninvasive technique in treatment of respiratory failure","Noninvasive ventilation","High flow nasal oxygen","2026-04-07",{"date":622,"type":39},"2026-04-09",{"date":624,"type":39},"2025-06-01",{"date":600,"type":23},{"name":627,"class":46},"Minia University",{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":633,"acronym":634,"eligibilityCriteria":635,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":636,"targetDuration":4,"studyType":24,"phases":638,"briefSummary":640,"conditions":641,"keywords":642,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":620,"lastUpdatePostDateStruct":645,"startDateStruct":647,"completionDateStruct":649,"leadSponsor":651,"locationsCount":141},"100620564","phase-2-transpulmonary-assessment-for-individualized-lung-optimization-in-obese-patients-100620564","NCT07359261","Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients","Transpulmonary Assessment for Individualized Lung Optimization in Patients Living With Obesity Research - Positive End-Expiratory Pressure","TAILOR-PEEP","Inclusion Criteria:\n\n* Age 18 years or older\n* Body mass index ≥30 kg\u002Fm²\n* Intubated and receiving passive mechanical ventilation\n* Within 24 hours of intubation\n* Anticipated need for mechanical ventilation for at least 48 hours\n\nExclusion Criteria:\n\n* Known or suspected esophageal varices\n* Esophageal surgery within 3 months\n* Known esophageal stricture or perforation\n* Active upper gastrointestinal bleeding\n* Severe coagulopathy (INR \\>3.0 or platelet count \\\u003C30,000\u002FμL)\n* Known or suspected intracranial hypertension without intracranial pressure monitoring device demonstrating controlled intracranial pressure (\\\u003C20 mmHg)\n* Severe hemodynamic instability at treating physician discretion\n* Known pregnancy\n* Moribund state with expected survival \\\u003C48 hours\n* Receiving extracorporeal membrane oxygenation (ECMO)\n* Open abdomen post-operatively\n* Previous enrollment in this study\n* Any other contraindication to esophageal balloon placement as determined by clinical team",{"count":637,"type":23},30,[639],"PHASE2","This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with high body mass index (BMI) mechanically ventilated patients at the Edmonton Zone. The study will enroll 30 patients with body mass index (BMI) \\>=30 kg\u002Fm2 who require invasive mechanical ventilation, randomizing them in a 1:1 ratio to receive either esophageal pressure-guided PEEP titration or standard care management. The primary objective focuses on establishing the feasibility of conducting a larger definitive trial, while secondary objectives examine differences in applied PEEP levels, respiratory mechanics, and clinical outcomes between groups. The intervention protocol targets end-expiratory transpulmonary pressure of 0-2 cmH2O.",[30],[643,644,73],"PEEP","obesity",{"date":646,"type":39},"2026-04-13",{"date":648,"type":39},"2026-02-05",{"date":650,"type":23},"2027-01-01",{"name":652,"class":46},"University of Alberta",{"id":654,"slug":655,"hasResults":12,"nctId":656,"briefTitle":657,"officialTitle":658,"acronym":4,"eligibilityCriteria":659,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":660,"enrollmentInfo":661,"targetDuration":4,"studyType":24,"phases":662,"briefSummary":663,"conditions":664,"keywords":665,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":620,"lastUpdatePostDateStruct":670,"startDateStruct":671,"completionDateStruct":673,"leadSponsor":675,"locationsCount":88},"100550199","low-and-high-flow-suctioning-in-intubated-infants-100550199","NCT06443970","Low and High Flow Suctioning in Intubated Infants","Physiological Consequences of Low and High Flow Endotracheal Suctioning Devices in Intubated Preterm and Term Infants","Inclusion Criteria:\n\n* Preterm and term infants with birth weight more than 1000g receiving ETT suctioning\n\nExclusion Criteria:\n\n* Infants with cyanotic congenital heart disease and cardiac rhythm disorders (arrythmias) will be excluded from the study.","28 Days",{"count":637,"type":23},[26],"Preterm and term intubuted infants in the NICU will undergo two sequential suctioning procedures: a new, FDA-approved suction device called EXSALTA (ED) and the standard conventional wall (SCW). The physiological consequences, i.e. changes in heart rate (HR), oxygen saturation (SpO2), cerebral oxygenation (C-rSO2), and cerebral fractional oxygen extraction (C-FOE) between ED and SCW ETT tracheal suctioning system in both open and closed catheter system settings will be evaluated using a randomized cross over design in preterm and term infants receiving mechanical ventilation via an ETT. This study will evaluate the hypothesis that there will be significantly lower variations in HR, SpO2, C-rSO2, and C-FOE during ETT suctioning with ED compared to SCW suctioning systems under both open and close ETT suction settings.",[30],[666,667,668,669],"cardiorespiratory disturbances","neonates","EXSALTA","Endotracheal Suctioning",{"date":646,"type":39},{"date":672,"type":39},"2024-09-04",{"date":674,"type":23},"2027-01",{"name":676,"class":46},"Columbia University",{"id":678,"slug":679,"hasResults":12,"nctId":680,"briefTitle":681,"officialTitle":681,"acronym":4,"eligibilityCriteria":682,"healthyVolunteers":258,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":683,"targetDuration":4,"studyType":24,"phases":685,"briefSummary":686,"conditions":687,"keywords":688,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":690,"lastUpdatePostDateStruct":691,"startDateStruct":693,"completionDateStruct":694,"leadSponsor":696,"locationsCount":141},"100592687","diaphragmatic-physiology-similarity-index-may-titrate-hfnc-flow-setting-a-prospective-observational-study-100592687","NCT06996665","Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study","Feasibility and reproducibility：adult ICU patients\n\nMethodology for diaphragmatic motion synchrony:healthy adults and adult ICU patients Between-group comparisons and flow-titration study\n\nInclusion Criteria:\n\n1. Age ≥18 years old.\n2. Clear diagnosis of respiratory failure requiring respiratory support.\n3. Expected duration of respiratory support ≥24 hours or (high-flow\u002Fnon-invasive ventilation) ≥48 hours.\n4. Voluntary participation in this study and signed informed consent. If the participant is unable to read or sign the informed consent form due to incapacity (e.g., unconsciousness), the legal guardian must act as a proxy in the informed consent process and sign the form. If the participant cannot read the consent form (e.g., illiterate participants), a witness must observe the informed consent process and sign the form.\n\nExclusion Criteria:\n\n1. Severe chest wall deformities or diaphragmatic paralysis.\n2. End-stage disease with a predicted life expectancy of less than 24 hours.\n3. Inability to acquire STE (strains and echoes) images (e.g., severe subcutaneous emphysema, position limitations).\n4. Vulnerable groups other than critically ill patients\u002Felderly\u002Filliterate individuals, including those with mental disorders, cognitive impairments, pregnant women, etc.",{"count":684,"type":23},100,[26],"Study Objective This prospective observational study aims to investigate the role of the Diaphragmatic Physiology Similarity Index (DPSI) derived from speckle tracking ultrasound in titrating high-flow nasal cannula (HFNC) flow settings, and to evaluate its application in patients with acute respiratory failure.\n\nPrimary Research Questions\n\nTo characterize the features of the DPSI in healthy individuals and in patients with acute respiratory failure.\n\nTo assess the behavior of the DPSI under different HFNC flow settings in patients with acute respiratory failure.\n\nSecondary Research Questions\n\nFeasibility and inter-operator reproducibility of diaphragmatic speckle tracking.\n\nAssessment of the Diaphragmatic Contraction Synchrony Index.\n\nEvaluation of End-Diaphragmatic Residual Contraction (EDRC).\n\nAdditional fundamental parameters, including diaphragmatic displacement velocity and maximum displacement.",[30],[533,689,643],"Speckle Tracking","2026-03-22",{"date":692,"type":39},"2026-03-25",{"date":624,"type":39},{"date":695,"type":23},"2026-12-02",{"name":697,"class":46},"Sir Run Run Shaw Hospital"]