[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-function-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-function-loss":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100505038","phase-4-a-study-to-investigate-of-the-effects-of-opioid-exposure-on-the-ability-of-the-diaphragm-muscle-100505038",false,"NCT05856136","A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle","Investigation of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle to Generate Higher Force Behaviors","Inclusion Criteria:\n\n\\- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).\n\nExclusion Criteria:\n\n* Patients who refuse research participation.\n* Patients who are pregnant.\n* Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).","ALL","18 Years",{"count":19,"type":20},69,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.",[26,27],"Respiratory Function Loss","Respiratory Complication",[29,30],"elastography","ultrasound","RECRUITING","2026-06-18",{"date":34,"type":35},"2026-06-23","ACTUAL",{"date":37,"type":35},"2023-06-19",{"date":39,"type":20},"2027-01-01",{"name":41,"class":42},"Mayo Clinic","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100577092","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-application-on-respiratory-functions-in-stroke-patients-100577092","NCT06793800","Effect of Transcutaneous Auricular Vagus Nerve Stimulation Application on Respiratory Functions in Stroke Patients","Effect of TAVNS Application on Respiratory Functions in Stroke Patients","TAVNS","Inclusion Criteria:\n\n* Being a chronic stroke patient with an ischemic or hemorrhagic stroke diagnosis made 1-3 years ago\n* Having been diagnosed with stroke for the first time\n* Ability to understand and follow simple verbal instructions\n* Being between the ages of 40 and 80\n* No conditions affecting perioral muscles, such as facial paralysis or swallowing disorders\n* No visual, auditory, or communication problems\n* No cardiopulmonary disorders\n* No additional neurological, cardiovascular, orthopedic, or similar conditions causing balance problems\n* Mini Mental State Examination (MMSE) score ≥24\n* No surgical operations or Botox applications in the last 6 months\n* Scoring 2 or below on the Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Presence of infection, ulcer, or scar on the auricle\n* Metallic implants in the skull, hypersensitivity, injury, or inflammation inside the ear\n* Chronic pulmonary and\u002For cardiac diseases\n* Resting heart rate below 60 beats per minute\n* Devices such as pacemakers or cochlear implants\n* Uncontrolled hypertension\n* Chronic obstructive pulmonary disease (COPD) or asthma unrelated to stroke\n* History of surgical operation or Botox application within the last 6 months\n* Presence of aphasia, apraxia, or neglect syndrome\n* History of 2 or more strokes (SVO)\n* Comorbid conditions affecting respiratory functions (e.g., Multiple Sclerosis, Parkinson's, spinal cord injury, contractures, deformities after fractures, active upper or lower respiratory infections, etc.)\n* Lack of cooperation","40 Years","80 Years",{"count":55,"type":20},50,[57],"NA","The purpose of this study is to evaluate the effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (TAVSS) in improving respiratory muscle strength and function in chronic stroke patients. It aims to explore TAVSS as a potential complementary approach in enhancing rehabilitation outcomes for this population.",[60,26],"Hemiplegia",[62,63,64],"hemiplegia","Vagus Nerve Stimulation","Respiration","2026-03-31",{"date":67,"type":35},"2026-04-01",{"date":69,"type":35},"2025-08-05",{"date":71,"type":20},"2027-07-30",{"name":73,"class":42},"Fenerbahce University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":43},"100436153","shear-wave-elastography-compared-to-respiratory-function-testing-100436153","NCT04959526","Shear-wave Elastography Compared to Respiratory Function Testing","Comparison of Shear-wave Elastography to State-of-the-art Respiratory Function Testing to Measure the Range of Forces Generated by the Diaphragm Muscle","Inclusion Criteria:\n\n\\- Adult male and female healthy volunteers.\n\nExclusion Criteria:\n\n* Volunteers who are pregnant.\n* Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).",true,{"count":83,"type":20},24,[57],"The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts (e.g., maximal inspiratory pressure, maximal expiratory pressure, Valsalva maneuver), as well as maximal phrenic nerve stimulation.",[26,27],[88,89],"Elastography","Ultrasound","2026-03-12",{"date":92,"type":35},"2026-03-16",{"date":94,"type":35},"2021-07-28",{"date":96,"type":20},"2026-12",{"name":41,"class":42}]