[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"resynchronization-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:resynchronization-therapy":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100646153","restoration-of-synchronous-cardiac-function-due-to-physiologic-cardiac-pacing-modalities-with-clinical-endpoints-100646153",false,"NCT07684547","REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints","REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints RESYNC-PACE","RESYNC-PACE","Inclusion Criteria:\n\n* Age ≥18 years.\n* Symptomatic heart failure despite guideline-directed medical therapy.\n* Left ventricular ejection fraction (LVEF) ≤40%.\n* Indication for cardiac resynchronization therapy according to contemporary ESC guideline recommendations.\n* QRS duration ≥150 ms with either:\n\nLeft bundle branch block (LBBB), or Intraventricular conduction delay (IVCD).\n\n* Planned implantation of a CRT system\n* Ability to provide written informed consent\n* Expected survival greater than 24 months.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years and Age 100 \\\u003C years\n* Pregnancy or breastfeeding.\n* Inability or unwillingness to provide informed consent.\n* Life expectancy \\\u003C12 months due to non-cardiac comorbidities.\n* Active systemic infection or infection involving a cardiac implantable electronic device.\n* Reversible causes of heart failure expected to improve without CRT.\n* Participation in another interventional clinical trial that may affect study outcomes.\n* Inability to comply with follow-up requirements.\n* Missing essential baseline or follow-up data (retrospective cohort).\n* Any condition that, in the opinion of the investigators, would make participation inappropriate or interfere with study assessments.","ALL","18 Years","100 Years",{"count":21,"type":22},50,"ESTIMATED","24 Months","OBSERVATIONAL","The goal of this observational study is to evaluate the long-term clinical outcomes of physiologic cardiac resynchronization therapy (CRT) using conduction system pacing strategies compared with conventional biventricular CRT in patients with heart failure with reduced ejection fraction (HFrEF) and electrical dyssynchrony.\n\nThe main questions it aims to answer are:\n\n* Does physiologic CRT (including left bundle branch area pacing \\[LBBAP\\] and LBBAP-optimized CRT) reduce the combined risk of all-cause mortality and heart failure hospitalization compared with conventional biventricular CRT?\n* Does physiologic CRT improve cardiac function and reverse ventricular remodeling more effectively than conventional CRT?\n\nParticipants receiving physiologic CRT as part of routine clinical care will undergo standard follow-up evaluations, including electrocardiography, echocardiography, laboratory testing, and device interrogation. Clinical outcomes will be collected prospectively for 24 months and compared with a historical cohort of patients treated with conventional biventricular CRT.\n\nThe study will assess clinical outcomes, echocardiographic response, electrical resynchronization parameters, and device-related safety in a real-world heart failure population.",[27,28,29,30,31],"Heart Failure - NYHA II - IV","Left Bundle Branch Area Pacing","Left Bundle Branch Block","Intraventricular Conduction Delay","Resynchronization Therapy",[33,34,35,36,37],"carrdiac resynchornization therapy","Physiologic Pacing","Conduction System Pacing","Electrical Resynchronization","Physiologic CRT","NOT_YET_RECRUITING","2026-07-08",{"date":41,"type":42},"2026-07-10","ACTUAL",{"date":44,"type":22},"2026-06-29",{"date":46,"type":22},"2031-06-29",{"name":48,"class":49},"University of Pecs","OTHER"]