[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"retrograde-intrarenal-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:retrograde-intrarenal-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100651965","long-term-safety-of-uas-assisted-vs-sheathless-rirs-in-non-prestented-patients-100651965",false,"NCT07767773","Long-term Safety of UAS-assisted vs Sheathless RIRS in Non-prestented Patients","Long-Term Safety Outcomes of Ureteral Access Sheath-Assisted Versus Sheathless Retrograde Intrarenal Surgery for Renal Stones ≤20 mm in Non-Prestented Patients: A Retrospective Comparative Cohort Study With Active Follow-up","Inclusion Criteria:\n\n* Age ≥18 years at time of index RIRS.\n* Primary RIRS performed at Al-Azhar University Hospitals between Jan 1, 2020 and Dec 31, 2025.\n* Renal stone(s) with maximum diameter ≤20 mm on preoperative imaging.\n* No ipsilateral ureteral stent or nephrostomy before index RIRS.\n* Documented operative record specifying whether a UAS was used.\n* At least 12 months elapsed since index RIRS.\n* Available contact information allowing invitation for active follow-up.\n\nExclusion Criteria:\n\n* Primary ureteral stone treated during the same procedure.\n* Staghorn or \\>20 mm stone burden.\n* Prior ipsilateral ureteral stricture or reconstructive surgery.\n* Congenital renal\u002Fureteral anomalies affecting outcome (e.g., horseshoe kidney, duplicated system).\n* Incomplete operative or preoperative imaging records that preclude determination of eligibility or exposure (UAS use).\n* Additional ipsilateral ureteral procedure during follow-up that independently causes ureteral narrowing.\n* Refusal to participate in active follow-up or failure to attend after repeated attempts.","ALL","18 Years",{"count":19,"type":20},1200,"ESTIMATED","OBSERVATIONAL","This retrospective comparative cohort study will include adult patients who underwent primary RIRS for renal stones ≤20 mm at Al-Azhar University Hospitals between January 2020 and December 2025. Patients will be classified by whether a ureteral access sheath (UAS) was used during the index RIRS, and all eligible patients will be invited for active long-term follow-up (minimum 12 months) to assess the composite outcome of delayed ipsilateral ureteral stricture or new\u002Fprogressive ipsilateral hydronephrosis and other safety and efficacy outcomes. Propensity-score methods and adjusted regression analyses will be used to control confounding.",[24,25,26,27,28,29],"Renal Stone Disease","Ureteral Stricture","Hydronephrosis","Urolithiasis","Retrograde Intrarenal Surgery","Ureteral Access Sheath","RECRUITING","2026-08-16",{"date":33,"type":34},"2026-08-18","ACTUAL",{"date":31,"type":34},{"date":37,"type":20},"2027-12-25",{"name":39,"class":40},"Al-Azhar University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":5},"100640042","phase-2-tamsulosin-and-intraureteral-aminophylline-for-ureteral-access-during-rirs-100640042","NCT07623876","Tamsulosin and Intraureteral Aminophylline for Ureteral Access During RIRS","Comparative Efficacy of Tamsulosin, Intraureteral Aminophylline, and Their Combination in Facilitating Ureteral Access During Retrograde Intrarenal Surgery: A Multicenter Randomized Controlled Trial.","TAM-AMIN-UAS","Inclusion Criteria:\n\n* Age 18 years or older.\n* Unilateral renal stone 2 cm or less in maximal diameter on preoperative imaging.\n* Scheduled for primary retrograde intrarenal surgery.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Prior ureteral stenting on the study side.\n* Bilateral same-session retrograde intrarenal surgery.\n* Concomitant ureteral stone requiring primary semirigid ureteroscopy as the main procedure.\n* Known ureteral stricture or prior ureteral reconstructive surgery on the study side.\n* Active urinary tract infection or untreated positive urine culture.\n* Pregnancy.\n* Known allergy or contraindication to tamsulosin or aminophylline.\n* Significant cardiac arrhythmia, uncontrolled ischemic heart disease, seizure disorder, or hyperthyroidism.\n* Severe hepatic impairment.\n* Inability to comply with the 7-day preoperative medication protocol.",{"count":51,"type":20},322,"INTERVENTIONAL",[54],"PHASE2","This multicenter randomized controlled trial will evaluate whether preoperative tamsulosin, intraureteral aminophylline, or their combination can improve ureteral access during primary retrograde intrarenal surgery for renal stones. Adult patients with unilateral renal stones measuring 2 cm or less and planned placement of a 10\u002F12 Fr ureteral access sheath will be randomly assigned to one of four groups in a 2x2 factorial design. Participants will receive either tamsulosin or placebo for 7 days before surgery and either intraureteral aminophylline or intraureteral placebo during the procedure. The main outcome will be successful first-attempt placement of the planned 10\u002F12 Fr ureteral access sheath after study solution instillation, without active ureteral dilatation, sheath downsizing, prestenting with deferred surgery, or abandonment of the procedure due to access failure.",[57,28,58],"Renal Stones","Ureteral Access Sheath Placement",[60,61,62,63],"Retrograde intrarenal surgery","Tamsulosin","Intraureteral aminophylline","ureteral access sheath","2026-05-28",{"date":66,"type":34},"2026-06-03",{"date":68,"type":34},"2026-05-06",{"date":70,"type":20},"2027-05",{"name":72,"class":40},"Beni-Suef University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":52,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100577204","homework-in-retrograde-intrarenal-surgery-100577204","NCT06795256","Homework in Retrograde Intrarenal Surgery","Homework to Help with Stone Dissolution in Retrograde Intrarenal Surgery","Inclusion Criteria:\n\n* Patients with an indication for RIRC\n\nExclusion Criteria:\n\n* Patients with anatomic abnormalities such as horseshoe kidney, fragments in the calyx diverticulum, infundibular stenosis, pelvi-ureteral junction obstruction or ureteral stenosis.\n* Patients with morbid obesity, uncontrolled hypertension, previous cerebrovascular accident, skeletal deformity such as significant coronary artery disease or symptomatic gastro-esophageal reflux disease.\n* Patients with lumbar disc herniation who have undergone spinal surgery and are unable to undergo behavioral therapy.",{"count":81,"type":20},200,[83],"NA","To evaluate the effectiveness of this homework on stone clearance rates after retrograde intrarenal surgery (RIRS) by instructing the patient in the home environment and suggesting percussion and movement\u002Fposition changes to assist in spontaneous stone passage.",[28,86],"Stone, Kidney","2025-01-27",{"date":89,"type":34},"2025-01-29",{"date":91,"type":34},"2025-01-21",{"date":93,"type":20},"2025-11-30",{"name":95,"class":40},"Adiyaman University"]