[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rotator-cuff-tear-repair\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rotator-cuff-tear-repair":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100647979","evaluation-of-the-therapeutic-effect-of-local-application-of-tranexamic-acid-in-rotator-cuff-repair-100647979",false,"NCT07714473","Evaluation of the Therapeutic Effect of Local Application of Tranexamic Acid in Rotator Cuff Repair","Inclusion Criteria:\n\n* Age between 18 and 80 years;\n* Patients diagnosed with rotator cuff tear by shoulder MRI;\n* Patients scheduled for arthroscopic rotator cuff repair;\n* Ability to understand the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Severe open injury or infection around the surgical area;\n* Allergy to tranexamic acid;\n* Previous shoulder surgery;\n* Coagulation disorders;\n* Current anticoagulant therapy that cannot be discontinued;\n* Pregnancy.","ALL","18 Years","80 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective randomized controlled trial aims to evaluate the efficacy and safety of intraosseous tranexamic acid administration during arthroscopic rotator cuff repair. Eligible patients undergoing arthroscopic rotator cuff repair will be randomly assigned in a 1:1 ratio to receive either intraosseous tranexamic acid or intraosseous normal saline placebo. Tranexamic acid will be administered at a dose of 15 mg\u002Fkg through intraosseous injection into the proximal humerus after anesthesia induction.\n\nThe primary outcome will be intraoperative arthroscopic visual clarity assessed using a five-grade visual clarity scoring system during different surgical stages. Secondary outcomes will include irrigation fluid volume, operative time, and frequency of irrigation pressure adjustments. Safety outcomes will include perioperative complications and laboratory assessments.\n\nThis study will determine whether intraosseous tranexamic acid can improve visualization of the arthroscopic surgical field and optimize surgical conditions during rotator cuff repair.",[26],"Rotator Cuff Tear Repair","NOT_YET_RECRUITING","2026-07-15",{"date":30,"type":31},"2026-07-20","ACTUAL",{"date":33,"type":20},"2026-08-01",{"date":35,"type":20},"2026-12-30",{"name":37,"class":38},"Hua Luo","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":50,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":39},"100646553","preoperative-versus-postoperative-interscalene-block-in-arthroscopic-rotator-cuff-repair-100646553","NCT07689448","Preoperative Versus Postoperative Interscalene Block in Arthroscopic Rotator Cuff Repair","Pre-Procedure Versus Post-Procedure Administration of Interscalene Block in Arthroscopic Rotator Cuff Repair: Effects on Early Pain Control and Functional Outcomes","ISB-ARCR","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients undergoing primary arthroscopic rotator cuff repair.\n* Presence of a repairable small-, medium-, or large-sized rotator cuff tear confirmed by clinical and imaging evaluation.\n* Receipt of an ultrasound-guided interscalene nerve block as part of perioperative pain management.\n* Ability to provide informed consent and comply with study follow-up requirements.\n\nExclusion Criteria:\n\n* Irreparable rotator cuff tears.\n* Partial-thickness rotator cuff tears not requiring repair.\n* Revision rotator cuff repair procedures.\n* Concomitant shoulder procedures that could substantially influence postoperative pain or functional outcomes (e.g., shoulder arthroplasty, fracture fixation).\n* Previous surgery on the affected shoulder.\n* Contraindications to interscalene nerve block, including local anesthetic allergy, infection at the injection site, or severe neurologic disease affecting the brachial plexus.\n* Chronic opioid use or opioid dependence before surgery.\n* Inability to complete study questionnaires or follow the postoperative rehabilitation protocol.\n* Missing baseline or follow-up data required for outcome assessment.",{"count":49,"type":20},42,"6 Months","OBSERVATIONAL","This study is evaluating whether the timing of an interscalene nerve block affects pain control and recovery after arthroscopic rotator cuff repair surgery.\n\nAn interscalene block is commonly used to reduce pain after shoulder surgery. However, it is not known whether administering the block before surgery or after surgery provides better outcomes. Participants undergoing arthroscopic rotator cuff repair are assigned to receive the interscalene block either before the surgical incision or after completion of the procedure.\n\nThe study compares postoperative pain levels, opioid medication use, length of hospital stay, and ultrasound imaging quality during block administration between the two groups. Functional recovery is also assessed using patient-reported outcome measures during follow-up.\n\nThe investigators hypothesize that administration of the interscalene block before surgery may provide superior early pain control and reduce postoperative opioid requirements while maintaining similar functional outcomes compared with administration after surgery.",[26,54,55],"Interscalene Blocks","Rotator Cuff Tears",[55,57,58,59,60,61,62],"Arthroscopic Rotator Cuff Repair","Interscalene Nerve Block","Regional Anesthesia","Postoperative Pain","Preemptive Analgesia","Pain Management","2026-07-07",{"date":65,"type":31},"2026-07-08",{"date":67,"type":20},"2026-07-13",{"date":69,"type":20},"2026-10-20",{"name":71,"class":38},"Istinye University"]