[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"satiety-and-food-intake\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:satiety-and-food-intake":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,59,98,134,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":37,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100648044","effect-of-probiotics-on-appetite-regulation-in-adults-with-overweightobesity-100648044",false,"NCT07715955","Effect of Probiotics on Appetite Regulation in Adults With Overweight\u002FObesity","Probiotic Regulation of Food Intake Through Satiety Stimulation and Gut Microbiota Modulation","ProBiSat","Inclusion Criteria:\n\n* Men and women, aged between 20-70 years\n* BMI ³ 25 kg\u002Fm2\n* Stable body weight (weight gain or loss \\\u003C 3 kg in the past three months)\n* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study\n* No difficult venipuncture as evidenced during the screening visit\n\nExclusion Criteria:\n\n* Diabetic patients (type 1 and type 2)\n* Abuse of drugs\n* More than 2 units alcoholic consumptions per day for women and 3 for men\n* Use of products or dietary supplements known to interfere with the main outcomes 3 months prior to the start of the study as judged by the principal investigators\n* Gastrointestinal disease (including IBD and IBS)\n* Use of an investigational product within another biomedical intervention trial within the previous 1-month\n* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, autoimmune disease and rheumatoid arthritis\n* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident\n* use of lipid- and glucose lowering medication, corticosteroid use\n* Psychiatric diagnoses including clinical depression\n* Intolerances or dietary habits that might interfere with the study (i.e. lactose intolerance or veganism)\n* pregnancy\n* smoking, vaping\n* use of antibiotics up to 3 months prior to the study",true,"ALL","20 Years","70 Years",{"count":22,"type":23},98,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed probiotic supplement on satiety and gut microbiota composition in healthy men and women with overweight or obesity form 20-70 years old. The main question it aims to answer is:\n\nDoes the probiotic supplement increase feelings of satiety and alter gut microbiota composition?\n\nParticipants will:\n\n* Receive a daily dose of 6 g probiotic supplement (packed in sachets of 3 g) or placebo for 16 weeks.\n* Visit the research unit 3 times at baseline, week 8 and week 16 of the intervention for blood draws and delivering fecal samples.\n* Keep a study diary to report deviations from their daily habits and fill in food questionnaires.",[29,30,31,32,33,34,35,36],"Healthy","Overweight (BMI > 25)","Overweight , Obesity","Male","Female","Adults","Satiety and Food Intake","Gut Microbiota Modulation",[38,39,40,34,29,41,42,43,44,45],"Probiotics","Overweight","Obesity","Satiety","Food intake","Gut microbiota","Gut microbiota composition","Gut microbiota modulation","RECRUITING","2026-08-10",{"date":49,"type":50},"2026-08-12","ACTUAL",{"date":52,"type":50},"2026-03-18",{"date":54,"type":23},"2029-08-18",{"name":56,"class":57},"Maastricht University Medical Center","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":18,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":24,"phases":70,"briefSummary":71,"conditions":72,"keywords":80,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":58},"100650884","long-term-effects-of-avocado-consumption-on-health-in-pre-diabetic-individuals-100650884","NCT07752225","Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals","Effects of Long-term Avocado Consumption on Brain and Peripheral Cardiovascular Health in Pre-diabetic Individuals","Inclusion Criteria:\n\n* Men and women, aged between 40-75 years\n* Pre-diabetes: (A1C of 5.7%-6.4%, a fasting plasma glucose (FPG) of 100-125 mg\u002FdL, or a 2-hour oral glucose tolerance test (OGTT) result of 140-199 mg\u002FdL)\n* BMI ³ 25 kg\u002Fm2\n* Fasting serum total cholesterol \\\u003C 8.0 mmol\u002FL\n* Systolic blood pressure \\\u003C 160 mmHg and diastolic blood pressure \\\u003C 100 mmHg\n* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study\n\nExclusion Criteria:\n\n* Age less than 40 years old or older than 75 years\n* BMI \\\u003C 25 kg\u002Fm2\n* Type 1 or type 2 diabetes\n* habitual consumption of more than 1 avocado\u002F week\n* Left-handedness\n* Fasting serum total cholesterol \\> 8.0 mmol\u002FL\n* Current smoker, or smoking cessation \\\u003C 12 months\n* Abuse of drugs\n* More than 3 alcoholic consumptions per day\n* Use medication to treat blood pressure, lipid or glucose metabolism\n* Use of an investigational product within another biomedical intervention trial within the previous 1-month\n* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis\n* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident\n* Contra-indications for MRI imaging (e.g. pacemaker, surgical clips\u002Fmaterial in body, metal splinter in eye, claustrophobia)\n* Blood donation in the 8 weeks before the start of the study\n* Difficulties to draw blood","40 Years","75 Years",{"count":69,"type":23},34,[26],"Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.",[73,74,75,35,76,77,78,79],"Prediabetes","Brain Insulin Sensitivity","Cerebral Blood Flow","Food Reward","Brain Health","Vascular Function","Obesity & Overweight",[81,82,83,75,84,85,86,39,40,87,88],"Avocados","Brain insulin sensitivity","Brain vascular function","CBF","pCASL MRI","CANTAB","cognitive performance","brain health","NOT_YET_RECRUITING","2026-08-03",{"date":92,"type":50},"2026-08-07",{"date":94,"type":23},"2026-09-01",{"date":96,"type":23},"2028-08-31",{"name":56,"class":57},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":17,"sex":18,"minAge":106,"maxAge":67,"enrollmentInfo":107,"targetDuration":4,"studyType":24,"phases":109,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":58},"100625406","long-term-effects-of-walnut-consumption-on-brain-function-100625406","NCT07422220","Long-Term Effects of Walnut Consumption on Brain Function","Long-Term Effects of Walnut Consumption on Brain Function in Men and Women With Abdominal Obesity","WalBrain","Inclusion Criteria:\n\n* Men and women, aged between 45-75 years\n* Women postmenopausal: two or more years after last menstruation\n* Waist circumference of ≥102 cm for men and ≥88 cm for women (abdominal obesity)\n* Fasting plasma glucose \\\u003C 7.0 mmol\u002FL\n* Fasting serum total cholesterol \\\u003C 8.0 mmol\u002FL\n* Fasting serum triacylglycerol \\\u003C 4.5 mmol\u002FL\n* Systolic blood pressure \\\u003C 160 mmHg and diastolic blood pressure \\\u003C 100 mmHg\n* Stable body weight (weight gain or loss \\\u003C 3 kg in the past three months)\n* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study\n* No difficult venipuncture as evidenced during the screening visit\n\nExclusion Criteria:\n\n* Allergy or intolerance to walnuts\n* Left-handedness (effects on brain function differ between left- and right-handed adults)\n* Current smoker, or smoking cessation \\\u003C 12 months\n* Diabetic patients\n* Familial hypercholesterolemia\n* Abuse of drugs\n* More than 3 alcoholic consumptions per day\n* Use of products or dietary supplements (e.g., dietary fiber or antioxidant dietary supplements (vitamin C and E), fish or seaweed oil capsules) known to interfere with the main outcomes as judged by the principal investigators\n* Use of medication to treat blood pressure, lipid, or glucose metabolism\n* Use of an investigational product within another biomedical intervention trial within the previous 1-month\n* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases, and rheumatoid arthritis\n* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident\n* Contra-indications for MRI imaging (e.g., pacemaker, surgical clips\u002Fmaterial in body, metal splinter in eye, claustrophobia)","45 Years",{"count":108,"type":23},55,[26],"Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation. It is therefore important to investigate the specific effects of walnuts on cerebral blood flow responses before and after intranasal insulin administration, as well as their associated functional benefits. The investigators hypothesize that long-term walnut consumption improves vascular function and insulin-sensitivity in the brain, thereby enhancing cognitive performance and appetite control in abdominally obese men and women. Objective: The primary objectives are to investigate in abdominally obese adults the effects of 24-week walnut consumption on (regional) vascular function and insulin-sensitivity in the brain, while the investigators will also assess changes in cognitive performance and appetite-related brain reward activity (secondary objectives). Cerebral blood flow responses before (brain vascular function) and after the administration of intranasal insulin spray (brain insulin-sensitivity) will be quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-perfusion method Arterial Spin Labeling (ASL). Study design: This intervention study will have a randomized, controlled parallel design. The total study duration will be 24 weeks. Study population: Fifty-five abdominally obese men and (postmenopausal) women (aged 45-75 years) without a history of cardiovascular diseases or complaints will participate. This study population is expected to have a decreased cerebral blood flow at baseline and are also at increased risk of cognitive impairment, allowing for improvement by the intervention. Intervention: Study participants will receive daily 50 g (about 15% of energy) of raw walnuts (walnut intervention) or no walnuts (control intervention) for 24 weeks. Main study parameters\u002Fendpoints: At baseline and after 24 weeks (follow-up), participants will visit the research facilities for assessments. The primary endpoint is the difference in the cerebral blood flow response before and after intranasal insulin administration between the walnut and control intervention. Cognitive performance will be assessed, while the investigators will also focus on appetite-related brain reward activity (secondary outcomes).",[29,74,75,112,35,76,113,114,115],"Brain Vascular Function","Cognitive Performance","Abdominal Obesity","Cognitive Decline",[117,118,83,82,41,119,120,121,122,85,123,86,124,125],"Walnuts","Juglans","Food reward mechanisms","Cognitive performance","Abdominal obesity","Cognitive decline","fMRI","Intranasal insulin","Food cues","2026-07-23",{"date":128,"type":50},"2026-07-24",{"date":130,"type":50},"2025-10-01",{"date":132,"type":23},"2027-08",{"name":56,"class":57},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":17,"sex":18,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":24,"phases":146,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":165,"leadSponsor":167,"locationsCount":58},"100635534","sustainable-and-inclusive-use-of-alternative-proteins-in-mediterranean-supply-chains-cipromed-100635534","NCT07553936","Sustainable and Inclusive Use of Alternative Proteins in Mediterranean Supply Chains (CIPROMED)","Circular and Inclusive Use of Alternative Proteins in Mediterranean Supply Chains (CIPROMED)","CIPROMED","Inclusion Criteria:\n\n* Providing signed informed consent,\n* Being between 18 and 65 years of age,\n* Having a body mass index (BMI) within the normal range, defined as between 18.5 and 24.9 kg\u002Fm² or Having a body mass index (BMI) between 25.0 and 34.9 kg\u002Fm², inclusive, corresponding to the overweight category or, at most, class I obesity.\n\nExclusion Criteria:\n\n* Positive and documented history of allergy to legumes, insects, microalgae, shellfish, mollusks, crustaceans, snails, insect venom, house dust mites, or any component (ingredient or additive) present in the food prototypes tested, or a confirmed or suspected diagnosis of Celiac Disease.\n* History of severe allergic reactions to any type of allergen.\n* Pregnancy or Breastfeeding","18 Years","65 Years",{"count":145,"type":23},40,[26],"This study investigates the effects of foods enriched with alternative protein sources, including edible insects, microalgae, hemp, and legumes, on appetite regulation, satiety, food preferences, and metabolic health in healthy adults and individuals with overweight. The study is part of the CIPROMED project, which aims to support sustainable and circular food systems in the Mediterranean area.\n\nThe study consists of two phases. In the acute phase, participants will consume different protein-enriched bread products in a controlled setting following a randomized crossover design. Each participant will be exposed to multiple test conditions, allowing within-subject comparisons of postprandial responses. Outcomes assessed during this phase include satiety, hunger, food preference, craving, and short-term energy intake, measured using validated scales and dietary assessment tools.\n\nIn the chronic phase, participants will follow structured dietary interventions over a longer period within a Mediterranean dietary framework. Participants will be assigned to different dietary patterns including alternative protein-based foods and control products. This phase aims to evaluate the effects of repeated consumption of alternative protein sources on metabolic parameters, gastrointestinal tolerance, nutritional status, and behavioral responses.\n\nThe study aims to assess the acceptability and physiological effects of alternative protein sources and to compare their impact with that of traditional protein sources commonly used in Mediterranean diets.",[149,35,150,30,151],"Food Preferences","Appetite Regulation","Gut Microbiota",[153,154,155,156,150,39,157,158,159,41,160,151],"Alternative Proteins","Edible Insects","Hemp Protein","Legume Protein","Novel Foods","Microalgae (Protein)","Food Acceptability","Metabolic Health","2026-04-28",{"date":163,"type":50},"2026-05-04",{"date":52,"type":50},{"date":166,"type":23},"2027-01-31",{"name":168,"class":57},"University of Bologna",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":17,"sex":176,"minAge":177,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":24,"phases":181,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":58},"100602736","adding-chondrus-crispus-seaweeds-to-a-meal-effect-on-sensory-perception-physical-comfort-satiety-and-food-intake-100602736","NCT07127393","Adding Chondrus Crispus Seaweeds to a Meal: Effect on Sensory Perception, Physical Comfort, Satiety and Food Intake","Sensory Evaluation of Foods Formulated With Seaweeds and Their Effect on Satiety and Food Intake","Inclusion Criteria:\n\n* Young healthy adult males\n\nExclusion Criteria:\n\n* Having any diseases\n* Smoking, consuming cannabis\n* Skipping breakfast regularly\n* Disordered eating patterns\n* Taking certain medications that may affect the central and peripheral mechanisms of food intake regulation, cognitive performance and sedative medications\n* Food allergies and aversion towards seaweeds","MALE","19 Years","35 Years",{"count":180,"type":23},32,[26],"The study investigates the sensory characteristics, consumer perception and the effect on satiety and food intake of the meal with added Chondrus crispus seaweed produced by Acadian Seaplants in Atlantic Canada.",[35,184,185],"Sensory Evaluation","Physical Comfort","2025-08-11",{"date":188,"type":50},"2025-08-17",{"date":190,"type":50},"2021-09-30",{"date":192,"type":23},"2025-12-31",{"name":194,"class":57},"Mount Saint Vincent University"]