[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sciatic-radiculopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sciatic-radiculopathy":36},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,56,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":39,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100648278","acute-effects-of-neurodynamics-on-strength-and-endurance-in-athletes-100648278",false,"NCT07721220","Acute Effects of Neurodynamics on Strength and Endurance in Athletes","Acute Effects of Neurodynamics on Strength and Endurance in Athletes: A Randomized Control Trial","Inclusion Criteria:\n\n* Participants must be between 18 and 30 years of age.\n* Must be able to read, understand, and provide informed consent, in English.\n* Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).\n* Medically stable with no known contraindications to physical exertion.\n* Cleared for participation in strength or maximal-effort isometric testing.\n* Be able to perform lower extremity isometric testing without pain that limits maximal effort.\n* Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.\n* No medical condition that significantly alters lower extremity neuromuscular performance.\n* No history of lower extremity surgery in the past 12 months.\n\nExclusion Criteria:\n\n* Individuals younger than 18 or older than 30.\n* Acute lower extremity injury in the last 12 weeks.\n* Lower extremity surgery within the last 12 months.\n* Pain in either lower extremity that would limit maximal physical exertion.\n* History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.\n* Use of medications that significantly impact neuromuscular performance, strength or fatigue.\n* No supplementation that affects neuromuscular performance, strength, or fatigue.\n* Unable to read and understand English.\n* Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.",true,"ALL","18 Years","30 Years",{"count":21,"type":22},45,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.",[28,29,30,31,32,33,34,35,36,37,38],"Sciatic Leg Pain","Hamstring Muscle Tightness","Hamstring Muscle Strain","Hamstring Muscle Strength","Hamstring Injuries","Hamstring Injury Prevention","Hamstring Rupture","Sciatic Nerve Injury","Sciatic Radiculopathy","Lumbar Disc Herniation With Radiculopathy","Lumbar Disc Herniation",[40,41,42],"hamstring","sciatic nerve","athlete","RECRUITING","2026-07-20",{"date":46,"type":47},"2026-07-22","ACTUAL",{"date":49,"type":47},"2026-06-15",{"date":51,"type":22},"2026-07",{"name":53,"class":54},"High Point University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":5},"100613260","phase-1-study-to-evaluate-safety-of-c-1101-versus-sterile-saline-in-adults-with-chronic-painful-lumbosacral-radiculopathy-100613260","NCT07264270","Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","Inclusion Criteria:\n\n* Diagnosis of painful LSR (sciatica) radiating to or below the knee, with an inadequate response to conservative care\n* Body mass index \\\u003C 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Presence of clinically significant disease or any other painful condition that may interfere with assessments.\n* Any condition that currently requires blood or platelet transfusions.\n* Diagnosed with schizophrenia, bipolar disorder, or major depressive disorder.\n* Increased risk of bleeding or is taking anticoagulants or platelet aggregation inhibitors.\n* History or presence of autonomic neuropathy, diabetic neuropathy, or other peripheral neuropathies.\n* History of myocardial infarction within the last 6 months or congestive heart failure.\n* The presence of an active malignancy or tumor.\n* Have undergone a surgical procedure for back pain.\n* Recent use of immunosuppressants, oral steroids, or intravenous steroids.","65 Years",{"count":65,"type":22},24,[67],"PHASE1","The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline",[70,36,28,71,72,73],"Lumbosacral Radicular Pain","Sciatica","Lumbosacral Radicular Syndrome","Lumbosacral Radiculopathy",[71,75,76,77,73,78,79,80],"Sciatic Nerve Pain","LSR","back pain","Chronic Painful Lumbosacral Radiculopathy","non-opioid pain medication","transforaminal epidural injection","2026-03-16",{"date":83,"type":47},"2026-03-17",{"date":85,"type":47},"2025-12-03",{"date":87,"type":22},"2026-12-01",{"name":89,"class":90},"Consano Bio","INDUSTRY",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":119,"locationsCount":121},"100356729","transforaminal-epidural-injection-in-acute-sciatica-100356729","NCT03924791","Transforaminal Epidural Injection in Acute Sciatica","TEIAS","Inclusion Criteria:\n\n* Diagnosed with sciatica by GP\n* NRS leg pain of 6 or more on a 10-point NRS scale\n* Minimum duration of symptoms of 3 weeks and maximum duration of 8 weeks\n\nExclusion Criteria:\n\n* Age under 18 years\n* Condition preventing to receive transforaminal epidural injection\n* Severe scoliosis\n* Transforaminal epidural injection received in 6 months before randomization date\n* Surgery for sciatica at the same level\n* Surgery for sciatica at another level within one year before inclusion\n* Pregnancy",{"count":99,"type":22},142,[25],"Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery. However, patients may experience severe discomfort due to pain in the leg which can lead to decreased physical activity and socio-economic problems. An adequate therapy to alleviate symptoms during this period of 'wait-and-see' is lacking. In this study, patients will be randomized to treatment with transforaminal epidural injections or standard oral pain medication.",[71,103,36],"Sciatica Due to Intervertebral Disc Disorder",[71,105,106,107,108,109,110,111,112],"Acute sciatica","Transforaminal epidural injection","Leg pain","Lumbar spine","Back pain","Lumbar surgery","Herniated intervertebral lumbar disk","Cost-effectiveness","2023-10-18",{"date":115,"type":47},"2023-10-19",{"date":117,"type":47},"2019-06-01",{"date":51,"type":22},{"name":120,"class":54},"C.L.A.Vleggeert-Lankamp",2]