[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sepsis-associated-encephalopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sepsis-associated-encephalopathy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100651520","eeg-changes-and-cognitive-profiles-in-sepsis-patients-with-different-inflammatory-phenotypes-100651520",false,"NCT07760415","EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes","Electroencephalogram Changes and Cognitive Function Profiles in Sepsis Patients With Different Inflammatory Phenotypes","Inclusion Criteria:\n\n* Age ≥18 years and ≤90 years\n* First-time admission to the Intensive Care Unit (ICU)\n* Diagnosis of sepsis according to Sepsis-3.0 criteria (documented or clinically suspected infection plus Sequential Organ Failure Assessment \\[SOFA\\] score ≥2 points)\n* Expected ICU survival time ≥24 hours\n* Written informed consent provided by the patient or legal surrogate\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Cardiopulmonary-cerebral resuscitation (CPCR) performed during the current hospital admission\n* Pre-existing primary central nervous system (CNS) diseases, including:\n\nAcute cerebrovascular disease (e.g., hemiplegia, cranial nerve palsy) Central nervous system infection (e.g., pleocytosis in cerebrospinal fluid) Organic or metabolic encephalopathy (e.g., hepatic, renal, pulmonary, pancreatic, or severe inherited metabolic disorders) Drug-related encephalopathy (e.g., antipsychotic-associated encephalopathy, serotonin syndrome, neurotoxic antibiotics) Other structural or immunological brain diseases (e.g., traumatic brain injury, intracranial neoplasm, autoimmune encephalopathy)\n\n\\- Inability to cooperate with or tolerate scalp EEG electrode placement (e.g., extensive scalp trauma or open scalp infection)","ALL","18 Years","90 Years",{"count":20,"type":21},78,"ESTIMATED","OBSERVATIONAL","To characterize the electroencephalogram (EEG) features of sepsis patients with distinct inflammatory response phenotypes, dynamically track their evolutionary trajectories, and analyze their associations with long-term changes in cognitive function.",[25,26,27,28],"Sepsis","Sepsis Associated Encephalopathy","Sepsis and Septic Shock","Sepsis at Intensive Care Unit",[25,30,31,32,33],"Sepsis-Associated Encephalopathy","Electroencephalogram","Inflammatory Phenotype","Cognitive Dysfunction","NOT_YET_RECRUITING","2026-08-08",{"date":37,"type":38},"2026-08-12","ACTUAL",{"date":40,"type":21},"2026-08-01",{"date":42,"type":21},"2027-05-01",{"name":44,"class":45},"Xiangya Hospital of Central South University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100380196","establishment-of-a-cohort-of-patients-with-sepsis-associated-encephalopathy-sae-100380196","NCT04230447","Establishment of a Cohort of Patients With Sepsis-associated Encephalopathy (SAE)","Peking Union Medical College Hospital","SAE","Inclusion criteria:\n\n1. sepsis 3.0 diagnostic criteria;\n2. Estimated length of hospital stay\\> 24h;\n3. ages 18-89;\n4. Acute brain dysfunction: delirium, coma, epilepsy, focal neurological deficit;\n5. Patients who meet the non-infectious SIRS diagnostic criteria\n\nExclusion criteria:\n\n1. Diagnosis of patients with brain injury before admission, including Alzheimer's disease, craniocerebral injury, etc .;\n2. Primary brain injury (cerebral hemorrhage, cerebral infarction, etc.), secondary brain injury (liver brain, lung brain, uremia encephalopathy, pancreatic encephalopathy, metabolic encephalopathy, Wake encephalopathy, etc.);\n3. pregnant and lactating women;\n4. Those who have undergone bypass surgery in the past 3 months;\n5. Hearing and vision impairment;\n6. mental illness and melanoma;\n7. Abnormal coagulation, active bleeding\n8. Patients with infection at lumbar puncture site\n9. Meningeal leukemia patients\n10. Patients with other types of encephalopathy","89 Years",{"count":57,"type":21},3000,"In this study, the researcher involved the sepsis patients(defined by sepsis 3.0) in Peking Union Medical College Hospital. The SAE was defined as the Glasgow Coma Scale (GCS) score of less than 15 and the Non-SAE group GCS = 15. The control group was the non-infectious patients with acute disease strikes and the healthy control. After the sample collection, the RNA-sequence, metabolites and cytokines were under detection.",[30],[61],"Sepsis-associated encephalopathy","RECRUITING","2023-06-12",{"date":65,"type":38},"2023-06-15",{"date":67,"type":38},"2021-02-01",{"date":69,"type":21},"2030-01-14",{"name":71,"class":45},"Yi Li, MD"]