[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"serious-illness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:serious-illness":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100650418","phase-1-ai-dbt-for-serious-illness-100650418",false,"NCT07748312","AI-DBT For Serious Illness","Pilot Testing AI-Delivered Dialectical Behavioral Therapy Skills and Coaching in Older Patients With Serious Illness","Inclusion Criteria:1) Aged 60+, 2) diagnosis of serious, life limiting illness including stage 4 breast, prostate, or colon cancer; stage 3b or 4 lung or blood cancer, New York Heart Association Stage 3 or 4 CHF, or COPD with hypercapnia74 or CKD stage 4 or ESRD; 3) psychological distress rated 4 or higher on the distress thermometer;75-77 4.) has access to a mobile phone and 5.) speaks English or Spanish fluently.\n\n\\-\n\nExclusion Criteria:\n\n\\-","ALL","60 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","Lay \u002F General Audience Summary Many older adults living with serious illnesses experience high levels of emotional distress, including anxiety, sadness, fear, and feeling overwhelmed. These feelings often worsen as illness progresses and can make physical symptoms harder to manage, reduce quality of life, and increase the use of medications. Unfortunately, many people with serious illness cannot access mental health care because there are not enough providers, services are hard to reach, appointments are physically exhausting, or care is not available in their language.\n\nThis study will test a new way of delivering emotional support that does not require in-person therapy. The program teaches practical coping skills that help people manage strong emotions and stress. These skills are delivered through short videos and daily supportive check-ins using an automated phone or text system that people can use from home. The system is available in many languages and can be used on basic mobile phones, making it accessible to a wide range of patients.\n\nWe will enroll older adults with serious illnesses such as cancer, heart disease, lung disease, or kidney disease who are experiencing emotional distress. Participants will be randomly assigned to receive either their usual medical care alone or usual care plus the new skills program. We will examine whether people find the program easy to use, helpful, and acceptable, and whether it improves their confidence in managing difficult emotions and reduces distress.\n\nThe goal of this project is to develop a low-burden, widely accessible way to support emotional well-being for people living with serious illness. If successful, this approach could expand access to mental health support for patients who currently have few options.",[26,27,28],"Serious Illness","Distress, Emotional","Distress",[30,31,32,33,34],"serious illness","mental health","AI","DBT","distress","NOT_YET_RECRUITING","2026-08-03",{"date":38,"type":39},"2026-08-05","ACTUAL",{"date":41,"type":20},"2026-10-01",{"date":43,"type":20},"2028-05-15",{"name":45,"class":46},"Rutgers, The State University of New Jersey","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100593651","ai-assisted-personalized-legacy-program-reflections-my-story-for-patients-with-serious-illness-100593651","NCT07009210","AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness","Feasibility and Acceptability of AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness","Participant population: Adults with serious illness - defined as a health condition that carries a high risk of mortality\n\nInclusion Criteria for patients:\n\n1. Age ≥18 years\n2. English fluency\n3. Provide informed consent\n4. Ability to complete questionnaire(s) by themselves or with assistance\n\nExclusion Criteria:\n\n1. Other psychological co-morbidities such as untreated schizophrenia, bipolar disease\n2. Recent suicide attempt or psychiatric illness severe enough that hospitalization has been necessary in last 6 months\n3. Active delirium\n4. Advanced dementia\n5. Participation in concurrent legacy offerings through the palliative care clinic","18 Years",{"count":56,"type":20},20,[58],"NA","The purpose of this study is to determine if it is feasible and acceptable to recruit for and deliver the AI Assisted Personalized Legacy Program intervention to patients with serious illness.",[26,61],"Existential Distress",[63],"Legacy Work","RECRUITING","2026-06-15",{"date":67,"type":39},"2026-06-17",{"date":69,"type":39},"2025-08-11",{"date":71,"type":20},"2027-06-30",{"name":73,"class":46},"Mayo Clinic",2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":74},"100580545","participatory-approaches-to-qualitative-research-paq-comparing-two-approaches-to-patient-public-and-clinician-involvement-in-qualitative-research-100580545","NCT06838689","Participatory Approaches to Qualitative Research (PAQ): Comparing Two Approaches to Patient, Public and Clinician Involvement in Qualitative Research","Participatory Approach to Qualitative Research (PAQ): Comparing Two Methods of Engaging Stakeholders in Qualitative Research","PAQ","Inclusion criteria \\& Exclusion criteria across three sub-specialties:\n\nPediatric mental health\n\nInclusion:\n\n* Adults aged ≥18 years\n* Can communicate in English\n* Able to take part in research activities via a computer or a smartphone\n* Patients, care partners, clinicians, other healthcare professionals, teachers and school staff, health policy experts, and community members\n* Has lived experience or professional expertise relating to pediatric mental health\n\nExclusion:\n\n* Children \\\u003C18 years\n* Cannot communicate in English\n* Adults unable to provide verbal consent\n* Prisoners\n* Unable to take part in research activities via a computer or a smartphone\n\nGeneralized cancer screening\n\nInclusion:\n\n* Adults aged ≥21 years\n* Can communicate in English\n* Able to take part in research activities via a computer or a smartphone\n* Patients, care partners, clinicians, other healthcare professionals, health policy experts, and community members\n* Is eligible for population-based cancer screening tests (breast, prostate, cervical, colorectal cancer), or has lived experience or professional expertise relating to generalized cancer screening\n\nExclusion:\n\n* Children \\\u003C18 years\n* Cannot communicate in English\n* Adults unable to provide verbal consent\n* Prisoners\n* Unable to take part in research activities via a computer or a smartphone\n\nSerious illness experience\n\nInclusion:\n\n* Adults aged ≥18 years\n* Can communicate in English\n* Able to take part in research activities via a computer or a smartphone\n* Patients, care partners, clinicians, other healthcare professionals, health policy experts, and community members\n* Has lived experience or professional expertise relating to serious illness (defined as \"a health condition that carries a high risk of mortality and either negatively impacts a person's daily functioning or quality of life or excessively strains his or her caregivers.\"\n\nExclusion:\n\n* Children \\\u003C18 years\n* Cannot communicate in English\n* Adults unable to provide verbal consent\n* Prisoners\n* Unable to take part in research activities via a computer or a smartphone\n\nNote: We will not specifically exclude pregnant women, so they may be included incidentally.",{"count":84,"type":20},136,[58],"The goal of this trial is to compare two types of patient, public and clinician involvement (PPCI) in research: Consultative PPCI and Collaborative PPCI.\n\nThe study team will compare these methods of PPCI in a randomized clinical trial (RCT) in which PPCI participants will engage with research teams on one of three real qualitative research interview studies addressing topics: 1) pediatric mental health, 2) cancer screening and 3) serious illness. Qualitative interviews are conversations with people about their experiences and perspectives. In all three qualitative studies, PPCI participants will help us at every stage of the research, from design (making choices about how to set up the study) through dissemination (sharing findings).\n\nThe researchers do not know about any quantitative (numbers) evidence from RCTs about how well different PPCI approaches work. As far as the study team knows, this is the first RCT of PPCI approaches. Given this gap in knowledge, the research question is: How does a Consultative PPCI approach compare to a Collaborative PPCI approach in increasing engagement and partnership trust in research, particularly among historically underrepresented groups? The researchers' best guess (hypothesis), considering the information available, is that Collaborative PPCI will increase PPCI participant engagement, trust and the patient-centeredness of research more than Consultative PPCI.",[88,89,26],"Pediatric Mental Health Services","Cancer Screening",[91,92,93],"Pediatric mental health","Serious illness in elderly patients","cancer screening","2025-11-18",{"date":96,"type":39},"2025-11-19",{"date":98,"type":39},"2025-09-01",{"date":100,"type":20},"2027-10-31",{"name":102,"class":46},"Dartmouth-Hitchcock Medical Center"]